Yu blɔd sɛl dɛn nɔ de fɔm fayn? Lɛ wi lan bɔt di sik we dɛn kɔl Myelodysplastic Syndrome (MDS)!

Yu kin fil taya ɛn taya ɔltɛm? Sɔntɛnde, i nɔ kin izi fɔ yu fɔ blo ivin afta yu dɔn du smɔl wok? Ɔ yu notis brus ɛn blɔd de kɔmɔt ɔlsay na yu bɔdi? Pan ɔl we yu tink se dɛn tin ya na nɔmal tin, sɔntɛnde, rizin kin de biɛn dis we yu fɔ wɔri bɔt smɔl. Tide wi go tɔk bɔt wan pan dɛn kayn tin ya, we na myelodysplastic syndrome.

Wetin na maylodisplastik sindrom (MDS)?

Naw lɛ wi si wetin na dis Myelodysplastic Syndrome (MDS). Sɔm pipul dɛn kin kɔl am bak Myelodysplasia. Dis biɛn tɛm, dɛn kin kɔl am bak Myelodysplastic Neoplasm. Fɔ tɔk am simpul wan, na wan kayn kansa . bכt wetin de apin insay dis na dat di bεsik sεl dεm we de mek bכdi na wi bכdi – we wi kכl dεm (hεmatopoietic stem cells) – nכ de machכ fayn, dat min se dεn nכ de gro fayn fayn wan. Dɛn sɛl ya de na wi bon mɛro. So di prɔblɛm kin bigin we dɛn bɛsis sɛl ya nɔ de divɛlɔp fayn ɛn bi wɛlbɔdi rɛd blɔd sɛl, wayt blɔd sɛl, ɛn pletlɛt.

We yu bɔdi nɔ gɛt bɛtɛ wɛlbɔdi blɔd sɛl, yu kin gɛt siriɔs sik lɛk anemia. Yu kin gɛt infɛkshɔn bak bɔku tɛm ɛn blɔd bɔku tɛm. Insay sɔm pipul dɛn, MDS kin wɔs ɛn tɔn to kansa we dɛn kɔl akyu mayloid lukimiya (AML) .

Dis sik we dɛn kɔl MDS, nɔ kin apin so ɔltɛm . Insay Amɛrika, i kin ambɔg lɛk 4 pipul dɛn pan ɛvri 100,000 pipul dɛn ɛvri ia. If dɛn no se yu gɛt MDS, yu dɔktɔ dɛn go tray fɔ mek di sik nɔ go bifo kwik kwik wan, kɔntrol di sayn dɛn we yu gɛt, ɛn trit ɛni prɔblɛm we go kam.

Us kayn MDS de?

Dɔktɔ dɛn kin sheb dis MDS kɔndishɔn to difrɛn kayn dɛn. Dɛn kin luk di rizɔlt fɔ sɔm tɛst dɛn. Lɛ wi tek wan luk pan wetin dɛn tɛst dɛn de luk fɔ:

• Rɛd ɛn wayt blɔd sɛl dɛn we gɛt wɛlbɔdi ɛn di pletlɛt dɛn kɔnt: We yu rɛd blɔd sɛl dɛn nɔ bɔku, wi kin kɔl am anemia. Yu kin fil taya bad bad wan ɛn yu nɔ kin ebul fɔ blo fayn.
• Blɔd sɛl dɛn we nɔ machɔ, ɔ blast: Dɛn blast ya tan lɛk blɔd sɛl dɛn we nɔ machɔ. Dɛn kin tek tumɔs ples na di bon mɛro, ɛn dis kin mek i nɔ izi fɔ mek di blɔd sɛl dɛn we gɛt wɛlbɔdi. If yu nɔ gɛt bɛtɛ wayt blɔd sɛl dɛn we gɛt wɛlbɔdi, yu kin gɛt infɛkshɔn bɔku tɛm. Ɛn if yu nɔ gɛt bɛtɛ pletlɛt we gɛt wɛlbɔdi, i kin at fɔ lɛ yu stɔp fɔ blɔd.
• Sideroblast dɛn: .Dis na rɛd blɔd sɛl dɛn we nɔ machɔ. Wetin spɛshal bɔt dɛn na dat, instead fɔ yuz ayɛn fɔ mek ɛmoglobin, dɛn kin kip ayɛn. Yu no, ɛmoglobin na wan prɔtin we de ɛp wi rɛd blɔd sɛl dɛn fɔ kɛr ɔksijɛn go ɔlsay na di bɔdi. Ayɛn impɔtant fɔ dis. So, if di wan dɛn we de stɔdi bɔt sik dɛn si dɛn sideroblast ya, dat min se yu ɛmoglobin nɔ de wok fayn.
• di kromozom abnכmaliti: Kromozom na di pat dεm na wi sεl dεm we gεt jin dεm. Na DNA mek di jin dɛn. If tin nɔ de na dɛn kromozom ya, dat min se sɔntin dɔn afɛkt yu DNA ɛn mek di kromozom dɛn we de na yu blɔd sɛl dɛn chenj.

Wetin na di sayn dɛm fɔ di maylodysplastic syndrome?

Mɛmba se, sɔmtɛm yu kin gɛt MDS we yu nɔr sho ɛni sayn. Insay dɛn kayn tin ya, dɛn kin no di sik bay we dɛn de du blɔd tɛst ɔltɛm. Di men sayn we bɔku pipul dɛn kin gɛt na we dɛn nɔ kin gɛt bɛtɛ rɛd blɔd sɛl, ɔ we nɔ gɛt bɛtɛ blɔd. Bɔt di sayn dɛm fɔ anemia ɛn ɔda sayn dɛm fɔ MDS kin tan lɛk ɔda sik dɛm wae nɔr kin siriɔs.

So, if yu notis ɛni wan pan di chenj dɛn we de dɔŋ ya, mɔ if dɛn nɔ go afta sɔm wiks, mek shɔ se yu go to dɔktɔ.

• If yu fil se yu nɔ ebul fɔ blo (wi kin kɔl dis dispnea).
• If yu fil wik ɔ taya pasmak , ɛn di taya nɔ de stɔp ivin afta yu dɔn rɛst bɔku.
• If yu notis se yu skin dɔn pal pas aw i kin bi. Sɔntɛm if yu gɛt dak skin, di dɔktɔ go chɛk fɔ si if ɛni kɔlɔ dɔn lɔs insay yu yaylid dɛn we de dɔŋ, insay yu mɔt, ɛn insay yu nos.
• If yu brus ɔ blɔd izi pas aw yu kin blɔd.
• If yu notis smɔl smɔl rɛd dɔt dɛn we gɛt pin-point na yu skin, dɛn tin ya kin bi petechiae, we na smɔl smɔl blɔd vesel dɛn we de ɔnda di skin.
• If bɔku tɛm yu kin gɛt infɛkshɔn wit fiva .

Wetin kin mek pɔsin gɛt MDS?

I tan lɛk se tu men we dɛn de fɔ mek pɔsin gɛt MDS. Wan pan dɛn na bay we yu de du sɔm tin dɛn we de mek yu gɛt dis sik. Di ɔda wan na bay we i gɛt sɔm tin dɛn we pɔsin kin gɛt frɔm in jɛnɛtiks.

Aktiviti dɛm wae kin gɛt fɔ du wit MDS

• We yu dɔn gɛt kemotɛrapi ɔ redyushɔn tɛrapi fɔ wan kansa we yu bin dɔn gɛt trade. Dɔktɔ dɛn kɔl dis MDS we gɛt fɔ du wit di tritmɛnt (tMDS). Tipikli, di simptom dɛm fɔ tMDS kin apia lɛk fayv to sɛvin ia afta di tritmɛnt.
• If yu gɛt sɔm tin dɛn we kin mek yu gɛt kansa, lɛk tabak smok, peshɛnt sayd, ɛn sɔlvɛnt lɛk bɛnzin.
• If yu gɛt ebi ebi mɛtal lɛk mɛkuri ɔ lid.

Di kɔndishɔn dɛn we dɛn kin gɛt frɔm dɛn mama ɛn papa we kin gɛt fɔ du wit MDS

Bitwin 4% ɛn 15% pan di pipul dɛm wae gɛt dis sik dɔn gɛt dɛn jenɛtik kɔndishɔn wae de mek dɛn gɛt dis sik. Dɛn kayn kɔndishɔn dɛn ya na:

• Fanconi anemia: Dis na wan jεnεtik kכndyushכn we nכ kin apin we yu bon mכro nכ de prodyuz inof hεlty bכdi sεl dεm.
• Dyskeratosis congenita: Dis na ɔda kayn jɛnɛtik kɔndishɔn we nɔ kin apin so ɔltɛm. Na ya bak, yu bon mɛro nɔ de mek inof wɛlbɔdi blɔd sɛl dɛn.
• Daymɔnd-Blakfan anemia: Dis na wan sik we nɔ kin apin na di blɔd we nɔ kin apin so ɔltɛm we yu bon mɛro nɔ de mek inof rɛd blɔd sɛl.

Aw dɛn kin no se pɔsin gɛt di sik we dɛn kɔl myelodysplastic syndrome?

Dɔktɔ dɛn kin fala sɔm step dɛn fɔ no dis MDS kɔndishɔn:

• Kɔmplit Blɔd Kɔnt (CBC) ɛn difrɛns tɛst: Dɛn kin tek blɔd sɛmpul frɔm yu ɛn dɛn kin analayz yu rɛd ɛn wayt blɔd sɛl dɛn. I kin kɔnt bak di nɔmba fɔ ɛni kayn wayt blɔd sɛl.
• Peripheral blood smear: Dis kin chɛk fɔ si if di blɔd sɛl dɛn we de na yu blɔd sɛmpul, chenj, di kayn we, shep, ɛn saiz, ɛn i kin chɛk bak if yu rɛd blɔd sɛl dɛn gɛt tumɔs ayɔn.
• Saytojɛnɛtik analisis: Wan mɛdikal patɔlɔjis de luk pan blɔd sɛmpul ɔnda maykroskɔp fɔ si if ɛni chenj de na di kromozom dɛn na yu blɔd sɛl dɛn.
• Bɔn mɛrɔ bayɔpsi: Fɔ du dis tɛst, di dɔktɔ kin put wan nidul we gɛt ol insay yu hip bon, tek wan sɛmpul pan bon mɛrɔ, blɔd, ɛn bon, ɛn chɛk am wit maykroskɔp.

Wetin na di stej dɛm fɔ di maylodysplastic syndrome?

Dɔktɔ dɛn kin sheb di sik to stej dɛn bay di risk we di sik kin mek i bi akyu mayloid lukimiya (AML). Dɛn kin yuz wan risk-skɔring sistɛm we dɛn kɔl di Intanɛshɔnal Prɔgnostik Skɔring Sistɛm (IPSS) . Na sɔm tin dɛn we dɔktɔ dɛn kin tink bɔt:

• If yu gɛt ɛni sayn fɔ se yu nɔ gɛt bɛtɛ blɔd, yu de blɔd, ɔ yu gɛt infekshɔn.
• Yu de pan denja fɔ gɛt lukimiya.
• Sɔm chenj dɛn na yu kromozom dɛn.
• If yu bin gɛt MDS afta yu dɔn gɛt kemotɛrapi ɔ redyushɔn tɛrapi fɔ kansa.
• Yu ej ɛn yu jenɛral wɛlbɔdi.

Aw dɛn kin trit di sik we dɛn kɔl myelodysplastic syndrome?

Dɔktɔ dɛn kin tink bɔt bɔku tin dɛn we dɛn de plan fɔ trit MDS:

• Di kayn MDS we yu gɛt.
• If yu gɛt kɔndishɔn lɛk anemia, blɔd, ɔ infɛkshɔn bikɔs ɔf MDS.
• If yu bin gɛt MDS afta yu dɔn gɛt kemotɛrapi ɔ redyushɔn tɛrapi fɔ kansa.
• yu ej.
• Yu jenɛral wɛlbɔdi.

Di tritmɛnt fɔ myelodysplastic syndrome kin inklud sɔpɔt fɔ kia ɛn tritmɛnt dɛn we de pwɛl di blɔd sɛl dɛn we nɔ fayn .

Sɔpɔtiv Keya

Dis kin inklud:

• Blɔd transfyushɔn ɔ blɔd gi: If yu gɛt anemia, yu kin gɛt rɛd blɔd sɛl. If yu gɛt prɔblɛm wit blɔd, yu kin gɛt pletlɛt transfyushɔn.
• Erythropoiesis-stimulating agents (ESA): Dis tritmɛnt de mek yu gɛt mɔ machɔ rɛd blɔd sɛl dɛn.
• Antibayɔtik: MDS kin afɛkt yu wayt blɔd sɛl dɛn, ɛn dis kin mek yu gɛt mɔ sik. So, dɛn kin gi am antibayɔtik.

Tritmɛnt fɔ pul di blɔd sɛl dɛn we nɔ fayn

Dis kin inklud:

• Kimotɛrapi: Dɛn kin yuz di sem kayn kemotɛrapi we dɛn kin yuz fɔ akyu mayloid lukimiya (AML) fɔ dis.
• Immunosuppressive therapy: Dɛn kin yuz dis tritmɛnt fɔ sɔm sɔbtayp dɛn fɔ MDS. Dis tritmɛnt de stɔp di imyun sistɛm we de wok pasmak ɛn i kin ɛp fɔ ridyus di nid fɔ transfyushɔn blɔd.
• Stem sel transplant: Dis min se yu fɔ chenj yu yon sɛl dɛn we de mek blɔd wit stem sɛl dɛn, we na frɔm yu ɔ pɔsin we gi yu blɔd. Dɛn kin pul dɛn stem sɛl ya frɔm yu blɔd ɔ bon mɛro. Dɛn kin kip dɛn sɛl ya na friza we yu de tek kemotɛrapi, dɔn dɛn kin thaw dɛn ɛn gi dɛn bak insay yu bɔdi tru wan infushɔn we dɛn kin put insay yu bɛlɛ. Dɔn dɛn kin alaw dɛn sɛl ya fɔ gro na yu bɔdi ɛn mek nyu blɔd sɛl dɛn.

Ɛni wan pan dɛn tritmɛnt ya kin gɛt difrɛn sayd ɛfɛkt ɛn kɔmplikeshɔn dɛn. We yu de tink bɔt aw fɔ trit yu, i rili impɔtant fɔ aks yu dɔktɔ bɔt di sayd ɛfɛkt ɛn prɔblɛm dɛn we ɛni we fɔ du am kin gɛt.

Pipul wae gɛt maylodysplasia kin bɛnifit frɔm palliativ kia . Dis kia kin ɛp fɔ mɛn di sayn dɛm fɔ MDS ɛn di sayd ɛfɛkt dɛm we di tritmɛnt kin gɛt. Ɛn di impɔtant tin na dat, i kin ɛp fɔ kɔntrol di strɛs we pɔsin kin gɛt we i de liv wit dis kayn sik we nɔ de mɛn.

Yu tink se dɛn kin mɛn di sik we dɛn kɔl myelodysplastic syndrome?

Di wangren we fɔ mɛn MDS kɔmplit wan na fɔ transplant stem sɛl we go wok fayn . Bɔt i sɔri fɔ no se nɔto ɔlman kin gɛt dis tritmɛnt. Aks yu dɔktɔ if dis kayn transplant fayn fɔ yu ɛn if na opshɔn we yu fɔ tink bɔt.

Wetin na di layf we pɔsin we gɛt myelodysplastic syndrome kin liv?

Myelodysplastic syndrome na siriɔs wɛl bɔdi prɔblɛm wae kin mek pɔrsin gɛt prɔblɛm wit in layf.Dɔn bak, dis na rili kɔmpleks wɛlbɔdi prɔblɛm, ɛn ɔlman kin afɛkt difrɛn we. Yu dɔktɔ na di bɛst say fɔ no bɔt yu wan wan sityueshɔn ɛn di prɔgnosis.

Yu tink se dɛn kin mek dɛn nɔ gɛt di sik we dɛn kɔl myelodysplastic syndrome?

Nɔ, bɔt if yu ɔndastand di tin dɛn we kin mek yu gɛt MDS, dat kin ɛp dɔktɔ dɛn fɔ no ɛn trit MDS kwik kwik wan. Myelodysplastic syndrome kin gɛt fɔ du wit kemotɛrapi ɛn redyushɔn tɛrapi, ɛn bak we pɔsin kin gɛt sɔm kemikal ɛn ebi ebi mɛtal dɛn. Tɔk to yu dɔktɔ bɔt yu mɛdikal histri ɛn ɛni klos, lɔng tɛm we yu de yuz kemikal ɛn ebi mɛtal. Dɛn kin ɛp yu fɔ no aw yu kin gɛt prɔblɛm wit yusɛf.

Aw a kin kia fɔ misɛf?

MDS kin afɛkt ɔlman difrɛn we. Sɔm pipul dɛn gɛt MDS bɔt dɛn nɔr kin gɛt ɛni sayn. If na so i bi fɔ yu, yu dɔktɔ kin tɛl yu fɔ du blɔd tɛst ɛvri tri mɔnt fɔ wach di chenj dɛn we de apin na yu blɔd stem sɛl dɛn. If yu gɛt MDS ɛn yu de gɛt sɔpɔt fɔ kia fɔ yu, lɛk fɔ gi yu blɔd, yu go nid ɔda tritmɛnt dɛn fɔ mek yu nɔ gɛt bɔku blɔd. Na sɔm tin dɛm wae yu kin du fɔ sɔpɔt yu tritmɛnt:

• If yu de yuz tin dɛn we dɛn kin yuz fɔ smok (inklud fɔ smok ɛn fɔ vap), tray fɔ lɛf fɔ smok. Aks yu dɔktɔ bɔt di program dɛn fɔ lɛf fɔ smok.
• Mek yu gɛt wɛlbɔdi wet fɔ yusɛf.
• Fɛn tin dɛn we yu kin du fɔ yu bɔdi we yu lɛk ɛn du dɛn ɔltɛm.
• Mɛmba se MDS na sik we nɔ de mɛn, ɛn dɔktɔ dɛn kin trit am bɔt dɛn nɔ kin mɛn am. Nɔto ɔlman go ɔndastand wetin yu de go tru. Fɔ tɔk to ɔda pipul dɛn we dɔn pas di sem tin dɛn we yu kin du, dat kin ɛp. Yu mɛdikal tim kin ɛp yu fɔ fɛn program ɛn tin dɛn lɛk dis.

Pan ɔl we MDS na sik we nɔ de mɛn, i nɔ min se yu fɔ liv yu layf we yu nɔ gɛt op. Tritmɛnt dɛn de we kin ɛp fɔ kɔntrol di sik.

Ustɛm a fɔ go na di imejensi rum?

Myelodysplastic syndrome kin mek yu nɔ gɛt blɔd, yu gɛt prɔblɛm wit blɔd, ɛn yu gɛt infɛkshɔn. Yu fɔ rili go na di imejensi rum if yu gɛt:

• If yu gɛt fiva we pas 38.3 digri sɛlshiɔs (100.4 digri F) ɔ pas dat, fiva na sayn fɔ sho se yu gɛt infekshɔn.
• If yu de blɔd we yu nɔ ebul fɔ kɔntrol.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Bikɔs myelodysplastic syndrome na wan sik wae nɔr kin bɔrku, yu kin gɛt bɔrku kwɛstyɔn bɔt am. Na sɔm kwɛstyɔn dɛn we yu kin aks yu dɔktɔ:

• Yu tink se MDS na kansa?
• Aw MDS kin afɛkt mi?
• Yu tink se mi MDS go mek a gɛt siriɔs wɛlbɔdi prɔblɛm? If na so i bi, us kayn?
• A nɔ gɛt ɛni simptom. Wetin a kin du fɔ delay di divɛlɔpmɛnt fɔ di kɔndishɔn dɛn we gɛt fɔ du wit MDS?

Faynal Mɛsej fɔ Tek-Hom

If yu gɛt myelodysplastic syndrome (MDS), na wan kayn kansa we na wan sik we nɔ de mɛn. Nɔr sik nɔr kin izi, bɔt fɔ liv wit wan sik wae nɔr de mɛn min fɔ dil wit de pwɛl hat sik wae e kin gɛt. Bɔt fɔ liv wit MDS nɔ min se yu fɔ giv ɔp op. Tritmɛnt dɛn de we kin ɛp fɔ kɔntrol MDS. Yu kin fit fɔ gɛt klinik trial we de luk fɔ nyu tritmɛnt fɔ myelodysplastic syndrome. Tin dɛn de bak we yu kin du fɔ yusɛf. Aks yu dɔktɔ bɔt aw yu de chenj yu layf, lɛk fɔ it fayn ɛn fɔ du ɛksɛsayz. Dɛn tin ya kin ɛp yu fɔ gɛt wɛlbɔdi as yu ebul. Nɔ ɛva fred, ɛn nɔ sɔfa yu wan. Tɔk to yu dɔktɔ bɔt ɔltin, ɛn gɛt di ɛp we yu nid.

` Maylodysplastic syndrome, MDS, myelodysplasia, blɔd kansa, bon mɛro, anemia, blɔd sɛl