Omusawo bw’akugamba nti olina kookolo w’amabeere , oteekwa okuba nga wawulira okutya n’okukankana kungi. ‘Kati nkole ntya?’, ‘Nnaweebwa ddagala ki?’, ‘Nja kukola chemo ?’. Ebibuuzo bingi biteekwa okuba nga byajja mu birowoozo. Tukimanyi nti okulwanyisa kookolo si lugendo lwangu. Naye ssaayansi w’obusawo ow’ennaku zino akulaakulana nnyo. Mu kiseera nga kino, leero twogera ku kukeberebwa okw’enjawulo okuyamba abasawo okusalawo ddala obujjanjabi bwe banakuwa.
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Oncotype DX kye ki?
Mu ngeri ennyangu, Oncotype DX kigezo kya njawulo ekitunuulira mu bujjuvu obutoffaali bwo obwa kookolo w’amabeere . Si kukebera musaayi bulijjo. Ekozesa ekitundu ky’ekitundu kya kookolo ekyaggyibwa mu biopsy okukakasa kookolo wo oba okuva mu kulongoosebwa okuggyamu ekizimba.
Okukebera kuno kutunuulira emirimu gy’obuzaale obumu munda mu butoffaali bwa kookolo. Okufaananako n’obutoffaali bwaffe bwonna, obutoffaali bwa kookolo nabwo bulina obuzaale. Obuzaale buno bwe busalawo enneeyisa ya kookolo, kwe kugamba, engeri gy’ali, engeri gy’ayinza okusaasaana amangu, n’engeri gy’ayinza okuddamu oluvannyuma lw’okujjanjabibwa.
Okugezesebwa kwa Oncotype DX essira kulissa ku buzaale 21, y’ensonga lwaki oyinza okuwulira nga kiyitibwa “21-gene signature” test. Bwe beetegereza enkola z’obuzaale buno, abasawo basobola okuyiga ebintu bingi ebikulu ebikwata ku kookolo wo.
Ani alagirwa okukola ekigezo kino?
Okukebera kuno tekyetaagisa ku buli mulwadde wa kookolo w’amabeere. Omusawo wo atera okukuwa amagezi okukebera kuno singa oba olina emu ku mbeera zino wammanga:
- Bw’oba olina kookolo mu kiseera ekisookerwako (Stage I oba II): Kino kitegeeza nti kookolo tannasaasaana mu bitundu by’omubiri eby’ewala.
- Singa kookolo aba estrogen-receptor positive (ER+): Kino kitegeeza nti obutoffaali bwa kookolo bukula olw’obusimu obuyitibwa estrogen obukolebwa omubiri gwo. Kookolo ow'ekika kino atera okujjanjabibwa n'obujjanjabi bw'obusimu .
- Singa kookolo aba tannasaasaana mu bitundu by’omubiri ebiyitibwa lymph nodes mu kigere.
Okugatta ku ekyo, okukebera kuno oluusi kuyinza okukolebwa ku bantu abalina kookolo asoose nnyo ayitibwa DCIS (Ductal Carcinoma in Situ) , okuyamba okusalawo oba obujjanjabi obw’amasannyalaze (radiation therapy) bwetaagibwa.
Ekisinga obukulu nti obuyambi obusinga okuva mu kukeberebwa kuno bwe bulagirizi bw’ofuna mu kusalawo oba weetaaga obujjanjabi bwa ddagala oba nedda ng’oggyeeko obujjanjabi bw’obusimu.
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Okukebera kwa Oncotype DX kukuwa “Recurrence Score” wakati wa 0 ne 100. Obubonero buno gye bukoma okuba obunene, emikisa gya kookolo okudda oluvannyuma lw’okujjanjabwa gye gikoma okubeera waggulu. Kyokka engeri obubonero buno gye busomebwamu ejja kwawukana katono okusinziira ku myaka gyo.
| Obubinja bw’obubonero | Akabi | Okuteesa Okusoboka |
|---|---|---|
| 0 – 25 nga bano | Obulabe butono | Obujjanjabi bwa hormone bwokka buyinza okuba nga bumala. Emikisa mitono nnyo egy’okuganyulwa mu ngeri endala okuva mu bujjanjabi bw’eddagala. |
| 26 – 100. Ebiwandiiko | Obulabe obw’amaanyi | Obulabe bwa kookolo okuddamu bungi. Obujjanjabi bwa ddagala buyinza okulagirwa awamu n’obujjanjabi obw’obusimu. |
| Obubinja bw’obubonero | Akabi | Okuteesa Okusoboka |
|---|---|---|
| 0 – 15 nga bano | Obulabe butono | Obujjanjabi bwa hormone bwokka buyinza okuba nga bumala. Emikisa mitono egy’okuganyulwa mu ngeri endala okuva mu bujjanjabi bw’eddagala. |
| 16 – 20. Ebiwandiiko | Obulabe obutono-obw’omu makkati | Obujjanjabi bw’eddagala buyinza okukuwa omugaso omutono, naye olina okuteesa n’omusawo wo oba omugaso ogwo guba gwa mugaso bw’ogeraageranya n’ebizibu ebivaamu. |
| 21 – 25 nga bwe kiri | Obulabe obwa wakati | Emigaso gy’eddagala eriweweeza ku bulwadde buno giyinza okusinga obulabe bw’ebizibu ebivaamu. Kino olina okukiteesaako n’omusawo wo era osalewo. |
| 26 – 100. Ebiwandiiko | Obulabe obw’amaanyi | Obulabe bwa kookolo okuddamu buli waggulu. Obujjanjabi bwa kemiko businga kusemba wamu n’obujjanjabi bw’obusimu. |
Akabonero kano kokka ke kalina okusalawo obujjanjabi?
Si bwe kiri ddala. Kino kikulu nnyo. Obukodyo bwa Oncotype DX nsonga emu yokka ey’amaanyi okukuyamba okusalawo. Omusawo wo ajja kulowooza ku bintu ebirala bingi nga tannaba kukola nteekateeka ya bujjanjabi esinga obulungi gy’oli.
Okugeza nga:
- Sayizi y’ekizimba
- Ekipimo ky’ekizimba
- Omuwendo gw’ebirungo ebikwata obusimu mu butoffaali bwa kookolo
- Emyaka gyo n’obulamu bwo okutwaliza awamu
Ensonga zino zonna zikwatagana ne zisalawo ekisembayo. N’olwekyo, lipoota eno ey’okukebera kye kimu ku bikozesebwa ebiyinza okuyamba omusawo wo okukukolera enteekateeka y’obujjanjabi esinga obulungi.
Waliwo okukebera obuzaale obulala nga kuno?
Yee, waliwo ebigezo ebirala ebiwerako eby’obuzaale ebikozesebwa ku kookolo w’amabeere. Naye ekisinga okukozesebwa n’okutuusa kati ye Oncotype DX. Ka tuyige mu bufunze ku balala.
- MammaPrint: Kino kikebera obuzaale 70. Kiyamba okulagula obulabe bwa kookolo okusaasaana ebweru w’amabeere. Kiyinza okukozesebwa ku bika byombi ebya ER+ ne ER-.
- Mammostrat: Kino kikebera obuzaale 5 era kipima obulabe bwa kookolo w’amabeere alina obusimu (hormone-receptor positive) mu kiseera ekisookerwako okudda.
- Prosigna: Kino kikozesebwa ku kookolo w’amabeere alina obusimu mu bakyala abava mu nsonga. Yeekenneenya obuzaale 58 n’eragula obulabe bwa kookolo okudda awalala mu mubiri mu myaka 10.
Bino byonna bigezo bya mulembe. Omusawo wo y’ajja okusalawo oba weetaaga ekimu ku bino n’ekisinga okutuukirawo.
Obubaka Obutwala Awaka
- Oncotype DX kigezo kya njawulo okwekenneenya obuzaale bw’obutoffaali bwa kookolo w’amabeere okuyamba okuzuula obulabe bw’okuddamu okulwala kookolo n’okumanya oba kyetaagisa okuweebwa eddagala.
- Kino kikolebwa n’ekitundu ky’ekitundu kya kookolo ekiggiddwa mu biopsy oba okulongoosebwa, so si mu musaayi.
- Okugezesebwa kuno tekyetaagisa ku buli muntu. Kisinga kukozesebwa ku kookolo ali Stage I/II, ER+, era nga tesaasaana mu nnywanto.
- Obukodyo bw’okukeberebwa kitundu kimu kyokka ku nteekateeka y’obujjanjabi. Omusawo ajja kulowooza ku bintu ebirala bingi, gamba ng’obunene bwa kookolo, obuzibu bwe, n’emyaka gyo.
- Bw’oba olina ekibuuzo kyonna oba ekikweraliikiriza ku nsonga eno, kakasa nti oyogera mu lwatu n’omusawo wo . Mazima ddala ajja kukuyamba okulonda ekisinga obulungi gy’oli.
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