If yu gɛt dayabitis, yu go dɔn no se as tɛm de go, i kin afɛkt yu yay. Nɔr kin si fayn fayn wan, yu kin flot, ɛn yu kin blaynd kɔlɔ na di kɔmɔn sayn dɛm fɔ dis sik. Yu go dɔn yɛri bɔt injɛkshɔn na yu yay as tritmɛnt fɔ dis sik. Dɛn injɛkshɔn ya kin mek yu si fayn ɛn stɔp fɔ pwɛl yu yay mɔ. Tide, wi go tɔk bɔt wan pan dɛn kayn nyu drɔgs ya, we go rili ɛp yu.
Aw dis Vabysmo mɛrɛsin de wok fɔ di yay?
Fɔ tɔk am simpul wan, we pɔsin we gɛt dayabitis gɛt ay blɔd shuga fɔ lɔng tɛm, di dilik blɔd vesel dɛn we de insay in yay kin bigin fɔ pwɛl. dis damej de apin na di retina, we na di layt na di yay we de proכses di imej dεm. Wi kin kɔl dis kɔndishɔn dayabitik rɛtinopati .
Dɛn blɔd vesel ya we dɔn pwɛl kin lik wata ɛn blɔd smɔl smɔl go insay di retina. As di sik de wɔs, di yay kin tray fɔ mek nyu blɔd vesel dɛn fɔ tek di ples fɔ di wan dɛn we dɔn pwɛl. Bɔt dɛn nyu vessel dɛn ya rili wik, ɛn dɛn kin lik mɔ wata.
So wetin na makula ɛdima?
Wan spɛshal say de na di retina we dɛn kɔl di makula . Dis na wetin de ɛp wi fɔ si tin dɛn bifo wi yay, dat na wi stret vishɔn, klia wan. As wi bin dɔn tɔk, we wata kɔmɔt na di blɔd vesel dɛn, dis makula kin bigin fɔ swel. Wi kin kɔl dis dayabitik makyula ɛdima .
Dis na we di vishɔn nɔ kin shayn bɛtɛ, i kin si tu tɛm, blak spat dɛn kin apia, ɛn di kɔlɔ dɛn kin tan lɛk se i nɔ de shayn bɛtɛ. Sɔm pipul dɛn kin ivin lɔs dɛn yay kpatakpata.
Wetin spɛshal bɔt Vabysmo?
di men gol fכ trit dis kכndyushכn na fכ stכp di damej we di rεtina de pwεl. Bɔku kayn mɛrɛsin dɛn de we dɛn kin injɛkt na di yay fɔ dis. Bɔku pan dɛn mɛrɛsin ya kin wok bay we dɛn kin blok wan prɔtin we dɛn kɔl VEGF . Fɔ tɔk am simpul wan, VEGF na wan impɔtant tin we de ɛp fɔ mek dɛn nyu blɔd vesel dɛn we wi nɔ want ɛn we wik. so we dεn blכk VEGF, dεn de kכntro di fכmeshכn fכ nyu vεsεl dεm.
Di aktif ingridiɛnt fɔ Vabysmo na Faricimab . Dis drɔg, lɛk ɔda drɔgs, de blok VEGF. Bɔt apat frɔm dat, dis drɔg de du ɔda tin. Dat min se i de blok wan ɔda prɔtin we dɛn kɔl Ang-2 (angiopoietin-2) . we dis Ang-2 protin de inkrεs na di yay, di bכdi vεsul dεm nכ de stebul εn dεn de lik mכr wata.
so, biכs Vabysmo de blכk כl tu di VEGF εn Ang-2 di sem tεm, i de stכp nyu bכdi vεsul fכ fכm εn stεbyul di bכdi vεsul dεm we de naw, we de ridyus di fכluid lik. Dis dual akshon na im mek Vabysmo yunik.
Wetin di risach we dɛn bin du bɔt dis mɛrɛsin sho?
Dɛn dɔn du tu big klinik trial fɔ no if Vabysmo sef ɛn if i wok, we involv bɔku pipul dɛn we gɛt dayabitis ɛn makula dijɛnɛreshɔn frɔm difrɛn kɔntri ɛn etnik grup dɛn ɔlsay na di wɔl.
Insay dɛn tray ya, dɛn kɔmpia Vabysmo wit wan drɔg we dɔn ɔlrɛdi de we dɛn kɔl Aflibercept (Eylea) , we de blok VEGF nɔmɔ. Di wan dɛn we tek pat pan di trayal nɔ bin no us drɔg dɛn de tek. Ɔlman bin gɛt bɔku injɛkshɔn, bɔt sɔm pipul dɛn nɔ bin gɛt bɛtɛ injɛkshɔn pas ɔda wan dɛn.
Wetin na di tin dɛn we dɛn dɔn du we dɛn du di risach?
Di tin dɛn we kin apin kin rili ɛnkɔrej wi.
Fɔ mek di yay si fayn fayn wan
Afta wan ia we dɛn bin dɔn gɛt tritmɛnt, di vishɔn fɔ di wan dɛn we tek ɔl tu di Vabysmo ɛn Aflibercept bin dɔn bɛtɛ pas di tɛm we dɛn bigin di stɔdi. Dis min se ɔl tu di mɛrɛsin dɛn bin wok di sem we fɔ mek pɔsin si fayn .
Di nɔmba fɔ di injɛkshɔn dɛn we dɛn nid (dis na di tin we impɔtant pas ɔl!)
Na dis say dɛn bin si di big difrɛns.
Insay di fɔs mɔnt dɛn we dɛn bin de du di risach, dɛn bin de gi ɔlman di vaysin wan tɛm insay di mɔnt, bɔt afta dat dɛn bin chenj di tɛm we dɛn bin de gi di vaysin.
- Di wan dɛn we bin gɛt Aflibercept bin kɔntinyu fɔ gɛt di vaysin ɛvri 8 wik (dat na ɛvri 2 mɔnt) afta di fɔs 5 mɔnt.
- Dɛn bin trit di wan dɛn we bin gɛt Vabysmo akɔdin to "personal dosing schedule," we min se dɛn bin de asɛs ɛni pɔsin in yay kɔndishɔn ɛn gi di vaysin ɛvri 4, 8, 12, ɔ 16 wik, as i fayn.
di risal sho se pas 70% pan di wan dεm we gεt Vabysmo bin כnli nid fכ shot εvri 12-16 wik (dat na εvri 3-4 mכnt) . Dɔn bak, nɔ difrɛns nɔ bin de pan di we aw dɛn bin de si di mɛrɛsin fayn fayn wan bitwin di wan dɛn we bin de tek di mɛrɛsin ɛvri 3-4 mɔnt ɛn di wan dɛn we bin de tek di mɛrɛsin ɛvri 2 mɔnt.
Dis min se Vabysmo tritmɛnt kin ridyus di nɔmba fɔ pipul dɛn we kin go na ɔspitul fɔ injɛkshɔn , pan ɔl we dɛn kin kɔntinyu fɔ si fayn fayn wan. Aw i izi fɔ mek yu nɔ go na ɔspitul bɔku tɛm, nɔto so?
| Tritmɛnt | Kɔmɔn Injɛkshɔn Intɛval |
|---|---|
| Vabysmo (Farisimab) we dɛn kɔl Vabysmo (Farisimab) . | 12 to 16 wik (ɛvri 3-4 mɔnt) . |
| Aflibercept (Eylea) we de wok fɔ di kɔmni. | Wan tɛm ɛvri 8 wik (wan tɛm ɛvri 2 mɔnt) . |
Yu tink se di mɛrɛsin go kɔntinyu fɔ wok afta di fɔs ia?
Yɛs. Dɛn bin du dis stɔdi fɔ tu ia. Wetin dɛn fɛn na dat afta tu ia, lɛk 78% pan di pipul dɛn we tek Vabysmo bin jɔs nid di mɛrɛsin ɛvri 3-4 mɔnt . Ɛn dɛn vishɔn bin stil fayn lɛk aw i bin de insay di fɔs ia.
Bikɔs di pwɛl hat we pɔsin kin gɛt we i gɛt dayabitis kin go bifo as tɛm de go, dɛn rizɔlt ya sho se ɔl tu di Vabysmo ɛn Aflibercept kin ɛp fɔ mek di yay nɔ pwɛl fɔ lɔng tɛm. Vabysmo kin ajɔst dis rizɔlt bak wit smɔl tritmɛnt.
Aw fɔ gɛt dis tritmɛnt?
Vabysmo na wan wata we de kɔmɔt na di wata. Na injɛkshɔn we dɛn kin put insay di yay we dɔktɔ we dɔn tren kin gi am dairekt insay di yay . Yu nɔ go ebul fɔ du dis na os.
We yu bigin fɔ trit yu, yu go fɔs gɛt 4 injɛkshɔn ɛvri 4 wik . Dɔn yu dɔktɔ go chɛk yu yay ɛn disayd if yu fɔ kɔntinyu fɔ gi yu injɛkshɔn fɔ 4, 8, 12, ɔ 16 wik, i go dipen pan aw yu yay de. Bɔrku pipul dɛn kin jɔs nid injɛkshɔn ɛvri 3-4 mɔnt.
We dɛn de gi yu injɛkshɔn, di dɔktɔ go yuz smɔl tin fɔ mek yu yay opin. Dɔn, dɛn go put drɔp na yu yay fɔ mek i nɔ gɛt di sik ɛn fɔ mek i nɔ gɛt di sik. Dɔn, dɛn kin gi di injɛkshɔn wit wan rili fayn nidul. Yu nɔ go fil ɛni pen insay dis tɛm.
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Lɛk ɛni mɛrɛsin, dis wan kin gɛt smɔl smɔl sayd ɛfɛkt dɛn.
- Di kɔmɔn sayd ɛfɛkt dɛm: Yu kin si blɔk fɔ shɔt tɛm afta di injɛkshɔn. Dis na nɔmal tin. Nɔ drayv ɔ yuz mashin dɛn insay dis tɛm. Yu vishɔn go kam bak to nɔmal tin insay shɔt tɛm.
- Siriɔs sayn dɛm wae yu fɔ wach fɔ: Nɔr kin bɔrku tɛm, sɔm kayn siriɔs sik kin kam. Yu fɔ rili no bɔt dɛn tin ya.
- I tan lɛk se blak spat ɔ strek dɛn de flɔt bifo di yay.
- Layt de flash lɛk laytin .
- Fɔ fil lɛk se dɛn de drɔ kɔtin bifo di yay.
- Di pen we de mek yu yay bad bad wan .
If yu gɛt ɛni wan pan dɛn sik ya, nɔ de te . Go to dɔktɔ wantɛm wantɛm. If i pɔsibul, go na di ɔspitul in ETU (Imergency Treatment Unit) fɔ gɛt tritmɛnt. Dɛn tin ya kin bi sayn fɔ se yu gɛt siriɔs sik.
Ɛni prɔblɛm de wit ɔda mɛrɛsin dɛn?
Naw, dɛn nɔr no bɔt di intarakshɔn bitwin Vabysmo ɛn ɔda mɛrɛsin dɛm.
Bɔt, dis rili impɔtant: Mek shɔ se yu tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin we yu de tek, lɛk di mɛrɛsin dɛn we dɛn kin gi yu, vaytamɛn dɛn, ɛbul prɔdak dɛm, ɛn tradishɔnal mɛrɛsin dɛm.
Mɛsej we dɛn kin kɛr go na os
- Vabysmo na nyu, dual-aktin vaysin we de trit dayabitik makyula ɛdima (DME).
- dis de blכk tu protin dεm (VEGF εn Ang-2) we de kכntro di fכmeshכn fכ nyu bכdi vεsul dεm εn fכ lik fכ wata.
- Dis kin mek bɔku pipul dɛn ebul fɔ ridyus di frɛkuɛns fɔ di vaysin to ɛvri 3-4 mɔnt we dɛn de kip di sem vishɔn impɔtant.
- Dis na injɛkshɔn we dɔktɔ kin gi di yay, ɛn i rili impɔtant fɔ gɛt tritmɛnt di rayt tɛm.
- If yu gɛt siriɔs pen na yu yay, layt de flash, ɔ yu de kɔba yu yay lɛk vel afta yu dɔn gɛt di vaysin, go to dɔktɔ wantɛm wantɛm.
- Ɔltɛm tɔk to yu yay dɔktɔ us tritmɛnt we bɛtɛ fɔ yu sik.
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