I nu emaw, i pa emaw, i hriat mi emaw chuan theihnghilh a tizual em? I chabi awmna hmun emaw, mi hming emaw ang chi thil tenau te theihnghilh hi Alzheimer natna chhinchhiahna hmasa ber a ni thei. He natna khirh tak hi damdawi la awm lo mah se, he natna zual zel tur tikhawlo thei damdawi thar chu US FDA (Food and Drug Administration) chuan a pawm kim tawh a ni. Hei hi khawvel hmun hrang hranga damlote tan beiseina ropui tak a ni tak zet a ni. Chuvangin he damdawi thar, Leqembi chungchang hi tlem han sawi belh leh ila.
He damdawi thar Leqembi an tih hi eng nge ni?
Hriatthiam hmasak tur chu hei hi Alzheimer natna damdawi a ni lo tih hi a ni. Mahse, a ṭangkai hle. Natna kal zel dan a tikhawlo thei a ni. Research atanga a lan dan chuan thla 18 chhungin natna zual zel chu 27% velin a ti hniam thei a ni.
Tûnah chuan, ‘A danglamna a thlen tak tak ang em?’ tiin i ngaihtuah mai thei. Ni e, a ni ngei ang. Ngaihtuah teh, he damdawi eitu hian damdawi ei lo aiin thla 5 chhung zet a dam rei thei ang a, symptoms a na zual lo ang a, mahni hna a thawk thei ang a, chhungte nen an hlim thei ang a, a tu leh fa graduate hmu turin a kal thei ang... Hetiang thil tih tur hian chu extra time chu engtiang chiahin nge a hlu? Chu hun chu he damdawi hian hlawkna lian ber a ni.
Mahse hei hi hriat reng a pawimawh: Leqembi hi Alzheimer’s disease , mild cognitive impairment nei tan chauh hman a ni. Natna zual zawk nei tan chuan a thawk thei dawn lo.
He damdawi hian engtin nge hna a thawh?
Hei hi hrethiam tur chuan entirnan tlem han la ila. Alzheimer natna vei te thluak ah hian duh loh protein pakhat amyloid plaques an tih chu a awm a. Tui pipe-a bawlhhlawh a tlakbuak a, zawi zawiin pipe-a a tlakbuak ang mai a ni. Heng proteins te deposition avang hian thluak cell inkara inbiakpawhna a tibuai a, zawi zawiin cell te chu an thi tan ta a ni. Hei vang hian hriatrengna a bo a, nungchang a inthlak thin.
He damdawi, Leqembi tia koh hian thluaka amyloid plaques lo awm tawhte chu a target a, a paih chhuak thin. Damdawi chi khat, monoclonal antibodies an tih zingah a tel a ni. He damdawi hi damlo hnenah thla khatah vawi hnih IV infusion hmangin pek thin a ni.
He damdawi chungchanga thil pawimawh thenkhat chu table pakhatah han thlir ila.
| Leqembi (lecanemab) chungchang tawi te te | |
|---|---|
| Damdawi chi hrang hrang | Antibody chi khat damdawi a ni. |
| Tu tan nge a inhmeh? | Alzheimer natna hmasa ber, hriatna lama harsatna nei lo tan chauh. |
| Main advantage a ni | He natna darh dan hi thla 18 chhungin 27% velin a tlahniam a ni. |
| Engtin nge kan pek ang | Thla khatah vawi hnih vein (IV infusion) hmangin pek thin a ni. |
| A pawimawh ber limit | Hei hian natna a tidam lo. Natna khirh tak nei tawhte tan chuan a tangkai lo. |
Hei hi hman hian risk a awm em?
Awle. Damdawi zawng zawng ang bawkin he damdawi hian risk leh side effect engemaw zat a nei a. Dik tak chuan FDA chuan he damdawi hi "black box warning" a tichhuak a, hei hi safety warning level sang ber a ni . Chumi chhan chu ARIA an tih condition vang a ni.
ARIA chu eng nge ni?
ARIA hi Amyloid-Related Imaging Abnormalities tihna tawi a ni. A awlsam zawngin, he damdawi hian mi thenkhat chu thluak a ti na thei a, thisen chhuak tenau (microbleeds) emaw a thlen thei bawk . Chûngte chu a pawi lo tlangpui laiin, a châng chuan nunna atana hlauhawm tak a ni thei bawk.
- APOE4 gene: APOE4 gene mutation copy hnih nei te chu midang aiin he ARIA natna hi an vei theihna a sang zawk.
- Blood Thinners: Thil pawimawh tak dang pakhat chu Doctor-te chuan thisen tithianghlimtu ei mek tan he damdawi hi hman loh turin nasa takin an vaukhân a ni. A chhan chu i tih chuan thisen tlemte chu thisen lian, nunna atana hlauhawm (macro-bleed)-ah a chan theihna chance a sang hle. A châng chuan hei hian seizures, damdawi ina dah, a nih loh leh thihna thlengin a thlen thei a ni.
Chuvangin, he damdawi hi i ei tan hmain heng hlauhawm zawng zawng hi i doctor nen chiang taka sawiho a, a tul anga test neih a, hei hi i tan a tha em tih finfiah a pawimawh hle.
Chuti a nih chuan engtin nge ka tih ang?
Nang, he thuziak chhiartu hian nangmah emaw, i hnaih ber tu emaw hian Alzheimer natna chhinchhiahna hmasa ber a nei tih rinhlelhna tlemte pawh i neih chuan, a tha ber chu tihkhawtlai lova doctor pan a, dik taka hriat chian hi a ni.
A chhan chu a hmaa kan sawi tawh ang khan Leqembi ang damdawi hi natna bul tan tirh lamah chauh a tangkai a ni. I tihkhawtlai chuan inenkawlna hun remchang i hloh mai thei. Tin, heng ang damdawi thar hi a man a to thei tlangpui bawk. Chuvangin enkawlna i tan hmain chutiang lam chu i doctor nen inbiakna neih hmasak phawt a tha.
Mithiamte chuan nakin lawkah chuan miten natna lanchhuahna an lan chhuah hmaa natna hriatchhuah leh ven theihna tur enkawlna a awm dawn niin an ngai. Hnute cancer leh prostate cancer te hi a hmaa kan hriatchhuah leh kan enkawl theih ang bawkin, ni khat chu Alzheimer natna hi kan hmuchhuak hmasa thei ang a, kan veng thei bawk ang. Chumi hma chuan Leqembi ang ruihhlo hian kan zavai tan beiseina nasa tak min pe a ni.
Take-Home Thuchah a ni
- Leqembi hi Alzheimer natna damdawi a ni lo. Natna hi a tir lamah chauh a zual zel tih a tikhawtlai a ni.
- He damdawi hian thluaka amyloid plaques tha lo tak tak awmkhawm chu a paih chhuakin hna a thawk a ni.
- Brain swelling emaw small hemorrhages (ARIA) ang chi side effect na tak a awm theihna a awm a, chuvangin a hlauhawm zawng zawng chu doctor nen sawiho a pawimawh hle.
- He damdawi hi thisen tina damdawi ei thin emaw, natna khirh tak nei te tan a tha lo.
- Nangmah emaw, i hnaih ber tu emaw chuan hriatrengna lama harsatna i neih chuan, tihkhawtlai lohvin damdawi lam thurawn zawng rawh. Enkawlna atan chuan a hmaa hriat chian a pawimawh hle.
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