I taksa pum puiah hian allergy i nei fo em, i taksaah hmun sen leh i chet chhuak fo thin em? Hei hi Mastocytosis a ni thei!

I taksaah hian vun sen, itchy, leh a chang chuan na tak tak i nei fo em? A nih loh leh thil tenawm ber pawh ni tam tak chhung chu allergy na tak i nei em? "Allergic reaction dang ka nei leh ta" tih i ngaihtuah mai thei. Mahse, a chang chuan heng symptoms hnung lamah hian kan hriat ngai loh natna awm lo tak a awm thei. Chutiang dinhmun pakhat chu `(Mastocytosis)` a ni. A hming hi a mak deuhin a lang thei a, mahse a awlsam zawngin sawi ila.

Mastocytosis chu eng nge ni? A awlsam zawngin...

Ngaihtuah teh, kan taksa chhungah hian security guard te tak te ang maia cell a awm a. ``Mast cells`` kan ti a. Heng ``mast cells`` te hi kan ``immune system``- a tel an ni.`` Kan ram security force ang mai an ni. Hmelma hrik, bacteria, leh allergen te taksaah an luh chuan heng ``mast cells`` te hi an rawn lang chhuak a, an indo thin.

Heng `(mast cells)` te hian hmelma te an chhan let hian chemical `(histamine) an tichhuak thin.` He `(histamine)` hian kan taksaah allergic symptoms (entir nan, itching, vun sen, swelling) a thlen thin. Heng `(mast cells)` te hian pum chhungah acid siamchhuah nan a pui bawk.

A tlangpuiin heng `(mast cell)` te hian an hna an thawk a, hmelma te chu an thunun a, chutah chuan an ngawi leh thin. Amaherawhchu, `(Mastocytosis)` vei taksaa thil thleng chu heng `(mast cells)` te hi a pangngai lo leh thunun theih loh khawpa pung hi a ni. Hetianga an pung hian heng cell-te hian `(histamine) an chhuah tam lutuk a ni.` Chu chu thil tenau ber pawh allergy lian tak i neih lai a ni a, a nih loh leh allergy i neih chuan mi pangngai aiin a na zawk a, a daih rei zawk bawk.

A pawimawh ber chu, Mastocytosis vei zawng zawng hi anaphylaxis , allergic reaction rang tak, na tak, leh nunna atana hlauhawm thei tur an vei theihna a sang zawk a ni. Hei hi kan hriat chian a pawimawh hle a ni.

Doctor-te chuan Mastocytosis hi an tidam kim thei lo nain, a natna lan chhuah dan chu an thunun thei a, harsatna lo awm thei apiang an enkawl thei bawk.

Mastocytosis chi hrang hrangte chu engte nge ni?

He natna hi chi hnih a awm a, chungte chu:

1. Cutaneous Mastocytosis: Hei hi naute leh naupang tê têah a awm tlangpui . Mahse, puitlingah pawh a awm thei. Heta thil thleng hi vunah ``mast cell`` pangngai lo tak tak a awm khawm a, chu chuan itchy red, dark red, brown, emaw mixed-color blisters leh spots a siam thin. Naupang te tak te pakhatin an taksaah hmun sen tam tak a neih thut a, an hrual chhunzawm zel ang mai a ni.

2. Systemic Mastocytosis: Hetiang chi hi puitlingah hmuh tur a tam ber.Hetah hian ``mast cells`` pangngai lo tak takte chu ruh chhunga taksa peng hrang hrang, ruhro, ruh, kan chaw ei dan, leh lungah te an pung khawm thin. Ngaihtuah teh, heng cell-te hi ruhroah hian a tam lutuk a nih chuan kan thisen cell siam dan a nghawng thei a ni. Tin, heng cell te hi pum chhungah an pun chuan pum acid an siam tam lutuk a, pumpuiah ulcer an siam thei bawk.

Hei hi natna tlanglawn tak a ni em?

Ni lo, hei hi a takah chuan thil awm lo tak a ni. Survey atanga a lan dan chuan mi sang sawm (10,000) zinga pakhat emaw, sang sawmhnih (20,000) zinga pakhat chauhvin he natna hi an vei niin an sawi. Chuvang chuan mi zawng zawngin kan hriat loh hi thil pangngai a ni.

Mastocytosis natna lan chhuahna awm thei te chu engte nge ni?

Heng ``mast cells`` te hi a pangngai lo taka an pung zel hian symptom hrang hrang a awm thei a ni. Heng symptoms te hi mi thenkhat tan chuan a na lo hle thei a, mahse thenkhat tan chuan a na thei hle.

• Ruh natna: I ruh na ang maia inhriatna.
• Diarrhea (ril na): Bathroom-a kal fo a ngai.
• Fainting (like losing consciousness): Vawikhatmah mit chu a rawn sen a, i hriatna hloh ang maiin i lang.
• Lungkhamna leh hlauhna awm reng: Chhan awm lova lungkhamna nei.
• Flushing: Taksa zawng zawngah vun a sen nghal vek.
• Itchy blisters or spots on the skin: Kan sawi tawh ang khan.
• Lu na: Lu na fo thin.
• Thisen sang hniam vanga luak chhuak: Ding atanga ding chhuakin luak chhuak tih hriatna.
• Joint pain: Ruh natna.
• Vunah a sen emaw, a sen emaw a awm: Hengte hi a na thei a, a na lo thei bawk.

Kum engzat nge Mastocytosis hi a intan?

Natna chi hrang hrang a zirin a danglam thei. A tlangpuiin:

• Cutaneous Mastocytosis: Hei hian nausen piang tharte pawh a nghawng thei a ni.
• Systemic Mastocytosis: Puitling kum 50 chunglam a vei tam ber.

Hei hi eng nge a chhan?

`(Mastocytosis)` hi kan pianpui thil a ni lo. `(KIT genes)` an tih genes mutations avanga lo awm a ni. Heng `(KIT genes)` te hi cell chi hrang hrang, kan thisen cell, `(mast cells)` te tihpunna tura puitu gene an ni. `(Mastocytosis) ah chuan heng mutated `(KIT genes)` te hian `(mast cells)` hnenah "a pung nasa lutuk a, thunun theih lohvin an thang lian" tih signal dik lo an pe thin.

Mastocytosis thlentu (triggers) te chu engte nge ni?

Hei hi mi tin a inang lo thei. Mi zawng zawng hian trigger inang an nei vek lo. Mahse, a tlangpuiin natna lan chhuahna tipung thei thil thenkhat a awm a:

• Vun hrual emaw, hrual emaw: Hei hi mi thenkhatah pawh thawmhnaw tight tak hak chauhvin a thleng thei bawk.
• Exercise leh taksa tihchak lutuk.
• Insect-in a seh emaw, a seh emaw:A bik takin rannung, rulhut, rulhut, leh rulhut te.
• Zu in a in thin.
• Chaw thenkhat: A bik takin chaw tui tak, tui tak tak.
• Damdawi thenkhat: Entirnan, natna tidamtu ``NSAIDs`` (Nonsteroidal anti-inflammatory drugs) an tih te, taksa ruh tichaktu te, leh anesthetics ``(anesthesia)`` te.
• Temperature inthlak danglam nghal: Tui lum takah zuang lut ang mai.
• Taksa emaw rilru lama harsatna: Hei hian nghawng lian tak a nei fo thin.

Mastocytosis natna avanga harsatna awm thei te chu engte nge ni?

He natna hian hriselna lama harsatna dang a thlen thei a, chung zingah chuan:

• Osteoporosis: Hei hian ruh a tichak lo va, awlsam takin a tikehsawm thin.
• Liver problems: Liver a lo hring chhuak a, hna a thawk tha lo.
• Cytopenia: Taksain thisen cell tha tawk a siam chhuah theih lohna.
• Hri kai fo thin.

Engtin nge Mastocytosis hi an hriat theih?

I doctor chuan i symptoms te a zawt ang a, i vun a enfiah ang. Chu bakah, test an ti thei bawk a, chungte chu:

• Thisen test: I thisenah enzyme pakhat ``tryptase`` an tih level enfiah thin ang che. He ``tryptase`` hi ``mast cells`` te hian hmelma an chhanlet hian an chhuah thin a ni.
• Bone scan: Ruh a chhiat leh chhiat loh enfiah nan.
• Bone marrow biopsy: Bone marrow sample lak a, mast cell pangngai lo awm leh awm loh enfiah a ni.
• Genetic tests: Systemic Mastocytosis i neih chuan KIT genes-a mutations awm leh awm loh test theih a ni.

Mastocytosis enkawlna tur engte nge ni?

Natna chi leh i natna lan chhuah dan azirin enkawlna kawng hrang hrang a inang lo. Doctor-te chuan natna lanchhuahna tihziaawm nan damdawi leh enkawlna dang an hmang tlangpui.

Mastocytosis atana damdawi hman chi hrang hrang:

• Pum natna atana anticids (H2 blockers): Pum natna leh gastritis ang chi thil atan.
• Antihistamines: Vun allergic symptoms, itching leh redness te a tiziaawm.
• Bisphosphonates for osteoporosis: Ruh tichaktu.
• Corticosteroids: A hring (swelling) a tihziaawm.
• Monoclonal antibodies: a bik takin damdawi omalizumab (Xolair®) ang chi te.
• Natna damdawi .

Enkawlna dang: 1.1.

• Ultraviolet (UV) light therapy: Vun chunga hmun dum awmte tihziaawmna.
• Targeted therapy hmanga enkawlna .
• Anaphylaxis natna atana hman tur epinephrine:Allergy na tak nei tan emergency treatment.
• Chemotherapy: Hei hi a tlem hle a, Mastocytosis chu cancer-ah a chantir chauhvin pek thin a ni.
• Allogeneic stem cell (bone marrow) transplantation: Hei hi mastocytosis natna khirh tak, buaithlak tak takah pawh ngaihtuah a ni. Mi tam zawk chuan hei hi an mamawh lo.

Enkawlna hian harsatna emaw, side effect emaw a nei em?

Ni e, enkawlna dang ang bawkin, Mastocytosis enkawlnaah hian side effect engemaw zat a awm thei. Ṭhenkhat chu tê tê an ni thei a, ṭhenkhat erawh chu a pawi zâwk thei bawk. Mastocytosis i vei chuan i doctor chuan i enkawlna tur leh a side effect awm thei te a hrilhfiah ang che.

Mastocytosis hi a dam kim thei em?

A tlangpuiin Mastocytosis hi natna, tihdam kim theih loh anga ngaih a ni a, mahse a natna lan chhuah dan control leh complication enkawl hmanga enkawl theih a ni

Hei hi damdawi awm thei awmchhun chu a hmaa kan sawi tawh ``allogeneic stem cell (bone marrow) transplantation'' hi a ni. Mahse, chu pawh chu natna khirh ber leh buaithlak ber nei damlote tan chauh a tha.

Hun kal zelah Mastocytosis hi a na zual em?

Enkawl loh chuan hun kal zelah a natna lan chhuah dan chu a na zual thei a, a bik takin systemic mastocytosis vei tan chuan mast cell pangngai lo tak takte hian ruhro leh chhungril taksa peng hrang hrang a nghawng chhunzawm zel avangin.

Mastocytosis hi ven theih a ni em?

Vanduaithlak takin, ni lo. KIT genes-a mutations avanga lo awm a nih avangin ven dan tur a awm lo. Mahse, Mastocytosis i neih chuan i allergic reaction tichhuaktu dik tak hriat a, a theih ang anga pumpelh a, i symptoms te chu i control thei a ni.

Entirnan, damdawi thenkhat trigger i neih chuan a list-a medical alert bracelet i bun a tha. Hei hian emergency a nih chuan eng damdawi nge i ei loh tur tih midangte a hriattir ang.

Systemic Mastocytosis i neih chuan epinephrine awmna self-injecting syringe keng reng a pawimawh. Hei hi allergy na tak, nunna atana hlauhawm, anaphylactic shock ang chi enkawlna atan hman theih a ni.

Engtin nge ka in enkawl ang? (Mastocytosis) A nunpui lai hian...

Mastocytosis hi natna tihdam kim theih loh a nih avangin hun engemaw chen chu i nunpui a ngai mai thei. Harsatna a awm thei. Mahse, i tanpui thei tur thil thenkhat chu hetiang hi a ni:

• I symptoms tichhuaktu chu chiang takin hria ang che.Mi tin trigger hi a inang lo vek. Diary-ah i dah duh mai thei a, i natna lan chhuah dan a nasat hun te, i ei leh in te, chutih laia i thil tih te chu i ziak chhuak duh mai thei.
• Stress hian heng symptoms te hi a ti na zual thei a ni. Stress enkawlna atana tanpuina i mamawh chuan i doctor hnenah stress management program chungchang zawt rawh. Meditation leh yoga ang chi thilte hian a pui thei ang.
• Medical alert bracelet vuah tur a ni. I damdawi lam dinhmun leh i ei loh tur damdawi eng pawh a tarlang tur a ni.
• Epinephrine auto-injector needle keng reng ang che. Allergy na tak a awm chuan nunna chhanhim thei a ni.

Engtikah nge ka doctor ka hmuh ang?

I doctor hnenah checkup reng reng i nei ang. I natna lan chhuah dan an enfiah ang a, a tul chuan i enkawl dan pawh an thlak danglam ang. Symptom thar i neih chuan, a nih loh leh i symptom a na zual a nih chuan doctor hnenah hrilh nghal rawh.

Engtikah nge Emergency Room-ah ka kal ang?

Damdawi hmanga thunun theih loh allergy na tak i neih chuan emergency room-ah kal nghal rawh. Chu chu thawk harsa, kawr khauh, luak chhuak nasa tak, hriatna hloh ang chi symptoms i neih chuan a ni.

Doctor hnenah eng zawhna nge ka zawh ang?

Mastocytosis i vei chuan doctor hnenah hetiang zawhna hi zawh a tha ang:

• Eng ang Mastocytosis nge ka neih?
• Ka neih chi hrang hrangte tan hian eng enkawlna nge awm?
• Enkawlna hian ka natna lan chhuah dan chu a ti bo vek dawn em ni?
• Eng symptom dang nge ka dinhmun a chhe zual zel tih tilang thei?
• Chatuan atan enkawlna ka lak a ngai dawn em ni?
• Form milder ka neih chuan ka prognosis chu eng nge ni?
• Clinical trial ka tel theihna tur a awm em?

A tawp berah chuan hriat reng tur (Take-Home Message) .

Mastocytosis hi thil awm lo tak a ni a, taksaa mast cells te chu a pangngai lo va, thunun theih lohvin a lo thang lian thin. Vun leh chhungril lam a nghawng thei a ni. Mi tam zawk chuan an symptoms te chu triggers te hriatchhuah leh pumpelh leh damdawi ei hmangin an enkawl thei a ni. Tin, allergy na tak enkawlna atan epinephrine injection hi kutphah taka dah a pawimawh bawk.

Hei hi a dam kim theih loh natna ni mah se, damdawi lam thurawn leh enkawl dan mumal tak nen chuan a natna lan chhuah dan thunun tum a, nun pangngaia nun i tum thei a ni. Hemi chungchanga zawhna dang i neih chuan doctor nen inbiakna neih hreh suh. An pui ang che.

` Mastocytosis, mast cells, histamine, allergy, vun natna, immune system, anaphylaxis