Yu kin si se yu de muv yu bɔdi we yu nɔ want? Mek wi tɔk bɔt Tardive Dyskinesia!

Sɔntɛnde, yu kin fil lɛk se sɔm pat dɛn na yu bɔdi, lɛk yu an ɔ yu leg, ɔ yu fes jɔs de muf we yu nɔ ebul fɔ kɔntrol? Ɔ pɔsin we yu sabi dɔn gɛt dɛn strenj tin ya afta we i dɔn tek sɔm mɛrɛsin dɛn? If yu dɔn yɛri bɔt dis kayn tin, den de kɔndishɔn wae wi go tɔk bɔt tide, wae dɛn kɔl Tardive Dyskinesia, go impɔtant to yu. Pan ɔl we na lɔng wɔd smɔl, lɛ wi jɔs ɔndastand wetin i bi.

Wetin na Tardive Dyskinesia?

Fɔ tɔk am simpul wan, Tardive Dyskinesia (TD) na wan nyurolɔjik sindrom, ɔ kɔlekɛshɔn fɔ simptom dɛm, we yu bɔdi in mɔsul dɛm de muv we yu nɔ want, we yu nɔ de kɔntrol. Lɛk aw yu an de shek shek ɔ yu fes de chenj wantɛm wantɛm.

Di men tin wae kin mek dis sik na wae dɛn kin yuse sɔm mɛrɛsin fɔ lɔng tɛm fɔ mɛntɛl sik, mɔr lɛk fɔs jɛnɛreshɔn antisaykotik mɛrɛsin (nyurolɛptik). Bɔt nɔto dɛn mɛrɛsin ya nɔmɔ kin mek pɔsin gɛt dis. Sɔm ɔda mɛrɛsin dɛn kin mek dis sik bak.

Di wɔd "Tardive" min "delay" ɔ "let." "Dyskinesia" min we yu nɔ want, dat na, we yu nɔ de kɔntrol di mɔsul dɛn we de muv. So pan dis kɔndishɔn, dɛn muvmɛnt ya we yu nɔ want fɔ muv kin apin afta yu bigin fɔ tek mɛrɛsin fɔ sɔm tɛm, sɔmtɛm fɔ lɔng tɛm. Bɔt sɔntɛnde dis sik kin apin ivin afta yu dɔn tek di mɛrɛsin fɔ shɔt tɛm. Dis sik kin apun mɔr pan pipul dɛm wae dɔn pas 65 ia, ivin if dɛn yuz di mɛrɛsin fɔ shɔt tɛm.

Aw kɔmɔn tin dis kin apin?

Risach pipul dɛm se at le 20% pan di pipul dɛm wae de tek fɔs jɛnɛreshɔn antisaykotik kin gɛt tardive dyskinesia. Dɛn nɔ bin dɔn stɔdi di rayt we aw dis sik kin apin wit ɔda kayn mɛrɛsin, so i nɔ kin izi fɔ gi di rayt nɔmba.

Wetin na di sayn dɛm wae de sho se yu gɛt Tardive Dyskinesia?

Tardive dyskinesia kin mek yu muv na ples lɛk dis wae yu nɔr kin ebul fɔ kɔntrol:

• Di mɔsul dɛn we de na yu fes
• Tɔng
• Nɛk
• Trunk mɔsul dɛn
• Limb dɛn we de na di bɔdi

Di muvmɛnt dɛn we yu nɔ want fɔ muv di fes:

• Lip-smacking ɔ sok muvmɛnt.
• Grimacing ɔ frowning fɔ natin.
• Fɔ stik di tɔŋ ɔ fɔ prɛs di tɔŋ insay di chɛst.
• Muvmɛnt dɛn we yu de muv fɔ chew.
• Puf di chɛst dɛn.
• Di ay we de blink kwik kwik wan / blepharospasm. Imajin aw i go vɛks if yu jɔs kɔntinyu fɔ blink yu yay.

Ɔda tin dɛn we pɔsin kin muv we pɔsin nɔ want:

• Fɔ muv finga dɛn we yu de muv ɔltɛm, lɛk we yu de ple piano.
• Fɔ push ɔ rɔk yu bɛlɛ.
• We yu de waka wit wan we we tan lɛk dɔk.
• Wae yu nɔr kin ebul fɔ sidɔm, wae yu kin fil ɔltɛm wae yu nɔr de rεst (akathisia). Dis kin bi sɔntin we nɔ kin rili fayn.

Dɛn sayn ya kin rili smɔl ɛn nɔr kin notis fɔ sɔm pipul dɛm, bɔt fɔ ɔda pipul dɛm dɛn kin so bad dat dɛn kin afɛkt di tin dɛm wae dɛn kin du ɛvride te dɛn nɔr kin ebul fɔ no .

Dɔktɔ dɛn kin yuz wɔd dɛn lɛk dis fɔ tɔk bɔt dɛn sik ya:

• Dystonia: Di mɔsul dɛn we nɔ de kɔntrol.
• Myoclonus: Na wan mɔsul we de jɔk wantɛm wantɛm, fɔ shɔt tɛm.
• Buccolingual stereotypy: Ripit muvmεnt dεm we involv di mכt εn tכng.
• Tiks: Di mɔsul dɛn kin kɔntrakt, mɔ na di fes.

Wetin na de tin wae kin mek yu gɛt Tardive Dyskinesia?

Di wan dɛn we de stɔdi bɔt dis nɔ no bɛtɛ bɛtɛ wan wetin kin mek dis sik. כltu di men aidia na dat i kin kכz bay we dεn de yuz dεn dεm we dεn kכl ``dopamine antagonists`` we de blכk di rεsεpכta dεm fכ di nyurotransmitta ``dopamine`` na di bren. Dis kin apin ilɛksɛf yu tek dɛn mɛrɛsin ya fɔ shɔt tɛm ɔ fɔ lɔng tɛm. Bɔt di risk kin bɔku we yu tek dɛn fɔ lɔng tɛm. Sɔntɛnde, TD kin apin afta yu dɔn stɔp dɛn mɛrɛsin ya, chenj di doz, ɔ ivin ridyus am.

Imajin, we yu tek dכpamin rεsεpכta blכk dεm fכ lכng tεm, di dopamin rεsεpכta dεm na di bren (especially dεn wan dεm na di basal ganglia, we na wan pat pan di bren we de εp fכ kכntrכl muvmεnt) kin bi εkstra sεnsitiv. dεn tink se dis muvmεnt we dεn nכ kכntrol de kכz fכ tu mכch dopamin כ di rεsεpכta dεm we de sεnsitiv pasmak.

apat frכm dopamin, dεn tink se כda nyurotransmit rεsεpכta dεm lεk sεrotonin, asetilkolin, εn GABA, de involv bak. Dis kin bi wae mek sɔmtɛm TD kin kam wit ɔda mɛrɛsin pas antisaykotik.

Us mɛrɛsin dɛn kin mek pɔsin gɛt Tardive Dyskinesia?

Tardive dyskinesia kin kam wae yu yuse dɛn mɛrɛsin ya:

• Antisaykotik mɛrɛsin / nyurolɛptik: Dɛn wan ya na di men tin we kin mek pɔsin gɛt dis sik.
• Metoclopramide ɔ ɔda mɛrɛsin we de mek pɔsin nɔ fil fayn.
• Sɔm mɛrɛsin dɛn we de mek pɔsin in at pwɛl .

Na smɔl tɛm nɔmɔ, dɛn mɛrɛsin ya kin mek pɔsin gɛt TD bak:

• Litiɔm we dɛn kɔl.
• Mɛrɛsin dɛn we de mek pɔsin nɔ gɛt sik.
• Antihistamin, mɔ di haydroksizin.
• Antimalaria na mɛrɛsin we dɛn kin gi fɔ malaria.

Antisaykotik mɛrɛsin ɛn TD

Dɛn kin yuse antisaykotik drɔgs (nyurolɛptik) mɔ fɔ trit mɛntɛl sik dɛm lɛk skizofrenia. Dɛn mɛrɛsin ya na dɛn kin mek pɔsin gɛt TD.

fכs jεnereshכn ("typical") antisaykotik dεm dεn tink se dεn gεt hכy risk fכ mek TD pas sεkכn jεnereshכn ("atypical") antisaykotik dεm.

Sɔm ɛgzampul dɛn bɔt fɔs jɛnɛreshɔn antisaykotiks:

• Klɔrpromazin `(Klɔrpromazin)`
• Flufenazin `(Flufenazin)`
• Haloperidol `(Haloperidol)`
• Pɛrfɛnazin `(Pɛfɛnazin)`
• Proklɔrpɛrazin `(Proklɔrpɛrazin)`
• Tioridazin `(Tioridazin)`
• Trifluoperazin `(Trifluoperayzin)`

Mɛtoklɔpramid ɛn tardiv diskinɛsia

Metoclopramide na wan mɛrɛsin we dɛn kin yuz fɔ trit kronik asid riflɔks (GERD), we na wan bad bad we fɔ gɛt gastritis. Dɛn kin yuz am bak fɔ trit di sik we dɛn kɔl gastroparesis we gɛt fɔ du wit dayabitis.

Strɔng asosieshɔn de bitwin mɛtoklɔpramid ɛn TD. Risk factor dɛm fɔ mek yu gɛt TD bikɔs ɔf dis mɛrɛsin na:

• Fɔ bi 65 ia ɔ pas dat.
• Fɔ bi uman.
• Fɔ gɛt dayabitis.
• Fɔ tek mɛtoklɔpramid fɔ 12 wik ɔ mɔ.

Antidipreshɔn ɛn TD

Dɛn kin yuse mɛrɛsin wae de mek pɔrsin fil bad fɔ trit pɔrsin wae gɛt pwɛl hat sik, wae pɔrsin de wɔri, ɛn wae pɔrsin kin fil bad. Dɛn mɛrɛsin ya kin mek pipul dɛn we dɔn pas 65 ia TD.Dis na bikɔs di bren kin chenj wit di ej. Dis kin ɔltɛm nɔr kin bɔku pas di TD wae kin kam wit antisaykotik mɛrɛsin.

Dɛn antidipreshan ya gɛt fɔ du wit `(TD)`:

• Trazodone (dis na sεrotonin mכdulet).
• Amitriptyline, clomipramine, ɛn doxepin (dɛn tin ya na trisayklik antidipreshan).
• Fluoxetine ɛn sertraline (dɛn na SSRI).
• Fɛnalzin ɛn rasagilin (dɛn na MAOI dɛn).
• Selegiline (we na MAOI bak) dɔn gɛt link to TD we dɛn tek am wit levodopa.

Litiɔm ɛn TD

Lithium na mɛrɛsin wae dɛn kin yuse fɔ trit pɔrsin wae gɛt dis sik. I gɛt fɔ du wit TD bak. Bɔt if yu tek lithium wit wan mɛrɛsin we de mek yu nɔ gɛt maynd, yu risk fɔ gɛt TD go bɔku pasmak.

Antiseizure mɛrɛsin ɛn TD

Dɛn kin yuz mɛrɛsin fɔ mek pɔsin nɔ gɛt sik ɛn fɔ mek i nɔ gɛt sik. Carbamazepine ɛn lamotrigine gɛt fɔ du wit TD, bɔt dɛn nɔ kin gɛt TD. Fɛnitoin dɔn gɛt fɔ du bak wit TD.

Antihistamin ɛn TD

Antihistamines de ɛp fɔ gɛt alɛji simptom dɛm. Hydroxyzine, in patikyula, dεn bin lεnk to TD if yu yuz am fכ lכng tεm.

Pipul wae dɔn pas 65 ia wae dɔn yuse phenothiazine (typical antipsychotics) kin gɛt TD wae dɛn de tek hydroxyzine.

Antimalarial ɛn TD

Antimalarial dɛm lɛk kloroquine ɛn amodiaquine gɛt fɔ du wit TD.

Wetin na de risk factor fɔ Tardive Dyskinesia?

Sɔm tin kin mek yu gɛt mɔr risk fɔ gɛt tardive dyskinesia. Sɔm pan dɛn na:

• Ej: Pipul wae dɔn pas 40 ia kin gɛt TD. Pipul wae dɔn pas 65 ia kin de pan denja pasmak bikɔs ɔf di chenj dɛm na di nervɔs sistɛm wae kin apin wit di ej.
• Jɛnda: Uman dɛn kin gɛt TD mɔ. uman dεm we dεn dכn mεnopos we de tek antisaykotik mεdikeshכn fכ lεk wan ia gεt 30% hכy risk fכ gεt TD.
• Race: Sɔm stɔdi dɔn sho se blak pipul dɛm na Amɛrika kin gɛt TD pas wayt pipul dɛm. Dɔn bak, pipul dɛn we kɔmɔt na Filipino ɛn Eshia nɔ kin gɛt TD pas di wan dɛn we kɔmɔt na Kɔkashian. (Dɛn nid fɔ du mɔ lokal stɔdi fɔ no aw dis kin apin to Sri Lanka.)
• Bipolar disorder: Pipul wae gɛt bipolar disorder kin gɛt mɔr sɛnsitiv to TD pas ɔda pipul dɛm wae dɛn de tek antipsychotic mɛrɛsin.

Risach pipul dεm de stכdi bak naw na di jεnεtik fכktכ dεm we de inkrεs כ dכn di risk fכ gεt TD.

Wetin na de prɔblɛm wae kin kam wit Tardive Dyskinesia?

di muvmεnt dεm we dεn nכ kכntro we dεn kin kכz fכ tardive dyskinesia kin rili nכ kɔmfyut. I kin afɛkt bak aw yu de liv yu layf ɛn aw yu de fil. Dis kin gɛt big impak pan yu maynd wɛl bɔdi. I kin mek i nɔ izi bak fɔ du ɛvride wok.

TD nɔ kin bi wan sik we kin kil pɔsin. Bɔt,Na sכm tεm, if TD bi siriכs εn afekt di larynx (we di vokal kכd dεm de - laryngospasm) εn di dayafragm (di mכsul we de εp yu fכ brith), i kin mek yu at fכ brith εn i kin mek yu layf de pan denja.

Aw dɛn kin no bɔt Tardive Dyskinesia?

Yu dɔktɔ go aks bɔt yu sik, yu mɛrɛsin histri, ɛn aw yu de tek mɛrɛsin. Yu dɔktɔ kin sɔprayz se yu gɛt tardive dyskinesia (TD) if yu de tek mɛrɛsin we dɛn no se kin mek yu gɛt tardive dyskinesia. Dɛn go du ɛgzam fɔ dɛn bɔdi ɛn ɛgzam fɔ di nyurolɔjik. Dɛn kin sɛn yu bak to spɛshal dɔktɔ, lɛk dɔktɔ we de mɛn yu nyuro, dɔktɔ we de mɛn pipul dɛn we nɔ de muv, ɔ dɔktɔ we de mɛn yu maynd.

Dɔktɔ dɛn kin yuz di Diagnostic and Statistical Manual of Mental Disorders (DSM-5) fɔ no if pɔsin gɛt tardive dyskinesia. Di DSM-5 , se fɔ mek dɛn no se i gɛt tardive dyskinesia, di sayn dɛn fɔ dɔn de fɔ at le wan mɔnt afta dɛn dɔn stɔp fɔ tek mɛrɛsin. If yu ol 40 ia ɔ smɔl pas dat, yu fɔ dɔn de tek mɛrɛsin fɔ at le tri mɔnt, ɔ if yu dɔn pas 40 ia, yu fɔ dɔn de tek mɛrɛsin fɔ wan mɔnt.

Yu dɔktɔ kin ɔda fɔ du ɔda tɛst fɔ no if yu gɛt TD ɔ fɔ pul ɔda tin dɛn we gɛt di sem kayn sik, lɛk di sik we dɛn kɔl Huntington. Dɛn tin ya kin bi tɛst we dɛn kin du na lɛbɔtri ɛn tɛst we dɛn kin du fɔ tek pikchɔ, lɛk CT skan ɔ MRI na di bren. Bɔt, TD na klinik diagnosis. Dis min se dɔktɔ dɛn kin mek di sik bay we dɛn gɛt gud gud mɛdikal istri ɛn we dɛn dɔn du gud gud wan fɔ chɛk dɛn bɔdi, ɛn dɛn nɔ kin du ɔda tɛst dɛn.

Wetin na di tritmɛnt fɔ Tardive Dyskinesia?

stכdi dεm pan di mεnejmεnt fכ tardive dyskinesia dεn sho miks risכlt. Sɔm stɔdi dɔn sho se di sik kin bɛtɛ we dɛn ridyus ɔ stɔp di doz fɔ di mɛrɛsin we de mek pɔsin nɔ gɛt maynd sik. Ɔda wan dɛn de sho se no difrɛns nɔ de.

Yu dɔktɔ kin se yu fɔ stɔp di mɛrɛsin we de mek yu gɛt TD, if i pɔsibul. Bɔt i sɔri fɔ no se nɔto ɔltɛm dis kin pɔsibul. Dis na bikɔs fɔ stɔp di mɛrɛsin kin mek di ɔndalayn kɔndishɔn we di mɛrɛsin bin de kɔntrol, wɔs.

If yu gɛt TD we yu de tek fɔs jɛnɛreshɔn antisaykotik, yu dɔktɔ kin chenj yu to sɛkɔn jɛnɛreshɔn antisaykotik.

Apat frɔm fɔ stɔp ɔ chenj di antisaykotik, di strɔng pruf fɔ di tritmɛnt fɔ TD de naw fɔ wan klas ɔf drɔgs we dɛn kɔl VMAT inhibitors. Naw dɛn dɔn sho se Deutetrabenazine ɛn valbenazine sef ɛn i kin wok fayn. If yu gɛt mɔdaret to siriɔs TD we de afɛkt yu kwaliti layf, yu dɔktɔ kin tɛl yu fɔ tek dɛn mɛrɛsin ya.

Yu tink se dɛn kin mɛn Tardive Dyskinesia? (Dɛn kin rivɛns am?)

Bɔt i sɔri fɔ no se, bɔku pan di kes dɛm wae gɛt tardive dyskinesia kin de fɔ lɔng tɛm, dat min se dɛn kin las fɔ lɔng tɛm. Pan ɔl we mɛrɛsin kin ɛp fɔ kɔntrol di sayn dɛm, dɛn nɔ kin ebul fɔ mɛn di sik ɔltogɛda ɔr kin chenj.

Wetin a fɔ ɛkspɛkt if a gɛt Tardive Dyskinesia?

Tardive dyskinesia nɔr kin afɛkt ɔlman di sem we. Di sayn dɛm kin kɔmɔt frɔm smɔl to siriɔs. Dɔn bak, pan ɔl we tritmɛnt kin ɛp sɔm pipul dɛn fɔ kɔntrol dɛn sik, i nɔ kin ɛp fɔ ɔda pipul dɛn. Yu dɔktɔ go wok wit yu fɔ fɛn di bɛst tritmɛnt plan. Dɛn kin gi yu gud aidia bɔt wetin fɔ ɛkspɛkt.

Yu tink se dɛn kin ebul fɔ avɔyd Tardive Dyskinesia?

Tardive dyskinesia na wan sik wae nɔr kin izi fɔ tɔk bɔt. Nɔto ɔlman we de tek sɔm mɛrɛsin dɛn go gɛt am.

If yu gɛt tin dɛn we kin mek yu gɛt dis sik, tɔk to yu dɔktɔ. Yu kin ebul fɔ mek yu nɔ gɛt tardive dyskinesia bay we yu yuz difrɛn mɛrɛsin. Fɔ mek yu nɔ gɛt bɔku TD, yu dɔktɔ go gi yu di smɔl smɔl mɛrɛsin fɔ di mɛrɛsin we de mek yu nɔ gɛt maynd fɔ di shɔt tɛm.

If yu de tek mɛrɛsin wae dɛn no se kin mek yu gɛt TD, tɔk to yu dɔktɔ bɔt fɔ gɛt rutin skrinin fɔ si if yu gɛt prɔblɛm wit yu muvmɛnt. If yu no di TD simptom kwik kwik wan, dat kin ɛp fɔ ridyus di kayn we aw dɛn kin tranga. I bɛtɛ fɔ mek dɛn du dɛn skrinin ya insay tri to siks mɔnt afta yu bigin fɔ tek mɛrɛsin we kin mek yu gɛt TD.

Aw a go tek kia ɔf misɛf if a gɛt Tardive Dyskinesia?

Yu dɔktɔ go wok wit yu fɔ tay yu tritmɛnt plan as nid de. Na sɔm ɔda tin dɛn we yu kin du fɔ manej TD:

• Du wan rutin symptom assessment wit yu dɔktɔ ɛvri tri to siks mɔnt.
• Kip rεkɔd fɔ yu sayn dɛm. If yu gɛt nyu sayn dɛn, mek yu dɔktɔ no.
• Praktis fɔ kia fɔ yusɛf, ivin fɔ du yu bɔdi wok. Ɛksesaiz kin ɛp fɔ pul sɔm sayn dɛm wae de sho se yu de muv.
• Tɔk to yu dɔktɔ bɔt di tin dɛn we yu de du ɛvride ɛn di kwaliti fɔ yu layf.
• If TD de afɛkt yu maynd ɛn soshal wɛlbɔdi, go to ɛp frɔm pɔsin we de gi advays bɔt yu maynd .

Ustɛm a fɔ go na di imejensi rum?

If yu gɛt prɔblɛm fɔ blo bikɔs ɔf tardive dyskinesia, kɔl 911 (1990 na Sri Lanka) wantɛm wantɛm ɔ go na di imejensi rum we de nia yu.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Tardive dyskinesia (TD) kin afɛkt pipul dɛn difrɛn we. Fɔ sɔm pipul dɛn, i kin rili afɛkt dɛn kwaliti fɔ liv. Bɔt mɛmba se yu dɔktɔ go wok wit yu fɔ wach ɛn manej yu TD. Dɛn kin rɛkɔmɛnd ɛn chenj wan tritmɛnt plan fɔ fit yu nid, ɛn tɔk bɔt aw fɔ kia fɔ yusɛf we go ɛp. Nɔ ɛva stɔp fɔ tek yu mɛrɛsin ɔ chenj di doz if yu dɔktɔ nɔ advays yu. Tɔk to yu dɔktɔ bɔt ɛni kwɛstyɔn ɔ tin we de mɔna yu.

` Tardive dyskinesia, muvmɛnt we yu nɔ want, mɛrɛsin sayd ifɛkt, antisaykotik, nyuropathi, dopamin, VMAT inhibito