Kan taksaa inthlak danglamna tenau thenkhat hi kan ngaihven vak lo a ni lawm ni? Mahse, a châng chuan chutiang inthlâk danglamna tê tê, entîr nân, i zun lan dân a danglam ang chi thil chu i ngaihtuah aiin hrisêlna lama harsatna lian zâwk chhinchhiahna a ni thei a ni. Vawiin hian chutiang chi natna hmuh tur awm lo, mahse ngaihtuahawm tak pakhat chu kan sawi dawn a ni. Hei hi Complement 3 Glomerulopathy, a tawi zawngin C3G an ti a.
A awlsam zawngin C3G chu eng nge ni?
I kal (kidney) hi i taksa chhunga thisen awmte tifai thei super filter angin ngaihtuah rawh. He filter chhungah hian thil chi hrang hrang, mesh ang chi, glomeruli an tih te chu a tha hle. Hengte hian thisen atanga bawlhhlawh awmte chu a filter a, chutah chuan zun angin a paih chhuak thin.
Kan taksaah hian immune system kan nei vek a. Kan taksa chhunga hrik lutte dotu defence army ang mai a ni. He sipaiah hian special force pakhat chu complement system kan tih hi a ni. A tlangpuiin he chakna hian min pui thin a, mahse C3G natna vei taksaah chuan he complement system hnathawh hi a tibuai thin. A awlsam zawngin, he defense army hian tihsual an nei a, kan kidney-a filter nalh tak chu an rawn bei tan ta a ni.
He attack hian filter mesh a tichhia a, thisena awm tur protein leh red blood cell ang chi thil te chu zun ah a awm tan thin. Hun a kal zel a, he chhiatna hi a pung a, kal hnathawh pawh a tlahniam zauh zauh a, a tawpah chuan kal a tichak lo va , dialysis a ngai ta a ni.
He natna lan chhuah dan engte nge ni?
C3G natna vei zawng zawng hian symptom inang an nei vek dawn lo. Mi thenkhat chuan heng symptoms hi eng emaw zat an nei thei a, thenkhat erawh chuan pakhat emaw pahnih emaw chauh an nei thei thung.
| Symptom a ni | Hei hian a awmzia chu... |
|---|---|
| Zun lan dan a inthlak danglam | I zun chu chhum, foam, emaw a rawng dum (red, pink, or brown) anga lang a nih chuan, hei hi zun chhungah protein leh thisen cell a awm vang a ni. |
| Taksa a hring chhuak | Swelling a awm thei a, a bik takin ke, ke ruh, kut leh mit vel emaw ah a awm thei. Hei hi taksain protein a tlakchham chuan a thleng thin. |
| Joint natna | Taksa immune system a thawh that loh vangin ruh natna a awm thei. |
| Thisen sang a sang | Kidney a chhiat chuan thisen sang control a nghawng bawk. |
| Chauh fo thin | Kidney-in hna a thawh that loh chuan bawlhhlawh taksaah a pungkhawm a, chu chuan chau leh chak lohna a thlen fo thin. |
| Hri kai fo thin | Complement system a malfunction hian taksain natna hrik a do theihna a tichak lo thei bawk. |
| Mit lama harsatna nei | Mi thenkhat chuan mit lama harsatna an nei thei bawk. |
Damdawi thar Fabhalta (Iptacopan) tih hi i zir chiang ang u .
C3G natna enkawlna atan doctor-te chuan thisen sang control thei leh zun a protein excretion tihtlem thei damdawi (ACE inhibitor, ARBs ang chi) an pe tlangpui. Cholesterol sang tan damdawi an pe bawk. A chang chuan immune system hnathawh control thei damdawi (glucocorticoids, mycophenolate mofetil) te pawh an hmang thin.
Mahse, Fabhalta hi a danglam bik a, C3G natna vei puitling zun atanga protein paih chhuah tihtlem nan damdawi pawm hmasak ber a ni.
He damdawi hian engtin nge hna a thawh?
Kan taksa chhunga defense system buaithlak tak (complement system) ka sawi tawh kha i hre reng em? Damdawi Fabhalta hian chu sipaiah chuan Factor B an tih protein bik hnathawh chu a tikhawlo a, a dik tak chuan, mahni kal (kidney) beitu sipai buai tak takte chu a ti thlamuang a ni. Hei hian kal (kidney) chhiatna a tihziaawm bakah proteinuria a control bawk.
Engtin nge damdawi hi ka hman ang?
Fabhalta hi capsule a ni a, ka ei tur a ni. Ni khatah vawi hnih ei theih a ni a, ei tur nen emaw ei loh pawhin ei theih a ni. A pawimawh ber chu capsule pum pui ei hi a ni. Capsule chu tichhia suh, tikehsawm suh, chew suh. Dose i miss a nih chuan i hriatreng veleh ei la, a bak chu a hma ang bawkin ei leh rawh.
Fabhalta hman tangkai dan zirchianna atanga a lan dan chuan he damdawi ei thinte hian thla 6 chhungin an zun atanga protein excretion chu 35% velin an tihtlem phah a ni. Kidney function vawng reng emaw, tihchangtlun emaw a pui bawk.
Side effects leh engtin nge kan enkawl ang?
Damdawi dang ang bawkin Fabhalta hian side effect a nei thei a ni. Side effects langsar ber chu khawsik chhinchhiahna, hnar khar, hnar luang , khuh, thawk hah, leh rilru na te hi a ni.
Mahse, he damdawi hi kan fimkhur em em tur thil pawi tak pakhat a awm. Chu chu, he damdawi hian complement system thenkhat a control avangin bacteria chi hrang hrang (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type B) avanga natna khirh tak tak kai theihna a awm tihna a ni. Heng natna hrik te hi nunna atana hlauhawm pawh a ni thei.
Chuvangin, he damdawi hi i tan hma kar hnih tal hian vaccine pek ngai zawng zawng (a bik takin meningitis leh pneumonia vaccine) te chu i hre reng tur a ni. Hemi chungchangah hian i doctor chuan thurawn a pe ang che.
| Heng symptoms te hi i neih chuan doctor pan nghal rawh! | |
|---|---|
| Khawsik (chills nei emaw nei lo emaw), rilru na, khuh, thawk harsa, thinlung na rang. | |
| Taksa na leh flu ang chi natna. | |
| Vun hring (clammy skin) a ni. | |
| Lu na reng reng, khawsik, luak chhuak, luak chhuak, kawr emaw hnungzang emaw a nghet lo. | |
| A tlangpui aia chau zawka inhriatna, buaina leh mit hmuh dan inthlak danglam. | |
Hengte hi side effect zawng zawng a ni lo tih hre reng ang che. I doctor hnenah symptoms tibuaitu i neih apiang sawipui rawh.
Enkawl laia test leh thil dang mamawh te
- Thisen test: He damdawi i ei lai hian i doctor chuan thisen test mumal tak a nei ang a, i taksain damdawi a dawn dan a enfiah ang. Fabhalta hian i cholesterol leh triglyceride level a tisang thei a, chuvangin hengte hi i check fo a ngai dawn a ni.
- Damdawi dang nena inzawmna: Damdawi dang i ei hian Fabhalta hnathawh dan a nghawng thei a ni. Damdawi i ei zawng zawng, vitamin leh herbal remedies te pawh hi doctor hnenah hrilh vek a pawimawh hle. Chumi hnuah chuan i tana enkawlna tha ber tur chu a rel thei ang.
- Special Safety Program: He damdawi hi natna khirh tak kai theihna a nih avangin special safety program (REMS program) hnuaiah pek a ni. I doctor chuan a hrilh ang che a, safety card a pe ang che. I enkawl chhung zawng leh damdawi i chawlhsan hnu kar hnih chhung chu card hi i bulah dah reng a pawimawh.
Take-Home Thuchah a ni
- C3G hi natna awm lo mahse na tak a ni a, immune system a tha lo avangin kal a tichhe thin.
- Fabhalta (Iptacopan) hi novel, targeted therapy a ni a, C3G vei te zun a protein excretion tihtlem nan pawm a ni.
- He damdawi hman hian natna khirh tak tak kai theihna a awm. Chuvangin, enkawl tan hmain a tul anga vaccine lak hmasak a pawimawh hle.
- I doctor hnenah symptom danglam tak emaw, side effect emaw i neih chuan hriattir nghal rawh. A bik takin natna hrik kai theihna chhinchhiahna, khawsik leh lu na nasa tak te chu fimkhur hle ang che.
- I doctor thurawn tel lo chuan i damdawi ei hi i tan ngai lo tur a ni a, i chawlhsan tur a ni lo va, i thlak tur a ni ngai lo.
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