Kan nerve te hi poison a ni thei ang em? Neurotoxicity chungchang hi han sawi ila!

A chang chuan chhan awm lovin i lu a buai thin em? I taksa pengte chu a hring vek em? A nih loh leh i hriatrengna chu a chhe zual ang maiin i hria em, a nih loh leh i rilru hmun khata dah harsa i ti em? Hetianga kan tih chhan pawh hi kan ngaihtuah ngai loh thil a ni maithei. Chu chu neurotoxicity a ni a, a nih loh leh damdawi lam hawia kan sawi angin neurotoxicity . Vawiin hian he thu hi chipchiar deuhin han sawi ila, a tha em?

A awlsam zawngin, neurotoxicity chu eng nge ni?

Neurotoxicity chu kan thawkna boruak, kan tui in, kan ei leh in leh kan thil hman thenkhatin kan nervous system a tihchhiat hian naturally occurring or human-made toxins ( neurotoxicants an tih) a ni. Kan nervous system hi network complex tak a ni tih i hria em? Kan thluak, kan ruhro, leh kan taksa pum puia nerve te a huam a ni . Hengte hi kan ngaihtuahna, kan tih, kan sawi, leh kan hriat zawng zawngte thununtu an ni.

Chuvangin, heng toxins te hian nervous system hnathawh dan a tidanglam thei a ni. Hêng inthlâk danglamnate hi a châng chuan a tê tê pawh a ni thei a, a châng chuan a na hle thei bawk . Inthlâk danglamna ṭhenkhat chu enkawl leh tihdam theih a nih laiin, ṭhenkhat chu dam chhûng zawng a ni thei. A chhe berah chuan he neurotoxicity hian thihna pawh a thlen thei a ni . Chu chu a hlauhawm êm êm tih han ngaihtuah teh!

A châng chuan, a tlangpuiin kan toxic lo thil, entirnan, damdawi ṭhenkhat pawh hi ei tam lutuk chuan neurotoxicity a thlen thei a ni. A nih loh leh, thil thenkhat, lead ang chi, a tlem berah pawh toxic thei a awm bawk.

He neurotoxicity hi nausen lo thanglian lai , naupang lo thanglian lai emaw puitling lai emaw a awm thei a ni . Mahse, nausen leh naupan laia heng toxins te hi a inhriat tawn avanga chhiatna thleng hi a tam zawk tlangpui. Tin, natna thenkhat nei, entirnan, jaundice (hyperbilirubinemia) emaw, Charcot-Marie-Tooth Disease (CMT) ang chi natna nei te pawhin he neurotoxicity hi an vei theihna a sang zawk bawk.

Heng neurotoxicants te hi engte nge ni?

Dik tak chuan heng nerve agents hi chi za tam tak a awm a. Gaseous, liquid, solid form-ah pawh an awm thei. Toxin thenkhat chuan a tlem lutuk pawhin, vawi khat a inhriat hnuah pawh natna lanchhuahna a thlen thei a ni. Midang erawh chuan symptoms siam nan a tam leh rei tak exposure an mamawh thung.

Entirna thenkhat chu hetiang hi a ni:

• Heavy metals: Entirnan, lead, mercury te hi a ni.
• Thilsiam dangte: Entirnan, mold thenkhat atanga carbon monoxide, arsenic, leh trichothecene mycotoxins te.
• Insecticide tih hi: 1.1.Entirnan, `(organophosphates)` leh `(chlorpyrifos)` te hi a ni. Hengte hi kan lo neihnaah kan hmang thin a ni lawm ni?
• Factory leh tihfai nana thila hmuh chhuah solvent: Entirnan, `(tetrachloroethylene)`.
• Thil siamna hmanrua: Entirnan `(vinyl chloride)`, `(toluene)`, `(formaldehyde)` leh `(polybrominated diphenyl ethers) (PBDEs)` te hi a ni.
• Ruihhlo leh Zu: Zu, Amphetamines, Opioids, Inhalants, leh Cocaine te.

Kan hormone system tichhe thei chemical chi hrang hrang, Endocrine-disrupting chemicals (EDCs) an tih te pawh a awm bawk. Entirnan Bisphenol A (BPA) (plastic thenkhatah hmuh tur), phthalates, leh polychlorinated biphenyl compounds (PCBs) te hi a ni. Hengte hian indirect takin neurotoxicity a thlen thei a ni.

Damdawi leh neurotoxicity inzawmna

Damdawi thenkhat, entirnan, antibiotics thenkhat leh antipsychotics thenkhat phei chuan chhan hrang hrang avangin neurotoxicity a thlen thei tih i hria em? Mahse , a tam zâwk chuan, heng damdawite hlâwkna hian neurotoxicity hlauhawmna aiin a tam zâwk daih a ni . Chuvang chuan doctor ten uluk takin an prescribe thin.

Damdawi thenkhat, a bik takin cancer enkawlna atana hman te hian neurotoxicity a thlen thei bawk.

• Platinum awmna damdawi: `(oxaliplatin)`, `(cisplatin)`, `(carboplatin)`
• Taxane damdawi: `(paclitaxel)`, `(docetaxel)` tih te hi a ni
• Vinca alkaloids: `(vincristine)`, `(vinblastine)` tih te hi a awm a
• Proteasome tihkhawtlai a ni
• Thalidomide analogs te pawh a awm

Chemotherapy chauh ni lovin, radiation therapy hian central nervous system a tichhe thei a, neurotoxicity a thlen thei bawk.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Dik tak chuan, zirchiangtute tan chuan he natna hi engtiang chiahin nge a awm tih chiang taka sawi a harsa a, nerve agent chi hrang hrang tam tak leh a lan chhuah dan hrang hrangte ngaihtuah chuan. Mahse, zirchiangtute chuan heng nerve agents te kan tawn hi a darh zau hle niin an sawi .

Hei hi a zau zia i hriatthiam theih nan entîrna pahnih ka rawn pe ang che:

• Zirna pakhatah chuan kum tin khawvêl pumah pesticide hmanga accidental poisoning maktaduai 385 vêl a awm tih a târ lang a , chu chuan kum tin mi 11,000 vêl an thih phah a ni.
• Kum tin lead poisoning vangin mi maktaduai khat vel an thi nia chhut a ni bawk . Khawvel puma naupang pathum zinga pakhat – chu chu naupang maktaduai 800 vel a ni – an thisenah lead a tam hle . Hei hi a pawi zia hi han ngaihtuah teh! Lead hi in hluiah paint-ah leh infiamna thenkhatah te hmuh tur a awm.

Eng nge a lan chhuah dan?

Nerve agent poisoning symptoms hi a inang lo thei hle. I toxin chi hrang hrang i tawn danah a innghat. Symptoms hi a na lo atanga a nasat thlengin a awm thei . A châng chuan toxin a inhriat hnuah natna lan chhuahna a lang nghal thei a, a lan chhuah theih nân kar tam tak, thla tam tak, kum tam tak pawh a la ngai thei bawk.

Taksa lama a lan chhuah dan thenkhat chu hetiang hi a ni:

• Balance leh coordination lama harsatna (kal tha thei lo, thil man harsat) .
• Diarrhea (ril a na) .
• Chauhna, hahna
• Lu na
• Chaw chakna
• Natna dinhmun, neuropathic pain ang chi te
• Muscle lama harsatna: chak lohna, cramps, twitching
• Nausea leh/ emaw, luak chhuak
• Ke ruh leh ke ruh (limbs) a natna (numbness) a awm
• Mut inthlak danglamna: mut theih lohna ang chi
• Thusawi harsa, tawng thiam lo (dysarthria) .
• Mit lama harsatna emaw, mit hmuhna hloh emaw

Tunah chuan rilru leh hriatna lama symptoms te hi eng nge ni tih i lo en ang u:

• Nungchang inthlak danglamna emaw harsatna emaw
• Thil hriat theihna tlahniam, entirnan, hriatna lama harsatna (mild cognitive impairment).
• Luak chhuak emaw, ngaihtuahna buai emaw
• Executive dysfunction: Hei hian rilru natna thunun harsa leh ngaihtuahna fim thei lo tihna a ni.
• A hma aia nasa zawka thinrim, chetsualna
• Hriatrengna hloh
• Mood a inthlak danglam thin

A pawimawh ber chu nangmah emaw, i fa emaw chuan an ngaihtuahna, nungchang, rilru put hmang, a nih loh leh taksa hriselnaah inthlâk danglamna emaw, harsatna emaw i hmuh chuan doctor pan hi a ni . Hei hi neurotoxicants vang pawh a ni thei a, mahse a chhan dang a awm thei bawk.

Emergency a awm tih hriattirna symptoms

A châng chuan neurotoxicity hi a rang thei hle a, a na hle thei bawk (acute neurotoxicity). Heng symptoms te hi a lo lang nghal thei a ni. A hnuaia symptoms te hi i neih chuan damdawi in pan nghal tur a ni. 911 (Sri Lanka-ah 1990) call emaw, damdawi in hnai ber pan emaw rawh.

Acute nerve poisoning symptoms te chu:

• Heart rate a inthlak danglam thin
• Confusion emaw delirium emaw a awm
• Thil hriatna hloh
• Psychosis, thil hmuh theih loh (hallucinations) te pawh a tel
• Seizures a awm thin
• Taksa lum leh vawt inthlak danglamna langsar tak (khawsik sang tak (hyperthermia) emaw taksa lumna hniam lutuk (hypothermia)) .
• Muscle chak lohna nasa tak a lo awm nghal
• Mit lama harsatna emaw, mit hmuhna hloh emaw
• Thâwk harsa

Nerve poisoning awm chhante chu engte nge ni?

A awlsam zawngin, a chunga kan sawi tak neurotoxicants te hian kan peripheral emaw central nervous system-a cell te a tihchhiat, a tihdanglam emaw, a tihlum emaw hian neurotoxicity a awm thin. A tam zâwk chuan, hei hian nerve cell, a nih loh leh neurons . I hria em, heng neurons te hi kan thluak, kan ruhro leh kan peripheral nerve-a signal thawn chhuaktu leh process tu ber an ni. Neuron chauh ni lovin, nervous system hmun dangte pawh a chhe thei a, entirnan , nerve khuh tu myelin .

Kan nervous system hi chutiang taka complex system a nih avangin neurotoxicity avanga chhiatna chu kawng hrang hrangin a lang thei a ni. Entirna tlemte chu hetiang hi a ni:

• Kan thluaka chemical pawimawh tak neurotransmitters (entir nan, dopamine) level inthlak danglamna leh an signaling.
• Thluak emaw, ruhro emaw a inflammation, emaw swelling (neuroinflammation).
• Thluaka structure inthlak danglamna, entirnan, thluaka gray leh white matter volume inthlak danglamna.
• Peripheral nerve chhehvela myelin sheath chhiatna.

Nerve agents nena inzawmna nei

Heng nerve agents te hi kan taksaah hian an luh theih dan hrang hrang a awm a:

• Thâwk chhuah hmangin
• Ei emaw in emaw hmangin (i ei leh in atanga) .
• Vun kaltlanga absorption hmangin

Heng toxins te hian nausen a nghawng thei bawk. Naupai laiin heng toxins te hi nu taksaah an lut a nih chuan thisen kaltlangin nausen hnenah umbilical cord hmangin an kal thei a ni . Chuvangin naupai lai hian damdawi thenkhat hi a tha lo hle a, a chhan chu nausen chungah neurotoxic effect a nei thei a ni.

Heng toxins te hi kan thisenah an luh chuan kan thluak venghimtu blood-brain barrier (BBB) ​​an paltlang thei a, central nervous system hmun thenkhat chu direct-in a nghawng thei a ni. A nih loh leh, a hmaa kan sawi tawh EDCs ang bawkin, taksa system dangte tihdanglamna hmangin thluak chu indirect-in a nghawng thei a ni.

Heng nerve agents te hi hmun hrang hrangah i inhmu thei a, a chhan chu heng toxins lo chhuahna hmun hi hmun tinah a darh vek a ni.

• Environment pollution: lirtheia tui chhuak, agriculture atanga emission, factory atanga emission.
• Tualchhung boruak bawlhhlawh: Park, sikul ang chi hmunah emaw, chu lai hmuna chemical accident atanga lo chhuak emaw a ni.
• Inchhung bawlhhlawh: Inchhung bungrua thenkhat, ei leh in atanga lo chhuak. Entirnan, faina tui thenkhat, insect spray leh paint te.

Eng harsatna nge awm thei?

Neurotoxicant thenkhat hian chronic neurological conditions a thlen thei tih kan sawi tawh a . A nasat chuan thihna pawh a thleng thei.

Neurotoxicant thenkhat, a bik takin nausen pian tirh leh naupan lai te hi a hnuaia thil engemaw zat nen a inzawm tih hmuhchhuah a ni:

• Attention-deficit/hyperactivity disorder (ADHD) a awm a, a rilru a hah lutuk a, a rilru a buai em em bawk a.
• Zirna lama harsatna nei te
• Lungngaihna
• Hlauhthawnna
Schizophrenia-rilru lam `(Schizophrenia)`
• Autism spectrum disorder (ASD) a awm a, a rilru a buai em em a, a rilru a hah em em bawk a.

Mahse hei hian neurotoxins exposure leh heng conditions te inzawmna a tilang chauh tih hriat reng a pawimawh. Researcher te hian heng toxins te hian direct takin heng natna hi a thlen em tih hi chiang takin an la hre lo. Heng neurotoxins te hian nghawng leh harsatna awm thei zawng zawng an zirchiang chhunzawm zel a ni.

Engtin nge hei hi i hmuh? (Diagnosis) tih a ni.

Nerve agent chi za tam tak a awm avangin leh nerve agents symptoms pawh a inang lo hle a, diagnosis atan chuan test leh exam engemaw zat a ngai thei a ni. I doctor chuan i symptoms leh medical history te a zawt hmasa ang che . Tichuan taksa leh thluak exam an nei leh ang.

Chu bakah, a hnuaia test te hi tih a tha thei bawk:

• Thiltih dan tehna
• Thisen test a ni
• Thil hriatna (cognitive test) te
• Electroencephalogram (EEG) hmanga chhut a ni.
• Mit enfiahna a ni
• Imaging test te, thluak MRI scan ang chi te
• Nerve kalpui dan zirchianna leh electromyography (EMG) hmanga zir chian a ni.
• Neuropsychological test leh assessment neih a ni
• Cerebral spinal fluid (CSF) hmanga thluak (Spinal tap / Lumbar puncture) hmanga thil tih dan (Spinal tap / Lumbar puncture) te enfiah a ni.

A then phei chuan doctor-te chuan neurotoxicity symptoms awm chhan dik tak an hmu thei lo mai thei .

Enkawlnate chu engte nge ni?

Enkawl dan tur chu i natna lan chhuah dan leh a thlentu neurotoxin chi hrang hrangah a innghat nasa hle. Enkawlnaah chuan toxin nena inzawmna tihbo emaw, tihtlem emaw a ni tlangpui a, chutah chuan a natna lan chhuah dan enkawl emaw, enkawl emaw a ni .

Eng ang thlirna nge ni ang? (Prognosis) tih a ni.

Neurotoxicosis vei tan chuan thil tam takah a innghat a, chung zingah chuan:

• Eng ang nerve agent nge a lo chhuah?
• Exposure engzat nge awm?
• Eng chen nge exposure a nih?
• Nervous system hi engzat nge chhiatna a thlen tawh?
• I kum leh i hriselna zawng zawng

Nerve agent thenkhat nena inzawm hian thihna a thlen thei a ni. A then phei chuan, chu exposure chu nunna atana hlauhawm tak ni mahse, nervous system chu a lo harh chhuak kim lo thei a ni. Thil dangah chuan enkawl hnuah dam kim theih a ni.

Engtin nge hei hi i pumpelh theih ang? (Invenna) 1.1.

Dik tak chuan, nitin nunah heng nerve agents te hi an darh zau zia ngaihtuah chuan, an vai hian pumpelh vek a harsa hle . Mahse, i exposure hlauhawmna tihtlem nan thil engemaw zat i tih theih a awm a:

• I in chhungah carbon monoxide detector dah la, kum khatah vawi khat a battery thlak rawh.
• Thianghlimna hmanrua emaw, inchhung chemical emaw chu pawlh khawm ngai suh. Chutianga tih chuan rah chhuah hlauhawm tak, thihna thlen thei hial a ni thei.
• I in chhungah toxin tha lo dang, lead ang chi test tir rawh.
• Thli quality tha lo (high air pollution) ni-ah chuan i window kha khar reng tur a ni.
• Ruihhlo leh zu hman loh tur.
• Naupai i nih chuan i doctor nen nerve agents exposure chungchang leh nausen hmasawnna a nghawng theih dan tur sawipui rawh.

A pawimawh ber chu heng nerve agents laka nangmah leh i chhungte venhim hi i mawhphurhna chauh a ni lo. State leh tualchhung sorkar, company leh mipuite mawhphurhna inzawmkhawm a ni. National Institute of Environmental Health Services (NIEHS) ang institution-te chuan boruak leh nerve agent-te hian mihring hriselna a nghawng dan an zirchiang chhunzawm zel a ni.

A tawp berah chuan thil hriat reng tur

Neurotoxicity hi thil chi hrang hrang avanga lo awm thei a ni a, symptom hrang hrang a awm thei bawk. Neurotoxicant zawng zawng ei loh a harsat laiin, nangmah leh i chhungte venhimna tur thil i tih theih a awm. Nangmah emaw i fa emaw hian neurological symptoms i neih chuan, emaw, neurotoxicants i hman chungchangah ngaihtuahna i neih chuan doctor pan ngei ngei tur a ni. Anni hi tanpui turin an awm a ni.

` Neurotoxicity, Neurological system, Toxins, Symptoms, Thluak hriselna, Invenna