I taksa defense system ngei hian trick a play che em? Autoimmune Pancreatitis chungchang hi awlsam takin i zir dawn teh ang!

Kan taksaah hian defense system mak tak kan nei a ni lawm ni? Chu chu immune system kan tih chu a ni. Natna thlentu hrik, bacteria leh virus te doin min venghim a ni. Mahse, han ngaihtuah teh, a châng chuan he kan invenna system tak tak hi kan taksaa cell ṭha tak takte nên a inthlau a, a rawn bei ṭan a nih chuan engtin nge ni ang? Chutah chuan a thleng ta a, ``Autoimmune Pancreatitis'' an ti a. A awlsam zawngin, nangmah ngei pawhin i immune system hian i pancreas do turin hna a thawk tan a.

``Autoimmune Pancreatitis'' tih hi eng nge ni? A awlsam zawngin...

I taksa immune system hi ram venghimtu sipai angin ngaihtuah rawh. He sipai hna chu pawn lam hmelma (germ leh virus ang chi) laka ram venhim hi a ni. Mahse `(Autoimmune Pancreatitis)` ah hian he sipai hian tihsual a nei a, mahni ram mi sual nei lo (chu chu pancreas chhunga cell hrisel tak takte) chu hmelma nia ngaiin an bei thin. Chuvang chuan pancreas chu a inflamed a, a hliam a, a hnathawh a tichhe bawk. Hei hi autoimmune pancreatitis kan tih chu a ni .

He natna hi engtiang chiahin nge a hluar?

Dik tak chuan `(Autoimmune Pancreatitis)` hi natna hmuh tur awm lo deuh a ni . Mi sang za zinga pakhat vel ah a awm tlangpui. Pancreas-a hun rei tak chhunga inflammatory conditions (`chronic pancreatitis`) kan lak chuan, heng zinga 2% vel chauh hi he `(Autoimmune Pancreatitis)` category-ah hian an tel a ni. Chuvangin, hei hi mi zawng zawng tuar thei natna a ni lo.

`(Autoimmune Pancreatitis)` chi hrang hrang a awm em?

Ni e, `(Autoimmune Pancreatitis)` hi chi hnih a awm ber. Eng nge an nih i en ang u.

1. Type 1 Autoimmune Pancreatitis a awm thei

Hei hi a tam ber chi a ni . Hemiah hian kan taksaah hian protein pakhat `(Immunoglobulin G4)` emaw `(IgG4)` emaw kan nei tam zawk. He `(IgG4)` hi antibody chi khat a ni. Taksa khawi hmunah pawh swelling emaw inflammation emaw a awm chuan he `(IgG4)` level hi a sang chho zel a ni.

Mahse he type hmasa berah hian harsatna chu pancreas chauh a ni lo. Kan taksa peng dangte pawh a nghawng thei bawk. Entir nan:

• Bile ducts: Hei hi tube -like tube a ni a, liver atanga small intestine thlenga bile a phur lut thin.
• Renal tubes: Kal chhunga tube awmte.
• Thin
• Chuap
• Gallbladder a ni
• Salivary glands te pawh a awm
• Thyroid gland a ni

Hetiang hmunah hian swelling leh damage a awm thei bawk.

2. Type 2 Autoimmune Pancreatitis a awm thei

Hetiang chi hian pancreas chauh a nghawng a ni . Heta thil thleng hi thisen var chi khat ``neutrophils`` an tih hian pancreas leh pancreatic ducts a tichhia a ni. Hetiang dinhmun hi naupang zawkte zingah hmuh tur a tam ber.Tin, inflammatory bowel disease (IBD) vei an tam zawk bawk.

`(Autoimmune Pancreatitis)` hi eng nge a chhan? Risk factors a awm em?

Researcher te chuan a chhan dik tak chu an la chhui chhuak zel a , mahse kum 50 leh 60 inkar ah a thleng tlangpui a, mahse a hmain a thleng thei. Hmeichhia aiin mipain he natna hi a let hnih zetin an vei tam zawk a ni .

A châng chuan, bacteria infection laka taksa immune system-in a chhân lêtna nia ngaih a ni. Tin, autoimmune disorder dang nei te pawhin an vei theihna a sang zawk bawk. Entir nan:

• (Hashimoto’s thyroiditis): Hei hian thyroid gland hnathawh a ti tlem (hypothyroidism).
• (Inflammatory bowel disease - IBD): A bik takin `(ulcerative colitis)` ang chi natna te hi a ni.
• (Primary biliary cholangitis) tih hi a awm lo.
• Retroperitoneal fibrosis: Pum hnunglam lining-a scar ang chi tissue lo awm.
• Rheumatoid arthritis: Ruhkawr natna (inflammation) a awm.
• (Sarcoidosis) natna (Sarcoidosis) a ni.
• (Sjögren-a natna) .

Hetiang autoimmune condition dang i neih chuan Autoimmune Pancreatitis pawh hi tlem tal ngaihtuah a tha.

`(Autoimmune Pancreatitis)` natna lan chhuah dan chu engte nge ni?

He natna hi a tir lamah chuan a lan chhuah dan a awm lo thei . Mahse, natna a zual zel chuan pancreatic ducts te chu a zim tan a, chu chuan pancreas atanga enzymes chhuak te chu a kal tlang thei tawh lo.

Pancreatic duct-a blockage chuan symptoms a thlen thei a, chungte chu:

• Upper abdominal na a awm
• Middle back na a awm
• Kawthalo
• Nausea/luak chhuak
• Rihna tihtlem

Pawimawh: Heng symptom thenkhat hi pancreatic cancer-ah pawh hmuh theih a ni. Chuvangin, heng symptoms te hi i neih chuan hlauthawng lo la, doctor pan nghal vat la, harsatna chu eng nge ni tih chiang takin i hre thei ang . `(Autoimmune Pancreatitis)` neih hian cancer i vei tihna a ni lo.

Tin, autoimmune pancreatitis hian pancreas-ah hian a hring thei a, cancer ni lo a tipung thei a, tuiin a khat cyst a siam thei bawk. Heng swellings, lumps emaw cysts te hi i pancreas lu-ah a awm chuan bile duct a tikhawlo thei a, chu chuan bile chu small intestine-ah a luang lut tha thei lo thei a ni. Bile-ah hian pigment pakhat bilirubin an tih a awm a. He bilirubin hi thisenah a awm khawm chuan jaundice a thlen thei a ni.Mit vun leh var chu a sen (jaundice) a lo ni a, i chau hle mai thei. Zun a bilirubin a pun chuan zun a thim thin . Bilirubin chu intestines ah a chhuah chuan stools chu pale-colored a ni thei .

`(Autoimmune Pancreatitis)` avanga harsatna awm thei te chu engte nge ni?

Pancreas inflammation rei tak hian natna a thlen thei a, taksa rihna a tlahniam thei a, pum chung leh hnungzang a na reng bawk. Tin, pancreas chhunga insulin siamtu cell te a chhiat chuan zunthlum a vei thei bawk.

IgG4 antibodies hian pancreas chauh ni lovin, taksa peng dangte pawh a bei thei a, a bik takin Type 1-ah chuan a bei thei a, chutiang taksa peng hrang hrangte chu:

• Bile duct hrang hrang a awm
• Salivary glands te pawh a awm
• Lacrimal glands a awm thin
• Thyroid gland (`Thyroid`) tih hi a awm lo.
• Kidney a ni
• Thinlung
• Lung leh pleura (lung chhunga lining) .

Engtin nge Autoimmune Pancreatitis hi an hriat theih?

He natna hi dik taka hriat theih nan leh pancreatic cancer a nih loh nan test eng emaw zat neih a ngai dawn a ni. Hetiang test hi i neih a ngai dawn a ni:

• Thisen test: Hengte hian IgG4 level sang lo tak tak a enfiah a, chubakah liver function leh thisen cell chi hrang hrang level a enfiah bawk.
• Imaging test: Hengte hian pancreas lian leh te, hliam a awm leh awm loh te, duct te a tawi em tih te an enfiah thin. Heng test entirnan `(CT scan)` leh `(MRI scan)` te hi a ni.
• Biopsy: Hei hi i pancreas atanga tissue te tak te la chhuakin microscope hmanga enfiah a ni. Hei hi Endoscopic Ultrasound (EUS) tih hming pu, minimally invasive endoscopic procedure hmanga tih a ni tlangpui. Hetiang tih danah hian i doctor chuan i pum leh i intestines-ah tube sei tak, flexible tak (a tawp khatah light leh ultrasound device awmna) a dah lut a, chu chuan i pancreas a en a. Chumi hnuah chuan i pum emaw, i chhungril emaw hmangin biopsy sample lak a ni. A châng chuan, surgeon chuan biopsy sample lak nan i vunah incision te tak te (laparoscopy) a siam a ngai mai thei.
• Corticosteroid trial: Hei hian natna hriat chian nan a pui bawk. IgG4 level a tlahniam a, i imaging test a ṭhat leh ṭhat loh en turin hun rei lote chhung steroid pek i ni.

Engtin nge `(Autoimmune Pancreatitis)` hi enkawl a nih?

Mak tak maiin, mi tlemte tan chuan he natna hi enkawlna engmah awm lovin a mah chauhin a reh thei . Mahse mi tam tak tan chuan enkawl a ngai a ni .

Autoimmune Pancreatitis hi corticosteroid hmanga enkawl a ni ber.Damdawi chi khat steroid an tih. Entirnan, damdawi `(prednisone)` emaw `(prednisolone)` ang chi. Heng damdawi te hian swelling tihziaawmna leh overactive immune system tihlumna hmangin hna an thawk a ni. Enkawlna hi steroid dose sang tak atanga tan a ni tlangpui. Tichuan dose chu tihhniam zauh zauh (`tapered`) a ni.

Complication i neih loh chuan enkawlna dang i mamawh lo tlangpui. Enkawlna mamawh chu harsatna chi hrang hrangah a innghat a ni. Pancreatic duct a narrowing (`duct narrowing`) a awm chuan duct hawn a, hollow mesh device (`stent`) hmanga tihchak dan tur tih theih a ni.

`(Autoimmune Pancreatitis)` ka vei loh nan ka veng thei ang em?

Dik tak chuan he natna hi a lo awm loh nan engmah tih theih a awm lo a , a chhan chu keimahni taksa hriselna (immune system)-a harsatna a nih vang a ni.

`(Autoimmune Pancreatitis)` vei te tan chuan eng nge an hmalam hun?

Mi tam zawk chu corticosteroid hmanga enkawl hnuah an dam tha hle , harsatna pawh a awm lo. Autoimmune pancreatitis neih hian i dam rei zawng a nghawng lo .

Mahse, `(Autoimmune Pancreatitis)` hi a lo lang leh thei (a lo lang leh thei) . Hei hi chi khatna (`Type 1`) nei zingah a tam hle. He natna hi hmuhchhuah a nih hnu kum thum chhungin a lo lang leh thei ber a ni. He natna vei leh tawh pawhin harsatna a nei tam zawk bawk.

Natna a lo awm leh chuan eng nge thleng ang?

Hlawhtling taka enkawl a nih chuan natna lo lang leh tawhte pawhin nun chak tak, hrisel tak an nei thei a ni .

Corticosteroids hman tan leh a ngai mai thei. Mi thenkhat chuan kum engemawzat chhung chu steroid hmanga enkawlna an chhunzawm zel a, chu chu natna lanchhuahna a lo lang leh tawh loh nan a ni. Doctor-te chuan overactive immune system enkawltu damdawi dang (immunomodulating leh immunosuppressive drugs) pawh an enchhin thei bawk.

Enkawl lai hian engtin nge ka awm ang?

Steroid hman hian side effect thenkhat a awm thei bawk . Entîr nân, pum na, chaw ei chakna, hahchawlhna leh mut harsat. Heng side effects te hian nitin nun a tibuai deuh thei a, mahse rei lo te chhung atan a ni . Autoimmune Pancreatitis enkawlna atanga hlawkna tam ber i hmuh theih nan, i doctor-in a tih angin steroids hi ei chhunzawm zel a pawimawh .

Side effects chu tuar theih loh khawpa buaithlak a nih chuan enkawlna i chawlhsan hmain doctor hnenah hriattir hmasa phawt ang che . I rilru hahdamna tur enkawlna dang a pe thei che a, i enkawlna tur ruahmanna pawh a thlak danglam thei bawk.

`(Autoimmune Pancreatitis)` enkawl hnuah engtikah nge hnathawh pangngaiah ka kir leh theih ang?

Steroid hmanga enkawlna hian kar tlemte chhungin `(Autoimmune Pancreatitis)` symptoms atanga rehdamna a pe tlangpui.Mi tam tak chu an natna lan chhuah dan a reh hnuah an hnathawh dan pangngaiah an kir leh thin.

Autoimmune Pancreatitis hi inflammatory condition awm lo tak a ni a, pancreas hnathawh a tichhe thei a ni. Pancreatic natna hre chiang doctor hmuh hian i mamawh enkawlna tha ber i hmu thei a ni. Mi tam zawk chuan steroid an ei hnuah an dam leh vek thin . Mi thenkhat chuan hun rei tak chhunga damna an hmuh theih nan Autoimmune Pancreatitis enkawlna dang an mamawh mai thei.

A tawp berah chuan hei hi hre reng ang che (Take-Home Message) .

• Autoimmune Pancreatitis hi natna hlauhawm tak a ni a, nangmah ngeiin i immune system hian i pancreas a bei thin.
• I pum natna, i taksa rihna tlahniam, emaw jaundice ang chi symptoms i neih chuan doctor thurawn la ngei ang che .
• Hei hi pancreatic cancer a ni lo va, mahse a symptoms chu a inang vek a, chuvangin diagnosis dik tak neih a pawimawh hle .
• Enkawlna ber chu corticosteroids a ni.
• Mi tam tak chu enkawl a nih chuan an dam tha hle a, mahse he natna hi a lo awm leh thei a ni.
• Dam chakna tur chuan doctor thupek dik taka zawm a pawimawh hle .

Nangmah chauh i ni lo tih hre reng ang che. Hetiang dinhmunah hian i rilruah ngaihtuahna tam tak a tlan kual hi thil pangngai a ni. Chuvangin, i doctor hnenah inhawng takin awm la, i zawhnate chu zawt rawh. I tanpui turin an lo kal a ni.

` Autoimmune Pancreatitis, Pancreatitis, Autoimmunity, IgG4, Pancreas hriselna, Pancreatitis Sinhala, Chaw ei leh in hriselna