Kan taksa thuruk thuchah: Cytokines chungchang hi a awlsam zawngin i zir ang u!

Kan taksa a damlo emaw, a hliam emaw hian a chhungah damna tur indona lian tak a thleng thin tih i ngaihtuah ngai em? Kan taksa pawn lam atanga lo chhuak virus leh bacteria ang chi hmelma te do turin kan sipai thiam tak tak kan nei a. Hei hi immune system kan ti a. Chuvangin he sipai hotu tur, thuchah inthleng tur leh hmêlma awmna hmun dik takah thawntu tur mi a awm a ngai a ni. Chu thuruk thuchahte chu tunlaia kan sawi tur cytokines te hi an ni.

Cytokines hi eng nge ni tak tak?

A awlsam zawngin sawi ila, cytokines hi protein te tak te, kan immune system-a cell inkara thuchah thawntu a ni. Kan taksa chhungah ‘WhatsApp group’ ang mai a ni. Infection emaw hliam emaw ang chi hlauhawm tak taksaah a lo thlen chuan immune cells te hian heng message te hi cytokines an tih te hi an chhuah tir thin. Heng message te hian immune cell dangte hnenah, "Hetah hian harsatna a awm a, lo kal thuai rawh u!", "Hei hi kan do tur hmêlma chi khat a ni," leh "Sipai tam zawk siam rawh" tih te a hrilh a ni.

I taksaah virus a lut ang tih han mitthla teh. Chutih lai chuan cell thenkhat chuan heng cytokine message te hi an thawn chhuak a, cell dangte chu virus do turin inbuatsaih turin an hrilh thin. Chumi awmzia chu heng palai te te te hi awm lo se chuan kan immune system hi a thawk tha thei dawn lo tihna a ni. Heng cytokines te hian kan immune system hrisel turin a pui a, hlauhawm a awm loh lai pawhin.

Heng cytokines chi hrang hrang hi a awm em?

Ni e, sipaiah hian rank hrang hrang a awm ang bawkin cytokine chi hrang hrang a awm bawk. Type tin hian hna bik an nei vek a. A chi hrang hrang thenkhat han thlir ila.

Tin, cytokines thenkhat chu a siamtu cell chi hrang hrang a zirin hming an vuah bawk:

• Lymphokines: Thisen var chi khat lymphocyte an tih atanga siam a ni.
• Monokines: Thisen var chi khat, monocyte an tih atanga siam a ni.

Cytokines hnathawh ber: inflammation control

Mi tam zawkin ‘Inflammation’ tih thumal an hriat hian thil tha lo, natna chhinchhiahna niin an ngai thin. Mahse inflammation hi a takah chuan kan immune system hian hmelma a do emaw, tissue chhia a siam that emaw tih chhinchhiahna pawimawh tak a ni. I kut zungtang i tan chuan a sen ang a, a hring ang a, a lum deuh ang tih han ngaihtuah teh, a dik em? Chu chu inflammation chu a ni.

Cytokines hian a hnuaia mite hi a signal ber a ni:

• Cell activation: Cell te kalna tur leh tih tur hrilh. Entirnan, immune cells te chu infection awmna hmuna hruai.
• Cell differentiation: Cell puitling lo chu "he natna do thei tur thisen var chi khat bik ni turin" an ti a.
• Cell proliferation: Cell tam zawk siamna signal, a nih loh leh cell tam zawk siamna signal. Entirnan, he signal hi natna lian tak dona atana thisen var tam zawk mamawh a nih chuan pek thin a ni.

Pro-inflammatory leh anti-inflammatory cytokines te a awm bawk

Hei hi car accelerator leh brake ang a ni. Kan taksa hriselna (immune system) chhanna dik tak control nan an pahnih hian an pawimawh hle.

• Pro-inflammatory cytokines: Hengte hi a ti chaktu an ni . Germ a lo luh chuan inflammation an siam a, immune response an ti chak bawk. Hengte hi insual tanna tur signal petu an ni.
• Anti-inflammatory cytokines: Hengte hi brake a ni . Hmelma an hneh hnuah chuan kan taksa hrisel tak takte tihchhiat belh zel chu an titawp a, inflammation tihziaawmin engkim chu a pangngaiah an hruai kir leh thin.

Engtin nge he thuchah inthlengna hi a lo awm?

Hei hi kalphung ngaihnawm tak a ni. Chabi leh keyhole nen tehkhin ila.

Cytokine chu key ang mai a ni . Thuchah dawng tur cell chung lamah chuan chu key nena inmil keyhole (receptor) a awm a. Cytokine (key) chu a kal a, chu cell-a receptor (keyhole) nen a inzawm chuan chu cell chuan thuchah chu a dawng ta a ni. Tichuan chu cell chuan chu thuchah ang chuan hna a thawk ta a ni.

Heng thuchah thawn dan hi kawng thum a awm a, chungte chu:

1. Autocrine signaling: Cell pakhat hian a hnenah thuchah a thawn a.

2. Paracrine signaling: Cell pakhat hian a bul hnaia cell awmte hnenah message a thawn thin.

3. Endocrine signaling: Cell pakhat hian thisen kaltlangin a atanga hla tak cell te hnenah thuchah a thawn thin.

Eng cell nge cytokines siam tam ber?

Cytokines hi kan immune system-a cell-te siam a ni fo thin. Mahse, anmahni chauh hi cell an ni lo. Kan taksaa cell chi dangte pawhin an siam chhuak thei bawk.

Immune cells te chu a ni

• Macrophage te hi an ni
• Dendritic cells te chu a awm a
• Lymphocytes te hi a awm a
• Monocytes te hi a awm a
• Neutrophils te pawh a awm
• Basophils te hi an ni
• Eosinophils a awm bawk
• Mast cells te chu a awm

Cell dangte pawh a awm

• Endothelial cells (thisen kalna kawng chhunga awm cell) .
• Epithelial cells hi kan taksa peng chunglam khuh tu cell te an ni.
• Connective tissue-a cell awmte (Fibroblasts, Stromal cells) te chu .
• Nerve chhehvela cell awmte (Schwann cells) .

Cytokine balance a bo chuan eng nge thleng ang?

Cytokines hi thil dang ang bawkin kan hriselna atan a pawimawh hle nachungin, a tam lutuk hi a tha lo. A châng chuan infection emaw, enkawlna ṭhenkhat emaw avang hian immune system chu a overstimulated a, control theih loh cytokines tam lutuk a siam chhuak tan thin.

Hetiang dinhmun hi Cytokine Release Syndrome (CRS) emaw cytokine storm emaw kan ti a. Kan taksa hriselna (immune system) chu a berserk ang mai a ni a, kan hmelma chauh ni lovin kan cell hrisel tak takte pawh a bei ta a ni. Hei hian inflammation nasa lutuk a thlen thei a, tissue a tichhia thei a, natna chi hrang hrang a thlen thei bawk.

Cytokines tam lutuk avanga natna lo awm thei te:

• Autoimmune diseases: Hetah hian immune system hian a cell hrisel tak takte chu a bei sual a ni.
• Metabolic disorders: Chaw ei leh in chaknaah a chantir danah harsatna a awm.
• Ngawt.
• Sepsis: Hei hi natna khirh tak a ni. Taksa a inflammation na tak chuan taksa peng lian tham tak takah thisen a kal tlem phah thin. Hei hi medical emergency a ni a, enkawl loh chuan thihna thlen thei a ni.

He natna chungchangah hian rinhlelhna i neih chuan doctor pan nghal a pawimawh hle a, thurawn la rawh .

Cytokine panel hmanga test a ni

I taksain cytokines a tam lutuk emaw, a tlem lutuk emaw chu doctor-te chuan an hre thei a ni. Thisen test hi cytokine panel an ti a . I thisena inflammation-a inrawlh cytokines level a teh thin. A result a zirin i doctor chuan inflammation i neih tam lutuk chuan inflammation control nan treatment a pe thei ang.