Yu taya wit layf bikɔs yu at pwɛl? Lɛ wi tɔk bɔt Ketamine (Ketamine for Depression) .

Imajin sɔmbɔdi we dɔn de sɔfa wit siriɔs pwɛl at fɔ 25 ia. Dɛn dɔn tray ɔl di mɛrɛsin ɛn tritmɛnt dɛn we de, bɔt dɛn nɔ gɛt ɛni rilif. Dɛn dɔn taya wit layf ɛn dɛn nɔ ebul fɔ du natin so dat dɛn nɔ ebul fɔ ivin grap na di sofa. Yu go biliv mi if a tɛl yu se wan drɔg we dɛn kɔl ‘Ketamine’ gi dɛn nyu layf? Dis na sɔntin we dɔn rili apin to sɔm pipul dɛn. Bɔt biɛn ɛvri sakrifays stori, wi kin yɛri bak bɔt pipul dɛn we dɔn lɔs dɛn layf bay we dɛn nɔ yuz dis drɔg di rɔŋ we. So, wetin rili na Kɛtamin? E kin ɛp fɔ gɛt maynd sik lɛk pwɛl hat? Yu tink se i fayn fɔ put am pan denja? Lɛ wi tɔk bɔt dis simpul wan ɛn klia wan.

Wetin na Kɛtamin?

Fɔ tɔk am simpul wan, Ketamine na rili wan anesthetic. Dat min se na drɔg we de mek pɔsin slip. Dis drɔg we dɛn bin yuz fɔs fɔ anestez animal dɛn insay di 1960s, di US FDA bin gri fɔ yuz am pan mɔtalman insay 1970. Dɛn bin yuz am bak fɔ trit sojaman dɛn we bin wund insay di Vietnam Wɔ.

Fɔ ɛgzampul, we tin apin, afta dɛn dɔn sev pɔsin we bin want fɔ kil insɛf, tɛm kin de we dɛn kin gi dis drɔgs na di ambulans fɔ kɔntrol di we aw dɛn de agyu. Na bikɔs ɔf tin dɛn lɛk dis, na in dɔktɔ dɛn bigin fɔ ɔndastand di pawa we i gɛt fɔ fɛt pwɛl hat. Imajin, afta i gi Ketamine to pɔsin we bin de kam jomp pan brij ɛn seda am, lɛk 9 mɔnt afta dat i se, "A nɔ tink bɔt fɔ kil misɛf insay 9 mɔnt." As mɔ ɛn mɔ stori dɛn lɛk dis de bɔku, dɔktɔ dɛn bin de tink se, "Sɔntɛm sɔntin de pan dis."

Bɔt wan dak say de fɔ dis. Ketamine na wan drɔg wae sɔm pipul dɛn kin yuse fɔ gɛt high. Sɔm pipul dɛn kin kɔl am ‘Spɛshal K’, ‘Supa K’. Dɛn kin injɛkt am, ad am to drink, ɛn yuz am fɔ mek sigrɛt.

Dis ɛkspiriɛns kin tek lɛk tu awa so. Na ɔnda dɔktɔ in sɔpɔtishɔn nɔmɔ dɛn fɔ tek am. Dis na bikɔs i kin gɛt siriɔs prɔblɛm lɛk fɔ nɔ no natin, fɔ gɛt ay blɔd prɛshɔn, ɛn fɔ blo sloslo . If yu nɔ yuz am di rayt we, i kin mek yu gɛt prɔblɛm dɛn we go de fɔ lɔng tɛm lɛk blad prɔblɛm ɛn fɔ tek drɔgs.

Aw a go gɛt Ketamine tritmɛnt?

Naw, di wangren tritmɛnt we FDA dɔn gri fɔ fɔ pwɛl hat na wan sprɛy we dɛn mek wit ketamin we dɛn kɔl Esketamine na in nos. Dɛn kin gi am ɔl na klinik we gɛt sɛtifiket to pipul dɛm wae gɛt tritmɛnt-rɛsistant mɛja dipreshɔn disɔda wae nɔr dɔn ansa at le tu ɔda antidipreshɔn. Afta dɛn dɔn gi di pɔsin di sprɛy, di mɛdikal wokman dɛn kin wach dɛn fɔ tu awa.

Ɔda we dɛn, lɛk intravenous (IV) Ketamine, nɔ gɛt FDA aprɔval yet fɔ saykayatrik tritmɛnt. Bɔt dɔktɔ dɛn de yuz dis we ɔnda dɔktɔ in sɔpɔtishɔn, bay we dɛn de du risach data, fɔ pipul dɛn we nɔ dɔn tek ɔda mɛrɛsin.

• Tritmɛnt: Dɛn kin gi di siks siks IV infushɔn fɔ tri wik.
• Di doz: Dɛn fɔ no di doz rili prɛsis, bikɔs wan rili smɔl doz de we kin wok fɔ dipreshɔn bɔt nɔto fɔ anestezi.
• Supavayshɔn: Dɔktɔ go de fɔ di wan ol 40 minit we dɛn gi am IV ɛn afta dat. Dɛn kin rɛdi fɔ ɛp wantɛm wantɛm if di pɔsin we sik gɛt ɛni prɔblɛm ɔ kɔnfyushɔn.

Aw e kin fil we dɛn de trit am?

Pipul wae dɔn gɛt dis tritmɛnt kin tɔk bɔt de ɛkspiriɛns difrɛn we. Wan uman we nem Krista, we bin dɔn gɛt pwɛl at ɛn wɔri frɔm we i smɔl, leta bin gɛt PTSD ɛn i bin gɛt pen we nɔ de dɔn. I se bifo dɛn trit am wit Ketamine, dɛn sik ya bin de kɔntrol in layf.

Jeff, di pesin we wi bin tok to bifo, tok abaut im ekspiriens dis we: "I bin laik se a de flot fo wata pul. Na di fes taim we a andastan di minin of di wod 'gladi ples'. Evritin we rilet to mi rial laif don disappear, and a no fil dat weit we a bin de kari around evriwia."

Afta tritmɛnt, as di ifɛkt dɛm we Ketamine gɛt de west, sɔm klinik dɛm kin gi tɔk bak wit di pɔsin fɔ ɛp dɛn fɔ put wetin dɛn lan frɔm di ɛkspiriɛns na dɛn layf. Dis kin gi di sikman chans fɔ tɔk bɔt ol tin ɛn pen.

Aw Ketamine de afɛkt di bren?

De amazing tin na dat, nɔr to de ‘dissociative experience’ wae yu kin gɛt wae yu de gɛt tritmɛnt wae de briŋ rilif frɔm pwɛl hat. Dat rilif de kam afta dat. Dat min se, di we aw yu bren de ansa afta yu dɔn gɛt Ketamin na di tritmɛnt.

Jɔs tink bɔt am dis we:

pan pipul dεm wae gεt lכng tεm, siriכs pwεl hat, sכm pan di imכtant kכnεkshכn dεm (synapses) we de transmit mεsej bitwin di nεv sεl dεm na di bren de lכs. Risach dɔn sho se insay 24 awa afta di fɔs doz fɔ ketamin, dɛn kɔnekshɔn ya we dɔn lɔs kin bigin fɔ gro bak. Di mɔr dɛn kɔnekshɔn ya de gro, na di mɔr de rilify frɔm pwɛl hat.

in כda wod dεm, di nεv sεl dεm na wi bren we de involv insay wi mכd de yuz wan kεmikכl we dεn kכl ``glutamate`` fכ kכmכnik wit dεn wan dεm. sכm pipul dεm we gεt diprεshכn gεt wik risεptor dεm na dεn bren we de rεspכnd to ``glutamate.`` Kεtamin de wok bay we i de bil dεn risεpshכn dεm ya bak εn εp di nεv sεl dεm fכ kכmכnik fayn fayn wan bak.

We dɛn ripɛnt di kɔnekshɔn na di bren dis we, ivin di mɛrɛsin dɛn we de mek pɔsin fil bad ɔ di saykotɛrapi we nɔ bin de wok bifo kin bigin fɔ wok.

Wetin na di sayd ɛfɛkt ɛn risk dɛm?

Ivin we dɛn yuz am ɔnda dɔktɔ in sɔpɔtishɔn, Ketamine kin gɛt sayd ɛfɛkt.

Risk fɔ gɛt adikshɔn

Yɛs, Ketamine na drɔg we kin mek pɔsin gɛt adikshɔn. Bɔt dɔktɔ dɛn se we dɛn trit dɛn ɔnda di rayt we fɔ kia fɔ dɛn ɛn akɔdin to di kɔrɛkt we aw dɛn de du am, di risk fɔ gɛt adikshɔn kin rili smɔl. De risk kin kam wae pɔrsin bigin fɔ yuse am fɔ in yone tin wae nɔr gɛt dɔktɔ advays.

Udat dis nɔ fayn fɔ?

Di tritmɛnt wae gɛt ketamin nɔr fayn fɔ pipul dɛm wae gɛt histri fɔ tek drɔgs ɛn gɛt maynd sik lɛk skizofrenia. Pipul wae gɛt bipola muud disɔda fɔ tek tɛm bak, bikɔs Ketamin nɔr kin rili mek pɔrsin gɛt manik episɔd. Na yu dɔktɔ fɔ disayd dis.