G6PD Deficiency hi eng nge ni? Hlau lovin i zir ang u!

G6PD Deficiency tih hi i hre tawh em? A hming hi a mak deuh pawh a ni mai thei. Mahse a takah chuan khawvela mi tam takin an neih thin genetic condition a ni a, mahse a tam zawkah chuan harsatna lian tham a thlen lo. Chuvangin, vawiin hian he G6PD tlakchhamna hi eng nge a nih, engvangin nge a lo awm tih leh kan hriat tur te kan sawi dawn a ni. Hlauh a ngai lo, awlsam takin engkim i sawifiah ang u.

G6PD Deficiency hi eng nge ni tak tak?

A awlsam zawngin sawi ila, G6PD tlakchhamna hi genetic condition a ni a, i taksaah G6PD level a hniam hle. Okay, tunah chuan G6PD chu eng nge ni tih i zawt ta. G6PD (Glucose-6-Phosphate Dehydrogenase) hi kan taksaah hian enzyme pawimawh tak a ni. He enzyme hnathawh ber chu kan thisen sen (red blood cells) te chhiatna chi hrang hrang laka venhimna a ni.

Hetiang tlakchhamna hi mi pakhat chu G6PD enzyme siamtu gene-a inthlak danglamna, a nih loh leh mutation neia piang a nih chuan a thleng thin. Chuvang chuan i thisen sen (red blood cells) te hian G6PD enzyme hi an siam chhuak tlem hle a ni.

Mahse hei hi a ni. G6PD tlakchhamna nei tam tak chuan symptom an nei lo . Nun pangngaiin an khawsa thin. Mahse, a chang chuan harsatna hi damdawi thenkhat, natna hrik, emaw ei tur thenkhat ang chi "triggers" vang a ni thei (hengte hi a hnuah kan sawi leh ang). Chutiang hunah chuan hemolytic anemia an tih natna a lo awm thei a ni. Chumi awmzia chu thisen sen (red blood cells) chu rang takin a chhe vek a, a chhe vek tihna a ni. A chang chuan nausen piang tharte hian G6PD tlakchham vangin jaundice na tak an nei thei bawk.

G6PD tlakchhamna hi i ngaihtuah aiin a tam zawk. Khawvel pumah mi maktaduai 400 leh 500 velin he natna hi an vei nia chhut a ni. Chuvangin i neih chuan i doctor chuan i thisen sen (red blood cells) te chu him taka dah turin a pui thei che a ni.

G6PD tlakchhamna chhinchhiahnate chu engte nge ni?

Kan sawi tawh ang khan G6PD tlakchhamna nei tam zawk hian symptom an nei lo tlangpui. Mahse, symptoms hi trigger pakhatin i thisen sen (red blood cells)-ah stress a siam a, a tihchhiat (hemolysis) chauhvin a lang thin. Chutiang a lo thlen chuan hetiang thil hi a thleng thei a ni:

• Chau lutuk tih hriatna
• Thinlung thawk chak tak ( tachycardia ) .
• Thâwk harsa ( Dyspnea ) .
• Vun sen emaw mit var emaw (hengte hi jaundice chhinchhiahna a ni ) .
• Vun dum ( hmui leh lei pawh a dum thei) .
• Dark yellow, orange emaw tea rawng emaw zun
• Spleen lian tak a awm

Heng chhinchhiahnate hi a lo awm nghal a, a nasat lutuk chuan hemolytic crisis an ti a ni. If you experience this , damdawi lam pan vat a pawimawh hle.

Nau piang tharte G6PD tlakchhamna chhinchhiahna

Nau piang tharte hian G6PD tlakchhamna chhinchhiahna langsar tak tak an nei tlem hle. A lan chhuah dan tlangpui chu jaundice a ni . Hei hi pian atanga ni rei lo te chhungin a lang tlangpui. Enkawl that loh chuan jaundice na tak chuan naute thluak a tichhe thei a ni. Hei hi kernicterus an ti a . Hei vang hian doctor ten nausen piang tharte chu G6PD tlakchhamna an rinhlelh chuan an test thin.

G6PD tlakchhamna hi eng nge ni?

G6PD tlakchhamna hi i G6PD gene a danglamna (variant) vang a ni. Hetianga danglamna hian i taksain G6PD enzyme a siam tha thei lo. He genetic variation hi i nu leh pate hnen atangin i rochun a, X chromosome hmangin i rochun a ni.

Hetiang genetic variation neih hian i thisen sen (red blood cells) ah G6PD level a hniam tihna a ni. G6PD enzyme hi a pawimawh hle a, a chhan chu thisen sen (red blood cells)-te'n "free radicals " an khawlkhawm tam lutuk loh nan a veng a ni. Free radicals hi thil hlauhawm lo tak a ni tlangpui. Environment-ah te, ei tur thenkhatah (fava bean, entirnan), damdawi-ah te pawh hmuh tur a awm.

Mahse, G6PD i neih tlem chuan trigger thenkhat (e.g. fava bean ei) hian heng free radicals tam lutuk hi i cell chhungah a lo awm khawm thei a ni. Hei hian oxidative stress tih dinhmun a siam a, chu chuan i thisen sen (red blood cells)-ah stress a siam a ni. A tawpah chuan heng cell te hi an chhe vek a, an chhe vek a ni. Hei hian thisen sen (red blood cells) a tihtlem a, hemolytic anemia a thlen thin .

He natna nena inzawm hemolysis thisen tlakchhamna thlentu (anemia) hi engte nge ni?

Researcher thenkhat sawi dan chuan fava bean ei hi a tibuaitu ber a ni . G6PD tlakchhamna nei mi pakhatin fava bean a ei hnua thisen tlakchhamna a neih chuan favism an ti a ni. Trigger langsar dangte chu:

• Hri kai: Hepatitis A leh Hepatitis B , Typhoid Fever , leh Pneumonia ang chi natna.
• Malaria damdawi hman thenkhat: Entirnan , Primaquine .
• Antibiotics thenkhat : nitrofurantoin , dapsone, leh sulfa damdawi te ang chi .
• NSAIDs (pawikillers): Aspirin leh ibuprofen ang chi .
• Meizial zu leh zu in tam lutuk.
• Rilru lama harsatna nasa tak.
• Taksa tihchakna nasa tak.

Risk factors te chu engte nge ni?

G6PD tlakchhamna rochun theihna tipungtu thil engemaw zat a awm a:

• Mipa leh hmeichhe thliarna:Mipa hian G6PD tlakchhamna an nei tam zawk. Hei hi a chhan chu mipa hian he genetic mutation kengtu X chromosome pakhat chauh an neih vang a ni. (Hmeichhia hian X chromosome pahnih an neih avangin pakhata harsatna awm chu a dangin a phuhruk theih hun a awm thin.)
• Geographical location: Hetiang dinhmun hi sub-Saharan Africa, Mediterranean region leh Southeast Asia-a chengte zingah a awm fo thin.
• Hnam: Zirchiangtute chuan America rama African hnam chhuak mipa 10% aia tam chuan G6PD tlakchhamna an nei niin an chhut.

Engtin nge G6PD tlakchhamna hi hriat theih?

Doctor-te chuan i medical history kimchang an zawt hmasa ang a, taksa enfiahna an nei ang. Tun hnaia damdawi i thlak emaw, natna hrik i vei em tih emaw an zawt thei bawk. I chhungkuaah G6PD tlakchhamna nei an awm leh awm loh an enfiah bawk ang.

G6PD tlakchhamna hriat theihna tur test te chu:

• Complete Blood Count (CBC): I thisen zam (red blood cell) awm zat a enfiah thin.
• Peripheral Blood Smear: Thisen smear-a thisen tlakchhamna chhinchhiahna a awm leh awm loh a enfiah a, chu chu thisen sen (red blood cells) pianzia dik lo emaw, a lian lo emaw a awm leh awm loh a enfiah thin.
• Bilirubin Test: Thisen sen hring chhe tawh atanga siam bawlhhlawh bilirubin level enfiah thin ang che.
• G6PD Test: I G6PD enzyme level te enfiah thin ang che.

G6PD tlakchhamna hi engtin nge enkawl a nih?

Doctor ten an dinhmun a zirin an enkawl thin. Entirnan, jaundice na lo tak i neih a, G6PD tlakchhamna i nei tih i hriat chuan jaundice symptoms chu an enkawl hmasa ang. Tichuan, eng trigger nge i pumpelh tur tih an hrilh ang che.

Mahse, a natna lan chhuah dan a nasat chuan a enkawl dan a danglam thin. Hemolytic anemia na tak i neih chuan thisen pek i mamawh mai thei .

I naute piang thar hian jaundice a vei a nih chuan i doctor chuan phototherapy (natural emaw artificial light hmanga enkawlna) hmangin a enkawl thei ang. A nasat zawkah chuan i naute chu exchange transfusion neih a ngai mai thei . Hei hian naute thisen hrisel lo tak tak lakchhuah a, a aiah thisen hrisel, pek chhuah hmanga thlak a huam a ni.

G6PD tlakchhamna hi ven theih a ni em?

Hei hi genetic condition a nih avangin a lo awm loh nan ven theih a ni lo. Mahse, hriselna lama harsatna lian tham a thlen hmaa hriat theih dan a awm. Chung zingah chuan:

• Nau piang tharte screening: Hetiang natna hi a tamna ram tam takah chuan nau piang tharte G6PD tlakchhamna hriat theihna turin screening programme siam a ni.
• Genetic testing: I chhungkuaa mi pakhatin G6PD tlakchhamna a neih chuan DNA test pawh a ngai mai thei.I doctor chuan chutiang ti turin a fuih thei che a ni.

Hetiang dinhmun hi ka neih chuan eng nge ka beisei theih ang?

G6PD tlakchhamna hi damdawi nghet tak a awm lo . Mahse, mi tam zawk chuan trigger an pumpelh chuan harsatna nei lovin an nung thei a ni. Tin, dam chhung pawh a nghawng lo.

Mahse, he dinhmun hian mi zawng zawng a nghawng dan inang lo. G6PD tlakchhamna nei tam tak chuan symptom an neih loh avangin an nei tih pawh an hre lo mai thei. Symptom nei tam zawk hi chu an na lo hle. Mahse, ṭhenkhat tân chuan trigger an tawh chuan hemolytic crisis an nei thei a, chu chuan nunna a tichhe thei a ni.

I doctor chuan i diagnosis a zirin i beisei theih tur chu a sawifiah thei ber ang.

Engtin nge ka in enkawl ang?

I doctor hnenah eng ei leh in nge i ei loh tur tih zawt rawh. Thurawn dang thenkhat chu hetiang hi a ni:

• Zu in tlem: Zu in tam lutuk hian i thisen sen (red blood cells) ah pressure a siam thei a ni.
• Meizial zuk loh tur: Meizial zuk hian i thisen sen (red blood cells) ah free radicals a awm khawm thei a.
• Exercise a tlem berah: Exercise na lutuk hian oxidative stress a tipung thei a ni.
• Chawlh hahdam tawk tum ang che: Mut hian i taksa hriselna a tichak a, chu chuan thisen peknaah thisen tlakchhamna thlen thei natna hrik dona kawngah a pui a ni.
• Stress enkawl: Stress nasa tak i neih chuan i stress enkawl dan tur doctor hnenah tanpuina dil rawh.

Pawimawh: I nau piang thar hian G6PD tlakchhamna a neih chuan hnute i pek laiin fava bean ei loh tur a ni . Pernicious anemia thlen thei compound te hi nu hnute hmangin naute hnenah a kal thei a ni.

Engtikah nge ka doctor ka hmuh ang?

G6PD tlakchhamna symptom i neih chuan engtik lai pawhin doctor hmu rawh. Symptoms a nasat a, a lo awm thuai chuan (hemorrhagic crisis chhinchhiahna) doctor pan nghal rawh .

Doctor hnenah eng zawhna nge ka zawh ang?

G6PD tlakchhamna i neih chuan zawhna zawh tur thenkhat chu hetiang hi a ni:

• Ka dinhmun hi engtiang chiahin nge a nasat?
• Eng ei leh in nge ka ei loh tur?
• Environment trigger ka pumpelh tur a awm em?
• Ka fa hian G6PD tlakchhamna a rochun theihna chance engzat nge awm?

A tawp berah chuan hriat reng tur (Take-Home Message) .

G6PD tlakchhamna hmuhchhuah hian mi zawng zawng a nghawng dan a inang lo thei. Dam theih a nih loh laiin, a tlangpuiin enkawl theih a ni. A pawimawh ber chu pernicious anemia vei theihna tipung thei triggers te hriatchhuah leh pumpelh hi a ni.Chu chu fava bean leh trigger dangte pumpelh tihna a ni thei. Tin, thil hrisel tak tak neih a pawimawh bawk a, chu chu chawlh hahdam tam leh zu in loh ang chi te hi a ni. G6PD tlakchhamna hian i nun a nghawng dan tur i enkawl theih nan i doctor hnenah thu zawt rawh. Hlauthawng suh, awareness hi defense tha ber a ni!

` G6PD tlakchhamna, hemolytic anemia, jaundice, genetic natna, thisen sen, fava beans, enzymes te