I pum chhungah gastrin a tam lutuk em? (Hypergastrinemia) chungchang hi han sawi ila!

I pum a nuam lo, i khat a, a nih loh leh chaw ei lama harsatna dang i nei fo em? A châng chuan a chhan chu i taksaa hormone `(Gastrin)` tih chu a pangngai aia tam a nih vang pawh a ni thei. Vawiin hian he natna `(Hypergastrinemia)` tih hi chipchiar tak leh awlsam takin kan sawi dawn a ni.

`(Hypergastrinemia)` tih hi eng nge ni? I hrethiam ang u!

A awlsam zawngin, `(Hypergastrinemia)` tih awmzia chu kan taksain chaw ei tur a ei theih nana puitu hormone `(Gastrin)` level hi a tul aiin a sang zawk tihna a ni. He `(Gastrin)` hormone hi kan pum hnuai lam, chu chu small intestine bulah, pum bang chhunga cell chi khat bik atanga siam a ni. Hei hi `(G cells)` kan ti a.

Tunah chuan en teh, he `(Gastrin)` hormone hian kan pum chu, "Okay, now secrete acid" tih hi a ni. He pum acid, chu chu `(gastric acid) hi kan tan a pawimawh hle. A chhan chu, he stomach acid hian kan ei tur kan digest tir a, chu chaw chhunga nutrients awmte, entirnan `(amino acids)` leh proteins te chu a hip lut thin.

Mahse, `(Hypergastrinemia)` avanga thil thleng thei chu a buaithlak deuh. A chang chuan pumpui acid (`hyperchlorhydria`) a siam tam thei a, a chang chuan pum acid tlem lutuk (`hypochlorhydria`) a siam thei bawk. Chuvangin `(Hypergastrinemia)` hian engtin nge a nghawng che tih hi damdawi lam dinhmun dang i neih te, i surgery te, leh damdawi i ei te ah a innghat a ni.

He natna hi tuin nge vei tam zawk?

Dik tak chuan he ``Hypergastrinemia'' an tih hi kum leh mipa leh hmeichhia pawh nise, tu chungah pawh a thleng thei a ni. Chuvang chuan kan zavaia kan hriat chian hi a tha a ni.

`(Hypergastrinemia)` hi engte nge ni?

Hetiang dinhmun hi a chhan hrang hrang a awm thei a, chung zingah chuan ``Hypergastrinemia'' te pawh a tel. An pahnih hi a hranin han thlir ila.

Pum acid tlahniam chhan

``Hypergastrinemia`` a lo awm chuan heng avang hian stomach acid siam chhuah dan pangngai chu a tlahniam thei a ni:

• Heartburn emaw GERD (Gastroesophageal Reflux Disease) atana anticids: Heng damdawi chi hrang hrang i hman reng chuan chu pawh chu a chhan a ni thei bawk.
• Chronic atrophic gastritis: Hei hi pum chhung bang zawi zawiin a chak lo va, hun kal zelah a lo hring chhuak thin.
• Colorectal cancer: Hei hi a nghawng thei bawk.
• `(H. pylori)` infection: `(Helicobacter pylori)` hi natna hrik, pum chhunga awm thei a ni. He natna hrik hi `(Hypergastrinemia).` thlentu a ni bawk
• Kidney failure: Hetiang dinhmun hi kal (kidney) hnathawh that loh vang a ni thei.
• Proton Pump Inhibitor (PPI) hman dan: 1.1.Gastritis, acid reflux, indigestion, emaw peptic ulcer natna atana PPI damdawi (omeprazole ang chi) hun rei tak hman pawh hi a chhan lian tak a ni.
• Vagotomy: Hei hian vagus nerve thenkhat lakchhuah a huam a. He nerve hi thluak atanga pum thlengin a kal a, thinlung leh chaw ei danah signal a keng tel a ni. He surgery hnuah hian hypergastrinemia a awm thei a ni.

Pum acid tihpun chhan

Tunah chuan pum chhunga acid siam chhuah tamna chhan (Hypergastrinemia) hi eng nge ni tih hi han en ila:

• Antral G-cell hyperplasia (pseudo-Zollinger-Ellison syndrome / Ps-ZES): Hei hi thil awm lo tak a ni. Zollinger-Ellison syndrome nen a inang a, mahse pancreas emaw small intestine (duodenum) hmun hmasa berah emaw gastrin siamtu tumor a awm lo.
• Gastric outlet obstruction: Hetiang dinhmun hi pum atanga small intestine panna kawng a inkharkhip hian a awm thei. Tui pipe khar ang maiin han ngaihtuah teh.
• Multiple endocrine neoplasia type-1 (MEN-1): Hetiang dinhmun hian adrenal glands, thyroid glands emaw parathyroid glands-ah neuroendocrine tumor a siam a.
• Retained antrum syndrome: Hetiang dinhmun hi tumor lakchhuah emaw, ulcer enkawl emaw tura operation hnua pum hnuai lam (the antrum) hmun te tak te a awm chuan a awm thei.
• Zollinger-Ellison syndrome (ZES): Hei hi tumor-in hormone gastrin a siam chhuah tam lutukna a ni. Hetiang dinhmun (ZES) hian chawhmeh natna a thlen thei a ni.

`(Hypergastrinemia)` natna lan chhuah dan chu engte nge ni?

`(Hypergastrinemia)` i neih chuan:

• Pum na: Pum na i nei fo thei.
• Chronic diarrhea: Ni eng emaw zat a awm thei.
• Pancreatic tumors: Hengte hi cancer emaw benign tumor emaw a ni thei.
• Stomach ulcers: Pum natna (inflammation) avanga natna lo awm thin.
• Esophagitis na tak: Esophagus-a inflammation leh natna nasa tak a awm.

Engtin nge doctor-te hian he natna hi an hriat theih?

Hypergastrinemia dik taka hriat theih nan doctor-te chuan i pum hian acid engzat nge a siam tih an hriat a ngai a ni. I thisena gastrin awm zat pawh an teh bawk.

• He test hma hian i doctor chuan hun engemaw chen chaw nghei (ei lo) turin a hrilh ang che .
• Tin, ``(PPI)`` hmangtu i nih chuan .Chu damdawi chu test hma kar khat vel khan i ei tawh loh a ngai dawn a ni.
• Tichuan, i thisen sample an la a, i Gastrin level an enfiah thin. A châng chuan, heng thisen sample te hi ni khatah vawi tam tak, ni engemaw zat chhungin an la thei a, i Gastrin level a danglam em tih an en thei bawk.

I doctor chuan hypergastrinemia a rinhlelh chuan, natna dang awm lo turin test dang a ti thei a, chung zingah chuan:

• Secretin stimulation test: Hei hi hormone secretin tih infusion pek che a ni a, chu chu i small intestine peng hmasa ber (duodenum) atanga siam a ni. I gastrin level nasa taka a san thut chuan Zollinger-Ellison syndrome chhinchhiahna a ni thei.
• Stomach pH testing: Hei hian i pum chhunga acid awm zat a enfiah thin. pH 2 aia tlem a nih chuan Zollinger-Ellison syndrome chhinchhiahna a ni thei bawk.

Hypergastrinemia hi engtin nge enkawl a nih?

Hypergastrinemia enkawl dan hi a chhan a innghat a ni.

• Colon cancer, esophageal obstruction, kidney disease, leh `(MEN-1)` leh `(ZES)` ang chi natna: Heng natna te hi enkawl a nih chuan (a tam zawkah chuan operation hmanga enkawl) `(Hypergastrinemia)` symptoms te pawh a reh thin.
• Atrophic gastritis (ACG) leh H. pylori infection: Heng natnate hi antibiotics hmanga enkawl theih a ni.
• Proton-pump inhibitors (PPIs): PPI i ei a nih chuan damdawi i ei tawh loh atanga ni nga atanga ni sarih chhungin hypergastrinemia hi a reh tlangpui.
• Retained antrum syndrome: Pum hnuai lam a antral tissue la awmte chu lakchhuah chuan extra stomach acid siam chhuah zat a ti tlem thei a ni.

A pawimawh ber chu i doctor nen i dinhmun enkawlna tha ber chungchang sawipui hi a ni.

`(Hypergastrinemia)` vei theihna hi ka tihtlem thei ang em?

Hun rei tak chhung anticids emaw PPIs hmang tawh i nih chuan hypergastrinemia vei theihna a awm. Chuvangin, he hlauhawmna hi engtin nge i enkawl ang tih hi doctor nen inbiakna neih a pawimawh hle.

`(Hypergastrinemia)` ka neih chuan eng nge ka beisei ang? Enkawl a nih loh chuan eng nge thleng ang?

Hypergastrinemia hi uluk taka enkawl a nih loh chuan taksaa gastrin level a sang reng a ni. Zirchiangtute chuan hei hian cancer cells te a tipung thei niin an ring. Entir nan:

• Thisen cancer: leukemia, lymphoma, leh multiple myeloma te ang chi te.
• Chaw ei kawng cancer a ni
• Pancreatic cancer natna a ni

Tin, hun rei tak `(Hypergastrinemia)` hian pum chhunga natna hrik `(gastric carcinoids)` emaw `gastric adenocarcinoma` emaw a thlen thei bawk. `(gastric carcinoids)` hi chi hnih a awm a:

• Type I gastric carcinoids: Hengte hi chronic atrophic gastritis natna nen a inzawm a ni.
• Hmeichhiaah a awm tam ber.
• Pum chhung hmun engemaw zatah hmuh theih a ni.
• Cancer vei theihna chance a tlem hle.
• Type II gastric carcinoids: Hengte hi ZES leh MEN-1 natna nen a inzawm a ni.
• Hmeichhia leh mipaah ​​pawh a awm thei.
• Pum chhung hmun engemaw zatah hmuh theih a ni.
• A chang chuan cancer (7% leh 12% inkar) ah a chang thei bawk.

`(Hypergastrinemia)` vei tan chuan eng nge a hmalam hun?

``Hypergastrinemia`` vei te hmalam hun hriselna dinhmun hi thil engemaw zat ah a innghat a ni:

• Natna thlentu a ni.
• Genetics lam thil a ni.
• Hriselna chanchin.
• Nunphung.

Mahse, enkawl dan dik a nih chuan ``Hypergastrinemia'' vei te hian nun active, normal tak an nei thei a ni.

`(Hypergastrinemia)` ka nei a, engtin nge ka in enkawl ang?

Hun rei tak chhung anticids emaw PPI emaw i ei a nih chuan medical checkup neih fo a pawimawh. Doctor rawn la, thurawn la rawh.

Engtikah nge Doctor ka hmuh ang?

Heng symptom thar zinga pakhat tal i neih chuan, emaw, i symptom awmsa te hi a na zual zel nia i hriat chuan doctor pan ngei ngei tur a ni a, full checkup la rawh.

Thil hriat reng tur te chu a tawi zawngin

Okay chuti a nih chuan, kan sawi tawh kha i hre reng ang u:

• Hypergastrinemia hi taksaa hormone gastrin tihpunna a ni.
• He hormone (Gastrin) hian pum chhunga acid awm zat a nghawng a (acid hian a tipung thei a, a tlahniam thei bawk).
• A chhan tam tak a awm thei – thil `(PPI)`/antacids hman chhunzawm zel, `(H. pylori)` infection, gastritis, `(Zollinger-Ellison syndrome)` ang chi te.
• Doctor-te chuan ``Gastrin'' level test hmangin hei hi an hmuchhuak thin.
• Enkawlna chu a chhan bulpui (underly cause) atanga thlir a ni.
• A natna lan chhuah dan hi ngaihthah suh, enkawl loh chuan tumor leh cancer-ah a chang thei a ni! Damdawi lam thurawn zawng nghal rawh.

He thu hi i tangkaipui ngei ka beisei. Hrisel takin awm rawh!

` Hypergastrinemia, Gastrin, Pum acid, Chaw ei dan, Zollinger-Ellison syndrome, H. pylori, PPI, Gastritis, Pum natna