Acetylcholine (ACh) chungchang hi i zir mai ang u: Kan taksa thuruk thuchah!

I taksa chhungah hian hna engzat nge kal zel, i hriat loh pawhin i ngaihtuah ngai em? Ngaihtuah teh, i thinlung na tak tak, i thaw dan, i hmel hmuh tawh i hriatreng dan te, i kut leh ke i chet dan te... Heng zawng zawng hi engmah lovah a thleng lo. Heng zawng zawng hnuaiah hian chemical messenger te tak te te an awm a. Vawiin hian kan taksaa palai pawimawh tak tak zinga pakhat chungchang kan sawi dawn a ni. A hming chu acetylcholine, a tawi zawngin (ACh) a ni.

Chuti a nih chuan he acetylcholine (ACh) hi tu nge ni?

A awlsam zawngin acetylcholine (ACh) hi chemical chi khat neurotransmitter an tih a ni. Kan thluak leh kan taksa peng dangte inkara telephone connection ang maiin han ngaihtuah teh. Chuvangin hengte (neurotransmitters) te hi chu inzawmna kaltlanga thuchah phur chhuak leh chhuak thin ‘messenger’ ang an ni.

Acetylcholine hi neurotransmitter tichaktu a ni a. Chumi awmzia chu he messenger hian nerve cell dang a pan a, "a tiharh a," "nudge tha tak a pe," a ti tihna a ni a, "Okay, tunah chuan i turn a ni ta, he message hi hmalam pan rawh," a ti a ni.

A hming hi a siamna thil pahnih atanga lak a ni. Acetyl group leh nutrient pakhat choline an tih a ni. He choline hi ei leh in atang hian kan hmu thei a ni. Egg yolks, soy, leh thlai leh nut ang chi thilah te a awm a ni. Kan thin (liver) atanga siam a ni bawk.

Acetylcholine hian kan taksaah hna pawimawh tak tak a thawk a. A bik takin voluntary muscle movement atan a pawimawh hle . Tin, thluak hnathawhnaah pawh hmun pawimawh tak a chang a, chu chu hriatrengna, ngaihtuahna, leh thil thar zir te hi a ni .

Engtin nge hei hi kan taksa chhungah a lo awm?

Kan taksaah hian enzyme pakhat ‘choline acetyltransferase’ tih kan nei a. Chef ang maiin han ngaihtuah teh. He enzyme hian a hmaa kan sawi tawh choline leh acetyl group te chu a inzawm khawm a, messenger acetylcholine (ACh) tui tak a siam a ni. Hetiang thil hi kan nerve cell tawp lamah a thleng thin.

Awle, tunah chuan he thuchah hi engtin nge a kal tih i en ang u.

Acetylcholine (ACh) siam a nih hnuah, post office-a lehkha dahkhawm ang maiin, nerve cell tawp lamah dah a ni. He stored ACh hi thluak atanga message a lo thlen chuan a chhuak thin.

Tichuan he ACh hi nerve cell pahnih inkar gap tenau takah a zuang lut ta a ni. He gap hi synaptic cleft an ti a. Lui kamah thuchah zuang chhuak ang maiin han ngaihtuah teh.

A bula nerve cell hian he ACh lo lut hi man theihna hmun bik a nei a. A dik tak chuan chabi nena inmil chabi ang mai a ni. Hengte hi receptor kan ti a. Acetylcholine hi receptor chi hnih a awm a, chungte chu:

1. Nicotinic receptor te hi a ni

2. Muscarinic receptor te hi a awm a

ACh key chu heng Ibi key pahnih zinga pakhatah hian a binding chuan message chu a hnuaia cell-ah a kal leh ta a ni. Chutiang chuan thuchah chu cell pakhat atanga cell dangah a kal a, hmun remchang (entir nan, taksa ruh) a thleng a ni.

Acetylcholine (ACh) hian kan taksaah eng thil nge a tih ber?

Acetylcholine (ACh) hian hna hrang hrang a thawk a. A hnathawh dan hi a inzawmna receptor a zirin a inang lo. A hnathawh ber berte han thlir ila.

Receptor chi hnih hi kan hriatrengna vawn nun atanga hriatrengna thar siam te, dahkhawmna te, leh hriatrengna thlengin engkim ah an inrawlh a ni . Tin, thluak-ah pawh an pawimawh hle a, kan ngaihvenna atan te, kan zir duhna atan te, leh mutna thuk tak (deep sleep stage) REM (Rapid Eye Movement) sleep an tih te tan pawh an pawimawh hle.

Hei hi tihziaawm a nih chuan eng natna nge lo awm thei?

Kan taksaa acetylcholine (ACh) level tlahniam hian damdawi lam harsatna lian tham engemaw zat a thlen thei a ni. A bulpui berte chu:

• Alzheimer’s disease: Hei hi a bul berah chuan hriatrengna tichhe thei natna a ni. Alzheimer natna vei te hian an thluak ah acetylcholine an nei tlem hle tih hmuhchhuah a ni.
• Myasthenia gravis: Hei hi autoimmune disorder a ni. Chumi awmzia chu kan taksa ngeiin min dodalna a thawk tihna a ni. Heta thil thleng hi kan antibody te hian kal in taksa ruh chhunga acetylcholine receptor (ACh) te chu a tichhia a ni. Tichuan ACh chuan thuchah a thawn thei lo a, chuvang chuan taksa ruhte chu a chak lo zauh zauh a.
• Lambert-Eaton myasthenic syndrome: Hei hian taksa ruh a tichak lo bawk. Mahse a chhan erawh a danglam thung. Heta thil thleng chu nerve cell-te hian ACh an chhuah tlem hle.

Acetylcholine (ACh) tichhe thei thil dangte .

Lungchhiatthlak takin mi thenkhat chuan acetylcholine hnathawh dan hriatna chu mi tichhe turin an hmang a ni.

Entirnan, nerve gas sarin leh insecticide thenkhat te hian kan sawi tawh ang khan clearing enzyme acetylcholinesterase chu inactivate in hna an thawk a. Hei hian ACh chu a pungkhawm thei a, taksa ruhte a ti paralyze a, thihna pawh a thlen thei a ni.

Tin, black widow spider venom ei hian ACh level nasa takin a tisang bawk. Hei hian taksa ruhte nasa takin a tikhawlo thei a, a tikehsawm thei a, a tichak lo thei bawk a, thihna thlengin a thlen thei bawk.

Hei hi target tur damdawi a awm em?

Awle. Acetylcholine target tu damdawi hi damdawi lam harsatna thenkhat enkawlna atan hman a ni.

Damdawi chi khat ber chu ‘cholinesterase inhibitors’ a ni. Heng damdawi te hian ACh tichhe thei enzyme chu block-in hna an thawk a ni. Hei hian ACh chu nerve cell inkar space-ah rei zawk a awm tir a, a hnathawh a tipung a ni. Heng damdawi (e.g. donepezil, rivastigmine) te hi ACh level hniamna, Alzheimer natna leh myasthenia gravis te enkawlna atan hman a ni.

Entirna dang chu Botulinum toxin , emaw kan hriat vek angin ‘Botox’ tih hi a ni. Nerve tawp atanga ACh chhuahna tur block-in hna a thawk a ni. Hei hian taksa ruhte chu a inzawm khawm ai chuan a ti hahdam zawk thin. Cosmetic atan (wrinkles tihtlem nan) leh migraine ang chi natna enkawlna atan hman a ni.

Hei hi pill angin kan ei thei ang em? Chaw a\angin kan hmu thei ang em?

Acetylcholine (ACh) ngei pawh hi pill anga ei theih a ni lo. Mahse, a siamna atana puitu nutrient, choline chu supplement atan ei theih a ni. Herbal supplement thenkhat, Ginkgo biloba te pawhin ACh level a nghawng nia rin a ni.

Mahse hetah hian i hriat reng tur thil pakhat a awm . Doctor emaw pharmacist emaw rawn hmasa lovin supplement engmah hmang ngai suh . Damdawi dang i ei lai nen an inzawm thei a, i tan pawh a tichhe thei bawk.

Mahse ei leh in atang hian choline hi natural takin kan hmu thei. A chhunga ei tur pawimawh thenkhat chu:

• Bawngsa thin a ni
• Eggs a ni
• Bawngsa
• Soybean, chickpeas te pawh a awm bawk
• Ar
• Cod sangha a ni
• Quinoa chuan a rawn ti a
• Mushroom, broccoli te pawh a awm bawk
• Bawnghnute