Ka tuyige ebisingawo ku glucagon ayamba okufuga ssukaali mu mubiri gwo.

Wali weebuuzizzaako engeri ssukaali mu musaayi gwaffe gy’afugibwamu? Waliwo ekintu eky’enjawulo ekiyamba ku kino ekiyitibwa Glucagon. Okufaananako n’omuzira omuto mu mubiri gwaffe, Glucagon akuuma ssukaali mu musaayi gwaffe obutakka nnyo. Leero, tugenda kwogera ku Glucagon eno mu bujjuvu era mu ngeri ennyangu ennyo.

Glucagon kye ki?

Mu ngeri ennyangu, glucagon busimu bwa butonde emibiri gyaffe bwe gikola . Omanyi kikolebwa obutoffaali bwa alpha mu pancreas yaffe. Omuwendo gwa glucose mu musaayi gwaffe bwe gukendeera, bwe tutalya okumala ebbanga eddene (okusiiba okumala ebbanga eddene), bwe tukola dduyiro ennyo, oba bwe tulya emmere erimu ebirungo ebizimba omubiri, glucagon ono afuluma.

Lowooza ku kino, glucose kye kika kya sukaali ekisinga mu musaayi gwaffe. Glucose ono tugifuna okuva mu carbohydrates mu bintu bye tulya n’okunywa. Ssukaali ono y’awa amaanyi mu bitundu by’omubiri gwaffe, ebinywa n’obusimu. Kiba nga petulooli w’emmotoka. Kale, omubiri gwaffe gutera okukuuma ssukaali ono mu musaayi ku mutindo omutuufu mu ngeri enzibu ennyo. Kino ka kibeere waggulu nnyo oba wansi nnyo, endwadde ez’enjawulo n’obutabeera bulungi bisobola okubaawo.

Empiso za glucagon n’okufuuyira mu nnyindo

Ng’oggyeeko glucagon esangibwa mu butonde, waliwo ne glucagons ezikoleddwa mu butonde. Bino osobola okubiweebwa ng’empiso oba ng’efuuyira ennyindo enkalu. Kino oyinza okuba nga wakirabye nga kikozesebwa mu mbeera ez’amangu naddala eri abantu abalina sukaali ow’ekika kya 1 , nga ssukaali mu musaayi akendedde mu bwangu (hypoglycemia). Glucagon aweebwa mu kiseera kino afulumya glucose eterekeddwa mu kibumba kyaffe era n’alinnyisa mangu ssukaali mu musaayi gwaffe. Kiringa okutuwa 'boost' entono.

Glucagon ekola ki ku mubiri gwaffe?

Singa olubuto lwo lukola bulungi, omubiri gwo gujja kufuga n’obwegendereza glucose mu musaayi gwo. Kino kisinga kukolebwa busimu bubiri obuyitibwa glucagon ne insulin . Okugeza ssukaali bw’akendeera ennyo (hypoglycemia), olubuto lwo lufulumya glucagon omungi. Glucagon ono ayamba okulinnyisa ssukaali mu musaayi mu ngeri eziwerako:

• Okusooka, glucagon egenda mu kibumba kyaffe n’akyusa glucose eterekeddwa eyo – gwe tuyita glycogen – n’afuuka ekintu kye tusobola okukozesa. Olwo ekibumba ne kigifulumya mu musaayi.
• Ekirala, glucagon asobola okulemesa ekibumba okutwala n’okutereka glucose, n’aleka glucose omungi mu musaayi.
• Ekyokusatu, amino asidiGlucagon era ayamba omubiri okukola glucose okuva mu nsonda endala.

Jjukira nti kiringa seesaw. Ssukaali bw’akendeera, glucagon akola, ate ssukaali bw’alinnya mu musaayi, insulini ekola!

Endwadde ki eziyinza okukwatagana n’obuzibu mu nkola ya glucagon?

Kati ka tulabe obuzibu obuyinza okuvaamu singa glucagon takola bulungi.

Bw’oba ​​olina ssukaali, omubiri gwo guyinza obutasobola kufulumya glucagon amala nga ssukaali mu musaayi mutono. Kino kiyinza okukuleetera okubeera ne ssukaali omutono mu musaayi emirundi mingi, oba wadde ssukaali omutono ennyo . Obulabe buno buba bungi naddala singa omira eddagala erikendeeza ssukaali mu musaayi nga insulini oba sulfonylureas.

Mu bantu abamu abalina ssukaali ow’ekika eky’okubiri, glucagon eyinza okuba waggulu okusinga eya bulijjo, okusinziira ku ssukaali mu musaayi. Eno era y’emu ku nsonga lwaki ssukaali ali mu musaayi.

Si kya bulijjo nnyo ebizibu by’okukola glucagon okubaawo nga tewali ssukaali, naye waliwo embeera ntono mwe kiyinza okubaawo:

• Obulwadde bw’olubuto: Singa ofuna ssukaali olw’obulwadde bw’olubuto n’omira insulini, oyinza n’okubulwa glucagon. Kino kyongera obulabe bwa sukaali omutono mu musaayi.
• Glucagonoma: Kino kizimba ekitali kya bulijjo nnyo mu lubuto. Kifulumya glucagon omungi ennyo. Kino kireeta obubonero nga ssukaali omungi, okusiiyibwa ku lususu, n’okugejja.
• Multiple Endocrine Neoplasia (MEN): Eno nayo mbeera ya buzaale etali ya bulijjo nnyo. Mu kino, ebizimba bikula mu nseke ezisukka mu emu mu nkola yo ey’endocrine. Kuno kw’ogatta n’olubuto.
• Ebizibu ebiva mu kuggyamu olubuto: Singa olw’ensonga ezimu ekitundu ky’olubuto lwo oba kyonna kiggyibwamu, obutoffaali obukola glucagon ne insulin bubula.

Bubonero ki obulaga ebizibu ebiva ku glucagon?

Nga bwe twayogeddeko emabegako, obutali bwa bulijjo mu miwendo gya glucagon buyinza okuvaako ssukaali omutono mu musaayi (hypoglycemia) oba ssukaali omungi mu musaayi (hyperglycemia). Ka tulabe obubonero obwo bwe buli.

Obubonero bwa sukaali omutono mu musaayi (Hypoglycemia) .

Kuba akafaananyi nga mukwano gwo, Nilanthi, amira eddagala eriwonya ssukaali. Olunaku lumu, amangu ago atandika okukankana, okutuuyana, n’okuwulira ng’aziyira. Era alabika ng’ayogera ebigambo bye eby’obuseegu. Singa obubonero buno bubaawo, kiyinza okutegeeza nti ssukaali mu musaayi gwe mutono nnyo.

Obubonero obutera okulabika mulimu:

• Okukankana, okukankana
• Okutuuyana n’okuwulira ennyogovu
• Okuziyira, okuwulira ng’omutwe guweweevu
• Okukuba kw’omutima
• Enjala
• Okukaluubirirwa okussa ebirowoozo ku kintu ekimu, okutabulwa

Ekikulu: Bw’ofuna obubonero buno, kikulu nnyo okulya ekintu ekirimu ssukaali, emmere oba ekyokunywa ekirimu ebirungo ebizimba omubiri amangu ddala nga bwe kisoboka . Kino kijja kuyamba ssukaali mu musaayi gwo okudda mu mbeera eya bulijjo. Bw’oba ​​otera okulaba obubonero buno, olina okulaba omusawo wo.

Obubonero bwa sukaali omungi mu musaayi (Hyperglycemia) .

Ssukaali omungi (hyperglycemia) atera okuva ku butabeera na insulini, so si buzibu bwa glucagon yokka. Wabula ebizibu bya glucagon ebitatera kubaawo nabyo bisobola okuvaako ssukaali omungi mu musaayi. Obubonero obusooka bwe buno:

• Ennyonta enfunda eziwera ne/oba enjala
• Okulaba okutali kwa maanyi
• Okufuka ennyo ( okufuka ennyo) .
• Okulumizibwa omutwe

Bw’oba ​​olina obubonero buno, kikulu nnyo okulaba omusawo.

Bikebere ki ebikolebwa okukebera emiwendo gya glucagon?

Bw’oba ​​olina obubonero obumu, omusawo ayinza okulagira okukeberebwa omusaayi okupima emiwendo gya glucagon. Mu kukebera kuno, omusawo oba nnansi akuggya omusaayi mu musuwa gwo ng’akozesa empiso. Olwo ne kisindikibwa mu laabu okukeberebwa.

Emiwendo gya glucagon egya bulijjo gye giruwa?

Mu budde obwabulijjo, omuwendo gwa glucagon gwe tusaanidde okuba nalyo mu musaayi gwaffe guli wakati wa picograms 50 ne 100 buli mililita (pg/mL) . Picogram kiba kimu kya kawumbi ka gram! Ssente entono nnyo, nedda?

Naye jjukira nti emiwendo gino egya bulijjo giyinza okwawukana katono okuva ku laabu okudda ku ndala. Era ziyinza okwawukana okusinziira ku bbanga ly’omaze ng’osiiba ne ssukaali gwe yali mu musaayi mu kiseera ky’okukeberebwa. Kale, bulijjo geraageranya ebyava mu kukebera kwo n’emiwendo egiri ku lipoota yo ey’okukebera omusaayi . Bw’oba ​​olina ekibuuzo kyonna, yogerako n’omusawo wo.

Ddi lwe nnina okulaba omusawo ku miwendo gya glucagon?

Bw’oba ​​olina obulwadde bwa sukaali era ng’otera okufuna ssukaali omutono oba omungi mu musaayi, kikulu okugenda ew’omusawo. Glucagon tetera kupimibwa mu bantu abalina ssukaali. Wabula kiyinza okwetaagisa okukyusa mu ngeri gy’okwatamu obulwadde bwa sukaali okukendeeza ku biseera bino.

Wadde ng’ebizibu ebirala ebikwata ku glucagon tebitera kubaawo, bw’oba ​​olina obubonero, kikulu okuzuula ekivaako. N’olwekyo, kakasa nti olaba omusawo wo.

Njawulo ki eriwo wakati wa Glucagon ne Glycogen?

Bano ababiri si be bamu? Glycogen ngeri ya glucose (ssukaali) eterekeddwa mu kibumba.Emibiri gyaffe gitereka glycogen okusinga mu kibumba n’ebinywa.

Glucagon busimu obulaga ekibumba okukyusa glycogen okudda mu glucose. Olwo glucose oyo n’ayingira mu musaayi era emibiri gyaffe gisobola okukozesebwa ng’amaanyi.

Kiki ekituuka ku glucagon mu kiseera ky’okusiiba?

Bwe tuba tusiiba, glucagon kikulu nnyo mu kukuuma ssukaali mu musaayi gwaffe nga takendeera nnyo. Kino kiri bwe kityo kubanga emibiri gyaffe tegifuna glucose mu mmere mu kiseera ekyo.

Bwe tusiiba okumala ebbanga eddene, glucagon ereetera omubiri okukola glucose okuva mu bintu ebitali bya carbohydrate – nga lipids, amino acids, ne proteins. Enkola eno eyitibwa gluconeogenesis .

Nsembayo, nnina okugamba... (Obubaka bwa Take-Home)

Kale, osanga okitegedde nti glucagon busimu bukulu nnyo obuyamba okukuuma ssukaali mu musaayi gwaffe nga mulamu ‘emabega w’empenda’. Kiyinzika nnyo nti olina obulwadde bwa sukaali oba ebizibu ebikwata ku glucagon.

Wabula bw’oba ​​otera okulaba obubonero obulaga nti ssukaali omutono oba ssukaali omungi, nsaba olabe omusawo. Olwo basobola okuzuula ekivaako ne bakuwa obujjanjabi bwe weetaaga. Okufaayo ku bulamu bwo kye kintu ekisinga obukulu.

` glucagon, sukaali mu musaayi, okukendeera kwa sukaali, sukaali, sukaali, olubuto, obusimu