I thisena protein mak tak mai hi i hre tawh em? (Cryoglobulinemia) I sawi dawn nia!

A chang chuan kan taksaah hian kan beisei loh thil a thleng thin a ni lawm ni? Vawiin hian condition pakhat kan sawi dawn a, chu chu a mak deuh hlek a, mahse hriat hlawh tak a ni. Hei hi cryoglobulinemia an ti a. A hming hi a buaithlak deuhin a lang thei a, mahse lungngai suh, awlsam takin han sawifiah ila.

Cryoglobulinemia tih hi eng nge ni? A awlsam zawngin...

A awlsam zawngin, cryoglobulinemia hi i thisena protein pangngai lo thenkhat, cryoglobulins tia koh te chu lumna hmuna i awm chuan an lo nghet a, an inzawm khawm a, an inzawm khawm a, clot an siam thin. Tui lum-a i dah chuan coconut oil freezing ang maiin ngaihtuah rawh. Mahse hei hi kan thisen chhungah a thleng thin. Hetiang dinhmun hi a takah chuan vasculitis chi khat a ni. I thisen kalna, i taksa pum puia thisen phurtu tube te tak te, inflammation, swelling ang maia inflammation a ni. Heng thisen kalna kawngte hi a nat chuan thisen kal dan a tibuai thei a ni. Chuti a nih chuan eng nge thleng? I vun, nerve, ruhkawr, ruh leh a pawimawh ber chu i kal ang chi chhungril lam thilte hi a chhe thei a ni. Hei hi cryoglobulinemic vasculitis an ti \hin.

Cryoglobulinemia chi hrang hrang a awm em?

Ni e, heng protein cryoglobulins an tih te hi antibody chi khat an ni bawk. Kan taksain antibody a siam chhuah chi hrang hrang a zirin cryoglobulinemia hi chi thum ah then theih a ni a, chungte chu:

• Type I Cryoglobulinemia: Hei hi i thisen nena inzawm cancer emaw, i immune system nena inzawm cancer emaw avanga lo awm a ni tlangpui.
• Type II Cryoglobulinemia leh Type III Cryoglobulinemia: Heng chi hnih hi chronic (chu chu hun rei tak chhung) inflammatory condition neia hmuh tam ber a ni. Entirnan, autoimmune natna vei teah hmuh theih an ni . A bik takin, Type II Cryoglobulinemia hi Hepatitis C virus (HCV) vei zingah a hluar hle. Heng chi hnih hi an inzawm khawm a, Mixed Cryoglobulinemia an ti a.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Cryoglobulinemia hi a takah chuan a awm lo hle.Mahse zirchiangtute chuan he natna hi mi engzat nge vei tih chiang takin an la sawi thei lo. Mi ṭhenkhat chuan an thisenah heng cryoglobulins hi a tlem hle a, mahse natna lan chhuahna engmah an lan loh avângin, zirchiangtute chuan he natna hian khawvêl pumah mi maktaduai khat zînga pakhat vêl a nghawng niin an chhut.

Eng nge a lan chhuah dan? Mi zawng zawng hian symptoms kan nei vek em?

Ni lo, cryoglobulinemia vei zawng zawng hian symptom an nei vek dawn lo. Mi thenkhat chuan engmah an hre lo mai thei. Mahse a lan chhuah tak tak chuan a lan chhuah dan tlangpui chu vun rawng purpura an tih hi a ni. Hei hi ke hnuai lam ah hian red spot emaw purple bruise angin a lang thin. I chau hle a, ruh natna pawh i nei thei bawk. Symptom dang pawh a awm thei bawk. Chung zingah chuan:

• Khua lumna hmuna an awm chuan kut leh/ emaw kea thisen kalna kawngte chu a inzawm khawm a, chu chuan a sen vek a ni. Hei hi Raynaud-a phenomenon an ti a.
• A taksa rihna tihtlem .
• Thisen sang (Hypertension).
• A hring, a bik takin ke ruh leh ke (Edema).
• Vun ulcer leh a chang chuan tissue thihna (gangrene) a awm bawk.
• Liver lian (Hepatomegaly) emaw, spleen lian (Splenomegaly) emaw a ni thei.
• Numbness , tingling, emaw, taksa peng hrang hranga chak lohna.
• Kidney a chhiat phah.

Ngaihtuah teh, hei hi khaw lum avanga i ke ruhte a sen mai mai a ni lo. Hei hi i taksa chhunga harsatna lian zawk chhinchhiahna a ni thei. Chuvang chuan hetiang thil hi fimkhur a pawimawh hle.

Cryoglobulinemia hi engte nge ni?

Researcher-te chuan cryoglobulinemia thlentu hi eng nge ni tih chiang takin an la hre lo. Mahse kan sawi tawh ang khan autoimmune disease chi khat vasculitis an tih a ni a, chu chu thisen kalna kawng inflammation a ni. Autoimmune disease chu i taksa ngeia immune system, natna laka humhimtu taksa defense system-in a tihsual avanga i taksa hrisel tak takte a rawn beih mai mai a ni. Hetianga thil lo thleng thei hi thil engemaw zat a awm a:

• Genetics: Chhungkuaa mi tu emawin a neih chuan a nghawng thei a ni.
• Damdawi chi thenkhat: Damdawi zawng zawng ni lo, thenkhat.
• Infection leh virus: A bik takin virus infection.
• Environment factors: Kan chhehvela thil awm thenkhat.

Cryoglobulinemia hi a chang chuan a chhan chiang tak awm lovin a mah chauhin a lo awm thei (hei hi idiopathic an ti a), mahse a tam zawkah chuan natna dang nen a inzawm tlat thung. Chung natna thenkhat chu:

• Hepatitis C infection: Hei hi link lian ber leh hmuh tam ber a ni.
• Thisen cell-a thil dik lo: Entirnan, cancer natna, lymphoma leh multiple myeloma te.
• Connective tissue natna: Entirna atan lupus hi a ni.

Hemi atan hian tute nge hlauhawm ber?

Cryoglobulinemia hian mipa aiin hmeichhia a nghawng nasa zawk niin a lang a, kum 50 chunglam zingah a tam ber.

Enkawl that loh chuan complication a awm thei em?

Ni e, a dik tak zet. Cryoglobulinemia hi enkawl tha a nih loh chuan i vun, tissue leh internal organs te chu a tichhe vek thei a ni. Harsatna lian tak tak lo awm thei thenkhat chu:

• Vun natna emaw, hliam dam lo emaw.
• Vun thihna (necrosis).
• Kidney tha lo a awm.
• Liver a tha lo.

Hengte hi natna khirh tak tak an ni tak zet a, chuvang chuan natna hi hriatchhuah leh enkawl vat a pawimawh hle.

Engtin nge doctor-te hian he natna hi an hriat theih?

Doctor i hmuh chuan i medical history a zawt hmasa ang a, physical exam a ti ang. Tichuan, i thisenah cryoglobulins awm leh awm loh enfiah turin thisen test bik an order ang. He thisen test hian eng chi cryoglobulin nge i neih tih a hriat theih bawk. Hei hian a chang chuan i natna chhan leh enkawl dan tur a hriat theih nan a pui thei bawk. He thisen test bakah hian i doctor chuan test dang engemaw zat a order thei a, chu chu a natna hriat chian nan leh a dinhmun hriatthiam nan a ni:

• Zun test (Urinalysis) a ni.
• A rilru X-ray a ni.
• CT scan (Computed tomography (CT) hmanga enfiah) a ni.
• Angiogram (thisen kalna kawngte dinhmun a en).
• MRA (magnetic resonance angiogram) emaw CT angiogram (CT angiogram) emaw hmanga enfiah a ni.
• Nerve conduction test a ni.
• Electromyography (EMG) test (muscle hnathawh dan en rawh).
• Biopsy (tissue tlemte, vun emaw, kal emaw atanga lo chhuak pawh ni thei, enfiah nan lak).

Hei hi engtin nge enkawl a nih?

Cryoglobulinemia enkawlna chu eng taksa peng nge a nghawng tih te, a chhiat nasat dan te, leh damdawi lam harsatna dang i neih leh neih lohah a innghat a ni.Cryoglobulinemia nena inzawm thei natna dang, hepatitis C te enkawl a pawimawh a, chubakah a kaihhnawih thei dang pawh enkawl a pawimawh bawk. Hei hi a chhan chu chutiang natna dangte enkawl hian a chang chuan cryoglobulinemia symptoms te chu a tihziaawm thei a ni. I natna lan chhuah dan a na lo a nih chuan, i doctor chuan over-the-counter pain reliever (NSAID ang chi) a rawn rawt thei che a, khaw lumna hmuna awm loh turin a fuih thei bawk che a ni I dinhmun enfiah turin check-up neih fo turin an rawt thei bawk. A nasat zawk, emaw, a nasat lam atanga a na zawkah chuan enkawl dan hi a danglam deuh thei a ni:

• Immunosuppressive drugs: Hei hi a enkawlna ber a ni. Corticosteroid, prednisone ang chi hi damdawi dang nena inkawp hian pek a ni fo bawk. Hei hi organ a nghawng dan leh a chhiat nasat danah a innghat a ni.
• Antiviral damdawi: I doctor chuan natna dang, hepatitis C ang chi i nei tih a hriat chuan antiviral treatment a rawt thei ang. Liver specialist (hepatologist) hnenah pawh an refer thei bawk.
• Biologics: Rituximab hi cryoglobulinemia enkawlna atana hman tlanglawn tak a ni. Biologics hi thil nung atanga siam protein complex tak a ni a, chu chuan immune system hmun bikte chu a target a, inflammation control nan a hmang thin.
• Plasmapheresis: Hei hi enkawlna dang a ni. I thisena cryoglobulins awm zat tihtlem hmangin hna a thawk a ni. Hetiang a nih avang hian i plasma (i thisen liquid part) atang hian cryoglobulins te chu lakchhuah a ni. Hei hian cryoglobulins te hian i thisen kalna kawng a tikhawlo lo va, thisen kal dan a tikhawlo a, taksa peng hrang hrang a tihchhiat loh nan a pui bawk.

Enkawlna avanga side effect leh complication awm thei te pawh i hrechiang ang u.

Cryoglobulinemia enkawlna atana doctor-te’n damdawi an pek hian side effect na tak tak a nei thei a ni. A bulpui ber chu ruh natna (osteoporosis) leh taksain natna hrik a do theihna a tlahniam a ni. Chuvang chuan Doctor hnenah checkup neih reng a pawimawh hle. Tichuan, i doctor chuan heng side effects te control nan damdawi dang a pe thei ang. Infection laka inven a pawimawh bawk. Chuvangin, natna hrik kai theihna tihziaawm thei tur vaccine chungchang hi doctor nen sawiho ang che.

Hetiang dinhmun hi ven theih dan a awm em?

Cryoglobulinemia awm chhan dik tak hriat a nih loh avangin ven dan tur chiang tak a awm lo. Mahse, khawsik laka invenna chuan a ṭanpui thei a ni .Symptom thenkhat control nan a pui thei a, chu chu Raynaud-a phenomenon ang chi hi a ni. Hepatitis C infection test neih a pawimawh hle bawk a, i neih chuan enkawlna lak a pawimawh hle bawk.

He natna vei mi pakhat tan chuan eng prognosis nge a awm?

I thlirna, chu chu natna chu eng ang nge a nih dawn tih hi thil engemaw zatah a innghat a ni:

• Damdawi lam dinhmun hnuaia awm dangte i neih.
• I taksa peng hrang hrang a tihchhiat nasat dan.
• Enkawlna i dawn hian engtiang chiahin nge i chhân lêt ṭhîn.

Tin, natna nasat dan hi mi hrang hrangah a inang lo bawk. Mi thenkhat chuan symptoms an nei lo tak tak thei a, an dinhmun a nasat em avangin enkawl ngai lovin an awm thei bawk. Mite tan chuan natna vei zatve emaw, natna khirh tak emaw nei tan chuan a hmaa hriatchhuah leh enkawl hian natna lan chhuah dan a tiziaawm thei a, hun rei tak chhunga harsatna awm thei tur pawh a veng thei bawk. I taksa peng hrang hrangte a chhiat reng loh chuan outlook a tha hle.

Engtin nge ka in enkawl ang? Tunge min pui turin awm?

I tih theih tha ber chu i medical team te nen thawhhona tha tak neih hi a ni. I cryoglobulinemia hian eng organ nge a nghawng tih a zirin doctor hrang hrang multidisciplinary team nen thawh dun a ngai mai thei. Chûng zîngah chuan:

• Joint leh connective tissue natna lama tui tak doctor (Rheumatologists) te.
• Dermatologist te an ni.
• Hematologist te an ni.
• Kidney natna lama tui tak doctor (Nephrologists) te.
• Cardiologist te an ni.
• Neurologist te an ni.
• Hepatologist te an ni.

I medical team te hi hre chiang rawh. Nangmah ngeiin thu sawi rawh. Zawhna zawt rawh. I enkawlna tur ruahmanna chungchangah ngaihtuahna i neih chuan sawi rawh. I doctor-te chu i thusawi ngaithla turin an awm a, i hriselna leh enkawlna tichhe thei zawng zawng chu i hriatthiam vek theih nan an awm a ni.

Engtikah nge Doctor ka hmuh ang?

Cryoglobulinemia symptom i neih chuan doctor pan nghal tur a ni. Tin, hepatitis C i vei a, heng symptoms zinga pakhat tal a lo lang a nih chuan doctor pan tur a ni. Enkawlna \ha tak pawh ni se, a chang chuan natna hi a lo lang leh thei (rel leh thei). Symptom thar i neih chuan, symptoms awmsa a zual a nih chuan emaw, symptoms a lo let leh chuan doctor pan tur a ni. Medical checkup neih fo leh follow-up neih fo hi a lo lang leh hma thei tur leh harsatna awm lo tur venna atan a pawimawh hle.

Doctor hnenah eng zawhna nge ka zawh ang?

Doctor i hmuh hunah hetiang zawhna hi zawh a tha ang:

• Eng thilin nge he natna hi ka neih chhan?
• Eng enkawlna nge i rawt?
• Enkawlna avanga side effect eng nge ka ngaihtuah tur?
• Hetiang dinhmun avang hian eng harsatna nge awm thei?
• Natna lo awm leh tawh lo turin eng nge ka tih theih ang?

Kan hriat reng tur pawimawh ber berte (Take-Home Message) .

Cryoglobulinemia nena nun hi a chang chuan a harsa thei hle. Damdawi ei avanga natna lan chhuah dan leh a side effect te hian i rilru hriselnaah nghawng lian tak a nei thei a ni. I nun kawng dang tam tak a nghawng thei bawk.

Mahse, nangmah chauh i ni lo tih hre reng ang che. I doctor hnenah tanpuina dil la, chutiang dinhmun tawk mek midangte inkhawm theihna tur support group zawng rawh. I thil tawn leh i hriatte sawi chhuah hian cryoglobulinemia natna vei turin a pui thei che a ni. Khawsik laka inven te, damdawi lam thurawn lak te, zu in loh te, ei leh in inthlau tak ei te hi a pawimawh vek a ni.

He thu hi i tan a tangkai ngei ka beisei. Hrisel takin awm rawh!