Kan taksa chhunga chakna mak tak mai! Endothelium chungchanga hriat tur zawng zawng!

Kan taksa chhunga thil tenawm tak tak, a bik takin kan thisen kalna kawng chhunga thil tenawm tak takte hian kan hriselna atan hna an thawk tih i ngaihtuah ngai em? Awle, vawiinah hian thil pawimawh tak tak kan sawi dawn a, mahse kan sawi tam lo pawh a ni mai thei. Chu chu endothelium a ni . A hming hi scientific deuhin lang mahse a takah chuan a awlsam khawp mai. Chipchiar takin sawi ila, a hlut zia i hrethiam mai ang.

Endothelium chu eng nge ni? A awlsam zawngin i hrethiam ang u.

A awlsam zawngin, i endothelium hi cell layer te tak te tak a ni a, chu chuan i thisen kalna leh lymphatic vessel zawng zawng chhung chu a line a ni . Tui pipe chhunga membrane te tak te lining ang mai a ni. Heng cell te hi endothelial cell kan ti a . Khawiah nge an awm?

• I arteries ah chuan .
• I thisen zam ah .
• I capillaries ah chuan .
• Tin , lymph capillaries ah pawh .

Ngaihtuah teh, endothelium hi i thisen leh i taksa peng dangte inzawmkhawmtu a ni a, an inkarah information leh nutrients a luang lut thei a ni. Chuvangin endothelium hi i taksa peng leh tissue zawng zawng tan a pawimawh hle. Endothelium hi khuhna mai a ni lo. Hnathawk buai tak ang mai a ni. I thisen a luang tha thei tur leh dinhmun nghet tak a neih theih nan hna ropui tak a thawk a ni. Chuvangin scientist te chuan endothelium hi endocrine organ ah an ngai a ni . Dik tak chuan hei hi i taksa peng lian ber zinga mi a ni tih i hriat chuan mak i ti hle ang! Heng endothelial cell te te chungah hian thil a thleng a nih chuan taksaah nghawng lian tak a nei thei a ni. A chhan chu heng cell te hian kan hrisel leh chak taka min vawn thatna kawngah hna ropui tak an thawk a ni. Chuvangin he endothelium leh a hnathawh dan hi hriat a pawimawh hle. Tichuan hetiang thil hi a thlen loh nan theihtawp kan chhuah thei ang.

Endothelium chi hrang hrang a awm em?

Ni e, kan sawi tum hi chi hnih lian tak a awm. An pahnih hian endothelial cell atanga siam an ni a, mahse an awmna hmun azirin danglamna tlem a awm.

• Vascular endothelium: Hei hi i thisen kalna kawng chhunga lining awm chu a ni. A awlsam zawngin sawi ila, endothelium hi thisen kalna tura puitu a ni.
• Lymphatic endothelium atanga lo chhuak: 1.1.Hei hi i lymphatic system ah a awm. Lymphatic vessels hi tube te tak te network ang mai a ni. Tissue-a tui tam lutuk (lymph kan tih) awm khawm chu an paih chhuak thin. Chuvangin, heng lymphatic vessels te endothelium hian lymph movement a pui thin.

Heng pahnih hi i cardiovascular health atan a pawimawh hle a ni .

He endothelium te tak te hian eng hna lian nge a thawh?

Endothelial cells te hi taksa chhunga an awmna hmun azirin hna an thawk dan a inang lo. Thisen kalna kawng endothelium hnathawh berte han thlir ila.

Thisen kalna kawng a zim (Vasoconstriction) leh a zau (Vasodilation) te

Endothelial cell hrisel tak tak i neih chuan i thisen kalna kawng zau (hawng) reng turin an pui a, chutiang chuan thisen chu engmah tihbuai lohvin a kal tlang thei a ni. Tin, chhungril leh pawn atanga stimuli an dawng bawk. Entirnan, i thisen kalna kawng bang a thisen pressure te, i stress level inthlak danglamna te, leh damdawi i ei te hian hei hi a nghawng thei vek a ni. Tin, khaw lum leh vawt inthlak danglamna pawh an chhang let thin. Ngaihtuah teh, khaw lum lai chuan , i taksa peng hrang hranga thisen kalna kawngte chu a inzawm khawm thin. Hei hian i taksa peng pawimawh tak takte hnenah thisen tam zawk a luang lut thei a, chu chu a lum theih nan a ni. In hot weather , an dilate a, thisen chu a kal tha zawk a, i taksa a ti lum thei bawk. When you exercise , i taksa peng hrang hranga thisen kalna kawngte chu a zau a, chu chuan an mamawh thisen leh oxygen a pe a ni. Chuvangin, eng thil pawh ti ila, endothelium hian i taksa chhunga organ leh tissue tin hian thisen dik tak an hmuh theih nan a pui thin.

Thisen atanga tui awmte tissue chhunga lut tur a control thin

A hrisel chuan endothelium chu a permeable deuh a ni . Chu chu a cell kaltlangin tissue chhungah tui a kal tir tihna a ni. Mahse, daltu tha tak angin a thawk bawk . Thil duh loh, toxin ang chi thisenah a luh loh nan a veng a ni. Mahse, natna state thenkhat, infection /sepsis -ah chuan endothelium chu a permeable deuh deuh thin. Hei hian infection dotu cell te chu tissue chhungah a lut thei a, a dam theih nan a pui bawk.

A tul lo taka thisen zam a veng (Prevents Thrombosis ) .

Thrombosis hi thisen zam a lo awm a, thisen kal dan a tikhawlo a, chu chuan harsatna lian tham a thlen thei a ni. I endothelium hian nitric oxide leh prostacyclin tih chemical a siam chhuak thin . Chungte chuan i thisen chu a ti thim a, a tizau lo bawk. Natna state thenkhatah chuan heng thilte hi siam chhuah mumal lo tak a ni. Hei hian thisen zam a tipung a ni.

Kan taksaah hian khawiah nge he endothelium hi a awm? Engtiang chiahin nge a lian?

I endothelium chu i taksa pum puiah a darh vek! Ngaihtuah teh, i thisen kalna endothelium chauhThisen kalna kawng hi mel 60,000 vel a sei a ni . I thinlung awmna hmun kawhhmuh turin mi i ngen chuan i rilru a kawhhmuh ang. I thluak awmna hmun kawhhmuh turin mi i ngen chuan i lu lam an kawhhmuh ang. Mahse, mi pakhatin endothelium entir turin i ngen a nih chuan i taksa peng eng pawh a kawhhmuh ang! Chu chu endothelium hi a danglam bikna a ni. Endothelial cells te hian i thisen kalna kawng chhungah an line a. I thisen nena inzawm tlat cell te an ni. Basal lamina ah an inzawm a ni . Endothelium leh he basal lamina te hian thisen kalna kawng chhungril ber, tunica intima . He tunica intima hian thisen a kal tluang thei a ni. Endothelium hi engzat nge a lian? I taksa peng lian ber zinga mi a ni. Surface area lam hawi chuan mi pangngai taksa chu a khuh a, square meter 3,000 leh 6,000 inkar a ni . Tin, endothelial cell trillion 1 chuang a pai bawk ! Hengte hi epithelial tissue atanga siam an ni . Endothelial cell te hi engtiang chiahin nge an te? Heng cell te hi microscope hmang chauhvin hmuh theih a ni . An lian zawng chu:

• Micrometer (micron) 30 atanga 50 vel a sei a ni.
• Micrometer 10 atanga 30 vel a zau a ni.
• Micrometer 0.1 atanga 10 vel a thuk a ni.

He cell lian thamzia ngaihtuah tur chuan nangmah ngeiin i sam kha han ngaihtuah teh. Sam pakhat hi micrometer 100 vel a sei a ni. Chuvangin, a sei ber (50 micrometers)-ah pawh endothelial cell chu sam diameter chanve chauh a ni! Chuvangin kan taksaah hian heng specialized cells trillion khat chuang kan nei thei a ni.

Endothelium leh Epithelium hi eng nge an danglamna?

Heng pahnih hi tissue khuhtu an ni a, mahse a danglamna tlem a awm.

• Endothelium hi taksa chhunga awm vek, pawn lam boruak nena inzawmna nei lo channel-ah a awm a. Entirnan, thisen kalna kawng leh lymphatic vessel.
• Epithelium hi pawn lam boruak nena inzawm kawngpuiah a awm a. Entirnan, i chaw ei leh thawk dan .

An pahnih hian an hnathawhna tur atana specialized an ni. The epithelium is usually more protective , pawn lam khawvel daltu angin a thawk thin. Endothelium hi taksa tana thisen leh thil dang supply turin specialized a ni.

Endothelium a chhiat chuan engtin nge ni ang? Chu chu endothelial dysfunction an tih condition a ni!

Endothelial dysfunction chu i endothelium-in a hna pangngai a thawh theih loh vang a ni. Hei hi thil pakhatin i endothelial cells a tihchhiat hian a thleng thin. He chhiatna hi damdawi lam dinhmun leh nunphung hrang hrang avanga lo awm thei a ni.

Eng thilin nge hetiang hi a thlen theih?

• COVID-19 ang chi hri kai te .
• Thisen sugar level sang (Hyperglycemia) .
• Thisen sang (Hypertension) .
• Thisen a cholesterol level sang (Hyperlipidemia) .
• Taksa tihchak loh.
• Meizial leh zuk leh hmuam hman.
• Sepsis ang chi natna khirh tak tak .

Endothelium a chhiat huna thil pawi ber chu atherosclerosis a ni.

Atherosclerosis chu hun kal zelah i thisen kalna chhunga plaque awm zauh zauh a ni. Scientist-te chuan atherosclerosis stage hmasa ber chu endothelium tihchhiatna a ni tih an hria a. Hei hi thisenah LDL (bad cholesterol) a tam vang emaw, zuk leh hmuam emaw, hun rei tak chhunga thisen sang vang emaw a ni tlangpui. I endothelium a chhiat chuan i taksa immune system a kick lut a, thisen var chi khat monocytes an tih chu artery wall chhia ah a thawn lut thin. Heng monocyte te hi chutah chuan an inkhawm a, artery chhungah inflammation an siam thin. Tichuan, cellular inthlak danglamna hrang hrang a awm a, a tawpah chuan "fatty streak" an tih thil a lo awm ta a ni. Chutah chuan plaque a lo awm tan ta a ni. Hun a kal zel a, he plaque hi a lo thang lian a, i thisen kalna kawng a ti tawi bawk. Hei hian thisen kal a ti tlem a ni. Chu mai ni lovin, he plaque hian thisen zam a tipung bawk. Chuvangin endothelium chhia nei te hian heng natna te hi an vei theihna chance a sang zawk a ni.

Tichuan he chhiatna avang hian eng natna dang nge lo awm thei ang?

• Coronary Artery natna a ni
• Lung natna (Heart Attack) a awm
• Myocardial Ischemia (thinlung ruh chhunga thisen kal tlem) .
• Peripheral Artery natna a ni
• Stroke- ang chi dinhmun
• Thrombosis ( thisen zam) .

Endothelial damage hian hetiang hi a tipung thei bawk:

• Ngawt
• Natna hrik kai theih
• Insulin laka inven theihna
• Kidney Natna a awm

Chuti a nih chuan engtin nge he endothelium hlu tak hi kan hrisel theih ang?

I taksaa free radicals awm zat tihtlem hmangin endothelial cells hrisel taka awm theihna turin i pui thei a ni. Free radicals hi atom nghet lo tak tak an ni. Taksa chhunga atom hrisel tak takte an tichhe thin. Antioxidants a awm bawkAntioxidants hi i taksa (a bik takin endothelium) free radicals laka vengtu thil a ni. Chuvangin, antioxidant tamna ei tur ei hi a pawimawh hle. Hetiang ei tur hian antioxidant a pai tam hle a:

• Brown rice (bran buhfai) 1.1.
• Citrus thei chi hrang hrang lemon leh orange leh a tui te
• Thlai dum dum (spinach, kale ang chi) .
• Oatmeal a ni
• Bell pepper sen leh sen (fish chili) .
• Sweet potato a ni
• Tomato leh tomato tui
• Thlai chi hrang hrang (whole grains).

I ei leh inah antioxidant tam zawk dah belh turin eng nge i tih theih tih doctor i zawt thei bawk. I doctor chuan dietitian hnenah a refer thei che a ni. Anni chuan inthlâk danglamna tê tê, ṭan awlsam tak siam tûrin an ṭanpui thei che a ni. Entirnan, Mediterranean diet zawm turin an rawt mai thei a, chu chuan i thinlung leh thisen kalna kawng a hrisel theih nan a pui tih hriat a ni.

Free radicals tipungtu thilte chu engte nge ni? Engtin nge an lakah kan inven theih ang?

Damdawi lam thil thenkhat, nunphung leh toxins te hian i taksaah free radicals a tipung thei a ni. Fimkhur tur thenkhat chu hetiang hi a ni:

• Boruak bawlhhlawh lutuk.
• Damdawi thenkhat, pesticides, leh factory tifai nan te.
• Sugar ei tam lutuk.
• Mut tam loh vang.
• Thau lutuk .
• Zuk leh hmuam atanga meikhu chhuak.

Heng free radicals te hi i do dan tur leh a chhiatna laka i taksa ven dan tur chungchang hi i doctor nen sawiho rawh. Kum tin check-up neih a pawimawh bawk a, i damdawi pekte pawh a hun taka ei a pawimawh bawk. I hriselna atana tha tur exercise program chungchang i doctor nen sawiho rawh. Heng thilte hian i thinlung leh i circulatory system a thawk tha thei hle. Tin, i endothelium hrisel taka awm tir turin an pui bawk.

Mi tin hian an dam chhungin engtik lai pawhin endothelium tichhe thei risk factor kan nei vek tih hre reng ang che. Mahse, nunphung hrisel tak i hman a, i damdawi lam dinhmun i enkawl chuan heng hlauhawmnate hi i tihtlem thei a ni.

A tawp berah chuan hriat reng tur pawimawh ber ber (Take-Home Message) .

Chuvangin, vawiin a kan sawi endothelium hi kan taksa peng mak tak leh pawimawh tak a ni tih tunah hian in hmu thei ta. Kan thisen kalna kawng chhunga thu, ngawi renga kan taksa pum hriselna rawngbawltu ang mai a ni.

• Endothelium hi thisen kalna kawng leh lymph kawng chhunga awm cell layer a ni.
• Hei hian hna pawimawh tak tak a thawk a, chu chu thisen kal dan tur control te, thisen zam tur venna te, tissue te thil inthlak danglam tura tanpui te hi a ni.
• Endothelium a chhiat (endothelial dysfunction) chuan natna khirh tak tak, lung natna leh stroke te a lo awm thei a ni.
• He endothelium hlu tak hi ei leh in tha zawm te, exercise lak te, meizuk loh te, leh nungcha hrisel dangte kan neih te hian kan humhim thei a ni.

I doctor nen i endothelium hriselna chungchang sawipui la, chuta tang chuan i taksa pum hriselna chungchang sawipui rawh. I nun hrisel tak tanpuitu ropui tak a ni ang!