PBC damdawi hmasa ber hian hna a thawk lo em ni? Step hnihna (Primary Biliary Cholangitis) chungchang hi han sawi ila

Liver natna PBC, a nih loh leh Primary Biliary Cholangitis tih i nei em? Chutiang a nih chuan, i doctor-in damdawi a pek hmasak ber chu i beisei angin a thawk ṭha lo mai thei. Ngaihtuah buai suh. Mi tam takin chutiang thil tawn chu an lo tawng tawh a ni. A pawimawh ber chu beiseina nei reng tur leh a hnua i tih theih tur hriat reng hi a ni. Vawiin hian hetiang hunah hian eng nge i tih theih tih leh eng enkawlna thar nge awm tih i sawi dawn nia.

A hmasa berah chuan PBC hi a awlsam zawngin eng nge ni?

PBC hi natna khirh tak, hun rei tak chhunga awm a ni a, kan taksa ngeiin kan liver chhunga bile duct te tak te te chu a bei thin. Heng bile duct te hi kan liver chhunga pipe te tak te angin han ngaihtuah teh. An hnathawh ber chu bile, ei tur ei tura puitu tui, liver atanga chhuah tir hi a ni.

Tunah chuan PBC chungchangah hian keimahni immune system cells te hian heng pipe te hi a tichhia a ni. Tichuan heng pipe te hi a block a, bile a luang tha lo va, liver chhungah a tang ta a ni. Car traffic-a a tlakbuak ang bawkin. Chutianga bile a pungkhawm chuan liver cells a tichhe tan thin. Hun a kal zel a, he chhiatna hian thin (liver)-ah hliam a siam thei a ni. Hei hi fibrosis kan ti a ni . Hetiang dinhmun hi a na zual chuan cirrhosis, liver failure an tih natna a thlen thei a ni.

Hei hi autoimmune natna dang nen chuan a danglam deuh hlek a ni. A chhan chu PBC hian autoimmune natna dang atana hman thin immune system titawp thei damdawi te hi a chhang tha lo hle a ni. A chhan pakhat chu natna hmuhchhuah a nih meuh chuan thin (liver) hi eng emaw chen a chhiat tawh vang pawh a ni thei. Mahse, lungngai suh, science hmasawnna nen, tunah chuan hei hi enkawl dan tha tak tak a awm ta.

Enkawlna hmasa ber: UDCA damdawi

PBC enkawlnaah hian thil tum lian tak tak engemaw zat a awm a, chungte chu natna zual zel tur tihkhawtlai te, a lan chhuah dan control te, leh liver chhiatna avanga harsatna lo thleng tur venna te hi a ni.

PBC i vei tih i hriat hnu chuan i doctor-in damdawi a ei tan tir hmasak ber tur chu Ursodeoxycholic acid , a tawi zawngin UDCA a ni mai thei. Brand name Ursodiol hmangin i hre mai thei. He damdawi hian liver-a bile awm chu a chhuah tir thei a, liver-a scarring (fibrosis) siam a ti tlem bawk. Hei hi a pawimawh a, a chhan chu scarring hi a tawpah chuan cirrhosis leh liver failure a thlen thei a ni.

Engvangin nge UDCA ringawt hi a tawk loh?

Research atanga a lan dan chuan UDCA ei thin damlo 25% atanga 50% inkar chuan damdawi atanga beisei angin result an hmu lo. Hei hian an liver function test-ah hmasawnna lian tham a awm lo tihna a ni.

Chutiang chuan UDCA a dawng tha lo chuan cirrhosis a vei theihna chu a let nga zetin a sang zawk a ni. Tin, he natna avanga thihna hlauhawmna pawh a let thum zetin a pung bawk. Chuvangin UDCA hian hna a thawk lo a nih chuan, i doctor nen i hmabak tur chungchang sawipui a pawimawh a, chu chu hman chhunzawm zel ai chuan.

Engvangin nge UDCA hian hna a thawk tha lo tih i ngaihtuah em? Chutiang a nih chhan chu eng emaw zat a awm thei.

Heng chhan pakhat emaw a aia tam emaw i neih chuan second-line treatment ngaihtuah a hun tawh . Hetah hian tum ber chu i thisen test result tihchangtlun mai a ni lo. I nunphung tichhe thei symptoms, tuar theih loh khawpa natna, hah lutuk, leh mut theih lohna te pawh control a pawimawh bawk . A chhan chu UDCA hian heng symptoms te hi a ti reh vak lo.

Second-line treatment: Heng duhthlan tur tharte hi engte nge ni?

PBC enkawlna kawng hrang hrangte chu a inthlak chak hle. Damdawi thar eng emaw zat chu pawmpuina hnuhnung ber a ni. Tuna enkawl dan tur leh enkawl dan tur lo thlir ila.

Obeticholic acid (OCA) hmanga siam a ni.

UDCA hian hna a thawk tha lo a nih chuan, emaw, UDCA i tuar thei lo a nih chuan, i doctor-in a ngaihtuah tur damdawi ber chu obeticholic acid , emaw OCA , a ni. A tlangpuiin Ocaliva brand hming hnuaiah a awm thin.

A chang chuan UDCA nen hian OCA pawh pek theih a ni. Chu chu damdawi pahnih hi hman dun a ni tihna a ni. OCA hi damdawi pawl pakhat farnesoid X receptor agonists an tih zinga mi a ni a . A awlsam zawngin sawi ila, a thiltih chu, .

1. Liver atanga bile siam chhuah a ti tlem.

2. Liver atanga bile chhuah tir turin a pui.

Chutiang chuan OCA chauh emaw UDCA nena hman a nih chuan liver function a tha a, liver scarring rate a tlahniam bawk.

PBC enkawlna field hi a inthlak danglam zel a, chuvangin i hriselna atan i doctor nen inzawmna nei reng tur leh enkawlna thar chungchang sawiho a pawimawh hle.