"Estrogen" hormone hi i hre tawh ngei ang, a dik em? Hmeichhe taksaah hmun pawimawh tak a chang a, hormone pawimawh tak a ni. Mahse, a chang chuan kan taksa tana \angkai em em estrogen hian cancer cell thenkhat tan "fertilizer" angin hna a thawk thei a, an than chak zawk nan a pui thei tih i hria em? Lungngai suh. Hei hi thupui buaithlak deuh a ni a, mahse i hriatthiam theih tur khawpa awlsam takin i sawi dawn nia.
A awlsam zawngin, heng estrogen-a innghat cancer te hi engte nge ni?
A hmasa berin hei hi kan sawi chiang hle a ngai a ni. Estrogen hormone hian cancer a thlen lo. Chu chu estrogen hi cancer thlentu a ni lo tihna a ni. Mahse, chhan dang vangin taksaah cancer cell a lo piang a nih chuan, chu cancer cell thenkhat chuan kan taksaa estrogen hormone atang hian an thanlenna tur, an inthen darh theihna tura an mamawh chakna leh tihchakna an hmu thin. Thlai chi thang nan fertilizer hman a nih ang bawkin heng cancer cell te hian estrogen an tih "fertilizer" hmangin rang takin an thang lian thin.
Hetiang hian han ngaihtuah teh. Cancer cell chu kawngkhar ang a ni. Chu kawngkaah chuan chabi dahna hmun a awm a (receptor kan ti). Hormone estrogen chu chutiang key ang chu a ni. Hormone estrogen chu a lo kal a, chu cancer cell-a receptor-ah a inzawm chuan chabi dahin kawngkhar hawn ang mai a ni a, cancer cell chuan, "Tun ah chuan insem la, pung rawh, leh darh rawh," tih thuchah a dawng ta a ni. Hormone estrogen-a innghat cancer-te chu estrogen-dependent cancer kan tih hi an ni .
Hetiang dinhmun hi hmeichhiate cancer chi hrang hrangah hmuh tur a awm ber.
- Hnute cancer a ni
- Ovarian cancer a ni
- Nausen pum/Endometrial cancer a ni
Heng cancer chi hrang hrangte enkawl hian oncologist-te chuan cancer cell-te hnena estrogen hormone a thlen theih lohna tur enkawlna (hormone therapy) an hmang thin.
Eng cancer-ah nge he natna hi a tam ber?
Mahse, hei hi hnute cancer nena inzawm hian sawi a ni ber . Breast cancer zawng zawng hi estrogen-a innghat an ni vek lo. Mahse chi thenkhat chu estrogen "ang" tak tak an awm. Heng thute hi i hnute cancer report-ah i hmu tawh mai thei.
- ER-positive (ER+) hnute cancer: Chumi awmzia chu cancer cell-te hian estrogen receptor an nei tihna a ni.
- HR-positive (HR+) hnute cancer: Chumi awmzia chu cancer cell-te hian hormone receptor an nei tihna a ni. Chumi awmzia chu hormone estrogen emaw progesterone emaw zinga pakhat emaw, pahnih emaw an chhang let tihna a ni.
- Luminal A hnute cancer a ni
- Luminal B hnute cancer a ni
- Triple positive hnute cancer a ni
Hei hi a buaithlak deuh a, mahse a awmzia zawng zawng chu hormone hian cancer hi a tipung a ni. Hei hi hriat hi enkawl dan tur ruahmanna siam nan a pawimawh hle.
Engvangin nge hetiang hi a lo awm? Eng thilte nge a hlauhawmna tipung?
Kan sawi tawh ang khan hei hi cancer cell (hormone receptor)-a protein bik awm vang a ni. Cell hrisel pawhin heng receptor te hi an nei ve bawk. Estrogen a lo kal a, a inzawm chuan chu cell te chu a thawk dan pangngaiin an thawk thin. Mahse cancer cell te hian he process hi an "hijack" a, an duh angin an inthen darh a, an lo thang lian ta a ni.
Estrogen hi mei tichhe thei match a ni lo tih hre reng ang che. Mei alh tawhah kerosene dah ang mai a ni. Mei chu a ti lian lehzual a ni.
Hetiang cancer vei theihna tipungtu thil engemaw zat a awm a. A bulpui ber chu hmeichhe taksain a dam chhunga hormone estrogen a tawrh tam lutuk hi a ni.
A hnuaia table atang hian heng risk factors te hi chiang takin i hre thei ang.
| Risk Factor a ni | A sawifiahna awlsam tak |
|---|---|
| Kum 12 tlin hmaa puitlin | I period tan hma chuan taksa chu hormone estrogen nen rei zawk a awm tihna a ni. |
| Menopause hi kum 55 hnuah a thleng thin. | Delayed menopause tih awmzia chu thlasik hun a rei zawk tihna a ni a, chu chuan estrogen exposure hun a tipung a ni. |
| Menopause avanga hormone replacement therapy (HRT) ei | Hormone hi pawn lam atanga pek a ni a, chu chu menopause (e.g., hot flashes) avanga harsatna awmte control nan a ni. Hei hian estrogen level a tisang bawk. |
| Estrogen a tam zawk | Taksa chhunga hormone estrogen leh progesterone inkara balance a tibuai a, chu chuan estrogen level a ti sang hle. |
| Thau lutuk | Taksa chhunga thau cell-te hian hormone estrogen an siam chhuak a, chuvangin taksa rihna a san chuan estrogen level pawh a sang thei bawk. |
| A rilru a buai em em a, a rilru a hah em em bawk a. . | PCOS hian hormone imbalance a thlen thei bawk a, hei hian estrogen level a tidanglam thei a ni. |
Tamoxifen damdawi chungchanga thil danglam tak
Hetah hian case bik a awm. Tamoxifen hi hormone-dependent hnute cancer tan damdawi tha tak a ni. Estrogen chu hnute cell thleng thei lo turin a block a, hna a thawk a ni. Mahse, hmeichhe menopause paltlang tawh uterus-ah chuan he damdawi hian estrogen ang bawkin kawng danglam takin hna a thawk tan a ni. Chuvangin, a tlem hle a, he damdawi hman hian estrogen-dependent uterine cancer vei theihna a awm. Hei hi thil thleng tlem hle mahse, i doctor chuan he thil hi a hriattir ang che a, a hun takah test tul tak tak a ti ang.
Doctor-te hian engtin nge hei hi an hmuh?
Cancer i vei nia i rinhlelh chuan i doctor-in a tih hmasak ber tur chu cancer cells sample tlemte la in lab-ah a thawn ang. Hei hi biopsy an ti a .
Laboratory-ah chuan he cell sample hi lak niin test a ni a, hormone estrogen leh progesterone nena inzawm thei receptor a nei em tih an enfiah thin.
- Test report-ah HR+ (Hormone Receptor-Positive) tih a awm a nih chuan estrogen, progesterone emaw hormone pahnih emaw hian i cancer a tipung tihna a ni.
- Test report-ah HR- (Hormone Receptor-Negative) tih a awm chuan heng hormone te hian i cancer thanna a nghawng lo tihna a ni.
He information hi enkawlna ruahmanna atan a pawimawh hle.
Enkawlnate chu engte nge ni?
Cancer hi hormone-dependent (HR+) a nih thu finfiah a nih hnuah doctor-te chuan hormone therapy tih damdawi an rawt ang. Hei hian hormone estrogen chu cancer cells te tana "chaw" a nih loh nan a titawp a ni. Hei hi kawng hrang hrangin tih theih a ni.
- Cancer cell-te hnena estrogen a thlen loh nan: Kawngkhar keyhole-a thil dah a, khar ang maiin damdawi hian estrogen receptor a block a ni. Tichuan estrogen chu a lo kal thei lo va, anmahniah a binding thei lo.
- Taksain estrogen a siam chhuah tihtawp: Damdawi pek a ni a, chu chuan estrogen siam chhuah a tihtlem emaw, a titawp emaw a ni.
- Estrogen chu thil dang hmanga thlak: A chang chuan lab-a siam hormone "fake", estrogen ang deuh mahse cancer cell-in a hman theih loh chu taksaah pek a ni. Chumi hnuah chuan cancer cell-te chuan hormone lem chu an la a, an bum a, an lo thang lian a, mahse an ti thei lo.
Hormone therapy chauh hi pek a ni lo tlangpui. Cancer chi leh a zau zawng a zirin enkawlna dang, surgery , chemotherapy, emaw radiation therapy te nen pek dun a ni.
Ei leh in atanga estrogens (phytoestrogens) te hian nghawng a nei em?
Hei hi mi tam tak tan pawh harsatna a ni. Thlai chaw thenkhatah hian kan taksaah estrogen ang maia thawk chemical compound a awm a. Hengte hi phytoestrogens kan ti a . Chungte entirnan soy, bawnghnute, leh whole wheat ang chi te hi a ni.
Heng phytoestrogens te hian estrogen-dependent cancer vei theihna a nghawng em tih hi zirchiangtute chuan an la pawm lo. Zirchianna thenkhat chuan taksaa estrogen level hniam nei tan chuan a hlawkpui thei niin an sawi. Mahse taksaa estrogen level sang tak nei tawhte chu engtin nge an nghawng tih erawh a la chiang lo. Chuvangin, he cancer chi hi i vei emaw, hlauhawm i nih chuan i doctor emaw, nutritionist emaw hnenah i ei leh in chungchang sawipui a tha ber.
Estrogen hi hmeichhe taksa dam khawchhuahna atana pawimawh tak hormone a ni. Kan reproductive system atanga ruh chakna thlengin a pui thin. Mahse he hormone pawimawh tak mai hian cancer chi hrang hrang a tichak thei a ni. I hnute, uterine emaw ovarian cancer i neih chuan i doctor chuan estrogen-a innghat a nih leh nih loh a hre duh ang. Chu thu hriat chuan i tâna enkawlna ṭha ber leh ṭha ber thlang tûrin a ṭanpui ang.
Take-Home Thuchah a ni
- Hormone estrogen hi cancer thlentu a ni lo. Chu chu estrogen hian cancer a thlen lo tihna a ni.
- Mahse, cancer chi thenkhat (a bik takin hnute, nausen pum leh ovarian cancer) te hian an thanlenna atan hormone estrogen hi "fuel" atan an hmang thin.
- Biopsy hmangin i cancer hi hormone-dependent (HR+) a nih leh nih loh a hriat theih.
- Cancer hi HR+ a nih chuan hormone therapy hmangin hlawhtling takin a control theih a ni.
- I risk factors, i ei leh in emaw, i enkawl dan emaw chungchanga zawhna i neih chuan, i biak tur tha ber leh tling ber chu i doctor hi a ni.
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