Obujjanjabi bwa kookolo nga okozesa obutoffaali bwo? Ka tuyige ku CAR T-Cell Therapy mu ngeri ennyangu!

Bw’omanya nti olina kookolo, owulira okutya n’okweraliikirira kungi. Naye olw’okukulaakulana kwa ssaayansi w’obusawo, leero waliwo enkola ez’omulembe ennyo ez’obujjanjabi ez’okulwanyisa kookolo. Leero, tugenda kwogera ku nkola empya era ey’amaanyi ennyo ey’obujjanjabi ebadde ekola obulungi ennyo mu kujjanjaba ebika bya kookolo ebiwerako , naddala ebyo ebikula mu musaayi.

Obujjanjabi bwa CAR T-Cell Therapy kye ki?

Mu ngeri ennyangu, CAR T-Cell Therapy ddagala lya busimu obuziyiza endwadde erikozesebwa okujjanjaba ebika bya kookolo ebimu eby’omusaayi . Obutoffaali bwaffe obw’abaserikale b’omubiri buli ng’abaserikale mu mibiri gyaffe. Obujjanjabi buno kye bukola kwe kutwala abamu ku bajaasi bano mu mubiri gwo, abayitibwa T cells ( T cells oba T lymphocytes ) , n’obafuula super fighters ezisaanyaawo obutoffaali bwa kookolo.

Kuba akafaananyi ng’otwala obutoffaali bwo obwa T mu laabu , n’oyingizaamu obuzaale obupya, n’obuwa “lenzi ey’enjawulo” esobola okutegeera obutoffaali bwa kookolo. Obutoffaali bwa T buno obukyusiddwa tubuyita CAR T-cells . `CAR` kitegeeza `Chimeric Antigen Receptor`. Olwo, obukadde n’obukadde bw’obutoffaali buno obulwanyisa ennyo (super-fighter cells) bukolebwa ne budda mu mubiri gwo. Olwo obutoffaali buno butambula mu mubiri gwo gwonna, ne bunoonya n’okusaanyaawo obutoffaali bwa kookolo. Oluusi, obujjanjabi buno busobola n’okuwonya kookolo w’omusaayi mu bujjuvu.

Bujjanjabi buno bukozesebwa ku bika ki ebya kookolo?

Mu kiseera kino, CAR T-Cell Therapy ekozesebwa ku bika bya kookolo ebimu byokka ng’obujjanjabi obulala bulemye oba kookolo w’akomyewo. Omulongooti guno wammanga gulaga ebimu ku bika bya kookolo bino.

Okay, kati ka tulabe engeri kino gye kikola.

Kino okukitegeera, ka tusooke tuyige ebisingawo katono ku butoffaali bwa T mu baserikale baffe abaserikale b’omubiri. Buli katoffaali mu mubiri gwaffe kalina obutoffaali obuyitibwa antigens ku ngulu. Bino biringa endagamuntu buli kasenge gye kalina. Obutoffaali bwa kookolo bulina endagamuntu ekyusiddwa, etali ya bulijjo.

Obutoffaali bwaffe obwa T bulina ebikwata . Ebikwata bino bye bitegeera abalumbaganyi ng’obutoffaali bwa kookolo obulina endagamuntu ezitali za bulijjo (antigens). Naye oluusi obutoffaali bwa kookolo buba bwa makubo nnyo. Zikweka obutoffaali buno obwa T.

Obujjanjabi buno busobozesa obutoffaali buno obutakoma ku kutta butoffaali bwa kookolo, wabula n’okwekutula n’okweyongera mu mubiri. Kino kitegeeza nti ofuna obutoffaali obulwanyisa kookolo okumala ebbanga eddene. Eno y’ensonga lwaki abasawo obujjanjabi buno babuyita “ddagala ramu.”

Enkola y’obujjanjabi ekola etya?

Enkola eno yonna ebaawo mu mitendera egiwerako.

Nga tebannaba kujjanjabwa

Okusooka olina okukung’aanya obutoffaali obweru naddala T cells okuva mu mubiri gwo. Kino kiyitibwa obulwadde bwa leukapheresis.Eno nkola efaananako n’okugaba omusaayi. Ekyuma kiggyamu omusaayi gwo, ne kyawula obutoffaali obweru bwokka, oluvannyuma omusaayi ogusigadde ne guzza mu mubiri gwo.

Olwo obutoffaali buno obwa T obukung’aanyiziddwa busindikibwa mu laboratory ey’enjawulo okufuulibwa obutoffaali bwa CAR T. Enkola eno esobola okutwala wiiki nga 3 ku 6. Mu kiseera kino, oyinza okuweebwa obujjanjabi obulala, gamba ng’eddagala eriweweeza ku kookolo, okusobola okufuga kookolo.

Bw’oba ​​weetegese okufuna obutoffaali bwa CAR T, ojja kuweebwa obujjanjabi obuyitibwa lymphodepleting chemotherapy okutangira omubiri gwo okugaana obutoffaali obupya.

Mu kiseera ky’obujjanjabi

Enzijanjaba entuufu nnyangu nnyo. Okufaananako n’okuwa omunnyo, obutoffaali buno obwa CAR T obupya obutondeddwa buyingizibwa mu mubiri gwo nga buyita mu musuwa (IV line) okumala eddakiika 5 ku 30. Mu kiseera kino, ojja kwetaaga okusigala mu ddwaaliro.

Oluvannyuma lw’okujjanjabwa

Olw’okuba buno bujjanjabi bwa maanyi nnyo, oluusi ebizibu eby’amaanyi bisobola okubaawo. N’olwekyo, oyinza okubeera mu ddwaaliro okumala ennaku nga 7-10 ng’omaze okujjanjabibwa. Kikulu nnyo okubeera mu kifo kyangu okutuukako mu ddwaaliro mwe wafunira obujjanjabi okumala omwezi ogusooka, ne bw’oba ​​ovudde mu ddwaaliro. Nate,

• Omuntu alina okubeera naawe essaawa 24 buli lunaku akulabirira singa oba olina ekizibu kyonna.
• Tovuga okumala emyezi ebiri ng’omaze okujjanjabwa. Ekyo weetaaga omuntu omulala.

Biki ebiva mu bujjanjabi buno?

Waliwo ebika by’ebizibu bibiri ebisinga okubeerawo era ebisaana okufaayo n’obujjanjabi buno. Ebizibu ebirala ebitera okuvaamu nabyo biyinza okubaawo.

Migaso ki n’obuwanguzi bw’obujjanjabi buno bye biruwa?

Ekirungi ekisinga obunene mu CAR T-Cell Therapy kwe kuba nti ewa essuubi eppya eri abalwadde abalemereddwa obujjanjabi obulala. Oluusi kisobola okuwonya ddala kookolo (okusonyiyibwa). Bwe kitaba ekyo, obujjanjabi buno busobola okwongera ku bulamu bw’abalwadde.

Okugeza, okunoonyereza okwakolebwa mu 2020 kwalaga nti abaana abasoba mu 85% abaafuna obujjanjabi buno olw’obulwadde bwa acute lymphoblastic leukemia (ALL) bawonye ddala oluvannyuma lw’okujjanjabwa. Ate era, 60% ku bo baali bakyalina kookolo oluvannyuma lw’omwaka mulamba. Naye kikulu okujjukira nti buno si bujjanjabi bwa buwanguzi 100% eri buli muntu, ddagala eri buli muntu. Wabula lino ddaala ddene mu maaso mu by’obujjanjabi bwa kookolo.

Ddi lw’osaanidde okulaba omusawo?

Kino kikulu nnyo. Ebimu ku bizibu ebiva mu CAR T-Cell Therapy naddala Cytokine Release Syndrome n’obuzibu bw’obusimu, biyinza okuteeka obulamu mu matigga .

Obujjanjabi buno bukyali mulimu mupya ogukyagenda mu maaso. Kale bw’oba ​​olina kookolo w’omusaayi, yogerako n’omusawo wo oba obujjanjabi buno bukusaanira.

CAR T-Cell Therapy, obujjanjabi bwa kookolo, kookolo w’omusaayi, obujjanjabi bw’abaserikale b’omubiri, obujjanjabi bw’abaserikale b’omubiri, obutoffaali bwa T, Sri Lanka