Yu dɔn ɛva yɛri di nem ‘Monoclonal Antibody’? Yu go dɔn yɛri dɛn de yuz dis nem as tritmɛnt fɔ kansa, ɔ fɔ sik dɛn lɛk Covid-19. Pan ɔl we na smɔl strenj ɛn big wɔd, dis na rili wan kayn mɛrɛsin we dɔn mek wan wɔndaful rivɔlɔshɔn pan wi mɛrɛsin. Nɔ wɔri, dis nɔ at fɔ ɔndastand. Tide, lɛ wi tɔk jɔs bɔt wetin na dɛn tin ya, aw dɛn de wok, ɛn us sik dɛn de yus fɔ.
Fɔ tɔk am simpul wan, wetin na monoklɔnal antibodi dɛn?
fכ כndastand dis, lε wi fכs lan bכt sכmtin we wi gεt na wi bכdi: ‘Antibodies’.
Imajin se wi bɔdi na kɔntri. Dɔn wi imyun sistɛm na di ami fɔ da kɔntri de. Dɛn kɔl di spɛshal sojaman dɛn we de na dis ami ‘Antibodies’. We ɛnimi we kɔmɔt na do, dat na sɔntin lɛk jem ɔ kansa sɛl (insay mɛrɛsin wi kin kɔl dɛn antijen ya ) kam insay di bɔdi, dɛn sojaman dɛn ya kin go ɛn kech da ɛnimi de ɛn gi sayn to ɔda sɛl dɛn fɔ pwɛl am.
naw, ‘monoclonal antibodies’ na spεshal tכp antibodi we wi de mek na labכtכri. Dɛn tin ya tan lɛk kɔpi dɛn fɔ di antibodi dɛn we wi gɛt na wi bɔdi.
- ‘Mono’ min ‘wan’.
- ‘Klɔnal’ min ‘klɔn’.
dat min se dεn lεk bכku ‘fכtokכpi' dεm fכ di sem antibodi. Dɛn mek dɛn fɔ atak wan patikyula ɛnimi nɔmɔ (antijen). Fɔ ɛgzampul, dɛn kin mek antibodi dɛn fɔ atak wan patikyula prɔtin nɔmɔ we de na di say we di kansa sɛl de. Yu kin si di nem dɛm fɔ dɛn drɔgs ya dɔn wit "mab" (e.g. Trastuzumab, Rituximab).
Fɔ tɔk am simpul wan, monoklɔnal antibodi na ‘mishɔl’ we dɛn mek na lɛbɔraytri fɔ pwɛl wan patikyula ɛnimi ɛn we nɔ de ɛva mis dɛn target.
Us kayn sik dɛn kin trit wit dɛn tin ya?
Naw dɛn de yuz dis teknɔlɔji fɔ mɛn bɔku bɔku sik dɛn. Frɔm we dɛn bin gri fɔ yuz di fɔs monoklɔnal antibodi drɔg insay 1986, dɛn dɔn mek bɔku bɔku mɛrɛsin dɛn.
| Di sik kategori | Diskripshɔn ɛn ɛgzampul dɛn |
|---|---|
| Kansa | Fɔ tɔch ɛn pwɛl di kansa sɛl dɛm lɛk bɔdi kansa, limfoma, ɛn lukimiya. |
| Dizayd dɛn we de mek pɔsin nɔ ebul fɔ fɛt insɛf | fכ kכntrכl di כva aktiviti fכ di imyun sistεm pan kכndishכn dεm lεk rεumatoid atraytis εn Krכn sik. |
| Infεkshכn dεm | Fɔ mek dɛn nɔ gɛt ɛn fɛt di vayrɔs dɛn lɛk di COVID-19 vayrɔs. |
| Ɔgan Transplant Rijɛkt | Fɔ mek di bɔdi nɔ rijek wan ɔgan lɛk kidni afta dɛn dɔn transplant am. |
| Ɔda sik dɛn | Dɛn kin yuz am bak fɔ ɔstioporosis, maygren, ay kɔlɔstrel, sɔm yay sik dɛn, ɛn sik dɛn na di nervɔs sistɛm. |
Aw dɛn kin gi dis tritmɛnt?
Bɔku tɛm dɛn kin gi dis mɛrɛsin as salin sɔlvushɔn insay wan vein (intravenous - IV) . Dɛn kin kɔl dis bak ‘infushɔn’. I go mɔs bi se dɛn go admit yu na ɔspitul ɔ klinik ‘infusion center’ fɔ wan de ɛn gi yu dis tritmɛnt fɔ sɔm awa.
- Fɔs tritmɛnt: If na di fɔs tɛm we yu de du dis tritmɛnt, yu kin aks yu fambul fɔ kam wit yu. Dis na bikɔs di dɔktɔ dɛn go de pe spɛshal atɛnshɔn to yu fɔ ɛksplen di tritmɛnt ɛn fɔ chɛk fɔ ɛni alɛji.
- Injεkshכn כnda di skin: sכmtεm, dεn kin gi dis mεdisin bak as injεkshכn כnda di skin (subkutan) . If na so i bi, yu dɔktɔ ɔ nɔs go sho yu aw fɔ injekt am yusɛf. Dɛn kin gi dɛn tin ya na di bɛlɛ ɔ di shɔl.
Di kayn we aw dɛn kin trit pɔsin
Dɛn kin yuz dɛn antibodi ya difrɛn we dɛn:
1. Naked Monoclonal Antibodies: Dɛn wan ya na tritmɛnt we de fɔ dɛnsɛf. Dɛn kin go dairekt to ɛn atak tin dɛn lɛk kansa sɛl dɛn, we kin stɔp dɛn fɔ gro ɔ gi sayn to di imyun sistɛm fɔ pwɛl dɛn.
2. Kɔnjɔgɛt Mɔnoklɔnal Antibɔdi dɛn:Dɛn tin ya tan lɛk ‘parsel’. Dɛn kin tay wan kemotɛrapi drɔg ɔ wan redioaktiv patikyula pan di antibodi ɛn sɛn am. di antibodi de fכn di εksakεt kεnsar sεl εn de ‘delivεr’ dis ‘pasεl’ de. Dis kin mek di sɛl dɛn we gɛt wɛlbɔdi nɔ pwɛl bɛtɛ.
3. Bispecific Monoclonal Antibodies: dεn kin atak tu tכgεt dεm wan tεm. I tan lɛk se yu gɛt tu an we de du tu wok. Fɔ ɛgzampul, we i de ol wan kansa sɛl wit wan an, di ɔda an de ol wan imyun sɛl, we de kɔnɛkt di tu togɛda ɛn ɛp fɔ pwɛl di kansa sɛl.
Wetin na di bɛnifit ɛn prɔblɛm dɛn we dis tritmɛnt de gi?
Di bɛnifit dɛn we pɔsin kin gɛt
- di tכgεt na spεsifi k: Tradishכnal tritmεnt lεk kεmothεrapi de pwεl כl di sεl dεm we de sheb kwik kwik wan (kansa sεl dεm εn bak hεlty ia εn skin sεl dεm). Bɔt bikɔs dɛn tin ya kin atak di sɛl dɛn nɔmɔ we de insay di sik dairekt wan, di sayd ɛfɛkt dɛn nɔ kin bɔku.
- Mɔ wok: Dɛn tin ya dɔn rili ebul fɔ mɛn sɔm sik dɛn, mɔ di kansa dɛn.
- Di sem standad: Bikɔs dɛn mek am na lɛbɔtri, ɔl di mɛrɛsin dɛn gɛt di sem kwaliti.
Risk dɛn we kin apin
Jɔs lɛk ɛni ɔda mɛrɛsin, dis tritmɛnt kin gɛt sɔm prɔblɛm dɛn. Bɔt nɔ wɔri, yu dɔktɔ go tich yu bɔt ɔl dis ɛn tek kia ɔf yu gud gud wan.
- Riakshɔn dɛn we pɔsin kin du wit di infushɔn: Dɛn tin ya na di kɔmɔn tin dɛn we kin apin we dɛn infuz am ɔ jɔs afta di infushɔn. Dɛn tin ya kin bi we yu bɔdi kin at, fiva, kol, i nɔ kin izi fɔ blo, yu kin swet, ɛn yu blɔd prɛshɔn kin chenj. כltεm dεn kin kכntro dεm bay we dεn slo di infushכn rεt.
- Siriɔs riakshɔn (rare): I nɔ kin apin so ɔltɛm, bɔt siriɔs riakshɔn kin apin.
- Akyu Anafylaksis: Na bad bad alɛji we kin apin wantɛm wantɛm.
- Saytokin Rilis Sindrom (CRS): di imyun sistεm kin bi ova aktif εn pwεl di כgan dεm.
- Sɛrum Siknɛs: Na atak we di bɔdi in imyun sistɛm de atak di mɛrɛsin.
Na bikɔs tin dɛn lɛk dis kin apin we di dɔktɔ ɛn nɔs dɛn kin rili tek tɛm wit yu, mɔ we dɛn de trit yu fɔ di fɔs tɛm.
Yu want fɔ tɔk to di dɔktɔ?
Yɛs, na fɔ tru. If yu gɛt ɛni kwɛstyɔn bɔt dis tritmɛnt, ɔ if yu want fɔ no if dis tritmɛnt fayn fɔ yu, tɔk to yu dɔktɔ opin wan. I go gi yu di bɛst advays bay aw yu de mɛn ɛn aw yu gɛt wɛlbɔdi.
Impɔtant: If yu gɛt sɔntin we yu nɔ bin de ɛkspɛkt afta yu dɔn gɛt tritmɛnt, mɔIf yu gɛt prɔblɛm fɔ blo, yu chɛst de pen, yu gɛt bad bad brus, yu nɔ ebul fɔ tɔk, ɔ yu chenj yu maynd, kɔl yu dɔktɔ wantɛm wantɛm, ɔ go na di Imejɛnsi Dipatmɛnt (ETU) na di ɔspitul we de nia yu.
Mɛsej we dɛn kin kɛr go na os
- monoklonal antibodi dεm na spεshal kayn protin we dεn mek na lab we de wok lεk pat dεm na wi yon imyun sistεm.
- Dɛn tin ya na wan we we dɛn kin yuz tide ɛn we kin wok fayn fɔ mɛn difrɛn sik dɛn, lɛk kansa, at at sik, ɛn COVID-19.
- Bikɔs dis tritmɛnt de wok pan di target, i kin gɛt smɔl sayd ɛfɛkt pas di tradishɔnal tritmɛnt dɛn.
- Riakshɔn lɛk fiva ɛn rash kin apin we dɛn gi di mɛrɛsin. Bɔt, siriɔs sayd ɛfɛkt dɛn nɔ kin apin so ɔltɛm.
- Ɔltɛm tɔk to yu dɔktɔ if dis tritmɛnt fayn fɔ yu ɛn wetin i fayn ɛn bad.
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