Yu kidni prɔblɛm dɛn kin afɛkt yu bon dɛn? Lɛ wi lan bɔt Renal Osteodystrophy!

Yu gɛt kidni sik, ɔ wetin wi dɔktɔ dɛn kɔl kronik kidni sik (CKD) ? Ɔ yu no pɔsin we gɛt dis sik? Bɔku pipul dɛn kin tink se we wi se kidni sik, na di kidni nɔmɔ i kin afɛkt. Bɔt di tru tin na dat, we wi kidni dɛn nɔ de wok fayn, i kin rili afɛkt bɔku ɔda tin dɛn na di bɔdi, mɔ wi skel sistɛm, dat na wi bon dɛn . So, tide wi go tɔk bɔt wan kɔndishɔn we wi bon dɛn kin wik ɛn mek prɔblɛm bikɔs ɔf kidni sik. Dɛn kin kɔl dis sik we dɛn kɔl renal osteodystrophy . Pan ɔl we di nem kɔmplikt smɔl, lɛ wi ɔndastand am simpul wan.

Wetin na Rɛnal Ɔstiɔdistrofi?

Fɔ tɔk am simpul wan, Renal Osteodystrophy na bon sik we kin afɛkt big pipul ɛn pikin dɛn we gɛt krɛse sik (CKD).

Naw, luk, wi kidni dɛn gɛt rili impɔtant wok. Dat na fɔ kɔntrol di lɛvɛl dɛn we di minral dɛn lɛk kalsiɔm ɛn fɔsfɔr de na wi blɔd. Dɔn bak, di kidni dɛn kin mek vaytamɛn D wok ɛn mek wan ɔmon we dɛn kɔl kalsitriɔl , we kin ɛp fɔ mek wi bon dɛn strɔng.

So, we di kidni dεm fεl כ nכ de wok fayn, dεn nכ kin kכntrכl di כmכnt כf dεn minral dεm ya εn di כmon we dεn kכl kכlsitriol. Na da tɛm de wi bon dɛn kin bigin fɔ wik smɔl smɔl . Dis kin mek di bon dɛn brok izi wan, we min se di bon dɛn kin brok .

Us minral ɛn ɔmon dɛn de ɛp fɔ mek wi bon dɛn gɛt wɛlbɔdi?

Bɔku impɔtant minral ɛn ɔmon dɛn de we de ɛp fɔ mek wi bon dɛn gɛt wɛlbɔdi ɛn strɔng. Lɛ wi lan smɔl bɔt dɛn.

• Kalsiɔm: Dis na di men tin we de mek wi bon dɛn. bon dεm lεk "kalsiכm bank" na wi bכdi. di kalsiכm nכ de nכmכ de mek di bon dεm strכng, bכt i impɔtant bak fכ bכku כda tin dεm, lεk di wok we di nεv sεstem de wok εn di mכsul dεm we de wok. Wi kidni dεm de εp fכ bεlε di kalsiכm lεvεl dεm na di bכdi.
• Fכsfכr: lεk kalsiכm, fכsfכr na imכtant minral bak na di bon dεm. wi kidni dεm de pul di fכs fכs we pasmak we di bכdi nכ nid εn de mεnten di bεlε bitwin di kalsiכm εn fכsfכr we de insay di bכdi.
• Calcitriol: Dis na di aktif fכm fכ vaytam in D. Na wi kidni dεm de mek am. Dis ɔmon de ɛp fɔ kɔntrol aw bɔku kalsiɔm we wi bɔdi de tek frɔm di it dɛn we wi de it ɛn i de ɛp bak fɔ mek wi paratayrɔyd gland dɛn wok.
• Fibroblast Grɔwth Faktɔ 23 (FGF23): .Dis na ɔmon we wi bon dɛn de mek. I de ɛp fɔ rigul di fɔsfɔr ɛn vaytamɛn D lɛvɛl. FGF23 lεvεl kin כlwayz εlevεt pan pipul dεm we gεt krεse sik na di kidni.
• Parathyroid Hormone (PTH): Dis ɔmon de kɔmɔt frɔm 4 smɔl smɔl gland dɛn we de biɛn di tayroyd gland na wi nɛk. Dɛn kɔl dɛn tin ya paratayrɔyd gland. di wok we dis PTH כmon de du na fכ rilis di kalsiכm frכm di bon dεm we di bכdi nid kalsiכm εn kip di kalsiכm lεvεl na di bכdi stebul.

Wetin na di men kayn Renal Osteodystrophy?

Bɔn dɛn kin gro we wi yɔŋ. Bɔt ivin as wi de big, wi bon dɛn nɔ kin jɔs sidɔm de. Dɛn de mek dɛn nyu ɛn mek dɛn ɔltɛm. Jɔs lɛk aw dɛn kin pul ol brik ɛn put nyu wan dɛn fɔ bil wɔl, na so di ol bon tisu kin brok ɛn nyu bon tisu kin fɔm. wi kכl dis prכsεs "bon tכnכv."

Renal Osteodystrophy kin apin if dis bon tכnכv tu fast כ tu slo. Fo men kayn dɛn de:

• Osteitis Fibrosa: Dis na wan sik we di bon tisu kin brok tu kwik. dis kin bi we di paratayroyd כmon (PTH) lεvεl dεm de inkrεs. Dɛn kɔl dis haypaparatayroydism .
• Osteomalacia: Dis na kכndyushכn we di bon tisu dεm de brok dכn, bכt nyu bon de fכm sכmtεm sכmtεm. Di bon dɛn kin tan lɛk spɔnj ɛn wik. dis kin bi bay we yu nכ gεt vaytam in D, mεtal tכksisiti, εn we di כmon FGF23 de prodyuz pasmak bikoz fכ sכm kayn kεnsar.
• Adynamic Bone Disease: Dis na di kכndyushכn we di bon tisu fכmeshכn εn ripa de rεdכks bכku bכku wan. di men tin we kin mek dis apin na di lכw lεvεl fכ di paratayroyd כmon (PTH).
• Mixed Renal Osteodystrophy: Dis kכndyushכn de kam togεda di simptom dεm fכ כl tu di Osteitis Fibrosa εn Osteomalacia.

Naw lɛ wi tɔk bɔt dɛn kayn tin ya smɔl mɔ.

Ɔsteitis Fibrosa we gɛt di sik

Bɔku tɛm wi kin yɛri se pipul dɛn we gɛt krɛse sik kin gɛt bɔku bɔku paratayrɔyd ɔmon (PTH). PTH de rispansabl fכ rilis di kalsiכm frכm di bon dεm insay di bכdi fכ bεlε di kalsiכm lεvεl na di bכdi. כltu, if di PTH lεvεl tu hכy, i de pul tu mכch kalsiכm frכm di bon dεm. dis kin mek fכmeshכn fכ fayv sist dεm insay di bon dεm, we kin mek di bon dεm wik.

Bɔku rizin dɛn de we mek di PTH lɛvɛl kin go ɔp:

• Calcitriol deficiency: We di kidni dεm dεn dכn pwεl, dεn nכ kin prodyuz calcitriol fayn fayn wan, we de mek PTH prodyuz bכku.
• Inkrεs fכ FGF23 lεvεl dεm:Dis kin bi wan fɔs sayn fɔ sik na di kidni. i kin bi bak di rispכns frכm di bon dεm fכ stכp di fכsfכr lεvεl na di bכdi fכ inkrεs.
• Fɔsfɔr we de go ɔp: Insay di sik we de na di kidni we nɔ de mɛn, di fɔsfɔr kin gɛda na di blɔd bikɔs di kidni dɛn nɔ kin ebul fɔ pul am fayn fayn wan. dis de mek bak di prodakshכn fכ PTH.

Osteomalasia we gɛt di sik

Di men tin we kin mek pɔsin gɛt dis sik na we i nɔ gɛt vaytamɛn D . Dis kin kɔmɔn pan pipul dɛm wae gɛt lɔng tɛm kidni sik.

Dɔn bak, sɔm mɛtal dɛn kin mek ɔsteomalacia bikɔs ɔf di mɛtal toxiciti . fכ egzampl, mεtal dεm lεk aluminiכm de ambɔg di bon fכmeshכn εn mεntenεns. Trade, sɔm mɛrɛsin dɛn we dɛn bin de yuz fɔ kɔntrol di lɛvul fɔ di fɔsfɔr (fɔsfɛt binder) bin gɛt aluminiɔm. Bɔt dɛn nɔ kin advays dɛn mɛrɛsin ya igen fɔ pipul dɛn we gɛt sik na dɛn kidni, mɔ di wan dɛn we de du dayalaysis . Naw, dɛn dɔn gɛt tin dɛn we nɔto aluminiɔm fɔsfɔr binder. We dɛn tek am wit it, dɛn kin mek di fɔsfɔr we de insay it nɔ go insay di blɔd.

Sɔm kayn kansa kin mek bak di ɔmon we dɛn kɔl FGF23 bɔku pasmak, we kin mek di ɔstiɔmalasia ɛn di bon dɛn brok.

Adynamic Bone Disease we pɔsin kin gɛt

dis na we di bon tisu fכmeshכn εn ripa de ridyus bכku bכku wan. Dis sik kin mɔna pipul dɛm wae gɛt siriɔs kidni sik ɛn di wan dɛm wae de du dayalaysis. Di men rizin fɔ dis na bikɔs di kalsiɔm ɛn vaytamɛn D we de na di bɔdi tu bɔku . We dɛn de trit kidni sik, sɔntɛnde dɛn kin gɛt ɛkstra kalsiɔm ɛn vaytamɛn D. pan ɔl we dis kin ɛp fɔ mek yu nɔ gɛt di rεnal ɔstiodistrofi, we kin kam bikɔs di bon dɛn kin tɔn, sɔm tɛm dɛn kin mek di paratayroyd ɔmon (PTH) lɛvɛl go dɔŋ tumɔs.

Bɔku ɔda rizin dɛn de:

• Kɔntinyu Pɛritonial Dayalaysis: Dis na wan kayn dayalaysis. Na ya, dɛn kin klin di blɔd insay di bɛlɛ. Dis difrɛn frɔm ɛmodayalis , we dɛn kin du tru wan vein na yu an. Sɔm peritoneal dialysis fluid dɛn gɛt bɔku kalsiɔm. Dis kin mek di PTH lɛvɛl smɔl.
• Dayabitis: Insay dayabitis, we di blɔd shuga lɛvɛl go ɔp ɛn we di insulin lɛvɛl go dɔŋ kin ridyus di PTH prodakshɔn bak.

Wetin na CKD-MBD (Kronik Kidni Disease-associated Mineral and Bone Disorder)?

We di minral ɛn ɔmon dɛn we de na wi blɔd nɔ de balans, i kin afɛkt wi at ɛn di blɔd vesel dɛn. CKD-MBD (Chronic Kidney Disease Mineral and Bone Disorder) na wan brayt tεm we inklud kכndishכn dεm lεk Renal Osteodystrophy εn rilatεd kכdivaskyul sik dεm.

Fɔ tɔk am simpul wan, we di kalsiɔm ɛn fɔsfɔr we de na di blɔd tumɔs, i kin mek pɔsin gɛt sik dɛn we de na di at ɛn di blɔd. di rizin fכ dis na wan prכsεs we dεn kכl kalsifikεshכn . Dat min se, di kalsiɔm kin gɛda ɛn put insay di blɔd vesel dɛn. Dis kin mek di wɔl dɛn na di blɔd vesel dɛn tik ɛn at. Dɛn kɔl dis atɛrosklɛrosis . Dis kin mek yu gɛt siriɔs sik lɛk ay blɔd prɛshɔn, at atak, ɛn strok. Imajin aw fa wan kidni prɔblɛm kin go!

Aw kɔmɔn tin na di Renal Osteodystrophy?

Dɛn se lɛk 15% pan di big pipul dɛm na Amɛrika gɛt krɛse sik na dɛn kidni. Bɔrku pan dɛm kin gɛt sɔm kayn rεnal ɔstiodystrophy. dis bon dεm we dεn dכn pwεl kin bi mכr afta di kidni dεm dכn fεl kכmplit, εn afta dεn dכn dayalysis fכ lכng tεm. Dis sik kin apin bak na Sri Lanka.

Wetin na di tin dɛm wae kin mek pɔrsin gɛt Renal Osteodystrophy?

Di men tin we kin mek pɔsin gɛt sik na di kidni sik we nɔ de mɛn (CKD) . Kidni sik de ambɔg di minral ɛn ɔmon lɛvɛl, ɛn i de ambɔg bak di nɔmal prɔses fɔ mek di bon dɛn ripɛnt (bon tɔn ɔva). If dis bon we de tɔn tu fast ɔ tu slo, ɔl tu kin mek di bon dɛn wik.

Wetin na di sayn dɛm wae de sho se yu gɛt Renal Osteodystrophy?

Di men sayn dɛm na di bon pen ɛn brok brok . Sɔm pipul dɛn nɔ kin gɛt ɛni sayn atɔl we di sik bigin. Dat na di pat we de mek pɔsin fred pas ɔl.

Yכŋ pikin dεm we gεt kidni sik kin gεt rεtardεshכn fכ gro biכs fכ rεnal כstiodystrophy. Dɛn kin gɛt bɔdi we nɔ fayn bak we dɛn kɔl rikɛt . Riket na wan kayn we we pikin kin gɛt di sik we dɛn kɔl osteomalacia. Dis min se di bon dɛn kin sof ɛn dɛn kin butu.

Aw dɛn kin no se pɔsin gɛt di sik we dɛn kɔl Renal Osteodystrophy?

Yu dɔktɔ go tek tɛm lisin to yu sik dɛn, yu mɛdikal histri, ɛn if ɛnibɔdi na yu famili dɔn gɛt dis kayn sik. Dɔn, dɛn go du wan ɛgzam pan dɛn bɔdi.

Bɔku tɛst dɛn de we dɛn kin yuz fɔ no dis sik kɔrɛkt wan:

• Blɔd tɛst: Dɛn tin ya kin chɛk di lɛvɛl we di kalsiɔm, fɔsfɔr, vaytamɛn D, ɛn paratayrɔyd ɔmon (PTH) de na di blɔd. Dɛn kin mɛzhɔ ɔda mak dɛn bak we de sho se di bon dɛn de tɔn, lɛk alkaline phosphatase . If yu gɛt sik na yu kidni fɔ lɔng tɛm, bɔku tɛm yu dɔktɔ go du dɛn blɔd tɛst ya fɔ chɛk fɔ si if dɛn chenj ya na dɛn lɛvul ya.
• Bone Biopsy: Dis na fɔ tek wan smɔl pat pan di bon ɛn tɛst am na lab. dis kin gi gud aidia fכ di density εn strכkchכ fכ di bon. Bɔt dis nɔto tɛst we kɔmɔn pasmak.
• Bone density test: Dɛn kin kɔl am bak DEXA scan , dis kin no aw yu bon dɛn strɔng ɛn aw dɛn kin brok.
• Imej tɛst: Tɛst lɛk X-ray , CT skan , ɛn MRI kin luk fɔ chenj dɛn na di bon dɛn. CT skan ɛn echocardiogram ( we na skan fɔ di at) bak fɔ luk fɔ di kalsiɔm we de na di blɔd vesel dɛn (calcification).

Mɛmba se nɔto ɔlman nid fɔ gɛt ɔl dɛn tɛst ya. Yu dɔktɔ go disayd us tɛst dɛn we yu fɔ du mɔ bay aw yu sik.

Wetin na di tritmɛnt dɛm fɔ Renal Osteodystrophy?

Di tritmɛnt we yu go gɛt go dipen pan aw dɛn dɔn pwɛl yu bon dɛn, di stej we yu kidni sik de, ɛn if yu bon dɛn de tɔn kwik ɔ slo. Bɔku men tritmɛnt dɛn de we yu kin pik:

• Chenj dɛn we yu de it: Yu dɔktɔ kin tɛl yu fɔ it tin dɛn we nɔ gɛt bɔku fosfɔr . Dis min se yu fɔ stɔp di it dɛn we gɛt bɔku fɔsfɔr (di it dɛn we dɛn dɔn prosɛs ɛn we dɛn pak) - lɛk it dɛn we dɛn kin put insay tin, instant noodles, ɛn sosish. If yu kidni sik bad bad wan, yu kin nid bak fɔ stɔp fɔ it tin dɛn we gɛt bɔku fɔs fɔs (e.g., sɔm dairy prodakt, nɛt, ɛn dray mit ɛn fish).
• Mɛrɛsin ɛn sɔpɔtmɛnt: Dɛn tin ya kin ɛp fɔ balans di minral ɛn ɔmon lɛvɛl. Fɔ ɛgzampul, dɛn kin gi yu di wan dɛn we de sɔpɔt di kalsiɔm ɛn vaytamɛn D, mɛrɛsin dɛn we de mek di paratayrɔyd ɔmon (PTH) smɔl, ɛn di tin dɛn we dɛn kin yuz fɔ tay di fɔsfɔr. Naw, dɔktɔ dɛn kin se dɛn fɔ yuz di tin dɛn we nɔ gɛt kalsiɔm fɔsfɔr bikɔs if yu gɛt bɔku kalsiɔm, dat kin mek yu gɛt adynamic bon sik.
• Paratayroyd ɔpreshɔn: If ɔda tritmɛnt dɛn nɔ wok, dɛn kin du ɔpreshɔn. Dis min se yu fɔ pul wan ɔ mɔ paratayroyd gland dɛn. Dɛn kɔl dis paratayroydɛktɔmi . Bɔku tɛm, at le wan paratayrɔyd gland kin lɛf. dis kin εp fכ mek di PTH lεvεl dεm nכ dכn tu lכw εn mek i gεt adynamic bon sik.

Apat frɔm ɔl dis, yu dɔktɔ go ɛp yu bak fɔ kɔntrol yu kidni sik. If yu fala di tritmɛnt plan fayn fayn wan, yu go ebul fɔ mek yu bon dɛn nɔ pwɛl mɔ.

Yu tink se dɛn kin mek dɛn nɔ gɛt di sik we dɛn kɔl Renal Osteodystrophy?

I at fɔ mek yu nɔ gɛt di sik we dɛn kɔl Renal Osteodystrophy ɔltogɛda. Bɔt bay we dɛn de manej di sik we dɛn kɔl kronik kidni sik (CKD) fayn fayn wan, dɛn kin kɔntrol di sik ɛn i kin slo fɔ go bifo.. Dat min se fɔ tek di mɛrɛsin we di dɔktɔ gi yu di rayt tɛm, fɔ fala di it we yu tɛl yu fɔ it, ɛn fɔ du di dayalaysis tritmɛnt dɛn fayn fayn wan rili impɔtant. Dɔn bak, fɔ du ɛksɛsayz, fɔ lɛf fɔ smok, ɛn fɔ lɛf fɔ drink rɔm kin ɛp bak.

Wetin pɔrsin wae gɛt Renal Osteodystrophy kin ɛkspɛkt?

No mɛrɛsin nɔ de fɔ dis sik we go de sote go pas fɔ transplant kidni . Pipul wae gɛt lɔng tɛm kidni sik kin lɔs dɛn kidni wok smɔl smɔl. Bɔku pipul dɛn kin dɔn wit dɛn kidni dɛn we nɔ de wok fayn ɛn dɛn kin nid fɔ du dayalaysis. Renal Osteodystrophy na wan kכmכn kכmplikεshכn fכ dis prכsεs.

Dɔn bak, bɔku pipul dɛn we gɛt krɛse sik na dɛn kidni kin gɛt at sik bak. At sik na de tin wae kin mek bɔrku pipul kin day bikɔs dɛn kidni nɔr de woke fayn.

Bɔt nɔ wɔri. Yu dɔktɔ go de chɛk yu minral ɛn ɔmon lɛvɛl ɔltɛm ɛn i go tɛl yu fɔ du tritmɛnt fɔ protɛkt yu bon ɛn at.

Ustɛm yu fɔ tɔk to dɔktɔ?

If yu gɛt krɛse sik (CKD), mek shɔ se yu tɛl yu dɔktɔ if yu gɛt pen ɔ yu bon stif . I kin bi sayn fɔ di rεnal ɔstiodystrophy.

Bɔrku pipul kin ɔlrɛdi no se dɛn gɛt krɛse sik na dɛn kidni wae i dɔn ɔlrɛdi go bifo. So, we yu de chɛk yu kidni ɔltɛm, dat kin ɛp fɔ no di sik na yu kidni kwik kwik wan. If i du dat, yu kin du tin fɔ mek i nɔ wɔs. Dis impɔtant mɔ if yu gɛt risk fɔ gɛt kidni sik (e.g., yu gɛt bɔku bɔku bɔdi, yu gɛt dayabitis, yu gɛt famili histri bɔt kidni sik, at sik, ɔr ay blɔd prɛshɔn).

Mɛsej we dɛn kin kɛr go na os

Okay, so lɛ wi rikap sɔm pan di tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt:

• Renal Osteodystrophy na wan bon sik wae de kam wit krεse sik na di kidni (CKD).
• we di kidni dεm nכ de wok fayn, di lεvεl dεm fכ di kalsiכm, fכsfכr, εn vaytam in D na di bכdi nכ de bεlε, εn di bon dεm kin wik.
• Bɔn pen ɛn brok brok na di men sayn dɛm, bɔt nɔr kin gɛt ɛni sayn fɔs.
• Dɔktɔ dɛn kin no dis sik bay we dɛn de du blɔd tɛst ɛn skan.
• Di tritmɛnt na fɔ kɔntrol di it we dɛn de it, fɔ tek mɛrɛsin, ɛn sɔntɛnde ɔpreshɔn.
• Di bɛst we fɔ kɔntrol dis sik na fɔ kɔntrol di sik na di kidni fayn fayn wan.
• If yu gɛt sik na yu kidni ɛn yu fil pen na yu bon, go to dɔktɔ wantɛm wantɛm.
• We yu de chɛk yu kidni ɔltɛm, dat kin ɛp fɔ no di sik na yu kidni kwik kwik wan.

Pan ɔl we yu nɔ go ebul fɔ wɛl ɔl dis sik, if yu gɛt di rayt tritmɛnt ɛn fala di advays we dɔktɔ gi yu, yu go ebul fɔ gɛt gud kwaliti layf. So nɔ panik, tɔk to yu dɔktɔ, ɛn du di tin dɛn we yu nid.

` Rεnal כstiodistrofi, kidni sik, bon sik, kalsiכm, fכsfכr, vaytam in D, paratayroyd כmon, CKD-MBD