Cancer natna vei hi a harsat zia kan hria. Mahse damdawi lam thiamna a lo thang chho zel a, tunlai hian cancer enkawl dan pawh a lo tha chho ta hle a ni. Tun hma ang bawka chemotherapy emaw radiation therapy emaw chauh ni lovin tunah chuan cancer cell chauh target leh bei thei enkawlna bik a awm ta. PARP inhibitors hi damdawi chi khat a ni a, cancer enkawlna khawvelah beiseina thar a rawn thlen a ni. Vawiin hian he thu hi awlsam takin, i hriatthiam theih dan tur angin kan sawi dawn a ni.
A awlsam zawngin, heng PARP Inhibitor te hi engte nge ni?
Hei hi hrethiam tur chuan kan taksa chhunga cell awmte hi han ngaihtuah hmasa ila. Kan taksaa cell tin hian DNA an tih hi a awm vek a. He DNA hi ‘master plan’ ang a ni a, chutah chuan cell pakhatin a hnathawh theihna tura a mamawh zawng zawng a keng tel vek a ni. A chang chuan he DNA hi a chhe thei bawk. A chhiat chuan kan taksa hian siamthatna tur mechanism bik a nei a.
He siamthatna kawngah hian a pawimawh ber pakhat chu protein PARP an tih hi a ni. PARP tih hi Poly (ADP-ribose) polymerase tihna a ni. A hming hi a buaithlak viau laiin a hna chu a awlsam hle: DNA-ah hian a chhe emaw, a chhe emaw a awm chuan PARP protein chu a lut a, a siam tha leh thin. Hei hi cell hrisel tan a pawimawh hle.
Mahse hetah hian buaina chu a awm. Cancer cell te pawhin he PARP protein hi an hlawkna tur atan an hmang bawk. Cancer cell te hi an inthen chak lutuk chuan an DNA a chhiat phah thin. Tichuan cancer cell chuan he PARP ‘bass’ hmang hian a DNA a siam tha a, a thang lian lehzual a, taksa pum puiah a darh tan ta a ni.
PARP inhibitor te hian PARP 'bass' hnathawh tur titawpin hna an thawk a ni. A dik tak chuan PARP protein hian DNA a siam that theih loh nan an veng a ni. Hei hian cancer cell chu a DNA siam that theih loh nan a veng a, a tawpah chuan cell chu a thi ta a ni.
Hengte hi targeted therapies an ti bawk a, a chhan chu heng damdawi te hian cell hrisel pangngai aiin cancer cell chak lohna chu a target a, a bei zawk a ni.
Heng damdawi te hi eng cancer chi hrang hrangah nge an hman?
PARP inhibitor damdawi hi cancer zual zawk emaw, metastatic zawk emaw tan hman a ni tlangpui. Mahse, cancer zawng zawng tan pek an ni lo. Genetic mutation bik nena inzawm cancer tan an tangkai ber.
BRCA gene leh PARP inhibitor te inzawmna
Kan taksaah hian cancer natna (cancer tumor) lo awm tur venna (protective genes) a awm a. A bulpui ber pakhat chu BRCA gene hi a ni . He BRCA gene hnathawh pakhat chu DNA chhiatna siamthat hi a ni. Chumi awmzia chu kan cell-ah hian DNA siamthatna system lian pahnih a awm tihna a ni a, pakhat chu PARP a ni a, pakhat chu BRCA a ni.
Tunah chuan han ngaihtuah teh, mi pakhat chu BRCA gene-a mutation neia piang a ni.Chumi awmzia chu a DNA siamthatna system pakhat chu a chak lo tawh tihna a ni. Tichuan a cancer cell chu DNA siamthat nan chu PARP system ah chuan a innghat vek tawh mai.
Chuti a nih chuan chutiang mi chu PARP inhibitor kan pek hian eng nge thleng? BRCA system chhe tawh bakah hian PARP system tha taka thawk thin chu kan titawp bawk. Tichuan cancer cell hian a DNA siam that dan tur a nei tawh lo. Hetiang ‘double hit’ avang hian cancer cell hi a chhe awlsam hle a ni.
Chuvangin PARP inhibitor hi BRCA gene mutations nei cancer tan chuan a tha hle a ni.
| Cancer chi hrang hrang PARP inhibitor hmanga enkawl |
|---|
| Hnute cancer a ni |
| Ovarian cancer a ni |
| Fallopian tube cancer a ni |
| Prostate cancer a ni |
| Pancreatic cancer natna a ni |
| Primary peritoneal cancer a ni |
Engtin nge he enkawlna hi pek a nih a, eng chen nge pek a nih?
He enkawlna thatna pakhat chu injection anga pek a ngai lo. Heng PARP inhibitor zawng zawng hi tablet emaw capsule emaw angin an awm vek a. Ni khatah vawi khat emaw vawi hnih emaw ei tura tih an ni tlangpui.
A chang chuan cancer chi i neih dan azirin he damdawi hi enkawlna awmchhun atan pek a ni thei bawk. A nih loh leh, enkawlna dang, chemotherapy ang chi te nen pawh pek dun theih a ni. Entirnan, mi pakhat chemotherapy pek a nih hnuah leh cancer cell chhia a nih hnuah he PARP inhibitor damdawi hi hman tan a ni. Tichuan, chu cancer cell chhia te chu anmahni insiamthat theihna chance chu a ti bo vek a ni.
Enkawl hun chhung hi mi hrang hrangah a inang lo. Mi thenkhat tan chuan he damdawi hi hun bituk chhung atan pek thin a ni a, chu chu chemotherapy an tih zawh atanga kum hnih atanga kum thum chhung atan pek thin a ni. Midang tan chuan damdawiin hna a thawh chhung zawng chhunzawm zel a ni a, chu chu cancer chu thunun theih a ni tihna a ni. Hemi chungchanga thutlukna tha ber chu i doctor nen inbia a , a enkawlna hlawkna leh a nghawng tha lo awm thei te tehkhin hi a ni.
He enkawlna hian a hlawkna leh a nghawng tha lo awm thei te
PARP inhibitor hian cancer hi a tidam kim lo mai thei. Mahse, an hlawkna lian ber chu "progression-free survival" an tihpun hi a ni. A awlsam zawngin sawi ila, heng damdawi te hian cancer control nan leh rei zawk control theih turin a pui thin. Hei hian damlo chuan natna a zual zel loh nan nun hrisel tak nei turin hun a nei tam zawk tihna a ni .
Cancer enkawlna dang ang bawkin hengte hian side effect a nei thei a, mahse mi zawng zawngin an vei vek lo.
| PARP inhibitor te hian side effect an nei tlangpui | |
|---|---|
| Taksa lama harsatna |
|
| Thisen test dan inthlak danglamna | |
| Risk rare mahse serious tak tak a awm | |
Engtikah nge doctor i biak nghal tur?
He enkawlna hun chhung zawng hian doctor nen inbiakpawhna tha tak neih a pawimawh hle . Symptom thar i neih chuan emaw, i symptom awm tawh zawng zawng a zual emaw chuan doctor hnenah hriattir nghal rawh. I dose chu a siamrem thei a, damdawi dang pawh a pe thei a, chu chuan side effects, nausea ang chi a pui thei bawk.
A hnuaia symptoms te hi i neih chuan doctor ko nghal vat rawh :
- Infection chhinchhiahna: khawsik, khawsik, leh khur.
- Lung infection (Pneumonitis) lan chhuah dan: Thâwk harsa, rilru hahna, emaw, thawk hah.
- Thisen zam chhinchhiahna: rang taka hring, sen, leh ke na, emaw, rilru na nghal leh thawk harsa.
Heng natna khirh tak tak te hi i neih chuan i doctor i ko nghal tur a ni a, a nih loh leh damdawi in hnai ber Emergency Department (ETU) ah i kal nghal tur a ni.
Take-Home Thuchah a ni
- PARP inhibitor hi ‘targeted therapy’ chi khat a ni a, cancer cell-te DNA siam thatna tur a titawp a, a tichhia a ni.
- Hengte hi BRCA gene mutations nei hnute, ovarian, leh prostate cancer ang chi natna tan a tangkai hle.
- He enkawlna hi pill emaw capsule emaw angin pek a ni a, cancer thanna control nan a pui a, hrisel taka awm theihna hun a tipung bawk.
- Enkawlna dang ang bawkin side effect a awm thei a, chuvangin enkawlna hun chhung zawng hian doctor nen thawhhona tha tak neih a pawimawh hle.
- I doctor chuan PARP inhibitor enkawlna hi i tan a tha em tih a rel ang a, i damdawi lam dinhmun, genetic test result leh hriselna zawng zawng ngaihtuah chungin.
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