Naawe tofuna buzibu kulekera awo kuvaamu musaayi wadde ng’osalako akatono? Ka twogere ku bulwadde bwa von Willebrand!

Oluusi olina akatundu akatono akasala nga tekakoma kuvaamu musaayi okumala ebbanga ddene? Oba otera okuvaamu omusaayi mu nnyindo? Mpozzi waliwo omuntu mu maka go alina ebizibu ebifaananako bwe bityo? Bwe kiba bwe kityo, kino kintu ekiyinza okuba ekikulu gy’oli. Leero tugenda kwogera ku mbeera etali ya bulijjo naye nga ya bulijjo ennyo eyitibwa von Willebrand Disease .

Obulwadde bwa von Willebrand kye ki?

Mu ngeri ennyangu, von Willebrand Disease bulwadde omusaayi gwaffe mwe gutazimba bulungi, ekitegeeza nti enkola eyamba okukomya omusaayi enafuwa. Kino kitera okuba eky’ensikirano , ekitegeeza nti abazadde basobola okuyisa obulwadde buno mu baana baabwe. Naye teweeraliikiriranga, waliwo obujjanjabi ku kino. Abasawo basobola okukuwa eddagala eriyamba ku nkola eno ey’okuzimba omusaayi.

Kiki ekituuka ku muntu alina obulwadde bwa von Willebrand?

Omuntu alina obulwadde buno ayinza okuvaamu omusaayi ogusukka ku gwa bulijjo. Lowooza ku ky’okusalako akatono oba okuggyamu amannyo kiyinza okutwala ekiseera ekiwanvu okulekera awo okuvaamu omusaayi. Abantu abamu batera okuvaamu omusaayi mu nnyindo. Ku bakyala, bayinza okuvaamu omusaayi mungi nga bagenda mu nsonga, oba bayinza okuvaamu omusaayi mungi nga bamaze okuzaala.

Mu mbeera ezisinga okuba ez’amaanyi ez’obulwadde buno, oluusi kuyinza okuvaamu omusaayi awatali nsonga etegeerekeka mu binywa oba mu bitundu ebigonvu. Kino kiyinza okuvaako okuzimba n’okulumwa ennyo. Ku balala, kiyinza n’okuviirako okukendeeza ku musaayi , nga kino kitegeeza obutaba na musaayi .

Embeera eno ya bulijjo etya?

Mu butuufu kino kye kizibu ekisinga okuvaamu omusaayi mu nsi yonna. Lipoota ezimu ziraga nti bukosa abantu nga 1% ku bantu b’omu Amerika. Mu nsi yonna, kiteeberezebwa nti abantu wakati wa 23 ne 110 ku buli bukadde bayinza okuba n’obulwadde buno. Wabula omuwendo guno guyinza okwawukana, kubanga abantu abamu bayinza okuba n’obuzibu bw’okuvaamu omusaayi naye nga tebazuuliddwa nti balina obulwadde bwa von Willebrand . Abantu abamu bayinza okuba nga bamaze emyaka nga bafuna ebizibu bino, naye tebazuulibwa okutuusa nga buyise.

Obulwadde bwa von Willebrand n’obulwadde bwa hemophilia kintu kimu?

Yee, wadde nga byombi bizibu mu kuzimba omusaayi, Obulwadde bwa von Willebrand mbeera etera okuba n’obubonero obutono era nga si bwa maanyi nnyo okusinga hemophilia . Naye ekyo tekitegeeza nti kintu kya kubuusa maaso.

Bubonero ki obulaga obulwadde bwa von Willebrand?

Abantu bangi abalina obulwadde buno bayinza obutaba na bubonero bwonna , oba obubonero obutono ennyo. Kyokka abo abalina obulwadde obw’amaanyi ennyo bayinza okufuna obubonero nga:

• Okuvaamu omusaayi mu nnyindo : Guno si musaayi gwa bulijjo gwokka. Kiyinza okuba nga kivaamu omusaayi okumala eddakiika ezisukka mu 10, oba okuva mu nnyindo emirundi egisukka mu etaano omwaka.
• Okuvaamu omusaayi okuva mu kiwundu: Okuvaamu omusaayi okuva mu kitundu ekitono oba ekiwundu ekirala okumala eddakiika ezisukka mu 10.
• Ebiwundu: Abantu abalina obulwadde buno bafuna ebiwundu mangu nnyo. Ebiwundu bino tebikoma ku lususu, wabula bisobola okuzimba katono ne bigulumizibwa ng’ekizimba. Ebiwundu bino era bisobola okuba ebinene okusinga ekinusu kya ssente ttaano.
• Obutabeera na kyumaOkukendeera kw’omusaayi olw’obutaba na kyuma : Okukendeera mu musaayi mbeera omubiri mwe tegulina butoffaali bumyufu bumala . Okukendeera kw'omusaayi olw'obutaba na kyuma kibaawo ng'omubiri gwaffe tegulina kyuma kimala kukola hemoglobin . Ekintu kino ekiyitibwa hemoglobin kiyamba obutoffaali obumyufu okutambuza omukka gwa oxygen. Kale, bwe tufiirwa omusaayi omungi, tusobola n’okufiirwa ekyuma ne tufuna embeera eno.
• Okuvaamu omusaayi oluvannyuma lw’okulongoosebwa: Abantu abalina obulwadde buno basobola okuvaamu omusaayi mungi, ne bwe baba balongooseddwa obutonotono, gamba ng’okuggyamu amannyo.
• Okugenda mu nsonga : Ku bakyala abamu, singa omusaayi gwe bavaamu mu nsonga guba mungi nnyo nga buli ssaawa balina okukyusa paadi oba tampon, oba ssinga bamala ennaku ezisukka mu musanvu, kiyinza okuba akabonero k’embeera eno.
• Okuvaamu omusaayi omungi oluvannyuma lw’okuzaala oba okuvaamu olubuto.
• Omusaayi mu musulo: Ka kibe nti olina omusaayi mu musulo oba omusaayi ng’omaze okuyita mu musulo, kiyinza okuba akabonero k’embeera endala ey’obujjanjabi. N'olwekyo , olina okulaba omusawo ddala .
• Omusaayi mu musulo (hematuria): Bw’olaba omusaayi ng’ofulumya omusulo naddala ng’omusaayi guwerekerwako okwagala okufulumya omusulo mu bwangu, tegeeza omusawo mu bwangu .

Ekisinga obukulu, bw’oba ​​olina obubonero buno obumu oba obusingawo, tobubuusa maaso olabe omusawo akuwe amagezi.

Kiki ekivaako Obulwadde bwa von Willebrand?

Buno bulwadde bwa buzaale . Kino kitegeeza nti obulwadde buno buva ku nkyukakyuka (mutation) mu buzaale bwaffe. Olw’enkyukakyuka zino ez’obuzaale, omubiri gwaffe tegusobola kukola bulungi puloteyina eyitibwa von Willebrand factor . Ensonga zino ze puloteyina eziyamba omusaayi gwaffe okuzimba.

Ensonga eno eya von Willebrand esangibwa mu plasma (ekitundu eky’amazzi eky’omusaayi gwaffe), platelets (obutoffaali obuyamba omusaayi okuzimba), ne mu bisenge by’emisuwa . Mu budde obwabulijjo, omusuwa bwe gwonoonese, obusimu obuyitibwa platelets bunywerera ku kitundu ekyonoonese, ne bukola ekizimba ky’omusaayi ne buyimiriza omusaayi.Von Willebrand factor y’eyamba platelets zino okunywerera obulungi. Kale, bw’ofiirwa ensonga eno ekimala, oba bw’ogifiirwa ddala, obutoffaali obuyitibwa platelets tebusobola kukwatagana bulungi. Olwo kitwala ekiseera ekiwanvu okuzimba omusaayi.

Abantu abasinga obulwadde buno babufuna nga basikira obuzaale obukyusiddwa okuva ku omu ku bazadde baabwe . Kino kiyitibwa obusika obufuga ( autosomal dominant inheritance ) . Abalala basobola okusikira obuzaale obukyusiddwa okuva mu bazadde bombi . Kino kiyitibwa autosomal recessive inheritance , era kye kika ky’obulwadde buno ekisinga okuba eky’amaanyi. Omuntu atambuza obuzaale buno obukyusiddwa alina emikisa 50% okuyisa enkyukakyuka eno mu baana be.

Ate era, oluusi obulwadde bwa von Willebrand buyinza okubaawo ng’ekizibu ky’embeera endala ez’obujjanjabi, gamba nga kookolo , obuzibu bw’abaserikale b’omubiri , endwadde z’omutima, n’endwadde z’emisuwa.

Abasawo bazuula batya obulwadde bwa von Willebrand?

Bw’olaba omusawo ajja kusooka kukubuuza ku bubonero bwo. Era bayinza okubuuza oba waliwo omuntu yenna mu maka go eyabadde n’obubonero obufaananako bwe butyo oba obuzibu bw’okuvaamu omusaayi. Oluvannyuma bayinza okukola ebigezo ebimu, gamba nga:

• Complete blood count (CBC): Kino kipima omuwendo gw’obutoffaali obumyufu, ebika by’obutoffaali obweru eby’enjawulo, n’obutoffaali obuyitibwa platelets mu musaayi gwo. Era epima obungi bwa hemoglobin mu butoffaali bwo obumyufu. Abantu abasinga abalina obulwadde bwa von Willebrand balina CBC eya bulijjo. Kyokka abantu abavaamu omusaayi omungi bayinza okuba n’obutoffaali obutono (hemoglobin) n’obutoffaali obumyufu obutono.
• Okukebera okukuŋŋaanyizibwa kw’obutoffaali obukola omusaayi (platelet aggregation tests): Kino kikebera engeri platelets zo gye zikwataganamu obulungi okuyamba okukola okuzimba omusaayi.
• Activated partial thromboplastin time test (APTT): Kino kikebera von Willebrand factor n’ebintu ebirala ebizimba omusaayi ebiyamba omusaayi okuzimba. Singa emiwendo gy’ebintu bino giba wansi okusinga ku gya bulijjo, kitwala ekiseera ekiwanvu omusaayi okuzimba.
• Okukebera obudde bwa Prothrombin (PT): Kino era kipima ensonga endala ezikwata omusaayi.
• Okukebera fibrinogen:Fibrinogen ye puloteyina endala eyamba omusaayi okuzimba.
• Okukebera antigen ya Von Willebrand factor: Kino kipima obungi bwa puloteyina ya von Willebrand factor mu musaayi gwo.
• Ristocetin cofactor test: Kino kyetegereza emirimu gya von Willebrand factor.
• Von Willebrand factor multimers test: Kino kitunuulira ensengekera y’ensonga.

Omusawo wo ayinza okwetaaga okukola okukebera omusaayi okuwerako okukakasa nti ozudde, kubanga ebintu ng’obusimu busobola okukyusa omutindo gwa von Willebrand factor mu musaayi gwo.

Waliwo ebika by’obulwadde bwa von Willebrand ebiwerako. Abasawo bajja kwongera okukebera okuzuula ddala ekika ky’olina. Ebika bino bye bino:

• Ekika 1: Kino kye kika ekisinga okubeerawo. Abalwadde wakati wa 60% ne 80% balina ekika kino. Abantu bano balina ekirungo kya von Willebrand factor ekitono mu musaayi gwabwe. Bayinza obutaba na bubonero. Bwe bakola bwe batyo, baba bagonvu nnyo.
• Ekika 2: Mu kika kino, ensonga ya von Willebrand tekola bulungi. Abantu bano bayinza okuvaamu omusaayi omutono oba ogw’ekigero. Abalwadde wakati wa 15% ne 30% balina ekika kino.
• Ekika 3: Kino kye kika ekisinga okuba eky’amaanyi. Era tekitera kubaawo nnyo. Bukwata abalwadde wakati wa 5% ne 10%. Abantu bano balina emiwendo gya von Willebrand factor emitono ennyo mu musaayi gwabwe, oba tebalina n’akatono. Kino kiyinza okuvaako obuzibu obw’amaanyi okuvaamu omusaayi.

Bujjanjabi ki obw’obulwadde bwa von Willebrand?

Abasawo obulwadde buno babujjanjaba n’eddagala ery’ebika eby’enjawulo:

• (Desmopressin): Buno busimu bukola bulungi. Kyongera ku mutindo gwa von Willebrand factor mu musaayi. Buno bwe bujjanjabi obusinga okujjanjaba obulwadde buno.
• Von Willebrand factor infusions: Abantu abamu baweebwa factor eno nga bayita mu musuwa okukomya okuvaamu omusaayi. Obujjanjabi buno osobola okubuweebwa nga tonnalongoosebwa. Abantu abamu abalina obulwadde obw’amaanyi bayinza okwetaaga okufuna obujjanjabi buno buli kiseera okusobola okukuuma emiwendo gy’ensonga mu musaayi gwabwe nga tegikyukakyuka.
• (Eddagala eritta obuwuka obuleeta endwadde):Eddagala lino likola nga litangira okuzimba omusaayi okutondebwawo. Omusawo ayinza okukuwa eddagala lino singa oba olongoosebwa amannyo oba ng’ofuna omusaayi omungi ng’ogenda mu nsonga.
• Empeke eziziyiza okuzaala: Zino ziyamba abo abavaamu omusaayi omungi mu nsonga. Ekirungo kya estrogen ekiri mu ddagala lino kyongera ku muwendo gwa von Willebrand factor mu musaayi.

Nsobola okukendeeza ku bulabe bw’okukwatibwa obulwadde buno?

Kino kitera kuba kya nsikirano . Singa bazadde bo balina obulwadde buno, osobola okubusikira omu oba bombi. Kale tewali kye tuyinza kukola kugiremesa kukula.

Bwemba nnina embeera eno, kiki kye nsuubira?

Abasawo basobola okujjanjaba obulwadde bwa von Willebrand, naye tebasobola kubuwonya ddala . Abantu abasinga balina ekika kya 1 oba ekika kya 2. Beetaaga obujjanjabi singa baba n’obuvune oba nga beetaaga okulongoosebwa. Abantu abalina ekika kya 3 bayinza okwetaaga obujjanjabi obutasalako okusobola okufuga omusaayi.

Nnina Obulwadde bwa von Willebrand. Nsaanidde kwerabirira ntya ?

Okuva abantu abasinga bwe balina obubonero obutono oba obw’ekigero, okubeera n’obulwadde buno kitegeeza okulowooza ku bintu ebitonotono:

• Weewale emirimu egiyinza okuvaako obuvune: Kirungi okwewala emizannyo egy’amaanyi, okugeza, omupiira, rugby, ne hockey.
• Buulira abasawo bo bonna omuli n’omusawo w’amannyo nti olina embeera eno: olwo basobola okuteekateeka engeri y’okufuga omusaayi oluvannyuma lw’okulongoosebwa.
• Tokozesa aspirin oba eddagala eririmu aspirin.
• Tokozesa ddagala eriziyiza okuzimba eritali lya steroid (NSAIDs) , nga ibuprofen, okuggyako ng’omusawo amanyi nti olina obulwadde bwa von Willebrand.
• Weewale okumira ebiriisa ebirimu vitamiini E, amafuta g’ebyennyanja, n’entungo.
• Lowooza ku ndagamuntu ey’okulabula kw’abasawo: Okwambala akakomo nga kano oba okutambula ne kaadi y’endagamuntu kiyinza okukuyamba okufuna obujjanjabi obutuufu mu mbeera ey’amangu.

Ngenda ddi mu ddwaaliro mu bwangu?

Genda mangu mu ddwaaliro essaawa yonna ng'ovaamu omusaayi nga tofuddeeyo . Ne bwe buba buvune butono, singa omusaayi tegukoma, kakasa nti ogenda mu basawo amagezi.

Bibuuzo ki bye nnina okubuuza omusawo?

Bw’oba ​​olina obulwadde bwa von Willebrand, oyinza okuba n’ebibuuzo ku ngeri obulwadde buno gye bunaakwatamu obulamu bwo. Bino bye bimu ku bibuuzo by’oyinza okubuuza omusawo wo:

• Lwaki nnafuna obulwadde buno?
• Abaana bange basobola okusikira obulwadde buno?
• Kino kinaayongera okusajjuka?
• Bujjanjabi ki obukolebwa ku kino?
• Biki ebiva mu bujjanjabi buno?
• Sijja kusobola kukola bintu ebimu, gamba ng’okutambula oba okuzannya emizannyo, olw’obulwadde buno?

Mu bufunze, ebintu bye tulina okujjukira bye...

Obulwadde bwa Von Willebrand bulwadde bwa bulijjo nnyo, obuva ku buzaale bw’okuzimba omusaayi. Abantu abasinga balina obubonero obutono oba obw’ekigero. Bayinza okuba nga batera okuvaamu omusaayi mu nnyindo, oba n’okusalako okutonotono kuyinza okutwala ekiseera ekiwanvu okulekera awo okuvaamu omusaayi. Abalala balina obubonero obw’amaanyi. Ng’ekyokulabirako, bayinza okuba nga bavaamu omusaayi mu binywa n’okulumwa ennyondo.

Abantu abamu bayinza obutamanya nti balina embeera eno okumala emyaka. Bw’oba ​​olina, kiyinza okukuwummuza okumanya lwaki olina obuzibu bw’okuvaamu omusaayi. Oyinza n’okweraliikirira nti n’abaana bo bajja kufuna embeera eno. Wadde ng’abasawo tebasobola kuwonya mbeera eno, basobola okugijjanjaba . Era basobola okuddamu ebibuuzo by’obuuza oba abaana bo banaagisikira. Era basobola okukuwa amawulire g’olina okubeera n’obulwadde bwa von Willebrand buleme kukulemesa kubeera mu bulamu obw’okukola, obwa bulijjo. Kale, teweeraliikiriranga, bw’okitegeera era n’okiddukanya obulungi, osobola okukibeera obulungi.