Pwɛl hat nɔto jɔs fɔ fil bad, na mɛrɛsin wae nid fɔ gɛt tritmɛnt. Sɔmtɛm, ivin afta dɛn dɔn yuse difrɛn kayn mɛrɛsin wae de mɛk pɔrsin fil bad, sɔm pipul dɛn nɔr kin gɛt pwɛl hat sik. Wi kin kɔl dis kayn kɔndishɔn tritmɛnt-rɛsistant diprɛshɔn. Tide, wi de tɔk bɔt wan mɔdan tritmɛnt we kin ɛp dɛn kayn pipul ya ɛn di wan dɛn we gɛt siriɔs pwɛl at wit dɛn maynd fɔ kil dɛnsɛf.
Wetin na Spravato? Aw i kin wok?
Spravato na wan sprɛy we dɛn kin yuz na in nos we gɛt di mɛrɛsin we dɛn kɔl esketamine . Na tritmɛnt we di US FDA dɔn gri fɔ insay 2019.
Yu go mɔs dɔn yɛri di nem ketamine bifo. Ketamin na wan mɛrɛsin we dɛn kin gi insay di bɛlɛ (IV) as mɛrɛsin fɔ mɛn pen ɛn anestetik na ɔspitul. Dɛn kin yuz am bak na vetɛriana klinik dɛn. Yu go dɔn yɛri di nem bikɔs sɔm pipul dɛn de yuz am di rɔŋ we fɔ gɛt ay ay ɛn gɛt hallucinations.
Spravato na wan spɛshal kayn ketamin. Fɔ tɔk am simpul wan, dis drɔg de wok pan di riseptɔ dɛn na wi bren we dɛn kɔl N-methyl D-aspartate (NMDA) risepta dɛn . Tru dis, e kin ridyus de sik wae de kam wit pwɛl hat bay wae i de chenj de kεmεkal wae de insay wi mכd.
Aw yu kam fɔ no aw dis mɛrɛsin de wok?
Dɛn dɔn du 4 klinik stɔdi fɔ tɛst di sef ɛn ɛfɛktiv we Spravato gɛt. Dɛn stɔdi ya bin gɛt big pipul dɛn we ol bitwin 18 ɛn 64 ia.
Dɛn bin yuz wan spɛshal skɔring sistɛm fɔ no aw pɔrsin gɛt pwɛl hat ɛn aw de sik kin bɛtɛ. Dɛn kɔl am di Montgomery-Asberg Dipression Rating Scale (MADRS) . Na kwɛstyɔn we gɛt 10 kwɛstyɔn dɛn. I kin aks bɔt tin dɛm lɛk aw yu de fil, aw yu de fil gilti, aw yu de slip, ɛn aw yu de tink bɔt fɔ kil yusɛf. Di mak de frɔm 0 to 60, wit ay mak de sho se yu gɛt mɔ siriɔs pwɛl hat . Afta tritmɛnt, di mɔ di MADRS skɔ nɔ fayn, na di mɔ di skɔ go smɔl, we de sho se di simptom dɛn dɔn bɛtɛ.
Wetin na di tin dɛn we dɛn stɔdi dɛn ya dɔn du?
Impɔtant: Dis na jɔs di tin dɛn we dɛn dɔn fɛn frɔm di stɔdi dɛn. Yu rizulyt kin difrɛn. Tɔk to yu dɔktɔ bɔt dis.
| Rizult fɔ Tritmɛnt-Resistant Dipreshɔn | |
|---|---|
| Kategori fɔ di tritmɛnt | Dikrɛshɔn pan di MADRS skɔ afta 4 wik |
| Spravato (56mg ɔ 84mg) tu tɛm insay di wik + ɔda antidipreshan | Bay lɛk 20 poɛnt so |
| Plɛsibo + ɔda mɛrɛsin we de mek pɔsin fil bad | Bay lɛk 16 pɔynt dɛn |
Dɛn rizɔlt ya sho se pipul dɛm wae bin yuse Spravato bin gɛt bɔrku ridɔkshɔn pan pwɛl hat sik. Di stɔdi dɛn sho bak se di wan dɛn we kɔntinyu fɔ yuz Spravato bin gɛt delay fɔ kam bak wit di sik.
| Rizult fɔ siriɔs pwɛl hat wit tin fɔ tink bɔt fɔ kil yusɛf | |
|---|---|
| Kategori fɔ di tritmɛnt | Dikrɛshɔn pan MADRS skɔ afta 24 awa |
| Spravato (56mg ɔ 84mg) tu tɛm insay di wik + ɔda antidipreshan | Bay lɛk 16 pɔynt dɛn |
| Plɛsibo + ɔda mɛrɛsin we de mek pɔsin nɔ fil bad | Bay lɛk 12 pɔynt dɛn |
Wetin spɛshal bɔt dis na dat Spravato de sho se di sik dɔn ridyus bad bad wan insay lɛk 24 awa afta yu dɔn yuz am . Tipik antidipreshan kin tek sɔm wiks fɔ sho di rizɔlt. So, dis kin rili impɔtant we ɛnitin apin we nɔ izi fɔ du.
Spravato kin intarakt wit ɔda mɛrɛsin dɛn?
Yes, yu nid fɔ tek tɛm wit ɔda mɛrɛsin dɛn we yu de tek Spravato.
- Blɔd prɛshɔn mɛrɛsin: Spravato kin mek blɔd prɛshɔn go ɔp fɔ sɔm tɛm. Dis risk kin bɔku if yu de tek ɔda kayn mɛrɛsin wae de mek yu nɔr gɛt pwɛl hat, lɛk monoamine oxidase inhibitor (MAOI) , ɔr tin wae de mek yu gɛt prɔblɛm wit yu atɛnshɔn. So, if yu de tek dɛn mɛrɛsin ya, yu fɔ de chɛk yu blɔd prɛshɔn ɔltɛm.
- Mɛrɛsin dɛm wae kin mek pɔrsin slip ɛn diziz: Spravato kin mek pɔrsin slip ɛn diziz. Dɛn sayd ɛfɛkt ya kin wɔs if yu yuz drɔgs we de pwɛl di sɛntral nervɔs sistɛm, lɛk bɛnzodiazepines (e.g., alprazolam, clonazepam), opioid (pen kil), ɛn rɔm .
If yu nɔ shɔ if yu fɔ tek dɛn mɛrɛsin ya, nɔ wɔri. Tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek . Dɔn i go disayd if Spravato rayt fɔ yu. Ɔltɛm, go to yu dɔktɔ bifo yu bigin ɛni nyu mɛrɛsin ɔ vaytamɛn.
Aw a go gɛt Spravato tritmɛnt?
Dis nɔto mɛrɛsin we yu kin bay na famasi ɛn kɛr go na os fɔ yuz.
Bikɔs ɔf di sayd ɛfɛkt ɛn di risk fɔ yuz Spravato di rɔŋ we, dɛn kin jɔs gi dis tritmɛnt na sɛtifiket tritmɛnt sɛnta dɛn . Dɛn sɛnta ya fɔ rɛjista ɔnda wan spɛshal program we dɛn kɔl Spravato REMS (Risk Evaluation and Mitigation Strategy).
1. Tɔk to yu dɔktɔ: If yu intres pan dis tritmɛnt, tɔk to yu famili dɔktɔ ɔr dɔktɔ we de mɛn yu maynd.
2. Riferal: If yu dɔktɔ tink se Spravato rayt fɔ yu, i go rifer yu to wan sɛtifiket tritmɛnt sɛnta.
3. Kɔnsultɛshɔn: Dɔn dɛn go gi yu kɔnsultɛshɔn na di tritmɛnt sɛnta. Na de, dɔktɔ dɛn go chɛk yu sik bak ɛn disayd mɔ if dis fayn fɔ yu.
4. Fɔ bigin tritmɛnt: If ɔltin fayn, yu kin bigin tritmɛnt di sɛkɔn tɛm we yu go.
Aw yu de yuz Spravato?
Dɛn kin tek dis wan ɔ tu tɛm insay di wik, na wan sɛtifiket sɛnta, ɔnda di sɔpɔtishɔn fɔ di dɔktɔ dɛn .
- Di doz ɛn aw fɔ yuz am: Yu dɔktɔ go disayd di doz we yu nid. Dɛn go tich yu bak aw fɔ yuz di nos sprɛy.
- Fɔ it ɛn wata: Bikɔs di mɛrɛsin kin mek yu nɔs ɛn vɔmit, i fayn fɔ mek yu nɔ it 2 awa bifo yu trit yu ɛn drink wata 30 minit bifo yu .
- Di tɛm we dɛn kin wach:Afta yu tek Spravato, yu dɔktɔ go de wach yu fɔ at le 2 awa fɔ chɛk fɔ chenj na yu blɔd prɛshɔn ɛn ɔda sayd ɛfɛkt dɛn.
- Drayv: Dis mɛrɛsin kin afɛkt di we aw yu de pe atɛnshɔn ɛn di we aw yu de disayd fɔ du sɔntin di de we dɛn de gi yu tritmɛnt. So, yu fɔ arenj fɔ mek pɔsin drayv yu go na os frɔm di tritmɛnt sɛnta . I bɛtɛ fɔ drayv ɔ du ɔda tin dɛn we nid fɔ pe atɛnshɔn di nɛks de afta yu dɔn slip fayn.
Wetin na di sayd ɛfɛkt dɛm ɛn aw dɛn kin avɔyd dɛn?
Spravato kin gɛt siriɔs sayd ɛfɛkt, na dat mek dɛn kin jɔs gi am ɔnda dɔktɔ in sɔpɔtishɔn.
- Drowsiness ɛn disorientation: I kin kam pan pɔsin we de slip pasmak, diziz, faint, ɛn dissociation kin apin.
- I nɔ kin izi fɔ yu fɔ blo: Di briz kin slo ɔ shalo. Dis kin bi mɔ if yu gɛt ɔda prɔblɛm dɛn we yu de blo ɔ yu de tek ɔda mɛrɛsin dɛn we de mek yu nɔ ebul fɔ blo fayn.
- Blɔd prɛshɔn we de go ɔp: Blɔd prɛshɔn kin go ɔp fɔ sɔm tɛm fɔ lɛk 4 awa afta yu dɔn tek di mɛrɛsin. If yu gɛt pen na yu chɛst, yu nɔ kin ebul fɔ blo, yu ed kin at bad bad wan, yu kin chenj yu yay, ɔ yu kin gɛt sik , tɛl yu dɔktɔ wantɛm wantɛm .
- Fɔ tink bɔt fɔ kil insɛf mɔr: Jɔs lɛk sɔm mɛrɛsin wae de mek pɔrsin fil bad, smɔl risk de wae sɔm pipul dɛn kin tink bɔt fɔ kil dɛnsɛf ɔr du tin wae dɛn kin du di fɔs tɛm wae dɛn tek Spravato. Tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni nyu ɔ siriɔs chenj na yu bihayvya ɔ tinkin.
- Risk fɔ adikshɔn: Risk de fɔ adikshɔn to dis mɛrɛsin. So, i impɔtant fɔ yuz am nɔmɔ ɔnda dɔktɔ advays ɛn di doz we dɛn tɛl yu fɔ yuz. If yu bin dɔn gɛt adikshɔn to rɔm, drɔgs, ɔ ɔda mɛrɛsin, tɛl yu dɔktɔ bɔt dat.
- Prɔblɛm dɛn we de na di yurinary system: Sɔm pipul dɛn dɔn ripɔt se dɛn kin chenj ɔ dɛn nɔ kin ebul fɔ pis. If dis apin, mek yu dɔktɔ no.
- Mama dɛn we gɛt bɛlɛ ɛn we de gi pikin dɛn bɛlɛ: Dɛn nɔ kin fayn fɔ yuz spravato we dɛn gɛt bɛlɛ ɔ we dɛn de gi pikin in bɛlɛ, bikɔs i kin afɛkt di pikin.
- Spravato (esketamine) na wan patikyula tritmɛnt fɔ pipul dɛm wae gɛt siriɔs pwɛl hat sik ɛn wae de tink bɔt fɔ kil dɛnsɛf wae nɔr dɔn ansa to tipik antidipreshan.
- Dis nɔto mɛrɛsin we pɔsin kin bay na famasi ɛn yuz am na os. Dɛn kin gi am nɔmɔ na tritmɛnt sɛnta dɛn we gɛt sɛtifiket, ɔnda dɔktɔ in sɔpɔtishɔn.
- Yu fɔ avɔyd fɔ drayv ɔ du ɛnitin we yu nid fɔ pe atɛnshɔn to di de we yu go gɛt di tritmɛnt. Yu go nid ɔda pɔsin fɔ ɛp yu fɔ rich na os.
- Siriɔs sayd ɛfɛkt lɛk ay blɔd prɛshɔn, fɔ slip pasmak, ɛn kɔnfyushɔn kin apin. Ripɔt ɛnitin we nɔ kɔmɔn to yu dɔktɔ wantɛm wantɛm.
- Tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, mɔ di mɛrɛsin dɛn fɔ ɔda mental sik ɛn mɛrɛsin dɛn we de mek yu nɔ fil pen.
- Na yu ɛn yu dɔktɔ nɔmɔ fɔ disayd if dis tritmɛnt fayn fɔ yu.
If ɛnitin apin, kɔl di Suwa Saria Ambulans Savis na 1990 , ɔ kɔl di mental wɛlbɔdi hotlayn na 1926. Ɔ go na di ɔspitul we de nia yu Imejɛnsi Tritmɛnt Yunit (ETU) .
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