He natna hi i hre tawh em? Microscopic Polyangiitis (MPA) hi eng nge a nih kan sawi dawn nia!

Chibai! Vawiin hian kan sawi dawn a, hriat tur awm lo, mahse a pawimawh hle thei dinhmun kan sawi dawn a ni. Microscopic polyangiitis an ti a, sap tawngin `(Microscopic Polyangiitis)` an ti a, a tawi zawngin `(MPA)` an ti bawk. A hming hi a buaithlak deuhin a lang thei a, mahse awlsam taka hriatthiam tum ila. Ngaihtuah buai suh, hrilhfiah turin ka rawn kal a ni.

He MPA hi eng nge ni tak tak?

A awlsam zawngin sawi ila, MPA hi natna hmuh tur awm lo tak a ni a, kan taksa chhunga thisen kalna kawng te tak te te chu a lo hring chhuak a, a nih loh leh doctor-te sawi angin a lo hring chhuak thin. Hetiang thisen kalna kawng hring hi vasculitis an ti tlangpui a ni . Ngaihtuah teh, kan taksaah hian tui pipe ang maia thisen phur thei vein te tak te tam tak a awm a. Chutiang vein chu a chhung lam atanga a lo hring chhuah chuan a chhunga thisen luang chu a tikhawlo a ni. Chuti a nih chuan eng nge thleng? Kan taksa peng pawimawh tak tak, chu chu taksa peng hrang hrang, chu thisen kalna kawngte chawm ngai te chu a chhe thei a ni. MPA-in a nghawng nasat berna hmunte chu:

• Kidney a ni
• Chuap
• Nervous system (kan nerve ang chi thil) .
• Vun
• Joints (kan ruh inzawmkhawmna hmun) .

Vasculitis chi dang, MPA ang chi symptom nei a awm tih hriat a tha a, chu chu Granulomatosis with Polyangiitis (GPA) an ti a ni. Tun hma chuan Wegener’s granulomatosis an ti thin. Natna pahnih enkawl dan hi a inang hle.

Chuti a nih chuan, he `Vasculitis` hi eng nge ni tak tak?

Vasculitis, a hmaa ka sawi tawh ang khan thisen kalna kawng a hring chhuak a ni. Chutiang a lo thlen chuan heng thisen kalna kawng bangte hi a chak lo thei a ni. A chang chuan an chak lo thei a, balloon ang maiin an bulge thei bawk – doctor-te chuan hei hi aneurysm an ti. A châng dangah chuan heng thisen kalna bangte hi a hring thei hle a, a puak darh thei bawk. Hei hian a chhehvel tissue-ah thisen a leak tir thin. Tui pipe chu clot-in a block ang bawkin vasculitis hian thisen kalna kawng a ti tawi a, a chang chuan a tikhawlo vek bawk. An kal tlanga thisen a kal theih loh avangin chu thisen kalna atanga oxygen leh nutrient dangte dawngtu taksa pengte chu a chhe vek a ni. MPA hian thisen kalna kawng te tak te leh lian lo te a nghawng ber a ni .

He MPA hi tute nge siam chhuah duh ber?

Hei hi a takah chuan natna hmuh tur awm lo tak a ni . Statistics atanga a lan dan chuan mi maktaduai tin (mi nuai sawm) zinga 13 atanga 19 inkar velin he natna hi an vei niin an sawi. Chu chu a tlem hle tihna a ni lawm ni? He natna hi kum eng pawhah a awm thei , mipa leh hmeichhiaah pawh danglamna a awm lo , an pahnih hian inang tlangin an vei thei.

Engvangin nge he MPA hi siam a nih?

Doctor-te chuan MPA lo awm chhan chiang tak an la hmu lo .. Hei hi cancer a ni lo va, natna hrik kai theih a ni lo va, chhungkua a kal tlang tlangpui a ni lo. Mahse, zirchianna tam takah chuan keimahni taksa hriselna (immune system) hian hei hi a mawhphurtu a ni tih hmuhchhuah a ni. A awlsam zawngin, kan taksa natna laka humhim tur sipai ang maia immune system chuan a thisen kalna kawngte chu a rawn bei sual tan ta a ni . Chu chu heng thisen kalna kawngte hi a lo hring chhuak a, taksa peng hrang hrangte a tichhia a ni. Chu chu vanduaithlak a ni lo maw?

MPA natna lanchhuahna chu engte nge ni? Engtin nge kan hriat chian?

MPA hian taksa peng hrang hrang a nghawng theih avangin a natna lan chhuah dan a inang lo hle . Mi zawng zawng hian symptom inang an nei vek dawn lo. Mi thenkhat chuan natna lan chhuah dan tlangpui an nei thei a, chungte chu:

• Chau tih hriat reng reng, rilru hah lutuk
• Khawsik
• Chaw chakna
• Rihna tihtlem

Chu bakah, a natna vei taksa peng hrang hrang a zirin symptom bik a awm thei bawk. Entir nan:

• Lung a nghawng chuan: Thâwk harsa, emaw thisen tlemte khuh chhuah.
• Nervous system a nghawng chuan: taksa peng hrang hranga hriatna danglam tak tak, ke ruh natna, a hnua chutiang hmuna hriatna hloh, emaw, ke ruh chakna tlahniam te.
• Vun a nghawng chuan: Vun natna, i.e., eczema -like spots.
• Muscle leh joint a nghawng chuan: chutiang hmunah chuan natna.

A pawimawh ber chu MPA hian kal (kidney) a tichhia a nih pawhin a tir lamah chuan symptom a lantir lo mai thei! Damlo chuan kal hnathawh nasa taka a tihchhiat hma chuan a hre lo mai thei. Chuvangin doctor-te tan chuan ` vasculitis` vei eng pawhah zun test neih a pawimawh tak zet a ni.

Heng symptoms zinga pakhat emaw a aia tam emaw hi a awm dun thei a ni.

Doctor-te hian engtin nge MPA hi an hriat chhuah?

MPA diagnose hi undercover investigation ang mai a ni. Doctor-te hian hmun hrang hrang a\angin thu an la khawm \hin. Natna rinhlelh a nih chuan a hnuaia mi ang hian an ti thin:

• I medical history chungchang an zawt thin: eng symptoms nge i neih leh eng chen nge i neih tawh tih an zawt thin.
• Taksa enfiahna an nei a: taksa peng engte nge a nghawng tih hriat nan leh natna dang, a lan chhuah dan inang lo tak takte chu paih chhuah a ni.
• Thisen test : taksaa eng taksa peng nge a nghawng tih hriat nan, a bik takin `antineutrophil cytoplasmic antibodies (ANCA)`Thisenah antibody a awm leh awm loh enfiah nan. He `(ANCA)` test hi `positive` a nih chuan `(MPA)` natna a awm nia rinhlelh chu finfiahna tha tak a ni. Mahse, he thisen test ringawt hian `(MPA)` a awm tih a finfiah thei lo va, he natna hi engtiang chiahin nge a active tih pawh a sawi chiang thei lo.
• Urine test: Zun chhunga protein emaw red blood cell tam lutuk emaw enfiah thin ang che (hei hi kal a nghawng em tih hriat a pawimawh hle).
• Imaging test: X-ray, computed tomography (CT) scan emaw magnetic resonance (MR) scan emaw hmangin lung ang chi hmuna thil dik lo awm leh awm loh enfiah theih a ni.

MPA rinhlelh a nih chuan a natna taksa peng atang hian tissue te tak te chu lakchhuah a ni a (biopsy) . Hei chauh hi vasculitis i neih leh neih loh finfiahna a ni. Mahse, biopsy hi medical test emaw, scan emaw, taksa enfiahna atanga thil danglam lo lang a awm chauhvin tih a ni.

MPA enkawl dan tur chu engte nge ni? (Tihdamna)

MPA enkawlna tum ber chu kan taksa hriselna (immune system) control hi a ni a, chu chu a thawk tha lo hle. Hemi atana hmanraw hman ber chu Immunosuppressive damdawi a ni. Heng damdawi hi chi hrang hrang a awm a, mahse damdawi tin hian side effect a nei a, chuvangin doctor thurawn hnuaiah chauh hman tur a ni.

• MPA hian vital organ systems nasa takin a nghawng a nih chuan , corticosteroids hi immunosuppressive damdawi dang, cyclophosphamide (Cytoxan®) emaw rituximab (Rituxan®) te nen pek thin a ni.
• Natna a na lutuk lo a nih chuan ``Corticosteroids'' nen hian damdawi `` Methotrexate '' tih hi hman hmasak theih a ni.

Enkawlna tum ber chu MPA-in a tihchhiat zawng zawng tihtawp a, natna chu a thunun theihna tur hmuna thlen a ni. Hei hi "remission" an ti a. Natna a lo ṭhat chhoh hmel hle a, doctor-te chuan corticosteroid dose chu an tihtlem zauh zauh a, a tawpah chuan tihtawp vek an tum ṭhin. Cyclophosphamide hman a nih chuan a remission a awm hma (a tlangpuiin thla thum atanga thla ruk chhung) chauh pek thin a ni. Tichuan, remission vawng reng turin immunosuppressant dang chu methotrexate-ah thlak a ni a, azathioprine (Imuran®) emaw mycophenolate mofetil (Cellcept®) emaw hman a ni. He maintenance treatment hun chhung hi mi hrang hrangah a inang lo thei. A tam zawkah chuan kum khat emaw kum hnih emaw tal a ni.Heng damdawi te hi pek a ni a, chutah chuan doctor te chuan a dose tihhniam a, tihtawp tumin an bei thin. Ngaihtuah teh, heng damdawi atana hman \henkhatte hi natna dang atan pawh an hmang \hin. Entirnan, taksa peng thlak hnua taksain a hnawl loh nan damdawi `(Azathioprine)` leh `(Mycophenolate mofetil)` tih te hi pek thin a ni. Damdawi `(Methotrexate)` an tih te hi natna chi hrang hrang, Rheumatoid arthritis leh psoriasis te tan pawh pek thin a ni. Damdawi `(Cyclophosphamide)` leh `(Methotrexate)` tih te hi cancer chi hrang hrang tan pawh dose sang takin pek thin a ni a, chutih lai chuan `(chemotherapy)` an ti bawk. Mahse hlau suh , `vasculitis` tan cancer tan a let 10 atanga a let 100 in a hniam zawkin an pe thin. Hetah hian heng damdawite hnathawh ber chu cancer cell tihhlum a ni lo va, immune system hnathawh control a ni. Rituximab hi damdawi chi khat, biologic agents an tih a ni. Immune system hmun bik target-in hna a thawk a ni. Tun hnaia zirchianna hrang hrangah chuan Rituximab hian Cyclophosphamide ang bawkin MPA na tak enkawlnaah a thawk tha hle tih hmuhchhuah a ni.

Heng damdawi te hian immune system a tichak lo a, natna khirh tak tak vei theihna a awm. Chu bakah, immunosuppressant damdawi tin hian side effects inherent a nei bawk. Chuvangin, heng damdawi hman hian side effects awm thei tur chu medical supervision hnuaia awm reng a pawimawh hle. A tir lamah chuan damdawi chu tuar theih ni mah se, hun kal zelah thil awmdan chu a danglam thei a ni. Damdawi lam thurawn zawm zel a, a tul anga test neih a pawimawh hle. A châng chuan damdawi i chawlhsan hnuah pawh hun rei tak chhûnga nghawng ṭha lo a neihte chu i fimkhur a ngai a ni.

MPA vei te tan dam leh theihna tur kawng eng nge awm? (Hmuh dan tur) .

MPA hi natna awm lo tak a nih avangin dam lehna statistics dik tak pek a harsa hle. Mahse, a vaiin MPA vei zinga 80% aia tam chu kum nga hnuah he natna hrik laka fihlim an ni . Heng result te hi natna nasat dan azirin a inang lo. MPA hi zawi zawiin a kal zel thei a, natna khirh tak ni mahse, damlo tam zawk chu an dam tha hle . Enkawlna hmasa ber tan leh damdawi lam enkawlna uluk tak hnuaia awm hian taksa peng hrang hrangte chhiatna chu a tlem thei hle. MPA vei nasat ber berte pawhin enkawlna an tan hma a, an doctor-te tih ang an tih chuan remission hun chhung an nei thei a ni. Remission hun engemaw chen hnuah pawh MPA hi a lo kir leh thei tho. Hei hi "relapse" an ti a. Hei hi MPA vei zinga 50% vel ah a thleng thin. Hetianga lo lang lehna hi i hmuhchhuah tirh laia i natna lan chhuah dan nen a inang thei a, a danglam thei bawk. Natna nasa tak lo thleng leh theihna tur tihtlem nan, .Symptom thar i neih chuan doctor hnenah report nghal a pawimawh. Thisen test leh imaging test atan doctor pan fo a pawimawh bawk. Relapse enkawl dan chu natna vei thar hmuhchhuah tawhte enkawlna nen a inang reng a ni. MPA vei tam tak chu remission-ah an kal leh thei a ni.

Chuti a nih chuan, kan sawi tawh atang hian eng thil nge hriat reng tur pawimawh ber?

Okay, tunah hian he `(MPA)` chungchang hi kan sawi tam tawh hle. Heng zawng zawng atanga i hriat reng tur pawimawh tak takte chu hengte hi a ni:

• (MPA) hi natna hmuh tur awm lo mahse na tak a ni thei a, taksa thisen kalna kawng te te chu immune system a thawh that loh avangin a lo hring chhuak thin a ni.
• A tam ber chu kal, lung, nerve, vun leh ruhkawr te a ni . Kidney hi a nghawng nasa hle nachungin, a tir lamah chuan symptoms a awm lo mai thei .
• Natna hi hriatchhuah a, enkawl hmasak a pawimawh hle.
• Enkawlnaah hian taksa hriselna titawp thei damdawi a tel a ni. Hengte hman hunah hian medical monitoring leh test neih fo hi a pawimawh hle.
• Natna chu a bo (remission) pawhin a lo let leh thei (relapse) . Chuvangin symptom tharte chu fimkhur rawh.
• I doctor nen inhawng takin inbiakna nei fo la , zawhna zawt la, i rilru put hmang sawi rawh. Chu chu a tha ber a ni.

He thu hi in tan a tangkai ngei ka beisei. Symptoms eng emaw zat chungchangah ngaihtuahna i neih chuan doctor thurawn lak theihnghilh suh.