Ka pum na a ni ka ti a, mahse hei hi GIST cancer a ni em? (Gastrointestinal Stromal Tumor) tih hi a awm lo.

A chang chuan pum na mai mai i nei em? A nih loh leh, chhan bik nei lovin, a danglam bik takin i chau tih i inhria em? Tunlai i ei leh in nen hian inzawmna nei niin i ngai mai thei a, gastritis case a ni mai thei bawk. Chu chu a tam zawkah chuan a ni thei. Mahse, a tlem hle nachungin, heng symptoms te hi cancer hmuh tur awm lo, a tam lo zawk chhinchhiahna a ni thei bawk. Chu chu vawiinah kan sawi dawn a ni. Chu chu GIST, a nih loh leh Gastrointestinal Stromal Tumor a ni. A hming i hriat veleh hlau suh, engkim chu awlsam leh chiang takin kan sawi dawn a ni.

A awlsam zawngin, he GIST hi eng nge ni?

GIST hi Gastrointestinal Stromal Tumor tihna a ni a . Heng thute hi han ṭhen darh ila.

• Gastrointestinal: Hei hian kan chaw ei dan a kawk a. Chu chu kan chaw ei kalna kawng - hmui, chaw kawng, pum, ril, leh intestine lian tihna a ni.
• Stromal: Hei hian kan taksa peng bang chhunga awm tissue chi khat bik a kawk a, chu taksa peng hrang hrangte tanpuitu atan a thawk a ni.
• Tumor: Hemi hi i hre tawh ngei ang. Hei hian tumor tihna a ni.

A awlsam zawngin GIST hi cancer natna hrik a ni a, kan chaw ei dan (a tam zawk chu pum emaw, intestine te) chhunga taksa peng pakhat wall-a cell chi khat bik atanga intan a ni.

Hei hi cancer chi khat hmuh tur awm lo tak a ni a, soft tissue sarcomas group-a tel a ni. Kan intestine wall-ah hian ``interstitial cells of Cajal.`` an tih cell bik a awm a, heng cell te hi kan intestines pacemaker angin ngaihtuah teh. Heng cell te hian chaw ei tur chu intestine kal tlanga nawr chhuahna atana rhythmic contractions mamawh chu control turin a pui thin. GIST tumor hi heng cell-ah hian chhiatna a awm chuan a lo awm a, chu chuan thunun theih lohvin a inthen darh thin.

Heng cyst te hi a chang chuan pencil eraser ang maia te pawh a ni thei. An têt chuan kum tam tak chhung chu natna lan chhuah lohvin an awm thei a ni. Mahse, cyst thenkhat chu zawi zawiin a lian a, kan rilru hahna thlen thei symptoms a siam tan thin.

GIST natna lan chhuahna awm thei te chu engte nge ni?

A tam zawkah chuan heng tumor te hi chhan dang vanga scan emaw surgery emaw an tih laiin accident-in hmuh tur a awm a, symptom engmah a awm lo. Mahse symptoms a awm tak tak chuan hetiang hian a lang thei. Hriatthiam awlsam tak table-ah dah ila .

Engvangin nge he GIST hi a lo awm? A chhan chu eng nge ni?

A tam zawkah chuan GIST thlentu ber chu kan gene pakhat a inthlak vang a ni. Kan taksaa gene awmte hi kan taksa thanlenna leh hnathawh dan tur zirtirna bu atan ngaihtuah rawh. He instruction book-ah hian phek pakhat `(KIT gene)` tih a awm a. He page-a thupek ang hian a hmaa kan sawi tawh `(interstitial cells of Cajal)` tih cell te hi siamin control a ni.

Mahse, a chang chuan, he `(KIT gene)` page-ah hian letter emaw thumal emaw hi a dik lo hle. Typing error ang mai a ni. Damdawi lamah chuan hei hi `(mutation)` an ti a. Hetiang tihsual avang hian KIT gene hian protein bik `(KIT CD117)` siam turin thupek dik lo a pe a ni. He protein dik lo avang hian chu cell te chuan "inthen zel, inthen zel" tih signal an dawng fo thin. Chu chu chu cell te chu thunun theih lohvin an lo thang lian a, tumor an siam ta a ni.

Heng genetic changes te hi kan dam chhung hian random takin a thleng fo thin. Chu chu kan pianpui thil an ni lo tihna a ni.

Mahse, a tlem hle a, he dinhmun hi thlah khat atanga thlah danga inthlak danglam thin genetic condition nen a inzawm thei a ni. Chung zinga ṭhenkhat chu:

• Familial GIST syndrome: Hei hi thil awm lo tak a ni. Chutiang a nih chuan naupang chuan nu leh pa pakhat hnen atangin KIT gene chhia chu a rochun a ni. Chutiang a nih chuan GIST tumor hi kum naupang takah a lo awm thei a, tumor pakhat aia tam a lo awm thei bawk.
• Neurofibromatosis type 1: Hei hi genetic condition a ni bawk. Taksa nerve tissue-ah tumor a siam thin. Hetiang natna vei te hian mipui zawng zawng aiin GIST vei theihna an nei sang deuh hlek a ni.
• Carney-Stratakis syndrome: Hei pawh hi thil awm lo tak, thlahtute atanga lo chhuak a ni. Hetiang natna vei te pawh hi GIST vei theihna a sang hle bawk.

Doctor-te hian engtin nge GIST hi an hriat chhuah?

A chunga kan sawi tak symptoms nei doctor i pan hunah chuan i symptoms chungchang a zawt hmasa ang che. Eng chen nge an awm tawh, engtin nge an awm tih, etc. Tichuan a enfiah ang che. Hei bakah hian natna thlen chhan dik tak hriat chian nan test eng emaw zat neih a rawt bawk ang.

Main test hrang hrang tih a ni

• Upper endoscopy: Hei hi test hmasa ber a ni fo thin. A awlsam zawngin sawi ila, camera te tak te inbun tube chu ka chhungah dahin chaw kawng, pum leh small intestine hmun hmasa ber chu enfiah a ni. Hei hian tumor leh thisen chhuah leh awm loh direct-in a check thei a ni.
• CT scan: Hei hian kan taksa chhungril cross-sectional image a la a. Chhangphut hrual hrual ang mai a ni. Hei hian tumor lian leh te, a awmna hmun te, leh taksa peng dang, thin (liver)-ah te a darh tawh em tih te chiang takin a tarlang thei a ni.
• Biopsy atanga lak chhuah:Hei hi 100% a natna finfiah nan test pawimawh ber a ni. Endoscopy emaw, hmanraw dang emaw an tih lai hian rinhlelh awm tumor atang hian tissue te tak te tak te an la chhuak thin. Tichuan, laboratory-ah microscope hmangin tissue chu GIST cells a nih leh nih loh enfiah a ni.
• PET scan: A then phei chuan, a bik takin cancer hian taksa peng dangah a darh tawh nia rinhlelhna a awm chuan he test hi tih theih a ni.

GIST enkawl dan tur chu engte nge ni?

GIST enkawl dan chu tumor lian leh te, a awmna hmun leh hmun danga a darh leh darh lohah a innghat a ni. Enkawlna chi hnih a awm a.

1. Surgery neih dan tur:

A tam zawkah chuan GIST tumor enkawlna tha ber chu operation hmanga tumor lakchhuah vek hi a ni. Tumor hi a te a, hmun dangah a darh lo a nih chuan operation ringawt pawh hian natna chu a tidam vek thei a ni.

2. Targeted Therapy hmanga enkawlna: 1.1 .

Hei hi GIST enkawlna lama revolutionary ber a ni. Chemotherapy pangngai ang lo takin heng damdawi te hi "smart bomb" ang mai an ni. A hmaa kan sawi tawh KIT protein chhia chu direct-in an target a ni. Chuvangin cell hrisel tak takte tihchhiatna a tlem hle.

• Surgery hma: Tumor a lian em em a, operation a harsat chuan he targeted treatment hi pek hmasak a ni a, chumi hnuah tumor a tlahniam hnuah surgery tih a ni.
• Surgery hnuah: Surgery hnua natna lo lang leh theihna a awm chuan, chu hlauhawmna tihziaawm nan heng damdawi te pawh hi pek thin a ni.
• Cancer a darh tawh a nih chuan: Tum hi a darh zau lutuk a, lakchhuah theih loh khawpin a darh a nih chuan, natna thunun nan leh a lan chhuah dan tihziaawm nan heng damdawi te hi i dam chhung zawng i ei a ngai mai thei.

GIST condition neia i nun hian eng nge i beisei theih ang?

Enkawl zawhah natna lan chhuah dan a tha thei a, a chang chuan natna hi a dam kim thei bawk. Mahse, GIST hi condition a ni a, a lo kir leh theihna chance a nei a ni. Chuvangin i oncologist nen inbiak reng a pawimawh hle a, ani hian enkawl hnuah pawh a enkawl ang che.

Thla 3 atanga thla 6 chhungin i doctor nen follow-up appointment i nei ang. Heng hun chhung hian test neih a ni ang a, a lo lang leh theihna tur chhinchhiahna te enfiah a ni ang.

• `CT scans` tih a ni
• `MRI scan a ni`
• `PET scans` tih a ni

Engkim a tha em tih enfiah nan hetiang test hi kan ti thin.

GIST hi thil awm lo tak a nih avangin, a chanchin i hriat chuan mangang leh hlauthawng tih hi thil pangngai tak a ni. Mahse, tunah chuan he natna hi enkawlna tha tak tak a awm tawh tih hre reng ang che. Nangmah chauh i ni lo. I medical team, chhungte leh i thiante chu tanpui turin an awm vek a ni. He natna chungchang hi zir la, zawhna zawt la, enkawlna tha tak hmachhawn rawh.