Cancer cell-te ‘chaw’ an neih loh nan damdawi i hria em? (Angiogenesis Inhibitors) te hi a tha hle.

Cancer tih thumal kan hriat pawhin hlauhna nasa tak kan nei vek a. Mahse tunlai hian medical science hian hma a sawn nasa hle. Cancer cell dotu damdawi mak tak tak hmuhchhuah a ni. Vawiin hian chutiang enkawlna bik pakhat chungchang kan sawi dawn a ni. A awlsam zawngin, hengte hian cancer cell-te ei leh in, chu chu thisen supply a titawp a, an thanlenna titawpin hna an thawk a ni.

Heng Angiogenesis Inhibitor te hi eng nge ni tak tak?

Hei hi hrethiam tur chuan entirnan tlem han la ila. Eng thing pawh hi a lian tur chuan tui leh ei tur tha a dawng chhunzawm zel a ngai tih han ngaihtuah teh. Chutiang bawkin tumor lianin taksa peng dangah a darh theih nan thisen supply tha neih a pawimawh hle.

Cancer tumor hi a tir lamah chuan a te hle a. Chutih lai chuan a chhehvela tissue hrisel tak tak atanga a mamawh nutrients te chu a la chhuak thin. Mahse tumor chu millimeter 1-2 vel a lo sei chuan a mah ngeiin thisen kalna kawng thar a siam a ngai a ni. Thlai pakhatin hnah thar a siam ang bawkin. Heng thisen kalna thar atang hian cancer tumor hian ‘a chawm’ a, a lian lehzual a, a darh tan thin.

Heng damdawi bik, Angiogenesis Inhibitors , tia koh te hian cancer cell te thisen kalna kawng thar siam lohna turin hna an thawk a ni. Hei hian cancer cell te thanna a tikhawlo a, a chang chuan cell te hi a tlem thei hle. He damdawi hian cancer chu a tidam kim thei lo nain, cancer thanna a thunun thei a, i hmangaih te nen rei vak lo i awm thei bawk.

He damdawi hian engtin nge hna a thawh?

Heng damdawi te hian kan taksaa thil thleng Angiogenesis an tih chu a block a. A tlangpuiin hei hi kan taksa tana thil pawimawh tak a ni. I kutah hliam i nei ang tih han ngaihtuah teh. Tichuan, chu cell hliamte chuan, ‘Min pui rawh!’ tih signal bik (SOS signal) an pe chhuak ta a ni. He signal avang hian hliam chhehvel thisen kalna atang hian thisen kalna kawng thar a lo piang a, chu chuan hliam chu thisen mamawh a pe a, a tidam a ni.

Tunah chuan hetah hian a pawi ber chu cancer cell te pawhin kan taksaa he thil tha tak hi an hlawkna tur atan an hmang thin a ni. Tin, signal ang chiah chu an thawn chhuak a, anmahni chawm tur thisen kalna kawng thar an siam bawk.

Angiogenesis Inhibitors te hian chu signaling system chu a tibuaitu a ni.

• He signaling system-a signal lian ber chu protein VEGF (Vascular Endothelial Growth Factor) tih a ni.
• He protein, VEGF hian cell chunglama receptor-te a binding chuan thisen kalna kawng thar siam turin thuchah a thawn a ni.
• Heng damdawi te hian kawng hrang hrangin he thil hi a titawp thin.

He damdawi hi eng dinhmunah nge hman a nih?

Doctor-te chuan cancer natna zual tawh emaw, enkawl hnua lo awm leh tawh emaw tan he enkawlna hi an rawt tlangpui. Entir nan:

• Thluak cancer a ni
• Hnute cancer a ni
• Cervical cancer a ni
• Colon cancer a ni
• Kidney cancer a ni
• Liver cancer a ni
• Lung cancer a ni
• Lymphoma leh Multiple Myeloma te a awm bawk
• Pancreatic cancer natna a ni
• Pum cancer a ni
• Thyroid cancer a ni
• Uterine cancer a ni

Tin, he damdawi chi, VEGF inhibitors tia koh hi mit natna thenkhat, mit chhunga thisen kalna kawng dik lo a lo thang lian zel avanga mit natna thenkhat enkawl nan pawh hman a ni bawk.

Enkawl lai hian eng nge thleng?

Heng damdawi te hi a ringawt pek a tlem hle. Cancer enkawlna dang, chemotherapy emaw immunotherapy emaw nena pek dun an ni fo. A awlsam zawngin sawi ila, angiogenesis inhibitor hian cancer chu a ei tur a hloh avangin a riltam tir a, enkawlna dangte chuan cancer cell te chu direct-in a that thung.

Damdawi chi hrang hrang i pek dan azirin ni khatah vawi khat emaw vawi hnih emaw pill angin i pe thei a, ni engemaw zat chhungin vawi khat saline nen thisenah (IV) i pe thei bawk.

Enkawl hun chhung hi damdawi chi hrang hrang i pek dan leh i damdawi lam dinhmun a zirin a innghat a ni. Mi thenkhat chuan damdawi a thawh chhung chuan an ei chhunzawm zel a. Mi dangte chuan a side effects an tuar theih loh hunah an chawlhsan a ngai a ni. Hei hi i doctor nena inbiakna leh enkawlna ṭhatna leh ṭhat lohna tehna hmanga tihfel vek a ni.

A hlauhawmna leh a side effect te chu engte nge ni?

Heng damdawi te hian side effect thenkhat chu a hlauhawm thei a, chuvangin hei hi hriat a pawimawh hle.

Hengte hi hlauhawm tak angin a lang thei a, mahse i doctor chuan i hriselna leh thisen test te chu a enkawl reng dawn a, chuvangin heng hlauhawmnate hi a tam zawkah chuan hriatchhuah leh enkawl theih a ni.

Engtin nge ka in enkawl ang? Engtikah nge doctor ka biak ang?

I tih theih pawimawh ber chu he damdawi hi i ei tan hmain a side effect awm thei te hriat chian hmasak hi a ni. Tichuan, i taksaa danglamna i hmuh chuan rang takin i hre thei a, i doctor hnenah i hrilh thei bawk. I doctor chuan chutiang side effects control turin damdawi dang a pe thei che a, i damdawi ei tur zat pawh a thlak thei bawk.

I natna lan chhuah thut, danglam tak i neih chuan damdawi lam pan nghal rawh. A bik takin stroke emaw heart attack emaw symptoms i neih chuan (e.g., rilru na tak, thawk harsa, hmai emaw, ke ruh emaw a bengchheng) i neih chuan damdawi in hnai ber Emergency Department (ETU) ah kal nghal rawh.

Hetiang thil hi a pianphung anga titawp thei thil a awm em?

Ni e, ei tur thenkhatah hian he angiogenesis process-a signal thenkhat awmte block thei compound a awm a. Heng ei tur te hi Mediterranean diet-ah hian a awm fo thin. Entir nan:

• Green tea a ni
• Olive hriak a ni
• Grape sen a ni
• Peanuts a ni
• Asparagus a ni

Doctor-te chuan heng natural compound hmang hian damdawi thar an zirchiang mek a, mahse chu zirchianna chu a la hmasa ber a la ni.

Mahse, ei leh in tha tak ei hian cancer enkawlna kawng zawh mek chu chak taka a awm theih nan kawng thui tak a zawh thei a ni. Chuvangin, balanced diet ei ngei ngei tur a ni.