Yu dɔn ɛva mek dɔktɔ tɛl yu bɔt wan smɔl chenj we yu wayt blɔd sɛl dɛn chenj we dɛn du yu blɔd tɛst? I kin bi se na Pelger-Huet Anomaly. Di nem kin tan lɛk big tin, bɔt nɔ wɔri , bɔku tɛm i nɔ kin siriɔs so. Lɛ wi tɔk bɔt dis smɔl mɔ, insay wan simpul we.
Wetin na di Pelger-Huet Anomaly?
Fɔ tɔk am simpul wan, Pelger-Huet Anomaly (PHA) na wan jenɛtik kɔndishɔn we de afɛkt nyutrofil, we na wan kayn wayt blɔd sɛl na wi bɔdi. Nyutrofil dɛn tan lɛk smɔl sojaman dɛn na wi bɔdi we de ɛp wi bɔdi fɔ fɛt di jem dɛn.
dis kכndyushכn de kכz fכ wan vεryushכn na wi DNA, spεshal wan insay wan jin we dεn kכl Lamin B Risεptor (LBR jin). dis LBR jin na in de εp di nyutrofil sεl dεm fכ divεlכp εn gro fayn fayn wan.
Naw luk, ɔl nyutrofil sɛl gɛt wan kɔntrol sɛnta, we wi kɔl nyukliɔs . dis nyuklios gεt כl di DNA infכmeshכn we di sεl nid fכ wok εn gro. nכmal wan, di nyuklios fכ wan hεlty nyutrofil kin sheb to tri כ mכr pat dεm. Bɔt di nyukliɔs fɔ nyutrofil na pɔsin we gɛt Pɛlga-Hyuɛt gɛt tu pat. I tan lɛk dɔmbɛl, we gɛt fat na ɔl tu di say dɛn ɛn wan tint midul. na sכm pipul dεm, dis nyutrofil nyuklios kin shep lεk oval, dat na, shep lεk eg.
bכt di imכtant tin ya na dat ivin if dεn bכn yu wit Pelger-Huette anomaly, bכku tεm yu nyutrofil sεl dεm de wok nכmal wan. Dis min se dɛn nɔr kin gɛt bɛtɛ prɔblɛm fɔ protɛkt yu frɔm sik. So, bɔku tɛm, i nɔ kin gɛt bɔku big big wɛlbɔdi prɔblɛm dɛn.
Wan ɔda sik de we dɛn kɔl Pseudo Pelger-Huet Anomaly (PPHA) . Dis kin apin to sɔm pipul dɛn leta na dɛn layf. PPHA kin apin as sayd ɛfɛkt fɔ sɔm mɛrɛsin ɔ as sayn fɔ ɔda kɔndishɔn, lɛk infɛkshɔn.
Wetin na di sayn dɛm fɔ Pelger-Huette anomaly?
Na ya wi nid fɔ pe atɛnshɔn pan di tu kayn we dɛn we wi bin dɔn tɔk bɔt.
Hɛridit Pɛlger-Huet Anomali (HPA) .
If yu gɛt Pelger-Huette anomaly (HPA), we yu kin gɛt frɔm yu mama ɛn papa, bɔku tɛm yu nɔ kin gɛt ɛni sayn. Sɔntɛm yu nɔ go ivin no se yu gɛt dis sik. Dɛn kin no am bay we dɛn du blɔd tɛst fɔ ɔda rizin.
Pseudo Pelger-Huet Anomali (PPHA) we de mek pipul dɛn no bɔt di sik.
Bɔt if yu gɛt pseudo-Pelger-Huette anomaly (PPHA), we min se i bin kam leta, yu kin gɛt sɔm sayn dɛn we gɛt fɔ du wit di ɔndalayn kɔndishɔn we mek i kam.Fɔ ɛgzampul, if PPHA na infɛkshɔn, sɔm sayn dɛn kin de lɛk fiva ɛn bɔdi pen we gɛt fɔ du wit da infɛkshɔn de.
Wetin kin mek Pɛlger-Huette anomaly?
Di rizin fɔ dis kin difrɛn bak dipen pan di tu kayn dɛn we wi bin dɔn tɔk bɔt.
Hereditary Pelger-Huette anomaly (HPA) we dɛn kɔl Pɛlga-Huɛt anomali (HPA) .
dis de kכz fכ wan mכtεshכn na di Lamin B Risεptor (LBR) jin, lεk aw wi bin se. dis LBR jin de instrakt wi bכdi fכ mek di protin dεm we i nid fכ protεkt nyutrofil sεl dεm εn gi dεm di rayt shep. insay Pelger-Huytt anomaly, dis jεnεtik mכtεshכn de disrupt da prכsεs de, we de mek di nyuklios fכ nyutrofil dεm tek da dכmbεl shep de. Dis na sik we mama ɛn papa kin gɛt frɔm in pikin dɛn.
Pseudo Pelger-Huette anomaly (PPHA) we de mek pipul dɛn no bɔt di sik.
Dis nɔto tin we pɔsin kin gɛt we i kam pan jɛnɛtiks. Bɔku tin dɛn de we kin mek pɔsin gɛt dis sik:
- Bon mכro sik dεm: εgzampl dεm na lukimiya kכndyushכn lεk myelodysplastic syndrome εn akyu mayloid lukimiya (AML).
- Sɔm infɛkshɔn: mɔ di sik dɛn we tik kin kam wit.
- Immunosuppressants: Dɛn mɛrɛsin ya, we dɛn kin gi fɔ sɔm sik dɛn, kin bi bak di kɔz.
- Radiation exposure: Fɔ ɛgzampul, we dɛn de trit kansa.
If dɔktɔ tɛl yu se yu gɛt `PHA` ɔ `PPHA`, i rili impɔtant fɔ tɛl di dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, ivin di vaytamɛn dɛn.
Wetin na de risk factor fɔ dis sik?
Di men risk factor fɔ Pelger-Huette anomaly (PHA) na fɔ gɛt biyolojikal mama ɔ papa wit di kɔndishɔn. Dis min se if yu mama ɔ papa gɛt PHA, yu gɛt lɛk 50% chans fɔ gɛt am. I tan lɛk se yu de flip kɔyn, yu nɔ go se fɔ tru, bɔt i kin apin.
Fɔ di `PPHA` kɔndishɔn, fɔ ɛkspos to di mɛdikal kɔndishɔn ɔ tritmɛnt dɛm we wi bin dɔn tɔk bɔt na di risk factor dɛm.
Ɛni prɔblɛm de wit dis sik?
Bɔrku tɛm, di hεriditri Pelger-Huette anomaly (PHA) nɔ kin mek big big kɔmplikeshɔn. Bikɔs, pan ɔl we i de chenj di we aw yu nyutrofil sɛl dɛn de luk, i nɔ de chenj aw dɛn de wok bɛtɛ. Dɛn kin kɔntinyu fɔ fɛt di jem dɛn.
Bɔt if yu gɛt pseudopelgar-huwat anomalous (PPHA), di ɔndalayn mɛdikal kɔndishɔn we mek i kam (lɛk lukimiya) kin mek yu gɛt prɔblɛm. So, e fayn fɔ tɔk to yu dɔktɔ bɔt dis ɛn no wetin fɔ ɛkspɛkt.
Aw dɔktɔ dɛn kin no se pɔsin gɛt wan sik we dɛn kɔl Pelger-Huette anomaly?
Dɔktɔ dɛn kin yuz blɔd tɛst mɔ fɔ no dis sik. Speshali, .Dɛn kin du wan tɛst we dɛn kɔl peripheral blood smear. Dis tɛst na fɔ tek wan drop pan yu blɔd sɛmpul, spre am tint wan pan glas slayd, ɛn luk am ɔnda maykroskɔp.
Na wan dɔktɔ we de mɛn sik dɛn ɔ pɔsin we de stɔdi bɔt blɔd kin chɛk dis.
if yu gεt Pelger-Huette anomaly, dis tεst go sho klia wan di כnusual shep fכ di nyuklios fכ yu nyutrofil sεl dεm (lεk dכmbεl).
Tritmɛnt de fɔ Pelger-Huette anomaly?
Na dis na di gud nyus! Hereditary Pelger-Huette anomaly (PHA) nɔ kin gɛt ɛni sayn, so i nɔ kin nid ɛni spɛshal tritmɛnt. Ivin if yu gɛt dis sik, yu kin liv nɔmal layf.
Bɔt pan di kes fɔ `PPHA`, i impɔtant fɔ trit di ɔndalayn sik we mek i kam. Wae da sik de dɔn wɛl, di `PPHA` kɔndishɔn kin go bak.
Ustɛm a fɔ go to dɔktɔ?
If yu kam fɔ no se yu gɛt Pelger-Huette anomaly, mek shɔ se yu tɛl yu dɔktɔ if yu gɛt ɛni nyu sayn (lɛk fiva, taya bad bad wan, infekshɔn ɔltɛm). Dɔn yu dɔktɔ kin no if di sayn dɛm gɛt fɔ du wit `PHA`, `PPHA`, ɔr ɔda tin.
We yu go si dɔktɔ, i fayn bak fɔ aks dɛn kwɛstyɔn ya:
- A gɛt ɛritaj `(HPA)` ɔ pseudo `(PPHA)` Pelger-Huette anomaly?
- I pɔsibul se mi pikin dɛn go gɛt dis sik? (If HPA)
- Aw ɔltɛm a fɔ go to dɔktɔ?
- Us sayn dɛn a fɔ no mɔ bɔt?
Wetin a fɔ ɛkspɛkt wit dis sityueshɔn?
Pelger-Huette anomaly (PHA) insɛf nɔ de mek yu fil pen ɔr mek big difrɛns na yu layf. Bɔku tɛm, i nɔ kin afɛkt di tin dɛn we yu de du ɛvride.
Bɔt if yu gɛt dis sik (especially di `PPHA` tayp), i kin bi sayn fɔ ɔda ɔndalayn wɛl bɔdi kɔndishɔn. Na dat mek dɔktɔ dɛn de wɔri bɔt am. If yu dɔktɔ sɔspɛkt se yu gɛt `PHA` ɔ `PPHA`, dɛn go du di tɛst dɛn we nid fɔ kɔnfɔm am, ɛn dɛn go tek step bak fɔ pul ɔda mɛdikal kɔndishɔn dɛn.
Yu kin gɛt Pelger-Huette anomaly (PHA) ɛn nɔr no am bikɔs yu nɔr gɛt ɛni sayn. Yu kin tink se, "If i nɔ de mɔna mi, wetin mek a de ivin tink bɔt am?" Na tru se yu nɔ go fil sik bikɔs ɔf dis patikyula sɛl muteshon. Bɔt i impɔtant fɔ mek yu dɔktɔ no bɔt am. Yu dɔktɔ de fɔ ɛp yu fɔ gɛt wɛlbɔdi. Ɛn i kin ɛp fɔ no bɔt dɛn smɔl smɔl tin ya na yu bɔdi. Jɔs bikɔs yu gɛt Pelger-Huette anomaly na jɔs ɔda tin we de mek yu "yu." Natin nɔ de fɔ wɔri bɔt.
Sɔma (Mɛsej we dɛn kin tek go na os) .
Okay, so lɛ wi rikap sɔm pan di tin dɛn we wi bin tɔk bɔt:
- Pelger-Huet Anomaly (PHA) na wan jεnεtik kכndyushכn we de mek di nyuklios fכ nyutrofil dεm, we na wan kayn wayt bכdi sεl, we nכ de shep.
- Bɔrku tɛm, dis nɔr kin denja ɛn nɔr kin mek pɔrsin gɛt sɔm kayn sik. di nyutrofil sεl dεm de wok nכmal wan.
- Tu kayn dis de: `HPA`, we na ɛritayt, ɛn `PPHA`, we leta kin kam wit ɔda sik ɔ mɛrɛsin.
- Bɔku tɛm, HPA nɔ kin nid tritmɛnt. Insay di kes fɔ PPHA, dɛn kin trit di ɔndalayn kɔz.
- Dɛn kin no dis sik tru blɔd tɛst (peripheral blood smear).
- If yu kam fɔ no se yu gɛt dis sik, nɔ wɔri. Bɔt, tɔk to yu dɔktɔ bɔt am ɛn gɛt di advays we yu nid. Tɛl yu dɔktɔ if nyu sayn dɛn de sho.
A op se dis atikul dɔn ansa bɔku pan yu kwɛstyɔn dɛn bɔt Pelger-Huette anomaly. Mɛmba se, wit ɛni wɛlbɔdi prɔblɛm, i bɛtɛ fɔ tɔk to yu dɔktɔ opin wan.
` Pelger-Huet Anomali, Nyutrofil, Wait Blɔd Sɛl, Jɛnɛtik Sik, Blɔd Tɛst, PPHA, HPA
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