Wi no aw i nɔ kin izi fɔ liv wit kansa. Bɔt we di sayɛns we dɛn dɔn lan bɔt mɛrɛsin dɔn go bifo, di we aw dɛn de mɛn kansa dɔn bɛtɛ pasmak tide. Bifo dɛn jɔs tek kimotɛrapi ɔ redyushɔn tɛrapi lɛk aw i bin de du trade, naw sɔm patikyula tritmɛnt dɛn de we de tɔch ɛn atak di kansa sɛl dɛn nɔmɔ. PARP inhibitors na wan kayn mɛrɛsin we dɔn briŋ nyu op na di wɔl fɔ tritmɛnt fɔ kansa. Tide, wi go tɔk bɔt dis simpul wan, di we we yu go ɔndastand.
Fɔ tɔk am simpul wan, wetin na dɛn PARP Inhibitors ya?
Fɔ ɔndastand dis, lɛ wi tink fɔs bɔt di sɛl dɛn we de na wi bɔdi. Ɛni sɛl na wi bɔdi gɛt sɔntin we dɛn kɔl DNA. dis DNA lεk ‘masta plan’ we gεt כl di instrכkshכn dεm we wan sεl nid fכ wok. Sɔntɛnde dis DNA kin pwɛl. We i pwɛl, wi bɔdi gɛt spɛshal we fɔ mek i fayn.
wan pan di men tin dεm we de mek dis ripa prכsεs na wan protin we dεn kכl PARP. PARP tinap fɔ Poly (ADP-ribose) polimɛras. pan ɔl we di nem tan lɛk se i kɔmplikt, in wok simpul: If i brok ɔ brok na di DNA, di PARP protin de go insay ɛn mek am bak. Dis impɔtant fɔ mek di sɛl dɛn gɛt wɛlbɔdi.
Bɔt na dis prɔblɛm de. di kεnsar sεl dεm de yuz dis PARP protin bak fכ dεn advantej. We di kansa sɛl dɛn sheb kwik kwik wan, dɛn DNA kin pwɛl. afta dat di kεnsar sεl de yuz dis PARP ‘bas’ fכ mek in DNA, gro mכr, εn bigin fכ spre כlsay na di bכdi.
di PARP inhibito dεm de wok bay we dεn de stכp di PARP ‘bass’ fכ wok. fכ bi prεsis, dεn de mek di PARP protin nכ de ripεr DNA. Dis kin mek di kansa sɛl nɔ ebul fɔ mek in DNA fayn, ɛn leta di sɛl kin day.
Dɛn kin kɔl dɛn tin ya bak targeted therapies , bikɔs dɛn mɛrɛsin ya de tɔch ɛn atak di wikɛd tin dɛn we di kansa sɛl dɛn gɛt pas di nɔmal wɛlbɔdi sɛl dɛn.
Us kayn kansa dɛn kin yuz dɛn mɛrɛsin ya fɔ?
Dɛn kin yuz PARP inhibitor drɔgs fɔ mɔ advans ɔ mɛtastas kansa. Bɔt dɛn nɔ kin gi dɛn fɔ ɔl di kansa dɛn. Dɛn kin wok mɔ fɔ kansa dɛn we gɛt fɔ du wit wan patikyula jɛnɛtik muteshɔn.
di rilayshכn bitwin di BRCA jin εn di PARP inhibito dεm
jin dεm de na wi bכdi we de protɛkt wi we de mek kansa tכmכro dεm nכ de. Wan pan di men wan dɛn na di BRCA jin . Wan pan di wok we dis BRCA jin de du na fɔ mek di DNA we dɔn pwɛl. dis min se tu men DNA ripa sistεm dεm de insay wi sεl dεm: wan na PARP, εn di כda wan na BRCA.
Naw imajin, dɛn bɔn pɔsin wit wan muteshon na di BRCA jin.Dat min se wan pan in DNA ripa sistɛm dɛn dɔn ɔlrɛdi wik. Dɔn in kansa sɛl dɔn ɔlmost dipen pan da PARP sistɛm de fɔ mek di DNA fayn.
So wetin kin apin we wi gi pɔsin lɛk dat PARP inhibitor? Apat frɔm di BRCA sistem we dɔn ɔlrɛdi brok, wi de stɔp di PARP sistem bak we bin de wok fayn. Dɔn di kansa sɛl nɔ gɛt we fɔ mek in DNA fayn. biכs fכ dis ‘dכbul hit’, di kεnsar sεl de pwεl izi izi wan.
fכ dat, PARP inhibito dεm na rili ifektiv tritmεnt fכ kεnsar dεm wit BRCA jin mכtεshכn.
| Men kayn kansa we dɛn trit wit PARP inhibitor |
|---|
| Brɔst kansa |
| Kansa na ovarian |
| Falopian tiub kansa |
| Prɔstat kansa |
| Kansa na di pankrias |
| Praymari peritoneal kansa |
Aw dɛn kin gi dis tritmɛnt ɛn fɔ aw lɔng?
Wan bɛnifit fɔ dis tritmɛnt na dat, dɛn nɔ nid fɔ gi am as injɛkshɔn. כl dεn PARP inhibito dεm ya kin kam insay di fכm fכ tablεt כ kapsul. Dɛn kin tɛl yu fɔ tek dɛn wan ɔ tu tɛm insay di de.
Sɔntɛnde, i kin dipen pan di kayn kansa we yu gɛt, dɛn kin gi dis mɛrɛsin as di wangren tritmɛnt. Ɔ, dɛn kin gi am togɛda wit ɔda tritmɛnt dɛn, lɛk kemotɛrapi. Fɔ ɛgzampul, afta dɛn dɔn gi pɔsin kemotɛrapi ɛn di kansa sɛl dɛn we dɔn pwɛl, dɛn kin bigin dis PARP inhibitor drɔg. Dɔn, i kin pul di chans fɔ mek dɛn kansa sɛl dɛn de we dɔn pwɛl kpatakpata kpatakpata.
Di tɛm we dɛn kin tek di tritmɛnt kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Fɔ sɔm pipul dɛn, dɛn kin gi dis mɛrɛsin fɔ wan patikyula tɛm, lɛk tu to tri ia afta dɛn dɔn dɔn di kemotɛrapi. Fɔ ɔda pipul dɛn, dɛn kin kɔntinyu fɔ du am fɔ as lɔng as di mɛrɛsin de wok, we min se dɛn kin kɔntrol di kansa. Di bɛst tin fɔ disayd bɔt dis na fɔ tɔk to yu dɔktɔ ɛn wej di bɛnifit dɛn we di tritmɛnt go gi yu ɛn di bad tin dɛn we go apin to yu.
Di bɛnifit ɛn di sayd ɛfɛkt dɛn we dis tritmɛnt kin gɛt
PARP inhibitor dɛn nɔ kin mɛn kansa ɔltogɛda. כltu, dεn big bεnεfit na dat dεn de inkrεs "progrεshכn-fri sכvayvεns." Fɔ tɔk am simpul wan, dɛn mɛrɛsin ya kin ɛp fɔ kɔntrol di kansa ɛn kip am ɔnda kɔntrol fɔ lɔng tɛm. Dis min se di pɔsin kin gɛt mɔ tɛm fɔ liv bɛtɛ layf we di sik nɔ go wɔs .
Lɛk ɛni tritmɛnt fɔ kansa, dɛn tin ya kin mek pɔsin gɛt sayd ɛfɛkt, bɔt nɔto ɔlman kin gɛt am.
| Kכmכn sayd ifekt dεm fכ PARP inhibito dεm | |
|---|---|
| Fɔ mek yu bɔdi nɔ fil fayn |
|
| Di chenj dɛn we de apin na di blɔd tɛst | |
| Risk dɛn we nɔ kin apin so ɔltɛm bɔt we kin rili siriɔs | |
Ustɛm yu fɔ kɔl di dɔktɔ wantɛm wantɛm?
I rili impɔtant fɔ de nia yu dɔktɔ ɔl di tɛm we dɛn de du dis tritmɛnt. If yu gɛt ɛni nyu sik ɔ if ɛni wan pan di sik dɛn we yu dɔn gɛt dɔn wɔs, tɛl yu dɔktɔ wantɛm wantɛm. I kin ebul fɔ ajɔst yu doz ɔ gi yu ɔda mɛrɛsin fɔ ɛp wit di sayd ɛfɛkt dɛn lɛk fɔ nɔs.
If yu gɛt dɛn sik ya, kɔl yu dɔktɔ we yu nɔ de te :
- Sayn dɛm fɔ se yu gɛt infekshɔn: fiva, kol, ɛn shek.
- Di sayn dɛm we de sho se yu gɛt lɔng infɛkshɔn (Nimonitis): I nɔ izi fɔ blo, yu kin fil se yu chɛst tayt, ɔ yu kin swɛt.
- Sayn dɛn we de sho se blɔd dɔn rɔtin: i kin swel wantɛm wantɛm, i kin rɛd, ɛn i kin fil pen na in leg, ɔ i kin pen na in chɛst wantɛm wantɛm ɛn i kin at fɔ blo.
If yu gɛt ɛni wan pan dɛn bad bad tin ya, yu fɔ kɔl yu dɔktɔ wantɛm wantɛm ɔ go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU) .
Mɛsej we dɛn kin kɛr go na os
- PARP inhibito dεm na wan kayn ‘targeted therapy’ we de stכp di kεnsar sεl dεm fכ rεpair dεn DNA εn destroy dεm.
- dis dεm kin wok bכku fכ kכndishכn dεm lεk brεst, ovarian, εn prכstat kεnsar wit BRCA jin mכtεshכn.
- Dɛn kin gi dis tritmɛnt lɛk pils ɔ kapsul ɛn i kin ɛp fɔ kɔntrol aw di kansa de gro ɛn mek yu gɛt mɔ tɛm fɔ gɛt wɛlbɔdi.
- Jɔs lɛk ɔda tritmɛnt dɛn, sayd ɛfɛkt kin apin, so i impɔtant fɔ wok togɛda wit yu dɔktɔ ɔl di tɛm we yu de trit yu.
- Yu dɔktɔ go no if PARP inhibitor tritmɛnt rayt fɔ yu, i go tek tɛm tink bɔt yu mɛdikal kɔndishɔn, di rizɔlt fɔ yu jenɛtik tɛst, ɛn ɔl yu wɛlbɔdi.
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