Era weeraliikirira obusimu bw’abasajja okweyongera mu mubiri? Ka twogere ku bulwadde bwa hyperandrogenism!

Obeera mweraliikirivu olw’enkyukakyuka ezimu mu mubiri gwo? Mpozzi ensonga eri nti obungi bwa androgen, ekika ky’obusimu bw’omusajja, bweyongera mu mubiri. Embeera eno mu by'obujjanjabi eyitibwa hyperandrogenism . Tofaayo, kino tujja kukyogerako mu ngeri ennyangu, mu ngeri gy’osobola okutegeera.

Ddala hyperandrogenism kye ki?

Mu ngeri ennyangu, hyperandrogenism kitegeeza nti omubiri gwo gulina ebirungo ebiyitibwa androgens bingi nnyo, ekika ky’obusimu bw’okwegatta. Androgens kikulu mu myaka gy’obuvubuka, obulamu bw’okuzaala n’okukula kw’omubiri.

Kati laba, obusimu ddagala mu mibiri gyaffe. Balinga ababaka. Zitambula mu musaayi ne zitegeeza ebitundu byaffe, ebinywa n’ebitundu ebirala eby’okukola ne ddi lwe tulina okukikola.

Androgens zikolebwa mu mubiri gwa buli muntu. Naye abasajja be basinga okufulumya. Abakazi bafulumya nga kimu kya kkumi n’ebiri ku bungi mu mubiri gw’omusajja. Testosterone y’emu ku nsonga enkulu mu androgens zino.

Androgens zikolebwa ensigo mu basajja ate enkwaso mu bakazi. Obusimu buno era bukolebwa endwadde z’ekibumba ezisangibwa waggulu w’ensigo zaffe. Era ziyamba okukyusa androgens enafu ne zifuuka ez’amaanyi mu bifo ng’amasavu n’olususu.

Obubonero bw’embeera eno eyitibwa hyperandrogenism, busobola okwawukana okusinziira ku myaka gyo n’ekikula kyo. Waliwo ebintu ebiwerako ebiyinza okuvaako ensonga eno, era waliwo n’obujjanjabi obugiyamba.

Hyperandrogenism ne PCOS kintu kimu?

Abantu bangi balowooza nti obulwadde bwa hyperandrogenism ne polycystic ovary syndrome (PCOS) bulwadde bwe bumu. Wadde nga waliwo enkolagana ey’oku lusegere wakati w’ebintu bino byombi, si bye bimu.

Hyperandrogenism kye kintu ekikulu mu PCOS. PCOS buzibu bwa busimu obutakwatagana obuva ku nkwaso okukola obusimu bw’abasajja obuyitiridde. Bukwata abakyala.

Kale, newankubadde nga PCOS kitera okuvaako obulwadde bwa hyperandrogenism, wayinza okubaawo ebirala ebivaako hyperandrogenism. Mu ngeri y’emu, PCOS erina obubonero obulala, gamba ng’ebizimba by’enkwaso, ng’oggyeeko obubonero bw’obulwadde bwa hyperandrogenism.

Ani asinga okukosebwa embeera eno? Kitera kitya?

Hyperandrogenism esobola okukwata omuntu yenna - abaana abato, abantu abakulu, buli muntu. Kyokka, kisinga kubeera mu bakyala abali mu myaka egy’okuzaala .

Wakati wa 5% ne 10% ku bakyala abali mu myaka egy’okuzaalaEmbeera eno ekosa. Ekyo kitegeeza nti kino si kya bulijjo nga bw’oyinza okulowooza.

Embeera eno tetera kukwata balenzi n’abasajja abakulu.

Bubonero ki obulaga kino?

Obubonero bw’obulwadde bwa hyperandrogenism bwawukana okusinziira ku kikula kyo n’okumanya oba oyise mu myaka gy’obuvubuka.

Naye wuuno ekintu ekikulu ky'olina okujjukira. Ne bw’oba ​​olina obubonero buno, omuwendo gwa androgen mu musaayi gwo guyinza okuba ogwa bulijjo. Kino kiri bwe kityo kubanga buli emu ku bubonero buno buyinza okuba n’ensonga endala. Ate era, ne bwe kiba nti okukeberebwa mu musaayi kulaga nti omuwendo gwa androgen gwo guli waggulu, oyinza obutaba na bubonero bwonna bunene.

Ekisinga obukulu kiri nti singa obubonero buno bulabika mu bwangu era mu bwangu, mazima ddala wandibadde olaba omusawo amangu ddala nga bwe kisoboka, kubanga mu mbeera ng’ezo, ekivaako kiyinza okuba ekizimba ekifulumya androgen.

Kati ka tulabe engeri kino gye kikwata ku bantu ab’enjawulo.

Ku bawala (nga tebannatuuka mu myaka gy’obuvubuka) .

• Ensigo ezigaziye .
• Embalabe n’olususu oluzitowa.
• Okukula kw’enviiri z’omubiri okuteetaagibwa (hirsutism) . Kino kitegeeza nti "enviiri eza kitaka enzirugavu" zikyusibwamu enviiri enzirugavu, enzirugavu ku bitundu ng'emimwa egya waggulu, ekirevu, ekifuba, olubuto, n'omugongo.

Ku baana abasajja (nga tebannatuuka mu myaka gya buvubuka) .

• Obusajja obugaziye .
• Enviiri okukula amangu oba okuyitiridde mu kitundu eky’obwannannyini n’enkwawa.
• Okuzimba eddoboozi.

Ku bakyala abakulu

• Embalabe n’olususu oluzitowa.
• Okukula kw’enviiri z’omubiri okuteetaagibwa ( hirsutism) .
• Enzirukanya ya buli mwezi etali ya bulijjo.
• Okukaluubirirwa okuzaala abaana (obutazaala) .
• Enviiri ezigwa mu ngeri y’abasajja ( androgenic alopecia) .

Ku basajja abakulu

Engeri kino gye kikosaamu abasajja abakulu esinziira ku oba obusimu obw’enjawulo buva mu nseke z’ekibumba oba ku kintu ekitwalibwa ebweru (nga empiso za anabolic steroid ). Singa ebirungo ebiyitibwa androgens ebiva mu nseke z’omubiri (adrenal glands) byeyongera, abasajja abakulu bayinza obutalaba nkyukakyuka yonna ya maanyi mu mubiri. Wabula kiyinza okukendeeza ku nkola y’ensigo ne kizibuwalira okuzaala.

Lwaki kino kigenda mu maaso? Ensonga ze ziruwa?

Obusimu obuyitibwa Androgen hormones bukolebwa enkwaso, endwadde z’ekibumba n’obutoffaali bw’amasavu mu bakyala, ate ensigo n’endwadde z’ekibumba mu basajja.

Waliwo obusimu obulala obuwerako obukosa okukola n’okufulumya ebirungo bino ebiyitibwa androgens. Okugeza , obusimu obukola ku luteinizing hormone (LH) ne adrenocorticotrophic hormone (ACTH) . Obusimu buno bwombi bufulumizibwa endwadde ya pituitary gland.

Singa ekimu oba ebisingawo ku bitundu bino, oba ekimu ku busimu buno, tekikola bulungi, hyperandrogenism eyinza okubaawo.

Waliwo ensonga enkulu eziwerako eziviirako kino:

• Obulwadde bwa Polycystic ovary syndrome (PCOS) - Kino kye kisinga okuvaako.
• Obulwadde bwa Congenital Adrenal Hyperplasia (CAH) .
• Obulwadde bwa Cushing .
• Ebizimba ebifulumya androgen.
• Eddagala erimu.

Kati katutunuulire buli emu ku nsonga zino mu bujjuvu katono.

Obulwadde bw’enkwaso eziyitibwa polycystic ovary syndrome (PCOS) .

Mu bakyala abato n’abakulu, PCOS y’esinga okuvaako obulwadde bwa hyperandrogenism obutasalako oluvannyuma lw’okutuuka mu myaka gy’obuvubuka. Wakati wa 80% ne 90% ku bakyala abalina obulwadde bwa hyperandrogenism nabo balina PCOS .

Mu PCOS, enkwaso zikola androgens nnyingi olw’emiwendo gya LH ne insulini egy’amaanyi obutasalako (hyperinsulinemia). Okugatta ku ekyo, insulini eyeeyongera nakyo kiziyiza ekibumba okukola puloteyina eyitibwa Sex Hormone Binding Globulin (SHBG) . Kino kyongera ku muwendo gw’obusimu obuyitibwa testosterone obw’obwereere mu musaayi.

Obulwadde bw’ekibumba obuzaalibwa nabwo `(CAH)`

Congenital adrenal hyperplasia (CAH) kibinja kya mbeera z’obuzaale ezikosa endwadde z’ekibumba.

Mu CAH, enkyukakyuka mu buzaale zireeta obutaba na enzyme eyitibwa 21-hydroxylase , eyamba omubiri okukola obusimu. Mu bantu bangi abalina CAH, obutaba na enzyme eno kireetera endwadde z’ekibumba okukola obusimu obulala obusingako, gamba nga testosterone.

Ekisinga okuvaako obulwadde bwa hyperandrogenism mu bakyala abalina obulwadde bwa adrenal hyperplasia ye non-classical congenital adrenal hyperplasia . Eno mbeera nga enziyiza 21-hydroxylase ebulamu ekitundu. Embeera eno ekosa abakyala nga 2% abalina obulwadde bwa hyperandrogenism.

Obulwadde bwa Cushing

Obulwadde bwa Cushing kika kya mbeera eyitibwa Cushing syndrome . Obulwadde bwa Cushing syndrome mbeera etatera kubaawo ng’omubiri gulina ekirungo kya cortisol ekisusse (nayo busimu).

Obulwadde bwa Cushing buva ku kizimba ekitali kya kookolo mu nseke z’omubiri (pituitary gland). Ekizimba kino kifulumya ACTH (adrenocorticotropic hormone) eyitiridde, eyongera ku muwendo gwa cortisol.

ACTH eyitiridde ereetera endwadde z’ekibumba okufulumya endrogens ezisukkiridde, nga kino kye kireeta hyperandrogenism.

Obulwadde bwa Cushing syndrome bulina obubonero obulala:

• Obubonero obuwanvuwa obwa kakobe ku lubuto.
• Okugejja amangu mu kitundu kya ffeesi, olubuto n’ensingo.
• Puleesa eri waggulu.

Bw’oba ​​olina obubonero nga buno, kikulu nnyo okulaba omusawo amangu ddala nga bwe kisoboka.

Ebizimba ebifulumya androgen

Ebizimba ebimu eby’endwadde z’ekibumba, oba ebizimba mu nkwaso oba ensigo, bisobola okukola n’okufulumya obuwuka obuyitibwa androgens. Kino kireetera androgen mu mubiri okubeera waggulu okusinga ku ya bulijjo. Embeera y'obulwadde bwa hyperandrogenism obuva ku bizimba bino etera okuba ey'amaanyi ennyo era ejja mu bwangu .

Obulwadde bwa Hyperandrogenism, obuva ku bizimba by’enkwaso oba mu kibumba, tebutera kubaawo. Bukwata abantu nga 0.2% bokka. Wabula bw’ofuna obubonero bw’obulwadde bwa hyperandrogenism mu bwangu, laba omusawo mu bwangu.

Eddagala erimu

Eddagala erimu era liyinza okuleeta obulwadde bwa hyperandrogenism. Eddagala erisinga okuvaako kino lye:

• Anabolic-androgenic steroids (zino ngeri za testosterone ezikoleddwa mu ngeri ey’ekikugu, bannabyamizannyo abamu gye bakozesa obubi okutumbula omutindo).
• Synthetic progestins (lino ddagala erireeta enkyukakyuka mu nnabaana era nga likozesebwa mu bintu eby’enjawulo).
• Eddagala eriweweeza ku bulwadde bw’okusannyalala ( eddagala eriziyiza okukonziba ).

Kino okisanga otya? (Okuzuula obulwadde)

Bw’oba ​​omukyala n’oteebereza nti olina obulwadde bwa hyperandrogenism, omusawo ajja kukukebera omubiri n’anoonya obubonero ng’enviiri ezikula nga toyagala. Era bajja kukubuuza ebibuuzo ebitonotono ebikwata ku byafaayo byo eby’obujjanjabi:

• Emyaka amabeere kwe gatandikira okukula.
• Emyaka enviiri gye zitandikira okulabika mu kifo eky’obwannannyini.
• Emyaka nga osooka okugenda mu nsonga.
• Oggyawo enviiri (shave, obaddeko laser hair removal)?
• Wali okozesezza eddagala eriyitibwa anabolic steroids oba testosterone nga tolina ddagala lya musawo?
• Ebintu nga emirundi gy’ogenda mu nsonga, ennaku mmeka gye zimala, n’omusaayi gw’ovaamu omusaayi.

Singa omusawo ateebereza nti olina obulwadde bwa hyperandrogenism, ajja kulagira okukeberebwa mu musaayi okukebera obusimu obumu. Ebigezo bino bisobola okuyamba okuzuula embeera eno.

Ebigezo bya ngeri ki ebikolebwa?

Bw’oba ​​olina obubonero bw’obulwadde bwa hyperandrogenism, omusawo ayinza okulagira okukeberebwa omusaayi nga bino:

• Omugatte gwa testosterone: Kino kipima obungi bwa ‘testosterone’ bwonna mu musaayi gwo. Omutindo guno guyinza okuba waggulu katono mu bakyala abalina PCOS. Singa eba waggulu nnyo, eyinza okuba ekizimba mu nkwaso oba ensigo.
• Testosterone ow’obwereere : Testosterone eno tesibibwa ku puloteyina yonna. Kino kibeera kitono nnyo ku mubiri gwonna ogwa testosterone. Omutindo guno era guyinza okweyongera mu bakyala abalina PCOS.
• Androstenedione : Buno busimu bwa steroid obulina kinene kye bukola ku mubiri. Wabula okusinga kikola ng’omutendera ogw’omu makkati mu kukola ekirungo kya testosterone ne estrogen mu mubiri. Singa emiwendo gyayo giba waggulu, PCOS eyinza okubaawo.
• Dehydroepiandrosterone sulfate (DHEAS) : DHEAS busimu bwa kwegatta obukolebwa endwadde z’ekibumba. N’olwekyo, kiraga bulungi nti adrenal androgen ekola. Kya bulijjo abakyala abalina PCOS okuba n’emiwendo gya DHEAS egyalinnya katono. Singa eba waggulu nnyo, kiyinza okuba akabonero k’ekizimba mu kibumba.
• 17-hydroxyprogesterone : Okupima omuwendo gwa 17-hydroxyprogesterone mu musaayi kye kigezo ekikulu okukebera oba waliwo obulwadde bwa non-classic congenital adrenal hyperplasia, embeera y’emu ku nsonga ezivaako hyperandrogenism.

Okuva bwe kiri nti wayinza okubaawo ebintu ebirala ebivaako obubonero bw’obulwadde bwa hyperandrogenism, omusawo wo ajja kulagira okukeberebwa omusaayi mulala okusobola okugaana n’ebivaako ebyo.

Okugatta ku ekyo, okukebera ebifaananyi nga kuno kuyinza okukolebwa okuzuula ekivaako obulwadde bwa hyperandrogenism:

• Okukebera eddoboozi ery’omu kifuba okukebera oba waliwo ebizimba by’enkwaso (akabonero akalala aka PCOS) oba ebizimba ebirala.
• Okukebera ebizimba by’endwadde z’ekibumba , okukebera kwa CT scan (Computed tomography - CT) oba MRI scan (Magnetic resonance imaging - MRI) kukolebwa.

Abasawo baluubirira okukendeeza ku kukola androgen okuva mu nkwaso oba endwadde z’ekibumba, okukendeeza ku miwendo gya androgen egy’obwereere, n’okuziyiza androgen okukola.

Wabula abantu abalina obulwadde bwa hyperandrogenism batera okunoonya amagezi g’abasawo okujjanjaba obubonero obukulu, gamba ng’enviiri ezitayagala, embalabe, n’okugenda mu nsonga mu ngeri etaali ya bulijjo.

Bujjanjabi ki obukolebwa ku kino?

Obujjanjabi bw’obulwadde bwa hyperandrogenism businziira ku kivaako. Okugeza nga:

• Obulwadde bwa adrenal hyperandrogenism busobola okufugibwa n’eddagala eriyitibwa corticosteroids erya dose entono .
• Singa wabaawo ebizimba mu nkwaso, ensigo oba endwadde z’ekibumba, kiyinza okwetaagisa okulongoosebwa. Mu bakyala abali mu nsonga oba abagenda mu nsonga nga balina obulwadde bwa hyperandrogenism obw’amaanyi, nakyo kiyinza okwetaagisa okuggyamu enkwaso emu oba zombi mu kulongoosa .
• Singa obulwadde bwa hyperandrogenism buva ku ddagala ly’omira, omusawo ajja kukuwa amagezi okukomya eddagala oba okukyusa n’odda ku ddagala eddala.

Eddagala eriziyiza obuwuka obuleeta endwadde (androgen) nalyo bujjanjabi bwa bulijjo eri obulwadde bwa hyperandrogenism. Ziziyiza ebikolwa bya androgens, nga testosterone.

Waliwo ebika by’eddagala eriweweeza ku bulwadde bwa antiandrogen:

• Empeke z’okuziyiza okuzaala ez’omu kamwa/ez’okuziyiza okuzaala ezirimu ethinyl estradiol (estrogen) ne antiandrogenic progesterone: Eby’okulabirako mulimu empeke ezirimu cyproterone acetate (e.g. Diane®-35), drospirenone (e.g. Yasmin®, Yaz®) oba dienogest (e.g. Valette®). Bino bisobola okujjanjaba embalabe, enviiri ezitayagala n’okugenda mu nsonga ezitali za bulijjo.
• Spironolactone (Spironolactone - Aldactone®) : Antiandrogen eno ejjanjaba embalabe n’okukula kw’enviiri okuteetaagibwa okuva ku busimu.
• Cyproterone : Eddagala lino liyamba okujjanjaba PCOS, okukendeeza ku busimu obuyitibwa testosterone, n’okukendeeza ku mafuta agavaako embalabe.

Obujjanjabi bw’obubonero

Abantu abalina obulwadde bwa hyperandrogenism bayinza okunoonya obujjanjabi naddala ku bubonero bwabwe:

• Embalabe : Obujjanjabi bw’embalabe mulimu eddagala eriweebwa ku mubiri, eddagala eriweebwa mu kamwa nga tetracycline , antiandrogens (omuli obujjanjabi bw’obusimu, empeke eziziyiza okuzaala), n’empeke za isotretinoin .
• Hirsutism (okukula kw’enviiri okuteetaagibwa) : Abakyala bangi abalina obulwadde bw’enviiri baddukira mu nkola nga okuzisiiga enviiri, okuzisenya, n’okuziggyamu layisi. Bayinza n’okumira empeke eziziyiza okuzaala.
• Okugenda mu nsonga ezitali za bulijjo : Abakyala basobola okukozesa enkola z’obusimu eziziyiza okuzaala okutereeza enzirukanya y’ensonga.

Obubonero buno bwe butaddamu ku bujjanjabi obwa bulijjo olw’obusimu obutakwatagana, omusawo wo ayinza okulowooza ku ddagala ery’amaanyi ennyo eriziyiza obuwuka obuleeta endwadde.

Kino tekiyinza kuziyizibwa?

Ebyembi, tewali ngeri ntegeerekeka ey’okuziyiza obulwadde bwa hyperandrogenism.

Tewali ngeri ekakasiddwa ey’okuziyiza PCOS, esinga okuvaako obulwadde bwa hyperandrogenism. Naye osobola okukola obutonotono okukendeeza ku bubonero bwo. Okugeza okulya emmere erimu ebiriisa, .Dduyiro buli kiseera n’okufuga obuzito bwo kiyinza okuyamba okukendeeza ku bikolwa bya PCOS ne hyperandrogenism.

Biki ebinaabaawo mu biseera eby’omu maaso? (Okuteebereza)

Embeera nnyingi ezireeta obulwadde bwa hyperandrogenism zeetaaga okujjanjabibwa obulamu bwonna. Oluusi, abakyala abalina obulwadde bwa hyperandrogenism olw’obulwadde bwa PCOS bajja kugejja nnyo era PCOS yaabwe ejja kugenda. Wabula abantu abasinga bajja kwetaaga obujjanjabi obulamu bwabwe bwonna okukendeeza ku bubonero bw’obulwadde bwa hyperandrogenism.

Obubonero bw’obulwadde bwa Hyperandrogenism busobola okukosa okwetwala kwo n’obulamu bw’obwongo. Singa obubonero buno bukuleetera okuwulira nga olina situleesi, okweraliikirira, ne/oba okwennyamira, kikulu okunoonya obuyambi okuva eri omusawo w’eby’omutwe oba omubuulirizi.

Ddi lwe nnina okulaba omusawo?

Bw’oba ​​ozuuliddwa ng’olina obulwadde bwa hyperandrogenism era ng’omira eddagala, ojja kwetaaga okugenda ew’omusawo buli kiseera okukakasa nti obujjanjabi bwo bukola bulungi.

Singa obulwadde bwa hyperandrogenism bukosa obulamu bwo obw’omutwe, kyetaagisa okugenda ew’omusawo w’eby’omutwe oba omubuulirizi akuyambe.

N’ekisembayo, obubaka obutwala awaka:

Obulwadde bwa Hyperandrogenism mbeera etera okubeera mu bakyala. Obubonero bwayo busobola okukuleetera okuswala n’obutabeera bulungi. Naye jjukira nti toli wekka, era embeera eno esobola okujjanjabibwa. Yogerako n’omusawo wo ku ngeri y’okujjanjaba. Ate era bwe kiba nga kikosa obulamu bwo obw’omutwe, kakasa nti ogenda ew’omusawo w’eby’omutwe oba omubuulirizi. Okufaayo ku bulamu bwo kye kintu ekisinga obukulu.

` Hyperandrogenism, Androgen, Testosterone, PCOS, Hirsutism, Embalabe, Obutakwatagana mu busimu, Obulamu bw'abakyala, Obutakwatagana mu busimu