Pancreas-ah hian tumor mak tak tak a awm em? (Intraductal Papillary Mucinous Neoplasm - IPMN) chungchang hi awlsam takin i zir ang u!

He natna hming sei tak hi eng nge ni? `Intraductal Papillary Mucinous Neoplasm` emaw `(IPMN)` emaw chu eng nge ni tih i ngaihtuah mai thei. A hming hi a hlauhawm deuhin hriatthiam harsa deuhin a lang thei a, mahse a awlsam zawngin i dah ang u. Nang emaw i hriat emaw chuan he dinhmun hi i hre tawh mai thei. Chuvangin, hlauthawng lo ila, eng nge a nih chiang takin i zawng chhuak ang u.

`IPMN` chu eng nge ni tak tak?

A awlsam zawngin, IPMN chu i pancreas duct chhunga tuiin a khat lump, a nih loh leh cyst a ni. Hengte hi cancer tak tak an ni lo a, mahse doctor-te chuan "precancerous" ah an ngai thung. Hei hian tunah chuan cancer vei an ni lo tihna a ni a, nakin lawkah chuan cancer vei an ni thei tihna a ni.

Ngaihtuah teh, a chang chuan thlai te tak te ang mai a ni. Thingkung lian tak a ni thei a, a ni lo thei bawk. Chutiang chu he `(IPMN)` tumor hi a ni. Zirchiangtute chuan pancreatic cancer vei zinga 20% leh 30% inkar emaw, mi sawm zinga pahnih emaw pathum emaw zingah cancer hi `(IPMN)` atanga intan niin an ngai. Mi thenkhat chuan kum tam tak chhung he tumor hi an nei thei a, symptoms engmah an lantir lo. `(IPMN)` hi surgery hmanga enkawl a ni a, a nih loh leh hun rei tak uluk taka enkawl a ni.

`IPMN` hi cancer a ni fo em?

Ni lo, IPMN zawng zawng hi cancer an ni vek lo . Chu chu hriatthiam hmasak ber tur a ni. Mahse, ṭhenkhat chu a tawpah chuan pancreatic ductal adenocarcinoma (PDAC)-ah an lo chang thei a ni. PDAC hi pancreatic cancer chi khat zingah chuan a tam ber a ni. Pancreatic cancer hi cancer chi khat a ni a, a tlem hle. United States-a cancer awm zawng zawng zinga 3% vel a ni. Mahse, cancer vanga thi zawng zawng zinga 7% chu pancreatic cancer a ni. Vanduaithlak takin a hmaa hriatchhuah a ni lo fo thin a, chutih lai chuan enkawlna a hlawk hle thei a ni.

Hetiang dinhmun hian tute nge a nghawng nasa ber?

Doctor-te tan chuan heng tumor hi mi engzat nge awm tih chiang taka sawi a harsa a, a chhan chu symptoms a siam lo fo a, hriat lohvin a awm fo thin. Mahse, zirchianna hrang hrangah chuan mipa kum 50 leh 70 inkar ah an tam ber tih hmuhchhuah a ni .

He `(IPMN)` hmang hian taksaah eng nge thleng?

IPMNs chhungah hian jelly ang maia tui thuk tak a awm a. Doctor te chuan mucin an ti a. Heng normal, cancer ni lo tumor te hi cancer ah an chan tan chuan he fluid mucin an tih hi an siam tam tan thin. Balloon te tak te tuiin a khat ang maiin han ngaihtuah teh. He mucin hi a lo punkhawm chuan i pancreas chhunga pancreatic ducts te chu a block thei a ni. Heng duct te hi tube te tak te te an ni a, ei tur digest thei an ni. An block chuan pancreas inflammation (pancreatitis) a thlen thei a ni .Hei hi dinhmun hrehawm tak a ni thei. A châng chuan he pancreas inflammation hi IPMN symptom hmasa ber a ni.

IPMN natna lan chhuah dante chu engte nge ni?

Hetiang natna vei tam tak hian natna an nei lo va, symptom bik pawh an nei lo. Chu chu he thila buaina chu a ni. A tam zawkah chuan he tumor chi hi chu an natna dang an neih leh neih loh an enfiah laiin an hmuchhuak mai mai a ni. Mahse, mi thenkhat chuan symptoms an nei thei a, chungte chu:

• Intermittent stomach pain: Mi thenkhat chuan chaw ei zawhah pum na an nei thei. Hei hian ei duhna a tichhe thei bawk.
• Tum loh taka taksa rihna tihtlem: Tum lovin i taksa rihna tihtlem chuan chu pawh chu a chhinchhiahna a ni.
• Nausea leh luak chhuak.
• Hnung lam natna.
• Oily poop/stool: Thlalak chu oil angin a lang a nih chuan.

A chang chuan heng tumor te hian natna dang ang bawkin symptoms a nei thei bawk. Entir nan:

• Jaundice: Bile ducts block vangin vun a sen thin.
• New-onset diabetes: Pancreas ngei pawh a chhiat avangin thisen sugar level sang.
• Pancreatitis: Pancreatic ducts block avanga lo awm a ni.

IPMN hi eng thilin nge a thlen?

Zirchiangtute chuan IPMNs hi kan cells thanna controltu emaw, tumor lo awm tur venna emaw genes-a inthlak danglamna (mutations) a awm hian a lo awm niin an ngai. Chumi awmzia chu kan taksa invenna (defence system) \henkhat chu a chak lo \hin tihna a ni. Chhungkaw zinga mi tu emaw chuan pancreatic cancer (PDAC) , a vei tawh a nih chuan , chu chhungkaw member dangte chu IPMN vei theihna chance a sang zawk a ni.

Engtin nge doctor-te hian hei hi an hriat chhuah?

Doctor-te hian `(IPMN)` an hriat theih nan `(imaging)` test hrang hrang an hmang ber. Chung zingah chuan test bik `Magnetic Resonance Cholangiopancreatography (MRCP)` tih hi a pawimawh hle. Hei hi `(MRI)` machine hmanga test a ni. Hei hian i liver, bile ducts, gallbladder, pancreas leh pancreatic ducts te thlalak chiang tak tak a la thei a ni. Doctor-te chuan he test hi an hmang a, pancreatic ducts-ah hian danglamna a awm em tih an enfiah thin.

Heng ``(IPMN)`` tumor te hi chi thum ah then an ni a:

• Main duct type (MD-IPMN): Hengte hi i pancreas main duct block tu tumor an ni. Hei hian main duct chu a lian thei a, a tizau thei bawk. Main duct diameter hi millimeter 3.5 vel a ni tlangpui. Millimeter 5 aia lian a nih chuan cancer a nih a rinawm zawk tih chhinchhiahna a ni thei.
• Branch duct type (BD-IPMN): Hengte hi tumor ang chi, main duct atanga branch chhuak, branch ang chi duct te tak tea lo awm thin an ni. Heng tumor te hi a tlangpuiin benign an ni .
• Mixed type (MT-IPMN): Hengte hi pancreas main leh branch duct-a lo awm tumor an ni.

`IPMN` hriat theihna tur test dang a awm em?

Ni e, test dang pawh a awm. Doctor-te pawhin Endoscopic Ultrasound (EUS) tih test an ti thei bawk. Hei hian pancreas leh tumor thlalak chiang tak tak a la thei a ni. He test neih chhung hian tumor sample te tak te, Fine-Needle Aspiration (FNA) an tih chu lak theih a ni (biopsy). Chumi hnuah sample chu microscope hmangin an enfiah a, cell chi hrang hrang (dysplasia) (cells te chu a pangngai lo angin an lang em) an enfiah a, cancer a nih theihna tur genetic test hmangin an enfiah bawk.

`Dysplasia` tih hi eng nge ni? Engvangin nge a pawimawh?

``Dysplasia'' tih awmzia chu microscope hmanga en chuan i cell te chu a pangngai lo angin a lang tihna mai a ni.

• ``High-grade dysplasia'' tih hian i cell te chu cell hrisel aiin cancer cell ang deuh an ni tihna a ni. Chu chu risk a sang zawk tihna a ni.
• Low-grade dysplasia tih awmzia chu cell thenkhat chu cancer cell ang deuhin an lang a, mahse cancer-a an chan theihna chance a tlem hle niin an ngai.

Doctor-te chuan a dinhmun (dysplasia) chungchang leh tumor genetic information hmangin IPMNs hi chi li-ah an thliar hrang a ni. Hei hi thupui thuk deuh a ni a, mahse a awlsam zawngin ka sawi ang:

1. Gastric-type IPMNs: Hengte hi pancreas branch ducts-ah an lo awm tam ber. A tlangpuiin low-grade dysplasia an nei thin. Hetiang tumor nei zinga 90% aia tam chu an hmuhchhuah atanga kum 10 hnuah an dam tawh a ni.

2. Intestinal-type IPMNs: Hengte hi pancreas main leh branch duct-ah te hmuh tur a awm. High-grade dysplasia an nei thei a, a tawpah chuan pancreatic cancer-ah an chang thei bawk. Hetiang tumor nei zinga 70% vel chu an hmuhchhuah atanga kum 5 hnuah an dam leh thin. He percentage hi kum 10-ah 50%-ah a tlahniam a ni.

3. Pancreatobiliary-type IPMNs: Hengte hi main leh branch duct-ah pawh hmuh tur a awm a, high-grade dysplasia an nei bawk. Hetiang tumor nei zinga 80% thleng hian invasive pancreatic cancer an vei thei a ni.

4. Oncocytic-type IPMNs: Hengte hi tumor chi khat, a tlem hle. Pancreatic duct bulpuiah an lo thang lian a, high-grade dysplasia an nei bawk. Hetiang tumor nei zinga a chanve vel chuan invasive pancreatic cancer an vei ang.

Pawimawh: Heng classification leh statistics te hian hlauthawng suh. Hengte hi thu tlangpui chauh a ni. I dinhmun dik tak chu i doctor chauhin a hrilh thei che a ni.

IPMN te hi engtin nge an enkawl?

If an IPMN is considered low risk , doctor-te chuan tumor hi ngun taka enkawl chhunzawm zel turin an rawt fo thin.Hei hi a chhan chu benign (IPMN) tumor tam zawk hi cancer a nih loh vang a ni. Mahse, i pancreas main duct-ah tumor i nei a, chu chu i risk sang deuh tihna a nih chuan, i doctor chuan tumor lakchhuah nan operation neih a rawt thei ang. Entirna thenkhat chu hetiang hi a ni:

• Distal pancreatectomy: Hei hian pancreas tail leh/ emaw taksa chu lakchhuah a ni. He surgery hi chu hmuna main ducts-ah tumor a awm chuan tih a ni.
• Total pancreatectomy: Hei hian pancreas zawng zawng, gallbladder, common bile duct, pum leh small intestine thenkhat, leh a tam zawkah chuan spleen te lakchhuah a ni. Hei hi operation lian tak a ni.
• Whipple procedure (pancreaticoduodenectomy): He surgery hi pancreas lu main ducts (pancreas leh small intestine inzawmna hmun zau ber)-a tumor awm tan chuan a tha thei ang. Pancreas lu, small intestine (duodenum) hmun hmasa ber, gallbladder, bile duct thenkhat leh a bul hnaia lymph node te lakchhuah a ni.

He surgery avanga harsatna awm thei te chu engte nge ni?

Surgery lian dang ang bawkin harsatna awm thei a awm bawk. Mi zawng zawng dinhmun a inang vek lo. Chuvangin, i doctor hnenah harsatna bik i tawh theih dan zawt la a tha ber.

Hetiang operation hnu hian eng chen nge a dam leh theih?

Hei hi mi tin a inang lo. Mahse, mi tam zawk chuan pancreatic surgery an neih hnuah ni engemaw zat damdawi inah an awm a ngai a ni. A dam kim theih nan kar tam tak emaw thla tam tak emaw a ngai thei.

Operation hnuah chemotherapy emaw radiation therapy emaw ka la tur em ni?

Zirna thenkhatah chuan operation hnuah chemotherapy leh/ emaw radiation therapy hian a pui thei tih hmuhchhuah a ni. Mahse, a enkawlnate hian a side effects pawh i ngaihtuah tel tur a ni. A châng chuan a side effects hian enkawlnate hlawkna a tluk pha thei bawk. Hemi chungchang hi doctor zawt la.

Ka doctor chuan `IPMN` chu enfiah turin a ti a. Chu chu eng nge a awmzia?

Hei hian i test-naah i IPMN chu benign a ni a, cancer a nih a rinawm loh tihna a ni. Doctor-te chuan heng benign tumor te hi imaging test (MRCP ang chi) hmangin an enfiah chhunzawm zel dawn a ni. Hei hian, "Hei hi i lo thlir reng ang u, eng emaw a danglam em tih i en ang u" tihna a ni.

IPMN ka vei theihna tur tihtlem nan eng nge ka tih theih ang?

Zirchiangtute chuan heng tumor te hi genes inthlak danglamna avanga lo awm niin an ngai. Chuvangin IPMN lo awm tur venna tur bik i tih theih a awm lo. Mahse, a hnuaia thilte hian pancreatic cancer i vei theihna zawng zawng tihtlem nan leh IPMN i vei theihna tur tehna atan a pui thei che a ni:

• I chhungte damdawi lam chanchin zir rawh.I chhungkuaa mi tu emaw chuan pancreatic cancer (PDAC) a vei tawh a nih chuan IPMN vei theihna i nei sang zawk a ni.
• Pancreatic cancer hi meizuk nen a inzawm tlat a ni. Zuk leh hmuam (cigarette, beedis, cigar) i hman chuan tihtawp tum ang che.
• Zu in kha tihtlem la, a nih loh leh zu in kha titawp vek rawh.
• I taksa rihna hrisel tak neih tum ang che.
• Type 2 diabetes hi ei leh in hrisel leh exercise hmanga ven tum ang che. Zunthlum i vei chuan i thisen sugar level control turin doctor nen thawk ho ang che.

IPMN nen hian eng chen nge i dam theih ang?

Cancer dang ang bawkin, damchhuahna atana thil pawimawh ber chu a hmaa hriatchhuah leh enkawl hi a ni. A pum puiin, IPMN chu pancreatic cancer-a a lo chan hmaa hmuhchhuah leh enkawl zinga 95% vel chu an hmuhchhuah atanga kum nga hnuah pawh an la dam reng a ni. I dinhmun chungchanga zawhna i neih chuan i doctor hi a tha ber a ni.

IPMN benign ka nei a. Engtin nge ka in enkawl ang?

A tam zawkah chuan heng tumor te hi cancer an ni lo. Mahse, "A ni mai thei" tih ngaihtuahna avanga stress leh lungkhamna awm hi thil pangngai a ni. Hetiang hian i inhriat chuan i doctor nen inbia ang che. Pancreatic cancer vei theihna chance tlem i neih chhan a sawifiah ang. Tin, pancreatic cancer vei theihna zawng zawng tihziaawmna tura i tih theih turte pawh a hrilh bawk ang che.

Intraductal Papillary Mucinous Neoplasm (IPMN) hi pancreatic ducts-a lo awm, pancreatic cancer ni thei tur tumor hming sei tak, a chang chuan a buaithlak hle. He tumor hian a tlangpuiin symptom a nei lo va, chhan dang avanga test an tih laiin accident-in hmuhchhuah a ni fo bawk.

I doctor-in IPMN i neih thu a hrilh che chuan i mangang mai thei. Mahse, he natna hi i neih hian cancer i vei ngei ang tihna a ni lo tih hre reng ang che. A tam zawkah chuan test dang neih belh leh chuan lump hi cancer (benign) a ni lo tih a chiang ang. I lump hi cancer a nih loh chuan i doctor chuan high-risk a nih leh nih loh a enfiah chhunzawm zel ang. Tin, a pawimawh ber chu, i lump hi high-risk nia hriat ni mah se, IPMN hmuhchhuah leh cancer a nih hmaa enkawl tawh zinga 95% vel chu hmuhchhuah a nih atanga kum nga hnuah pawh an la dam reng a ni.

I dinhmun chu eng pawh ni se, pancreatic cancer vei theihna tur tihziaawmna tur thil i tih theih a awm. Hemi chungchang hi i doctor nen inbia ang che. Amah/ani chuan lawm takin a pui ang che.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Okay, chuvangin tunah chuan kan sawi thin, ``(IPMN)`` hi hriatthiamna tha zawk in neih ka beisei. Hei hi thupui buaithlak deuh mahse, awlsam taka hriatthiam tum ila.

• IPMN chu pancreas ducts-a lo awm, cancer thlen theihna a ni . An vai hian cancer an ni vek lo.
• A tam zawkah chuan symptoms a lantir lo va , test dang neih laiin accident-in hmuhchhuah a ni.
• He natna hi `(MRCP)` leh `(EUS)` ang chi test hmanga hriat theih a ni.
• Enkawlnaah hian enfiah emaw, operation emaw pawh a tel thei a, chu chu tumor chi leh nasat dan azirin a ni.
• A hmaa hriatchhuah leh enkawl hi a pawimawh ber a ni.
• IPMN i nei tih an hrilh che chuan hlauthawng suh. I doctor nen inbia la, i dinhmun atana enkawl dan tur tha ber tur chu rel rawh.
• Tin, nunphung thlak danglam (meizuk bânsan, taksa rihna hrisel neih, etc.) te pawh ngaihtuah bawk la, chu chuan pancreatic cancer hlauhawmna a ti tlem thei a ni.

Hemi chungchanga zawhna dang i neih chuan doctor zawt hreh suh. Hrisel takin awm rawh!

` Pancreas, IPMN, Cancer, Pancreatic Cancer, Tumor, Symptoms, Enkawl dan