Eddagala lya kookolo nga tulina emibiri gyaffe? By’olina okumanya ku bujjanjabi bw’abaserikale b’omubiri

Bwe tuwulira ekigambo “kookolo,” okutya n’okweraliikirira bijja mu birowoozo byaffe. Ekyo kya bulijjo. Kyokka, olw’okukulaakulana kwa ssaayansi w’obusawo, enkola z’okujjanjaba kookolo ziteredde nnyo. Leero, ngenda kwogera nammwe ku nkola ey’ekitalo ey’obujjanjabi ekyusizza omuzannyo mu kulwanyisa kookolo n’okuleeta essuubi eppya eri abantu bangi. Kino kiyitibwa Immunotherapy. Mu ngeri ennyangu, mu kifo ky’okuwa eddagala ery’ebweru okulwanyisa kookolo , tukozesa okwekuuma kwaffe okumulwanyisa. Ka tulabe engeri kino gye kikola.

Kale, Immunotherapy kye ki?

Okusobola okutegeera kino, ka tutwale ekyokulabirako ekitono. If you have an allergy , nga okufuuwa enfuufu, oyinza okuba nga ofunye amasasi ga allergy. Amasasi galimu ekitono ennyo eky’ekirungo ekivaako alergy. Bw’eyingira mu mubiri gwo, abaserikale b’omubiri batandika okugikolako, naye nga tebakulwaza. Bw’oyongera ku ddoozi mpolampola, omubiri gwo gumanyiira ekirungo ekivaako alergy. Ekyo kitegeeza nti omubiri gwo guzimba obusimu obuziyiza endwadde.

Immunotherapy kintu ng’ekyo. Kookolo y’obumu ku butoffaali bwaffe bwe butandika okweyisa “obubi” obutafugibwa. Essuubi ly’obujjanjabi obw’obusimu obuziyiza endwadde kwe kuyamba enkola y’omubiri gwaffe ey’obutonde okutegeera “obutoffaali obubi” buno n’okwetendeka okubusaanyawo. Nga bwe tulwanyisa akawuka oba obuwuka obuyingira mu mubiri gwaffe.

Bika ki ebikulu eby’obujjanjabi bw’abaserikale b’omubiri?

Abanoonyereza bazudde engeri eziwerako abaserikale baffe abaserikale gye basobola okutegeera n’okusaanyaawo obutoffaali bwa kookolo. Ka tulabe ebimu ku bika ebikulu.

1. Adoptive T-Cell Immunotherapy (Obujjanjabi bwa T-cell obutendeke mu ngeri ey’enjawulo) .

Kino kiringa okutendeka amagye ag’enjawulo. Ekimu ku baserikale abakulu mu baserikale baffe abaziyiza endwadde kiyitibwa T-cells .

Mu bujjanjabi buno, abasawo baggya obumu ku butoffaali buno obwa T okuva mu kizimba kyo. Olwo mu laabu, banoonya ku butoffaali buno obwa T, kiruwa ekisinga okulwanyisa kookolo. Balonda “abaserikale abasinga obulungi,” ne babakola yinginiya w’obuzaale, ne babafuula ab’amaanyi ennyo, ne babakuza ne bafuuka obukadde n’obukadde.

N’ekisembayo, “eggye lino erya T-cell erya maanyi ennyo” lizzibwa mu mubiri gwo nga liyita mu IV. Kati obutoffaali buno bugenda butereevu okunoonya n’okusaanyaawo obutoffaali bwa kookolo.

Emu ku bujjanjabi obusinga okwettanirwa wansi w’omutendera guno ye CAR T-cell therapy . Akozesebwa ku balwadde ba leukemia mu baana n’abantu abakulu n’ebika bya kookolo ebiwerako, gamba nga lymphoma, ebitannaba kuddamu bujjanjabi bulala.

2. Ebiziyiza mu bifo eby’okukebera

Abaserikale baffe ab’omubiri era balina enkola ya “buleeki.” Bino biyitibwa ebifo ebikeberebwa. Buleeki zino ziriwo okulemesa abaserikale baffe abaserikale okulumba obutoffaali bwaffe obulamu mu ngeri eteetaagisa.

Naye obutoffaali bwa kookolo obw’obukuusa bweyambisa enkola eno eya buleeki. Bakola puloteyina ku ngulu kwazo ezikola ebifo bino ebikeberebwa, ne ziweereza akabonero eri enkola y'okwekuuma, nga zigamba nti, "Ndi omu ku bammwe, tonnumba." Kiba ng'omubbi ayambala yunifoomu ya poliisi.

Eddagala eriziyiza okukebera likola nga lifulumya "buleeki" eno ekwata obutoffaali bwa kookolo mu kifo. Kino kisobozesa obutoffaali bwaffe obwa T okutegeera kookolo ng’omulabe ne bumulumba.

Enkola eno ey’obujjanjabi kati ekozesebwa bulungi ku bika bya kookolo bingi, omuli kookolo w’amawuggwe, amabeere, ekibumba, n’olususu (melanoma).

3. Obuziyiza obuziyiza endwadde (Monoclonal Antibodies).

Zino zibeera antibodies, ezikoleddwa mu ngeri ey’enjawulo mu laabu. Ziringa "mizayiro" ezisobola okunoonya n'okukwata obutoffaali bwa kookolo.

Abaserikale baffe ab'omubiri tebasobola kuzuula butoffaali bwa kookolo bulijjo nga "obubi." Antibodies eziyitibwa monoclonal antibodies zigiyamba okukola ekyo. Obuziyiza buno bunywerera ku ngulu w’obutoffaali bwa kookolo. Olwo, kiringa bendera bw’ebuuka waggulu w’akatoffaali ako, ekyanguyira abaserikale b’omubiri okukalaba. Kiba ng'okugamba nti, "Wuno omulabe." Olwo obutoffaali bwa T busobola bulungi okusaanyaawo obutoffaali obwo obwa kookolo.

Antibodies ezimu eziyitibwa monoclonal antibodies zirina eddagala eriziyiza kookolo ( chemotherapy ) oba ebintu ebikola amasannyalaze ebizikwatako. Olwo antibody eno etwala eddagala butereevu mu katoffaali ka kookolo ne kalituusa.

4. Eddagala erigema kookolo

Bino bifaananako n’okugema okwa bulijjo. Waliwo ebika bibiri ebikulu:

• Eddagala eriweweeza ku bulwadde bwa kookolo: Lino lye ddagala erikuuma akawuka akayinza okuvaako kookolo. Ekyokulabirako ekisinga obulungi kwe kugema HPV (Human Papillomavirus) . Akawuka kano aka HPV kasobola okuleeta kookolo w’omumwa gwa nnabaana wamu n’ebika bya kookolo ebirala ebiwerako. Okugema eddagala lya HPV kiyinza okukendeeza ennyo ku bulabe obwo. Kikulu nnyo okwogera n’omusawo wo ku nsonga eno n’omanya ebisingawo.
• Eddagala erigema: Lino likoleddwa okutendeka abaserikale b’omubiri okulumba kookolo abeerawo edda mu mubiri.

Ebiseera eby’omu maaso eby’obujjanjabi bw’abaserikale b’omubiri bye biruwa?

Obujjanjabi bw’abaserikale b’omubiri (immunotherapy) bukyali mulimu ogukulaakulana amangu, kubanga buli kiseera bannassaayansi bagezaako okutegeera obulungi engeri abaserikale baffe abaziyiza endwadde gye balwanyisa kookolo.

Okugatta ku ekyo, okunoonyereza kugenda mu maaso okulaba oba obujjanjabi bw’abaserikale b’omubiri busobola okuweebwa nga bugattibwa wamu n’obujjanjabi obulala, gamba ng’obujjanjabi obw’eddagala, okulongoosa ebivaamu. Oluusi, ebika bibiri eby’obujjanjabi obuziyiza endwadde biweebwa wamu.

Naye wakyaliwo ekibuuzo ekinene ekitannaba kuddibwamu. Kwe kugamba, lwaki obujjanjabi buno, okufaananako n’obujjanjabi obulala, bukola bulungi nnyo ku balwadde abamu ate abalala tebukola bulungi. Okunoonyereza kukyagenda mu maaso okuzuula ensonga eziviiriddeko kino.

Obujjanjabi bw’abaserikale b’omubiri, obujjanjabi bwa kookolo, obujjanjabi bwa kookolo sinhala , T-cells, checkpoint inhibitors, monoclonal antibodies, CAR T-cell therapy, kookolo, Sri Lanka