I natna a ni em? I taksa pengte chu a hring vek tawh em? Hei hi Inclusion Body Myositis (IBM) a ni thei!

A châng chuan thil chelh harsa tak, button button vuah, a nih loh leh kal pawh harsa i ti em? "Aw, hei hi i tar huna thil thleng mai mai a ni," tiin i ngaihtuah mai thei. Mahse, a chang chuan, heng thilte hi chutiang chuan a awlsam lo. Vawiin hian kan sawi dawn a, thil awm lo tak, mahse hriat tur pawimawh tak tak kan sawi dawn a ni. Chu chu `Inclusion Body Myositis` an ti a, a tawi zawngin `(IBM)` tia hriat bawk.

`Inclusion Body Myositis (IBM)` tih hi eng nge ni? A awlsam zawngin i hrethiam ang u!

A awlsam zawngin sawi ila, `Inclusion Body Myositis` hi i taksa ruhte a tichak lo zauh zauh a, mahse natna a thlen tam lo. Kum 50 i tlin hnuah a intan tlangpui a, han ngaihtuah teh, thil te tak te `pinch` i harsat thei a, thil `grasp` harsa i ti thei a, i kal mai mai hian i tlu a, i tlu thei bawk. Hengte hi chhinchhiahna hmasa ber i hriat theihte chu a ni.

He dinhmun, `IBM` tia koh hi kum tam tak chhungin a lo thang zauh zauh thin. Nunna atana hlauhawm dinhmun a ni lo. Chumi awmzia chu a that lovang che tihna a ni. Mahse, hun kal zelah nitin hna thawh a harsat phah thei a, chu chuan eng emaw chen chu rualbanlohna a thlen thei a ni. A chang chuan, i taksa sir khat chauh a nghawng nasa zawk. Hetiang natna vei zinga a chanve vel chuan `si ei harsatna` an nei thei bawk.

Lungchhiatthlak takin IBM damdawi hi a la awm lo. Mahse, lungngai suh! Physical therapy hian i taksa chakna chu a rei thei ang bera vawng reng turin a pui thei che a ni.

Hetiang `IBM` dinhmun hi engtiang chiahin nge a awm?

Inclusion Body Myositis hi taksa chakna tichak lo natna pawl pakhat, myopathies an tih zinga mi a ni. Myopathies hi natna a ni a, i taksa ruh (muscle fibers) a bei a, a tichak lo bawk. Research atanga a lan dan chuan IBM hian puitling maktaduai zinga 5 leh 9 inkar a nghawng a ni. Hmeichhia aiin mipaah ​​a let thum velin a tam zawk bawk (3:1).

`Inclusion Body Myositis (IBM)` natna lan chhuah dan chu engte nge ni? I han chhui chiang teh ang!

IBM avanga taksa chak lohna hi a lo thleng zawi zawi hle. Limbs atang hian a intan fo thin. I ke, i kekawrte, emaw, i kut, i kutphah emaw, i kut zungtang emaw-ah chak lohna i hmu hmasa thei. Hetiang hian han ngaihtuah teh: mi thenkhat chuan kawr bun harsa an ti a, a nih loh leh an pen pawh a ziak mumal lo. Mi dangte chuan stairs chhoh harsa an ti a, a nih loh leh an kal lai chauhvin an tlu a, an tlu bawk.

Symptoms a na zual deuh deuh chuan hetiang hi i hmu mai thei:

• Kut, ke, ke, hip area, kutphah leh kut zungtang te chu zawi zawiin a chak lo chho zel a. Ngaihtuah teh, tun hmaa awlsam taka i chawi theih thin thilte kha i chawi thei lo va, chair atanga tho leh tur pawhin harsatna i nei thin.
• Kawr emaw, chaw kawng emawa ruh chak lohna. Hei hian lu ding nghet taka vawn a ti harsa thei a, chaw ei a ti harsa thei a, ei tur pawh a tikhawlo thei bawk.
• Muscle atrophy chu chiang takin a lang. Chumi awmzia chu taksa ruhte chu a lo tlem tawh a, a lo hring tawh hle tihna a ni.
• Taksa natna (`myalgia`) na lo, a awm fo thin. Amaherawhchu, he natna hi mi zawng zawngah a awm lo va, a lo awm a nih pawhin a na vak lo.

Entîr nân, i ṭhian pakhat Sunil-a i nei ang tih han ngaihtuah teh. Hun engemaw chen chu a teacup chu a chelh tha thei tawh lo a, a kut atang chuan a tla thla zel a ni. Chanchinbu chhiar tura a kal chuan a kut chu a nghing ang maiin a hria. A tirah chuan hahna mai mai niin a ngai a. Mahse a hnuah chuan hei hi `IBM` chhinchhiahna hmasa ber a ni thei tih a hrechhuak ta a ni.

Engvangin nge he `Inclusion Body Myositis (IBM)` hi a lo awm? Eng nge a chhan?

Dik tak chuan he natna `Inclusion Body Myositis` an tih hi `idiopathic` a ni. Chu chu chhan bik nei lovin a thleng niin a lang. `Myositis` chi dang ang bawkin, he thu-ah hian taksa ruh chhunga hun rei tak chhunga natna (`chronic inflammation`) hi taksa chak lohna thlentu ber a ni. Mahse, zirchiangtute chuan he inflammation hi engvangin nge a awm tih chiang takin an la hre lo. Immune system lama harsatna (`autoimmune disease`) vang pawh a ni thei niin an ring. Chu chu kan taksa vengtu cell te hian kan taksa ruh (muscle cell) te hi an rawn bei sual tihna a ni.

`Inclusion body` te pawh hi `IBM` nen a inzawm tlat a ni. Hengte hi protein clump pangngai lo, muscle cell chhunga awmte an ni. Viral infection, cell chhiatna, a nih loh leh genetic mutations avanga lo awm thei an ni . Heng `inclusion body` te hi `ALS` ang chi neurodegenerative diseases ah pawh hmuh tur a awm bawk. Cell hnathawh dan pangngai a tibuai thei a ni.

`Inclusion Body Myopathy` leh `Inclusion Body Myositis` inkar danglamna

A chang chuan `Inclusion Body Myositis` hi `sporadic inclusion body myositis (sIBM)` an ti bawk. `Sporadic` tih awmzia chu random-a thleng, emaw, chhan bik nei lo emaw tihna a ni. Hei hi rochun atanga lo awm, dinhmun inang lo tak tak atanga thliar hran nan a ni. Hrilhfiahna atanga lo piangte chu `hereditary inclusion body myopathies (hIMB)` an ti a. `Inclusion body myopathies` kan tih hian heng chi hnih hi an tel ve ve a ni. Tunah chuan random taka thleng `sIBM` chungchang kan sawi dawn a ni.

Engtin nge `Inclusion Body Myositis` hi hriat chhuah a nih? Eng test nge tih thin?

IBM i vei em tih hriat nan doctor chuan i symptoms te a zawt hmasa ang che a, i taksa ruh (muscles) te a enfiah hmasa ang. Inclusion body myositis symptoms hi condition dang, polymyositis leh myasthenia gravis te nen a inang thei a ni. I doctor chuan thil chiang tak tak a zawng ang a, chungte chu:

• Eng muscle nge a nghawng? (e.g., kut zungtang emaw, kekawrte emaw-ah?)
• Taksa kil khat chauh hian a nghawng nasa zawk em?
• Muscle atrophy hi chiang takin a lang em?
• Symptoms a lo lan tirh khan kum engzat nge i nih? (A tlangpuiin kum 50 hnuah)

Tichuan, condition dang ``rule out`` turin test engemaw zat tih theih a ni a, chu chu:

• Creatine Kinase (CK) test: Hei hian thisen chhunga enzyme bik awm zat a teh thin. He `CK` level hi taksa ruh chhiatna a awm chuan a sang thei a ni.
• Thisen test-ah hian virus leh autoimmune natna chi hrang hrang a awm leh awm loh enfiah a ni.
• Electromyogram (EMG): Hei hian i taksa peng hrang hranga electric hnathawh dan a teh thin. Muscle-ah hian needle te te dahin tih a ni.
• Nerve Conduction Study (NCS): Hei hian electrical impulse pakhatin i taksa ruh control tu nerve (motor nerves) a kal chak dan a teh a ni.

Muscle biopsy test a ni

Inclusion-body myositis i neih leh neih loh finfiah dan tha ber chu a natna taksa peng atanga tissue te tak te (biopsy) lak hi a ni. Pathologist chuan he tissue sample hi microscope hmangin a en ang. IBM i neih chuan sample-ah hian inclusion body (protein clumps, bubbles, emaw vacuoles pangngai lo) a hmu thei ang.

`Inclusion Body Myositis` hi damdawi tha tak a awm em?

Vanduaithlak takin inclusion body myositis hi enkawlna tha tak a awm lo. Inflammatory condition dang leh autoimmune diseases ang lo takin corticosteroids emaw immunosuppressant drugs emaw a dawng lo.

Mahse, beiseina bansan suh! I taksa ruh chakna chu a rei thei ang bera vawng reng turin physical therapy leh exercise neih fo hi a pawimawh hle. Exercise hian taksa ruh chak lohna nasa zawk a veng thei a ni.

Natna a zual zel a, nitin hna thawh a harsat deuh deuh chuan thil tih dan thar i zir a ngai mai thei. Hei hi occupational therapy hian a pui thei a ni. Entîr nân, incheina te, ei leh in te, leh thuziak lama ṭanpui nâna hmanraw chi hrang hrang hman dân an zirtîr thei che a ni. Mi ṭhenkhat chuan wheelchair hman dân an zir a ngai mai thei bawk. Chaw ei harsatna i neih chuan Speech-Language Pathologist (SLP) chuan a pui thei ang. Anni hian him taka ei dan tur an zirtir thei che a, ei tur exercise pawh an ti thei bawk.

`Inclusion Body Myositis` ka neih chuan eng nge ka beisei ang?

`IBM` i neih chuan a pung zauh zauh ang. A hmaa ka sawi tawh ang khan, .Hei hian i dam chhung a nghawng dawn lo. Mahse, i nunphungah nghawng a nei thei a ni. Mi dangte rinchhan emaw, tih dân thar i zir emaw a ngai mai thei. Mi tam zawk chuan kea kal theihna an hloh vek lo a, mahse thenkhat chuan kum 10-15 hnuah wheelchair an mamawh mai thei.

Inclusion-body myositis natna vei lai hian engtin nge ka in enkawl ang?

`Inclusion body myositis` nen hian rei tak i nun a ngai dawn a, hun kal zelah a harsa deuh thei bawk. Chumi hmachhawn dan tha ber chu i taksa leh rilru hriselna enkawl dan tur ruahmanna rei tak siam hi a ni. Chu chu i dam ṭhat theih nâna ṭanpui thei thil tih dân tê tête chu i tih chhunzawm zêl tihna a ni. Entir nan:

• I exercise program chu chhunzawm zel rawh. Physics therapy-ah i awm mai thei a, in lama exercise program-ah i inthlak tawh pawh a ni thei. Hetiang routine hi chhunzawm zel chuan i taksa ruhte chu a chak thei ang bera awm tir turin a pui ang.
• ``Wellness lifestyle'' zawm rawh.Ei i ei tha a, i mut tha a, stress i enkawl a, i inzawmna pawimawh tak tak i vawng reng a nih chuan a pumpuiah i rilru a hahdam ang.
• Support group hrang hrangah tel ve rawh. Nangmah ang bawka tawng tawh emaw, tawng tawh emaw midangte hnen atangin rilru chakna leh thurawn tangkai tak tak i dawng thei a ni. "Hetiang hi keimah chauh hi ka tawk lo" tih ang chi hi a ropui hle bawk.
• In leh hnathawhna hmuna inthlak danglamna (adaptation) te en rawh. Taksa lama harsatna nei te nitin hnathawh awlsam zawka siam thei tur mobility aid leh assistive device tam tak a awm a.
• Doctor hmu fo ang che. I doctor nen inzawmna nei reng rawh. I doctor hnenah chhinchhiahna thar i hmuh chuan, ei harsatna ang chi, emaw, natna lan chhuah tawh chu a zual zel a nih chuan hrilh nghal rawh.
• Clinical trial te hi han en teh. Researcher-te chuan inclusion body myositis-a pui thei tur enkawlna thar an zawng reng a ni. Heng fiahnaah hian i tel ve thei bawk.

He natna hi `Inclusion body myositis` tia koh hi midlife-ah a awm fo thin a, chutih lai chuan beiseina a awm lo. Natna tihdam theih loh, zual zel chu a lo vei thut mai hi tumahin an beisei lo. Nangmah ngaihsaktute hnena hmachhawn leh hrilhfiah chu a harsa deuh thei a, a bik takin he natna hi an la hre ngai lo a nih chuan.

Mahse hei hi hre reng ang che, hei hi natna lian tham tak a ni. Chuvangin, hmalam hun inthlauhna tur ngaihtuah a, chu mi ang zela inthlak danglamna siam hun a tam hle. Hei hian engtin nge a nghawng ang che tih hi tumahin chiang takin an sawi thei lo. Mahse,Optimistic approach hmang hian kum lo awm turteah i hriselna leh hriselna zawng zawng vawng reng turin thil tam tak i tih theih a awm.

Kan hriat reng tur pawimawh ber berte (Take-Home Message) .

Okay, chuvangin `Inclusion Body Myositis (IBM)` chungchang hi kan sawi nasa hle. A tawp berah chuan i hriat reng tur pawimawh ber berte chu hetiang hi a ni:

• IBM hi taksa chak lohna natna zual zel a ni a, kum 50 hnu lama awm tam ber a ni a , a na hi a na lo hle a, mahse hun kal zelah nitin hnathawhna a nghawng thei a ni.
• There is no cure for this , mahse physical therapy leh exercise hian a theih ang anga rei tak chhung taksa chakna vawng reng turin a pui thei a ni.
• A lan chhuah dan chu thil man harsa, kal laiin tlu, leh ei tur ei harsa te a ni thei .
• A chhan dik tak hriat a ni lo (`idiopathic`), mahse immune system lama harsatna a ni thei.
• He natna hi muscle biopsy hmangin chiang takin a chiang thei chauh a ni.
• Hei hi nunna atana hlauhawm a ni lo , mahse nunphung a nghawng thei a ni.
• Positive taka awm a, damdawi lam thurawn zawm a, a tul anga puihna dawn a pawimawh hle.

Nangmah emaw, i hriat miin emaw heng symptoms te hi i neih chuan doctor thurawn lak a tha ber. Nangmah chauh i ni lo tih hre reng ang che, tanpui thei tur mi an tam khawp mai!

` Muscle chak lohna, IBM natna, physical therapy, muscle natna, tar hriselna, ei harsa, thluak lam natna