Di dɔktɔ gi yu bak Sapropterin pils? Lɛ wi tɔk bɔt dis ditayli!

Adu! Tide wi go tɔk bɔt wan drɔg we nɔ kɔmɔn smɔl, bɔt fɔ sɔm pipul dɛn i rili impɔtant fɔ dɛn layf. Dat na Sapropterin we dɛn kɔl Sapropterin. If yu, pɔsin we yu sabi, ɔ yu yon pikin gɛt wan sik we nɔ kin apin so ɔltɛm we dɛn kɔl `Phenylketonuria`, we dɛn kin kɔl bak `(PKU)` fɔ shɔt tɛm, dat min se yu go dɔn yɛri bɔt dis drɔg. So, lɛ wi si wetin rili na dis mɛrɛsin, aw i de ɛp wi bɔdi, ɛn us tin dɛn we wi fɔ tek tɛm wit mɔ we wi de yuz am.

Fɔs, lɛ wi si, wetin na Phenylketonuria (PKU)?

Fɔ tɔk am simpul wan, `Phenylketonuria` na wan jɛnɛtik kɔndishɔn we dɛn kin gɛt frɔm dɛn mama ɛn papa. Pɔsin we gɛt dis kɔndishɔn nɔ kin ebul fɔ brok ɛn prosɛs wan amino asid we dɛn kɔl `Phenylalanine` fayn fayn wan. Yu kin de wɔnda, wetin na `Phenylalanine`? I de insay bɔku it dɛn we gɛt bɔku prɔtin we wi de it, fɔ ɛgzampul, milk, mit, fish, eg, ɛn nɛt.

So, insay pɔsin we gɛt `PKU`, dis `phenylalanine` (Phenylalanine) de bigin fɔ gɛda na di bɔdi. I tan lɛk se smɔl dɔti de gɛda. Dis akumulashɔn nɔ fayn, mɔ fɔ di bren. If dɛn nɔ kɔntrol dis we i smɔl, i kin mek di bren nɔ ebul fɔ divɛlɔp, ɛn tin dɛn lɛk prɔblɛm wit intɛlektual divɛlɔpmɛnt, chenj na di we aw pɔsin de biev, ɛn ivin ɛpilepshi kin apin. Na dat mek pipul dɛm we gɛt `PKU` fɔ fala spɛshal it we nɔ gɛt bɔku `phenylalanine` (Phenylalanine).

So aw Sapropterin de ɛp wit dis?

Dis na di say we di mɛrɛsin `Sapropterin` (Sapropterin)` de kam in. I nɔto mɛrɛsin fɔ `PKU`, bɔt i de ɛp fɔ ridyus di lɛvɛl fɔ `Phenylalanine` (Phenylalanine) na di bɔdi fɔ sɔm `PKU` pasɛnt dɛn (nɔto ɔl). Dat min se dis mɛrɛsin de ɛp di bɔdi fɔ brok dɔŋ `Phenylalanine` (Phenylalanine)` (Phenylalanine) smɔl bɛtɛ. Bɔt dɛn fɔ yuz am wit da spɛshal it de. Di dɔktɔ go disayd if dis mɛrɛsin fayn fɔ yu ɔ yu pikin, ɛn ɔmɔs fɔ gi.

Dis mɛrɛsin kin kam ɔnda brand nem dɛm lɛk ``JAVYGTOR`` ɔ ``KUVAN``.

Wetin na di tin dɛm we a nid fɔ tɛl di dɔktɔ bifo a bigin dis mɛrɛsin?

If yu ɔ di pɔsin we de tek dis mɛrɛsin gɛt ɛni wan pan dɛn tin ya, yu fɔ rili tɛl yu dɔktɔ bifo yu bigin di mɛrɛsin. I bɛtɛ fɔ lɛ yu nɔ ayd dɛn tin ya, bikɔs i kin afɛkt yu yon wɛlbɔdi.

• Yu gɛt ɛni prɔblɛm we nɔ kɔmɔn fɔ it? Fɔ ɛgzampul, anorexia ɔ bulimia.
• Yu gɛt fiva? Ɔ yu gɛt sɔm kayn infɛkshɔn?
• Yu gɛt sik na yu kidni?
• Yu gɛt liva sik?
• Yu dɔn ɛva gɛt sik we dɛn kɔl epilepsy?
• Yu gɛt alɛji fɔ Sapropterin, ɔda mɛrɛsin, it, day, ɔ tin dɛn we de mek yu nɔ pwɛl?
• Yu gɛt bɛlɛ? Ɔ yu de op fɔ gɛt bɛlɛ?
• Yu na mama we de gi pikin in bɛlɛ?

I rili impɔtant fɔ tɔk bɔt ɔl dis opin wan wit di dɔktɔ.

Okay, so aw a fɔ yuz dis mɛrɛsin?

Dis na sɔntin bak we yu nid fɔ no gud gud wan. Yu nid fɔ fala di rayt tin we di dɔktɔ se.

• Dɛn pils ya fɔ tek bay mɔt wit it .
• Tek di mɛrɛsin we yu dɔktɔ gi yu, jɔs lɛk aw i rayt na di prɛskrishɔn lɛbl, insay di mɔnt we dɛn tɛl yu fɔ tek, di tɛm we dɛn gi yu.
• Yu kin swɛla di tablɛt dɛn ɔl wit wata, ɔ yu kin sɔlv dɛn insay 4 to 8 ɔns (lɛk 120 to 240 mililita) wata ɔ apul jus.
• Di tin we impɔtant pas ɔl: Yu fɔ drink am insay 15 minit afta yu dɔn sɔlv am. Nɔ lɛf am fɔ lɔng tɛm pas dat.
• If yu want di tablɛt dɛn fɔ sɔlv kwik, yu kin krɔs dɛn ɔ stir dɛn fayn fayn wan wit spun we yu de sɔlv.
• Sɔntɛnde, yu kin si smɔl smɔl tin dɛn we de flɔt na di wata we di pils dɛn nɔ de sɔlv ɔl. Dis na nɔmal tin. If smɔl smɔl tin dɛn lɛf na di glas afta yu dɔn tek di mɛrɛsin, ad smɔl mɔ wata ɔ apul jus, stɔp am, ɛn drink dat bak. Da we de, yu go gɛt di ful doz fɔ di mɛrɛsin.
• Wan ɔda tin we yu kin du na fɔ krɔs di tablɛt dɛn ɛn miks dɛn wit smɔl it lɛk apul ɔ pudin.
• I rili impɔtant fɔ tek yu mɛrɛsin di sem tɛm ɛvride, di sem tɛm ɛvride. Nɔ tek pas wetin yu dɔktɔ tɛl yu fɔ tek, ɔ stɔp fɔ tek yu mɛrɛsin we yu nɔ aks am.

I spɛshal if dɛn gi am to yɔŋ pikin dɛn:

If yu de gi dis mɛrɛsin to yu smɔl pikin, yu fɔ rili tɔk to yu dɔktɔ we de mɛn pikin dɛn bɔt am. Pan ɔl we dɛn kin gi dis mɛrɛsin to pikin dɛn we yɔŋ lɛk wan mɔnt pan sɔm spɛshal kes dɛn, sɔm tin dɛn de we dɛn fɔ tek tɛm wit. So, fala di rayt tin we di dɔktɔ se.

Wetin fɔ du if yu tek bɔku mɛrɛsin?

If dat apin, dat min se if yu tink se yu dɔn tek mɔ mɛrɛsin pas aw yu bin tink, kɔl di pɔyzin kɔntrol sɛnta we de nia yu ɔ di ɔspitul imejensi rum wantɛm wantɛm. Nɔ west tɛm.

Impɔtant notis: Dis mɛrɛsin na fɔ yu nɔmɔ. Nɔ gi yu mɛrɛsin to ɔda pɔsin, ilɛksɛf dɛn gɛt di sem sayn dɛn we yu gɛt.

Wetin a go du if a mis wan doz fɔ tek mɛrɛsin?

If dis apin, tek di doz we yu mis as yu mɛmba. Bɔt if i dɔn lɛf smɔl fɔ lɛ yu tek yu nɛks doz, skip di doz we yu mis ɛn tek yu nɛks doz di tɛm we yu dɔn sɛtul. Nɔ ɛva tek tu dos wan tɛm.

Ɛni ɔda mɛrɛsin de we kin miks wit dis mɛrɛsin?

Yɛs, sɔntɛm i go de. Bɔku mɛrɛsin dɛn de we kin wok wit Sapropterin. Fɔ ɛgzampul:

• Avanafil `(avanafil)`
• Levodopa `(lɛvodopa)`
• Mɛtɔtreksɛt we dɛn kɔl
• Pemetrexed we dɛn kɔl Pemetrexed
• Pirimɛtamin
• Sildenafil `(sildenafil)`
• Tadalafil `(tadalafil)`
• Vardenafil `(vardenafil)`

Dis list nɔ kɔmplit. So, tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (we dɛn prɛskrib yu ɔ we yu nɔ de it), ɔyl, vaytamɛn, ɛn it we yu de yuz. Dɔn bak, tɛl yu dɔktɔ if yu de smok, drink rɔm, ɔ yuz drɔgs we nɔ rayt. Sɔm tin kin miks wit dis mɛrɛsin.

Wetin a fɔ tek tɛm mɔ we a de tek dis mɛrɛsin?

Dis na pat bak we rili impɔtant.

• Yu dɔktɔ go de chɛk yu sik ɔltɛm. So, nɔ mis fɔ go na di klinik dɛn di de dɛn we dɛn dɔn plan fɔ du ɛn mek dɛn du yu blɔd tɛst . Ɛspɛshali, yu fɔ de chɛk yu phenylalanine lɛvɛl ɔltɛm.
• I kin tek lɛk 4 wiks fɔ mek dis mɛrɛsin bigin fɔ wok pan di bɔdi. So nɔ wɔri.
• If yu sik nɔr de bɛtɛ, ɔr if i tan lɛk se dɛn de wɔs, tɛl yu dɔktɔ.
• I rili impɔtant: Yu go nid fɔ fala spɛshal it we yu de tek dis mɛrɛsin. Dis min se yu fɔ it it dɛn we nɔ gɛt bɔku phenylalanine. Yu dɔktɔ ɔ pɔsin we sabi bɔt it go ɛksplen dis to yu ditayli. Nɔ ɛva chenj di it we yu de it if yu dɔktɔ nɔ advays yu.

Wetin na di sayd ɛfɛkt dɛm we dis mɛrɛsin kin gɛt?

Lɛk ɔl di mɛrɛsin dɛn, dis wan kin gɛt smɔl smɔl sayd ɛfɛkt dɛn. Sɔm kin siriɔs, ɛn ɔda wan dɛn nɔ kin rili siriɔs.

If dɛn tin ya apin, yu nid fɔ tɛl di dɔktɔ wantɛm wantɛm!

• If na alɛji riakshɔn: I min se yu skin de rɔsh, it, ayv, yu fes, lip, ɛn tɔng de swel.
• If yu stɔl blak ɔ blɔd, ɔ if yu vɔmit blɔd.
• I nɔ kin izi fɔ yu fɔ blo.
• If yu fil se yu diziz, yu ed layt, ɔ yu fil lɛk se yu de kam fɔdɔm.
• Di sayn dɛm lɛk fɔ fidget, nɔr de rεst, fɔ tɔk tumɔs, ɛn fɔ rɔn rawnd (hyperactivity). (Dis na tru mɔ fɔ yɔŋ pikin dɛn)
• If yu gɛt siriɔs bɛlɛ pen.

Bɔku tɛm dɛn tin ya nɔ kin denja, bɔt if dɛn kɔntinyu fɔ de, tɛl yu dɔktɔ :

• Kɔf
• Stɔl we lɔs (dayarɛa) .
• Ed de at
• Nɔs, fɔ vɔmit
• Trot de at
• Nos we de rɔn, nos we dɔn stɔp

Dis list nɔ de inklud ɔl di sayd ɛfɛkt dɛn. If yu notis ɛnitin we nɔ kɔmɔn, aks yu dɔktɔ. Yu kin ripɔt bak di sayd ɛfɛkt dɛn to di FDA (Food and Drug Administration) na 1-800-FDA-1088.

Aw yu fɔ kip yu mɛrɛsin?

• Kip am usay pikin dɛn nɔ go ebul fɔ rich . Dis rili impɔtant.
• Stɔr na rum tɛmpracha (bitwin 20 ɛn 25 digri sɛlshiɔs / 68 ɛn 77 digri Fahrenheit).
• Kip di mɛrɛsin na di ɔrijinal kɔntena we i kam insay.Klos di bɔtul tayt wan.
• Nɔ yuz mɛrɛsin dɛn we dɔn pas. Trowe dɛn go.

Fɔ dɔn, fɔ mɛmba smɔl

Dis na jɔs sɔm pan wetin wi dɔn tɔk bɔt di mɛrɛsin `Sapropterin`. If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis mɛrɛsin, duya aks yu dɔktɔ, fama, ɔ ɔda pɔsin we de kia fɔ yu wɛlbɔdi biznɛs. Nɔ fred ɛnitin ɔ kip am to yusɛf.

Impɔtant tin dɛn fɔ mɛmba (Take-Home Message) .

Okay, so, wi go mɛmba yu bak di pɔynt dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt?

• Sapropterin na mεdikeshכn we de εp fכ kכntrכl di fεnylalanin lεvεl na sכm pipul dεm we gεt fεnylketonuria (PKU).
• Dis nɔto mɛrɛsin , ɛn dɛn fɔ yuz am nɔmɔ wit spɛshal it .
• Bifo yu tek mɛrɛsin, tɛl yu dɔktɔ bɔt ɔl yu wɛlbɔdi prɔblɛm ɛn ɔl di mɛrɛsin dɛn we yu de tek.
• If yu de dil di mɛrɛsin, drink am insay 15 minit.
• I impɔtant fɔ mek dɛn du di rayt tɛst dɛn di rayt tɛm.
• If yu gɛt ɛni ɔda bad bad tin we kin apin to yu, tɛl yu dɔktɔ wantɛm wantɛm.
• Nɔ chenj di it we yu de it if yu dɔktɔ nɔ advays yu.

If dɛn dɔn gi yu ɔ yu pikin dis mɛrɛsin, fala di dɔktɔ in instrɔkshɔn jɔs lɛk aw i tɛl yu. Na da tɛm de nɔmɔ yu go ebul fɔ gɛt di bɛst pan dis mɛrɛsin, kɔntrol yu `PKU` kɔndishɔn fayn fayn wan, ɛn liv wɛl bɔdi layf. A de wish yu ɔl di bɛst!

` Sapropterin, Fɛnilkɛtonuria, Fɛnilkɛtonuria, PKU, Fɛnilalanin, Fɛnillalanin, Mɛdisin, Drug, Sayd Ifɛkt