Engvangin nge liver natna PBC an tih hi hmeichhiaah a hluar zawk? (Primary Biliary Cholangitis - PBC) tih hi a tha hle a, a rilru a hah lutuk chuan a rilru a buai em em bawk a.

PBC tih hi i hre tawh em, thin natna a ni em? A hming hi i hre lo mai thei. Mahse, he natna vei mi sawm zinga 9 chu hmeichhia an ni tih i hria em? Chu chu a mak takzet a ni lawm ni? Chuti a nih chuan engvangin nge he natna hian hmeichhiate a beih ang? Hei hi eng nge a chhan? Vawiin hian he thu hi awlsam takin, in hriatthiam theih angin kan sawi dawn a ni.

I en hmasa ang u, PBC chu eng nge ni?

Okay, hei hi scientific hming deuh a ni a, mahse thil thleng chu a awlsam hle. PBC hi Primary Biliary Cholangitis tihna a ni a, kan taksa ngeia immune system chu haywire-a kal a, kan liver ngei pawh a bei thin natna a ni. Chutiang natna chu autoimmune disease kan ti a. Ngaihtuah teh, kan taksa invenna hi ram venghimtu sipai ang a ni. He sipai hna hi pawn lam atanga hrik leh virus lo chhuakte do a, natna laka min chhanchhuah hi a ni. Mahse a chang chuan he sipai hian tihsual a nei a, mahni ram chhunga mi sual lote chu an bei tan thin. PBC-ah pawh hetiang thil hi a thleng ve tho. Kan taksa hriselna (immune system) hian kan liver-a bile duct te te chu a bei thin. Heng bile duct te hi tube system pawimawh tak a ni a, chu chuan liver atanga bile siam chu intestines ah a phur a ni. Heng duct te hi a chhiat chuan bile a luang tha lo va, thin chhungah a awm khawm a, zawi zawiin thin a tichhia a ni.

Chuti a nih chuan engvangin nge hei hian hmeichhiate a nghawng nasa zawk?

Tunah chuan mi zawng zawngin zawhna lian ber chhanna hi han thlir ila. Researcher-te chuan hei hi a chhan chiang tak pakhat mah an la hmu lo. Mahse, thil pawimawh pathumin a thlen niin an ngai.

1. Hormone-te nghawng dan

I hria em, hmeichhe taksa hi mipa taksa nen a danglam hle. Chumi chhan ber chu hormone a ni. A bik takin hmeichhe nun kawng tinrengah hormone estrogen hian hmun pawimawh tak a chang a ni. Ngaihtuah teh, thla tin thlasik hun chhung, a bik takin menopause, kum 40-60 inkar a awm hian he estrogen hormone level-ah hian inthlak danglamna lian tak a awm a ni. Heng hormone inthlak danglamna hian kan immune system cell te hnathawh dan a nghawng nghal vek a ni. Estrogen hormone hian immune system a tichak lutuk thei a ni. Chu chu a hmaa kan sawi tawh "army" kha activate lutuk tihna a ni. Chutiang a nih chuan a cell ngei pawh a beih theihna a sang chho zel a ni. PBC hi he kum lama hmeichhia zingah hian a tam ber avangin he inzawmna hi kan ngaihtuah thei a ni.

2. Intestines-a bacteria awm

Hei hi i tan chuan thil thar tlem a ni mai thei. Kan rilru chhungah hian bacteria tha leh tha lo trillion tam tak a awm a. He bacteria community hi kan hriselna atan a pawimawh hle. Research atanga a lan dan chuan PBC vei theihna tur genetic predisposition kengtute hian midang aiin an rilruah bacteria chi hrang hrang an nei tih hmuhchhuah a ni. Tin, urinary tract infection (UTIs) nena inzawm tlangpui bacteria chi khat an nei sang zawk bawk. Chuvangin hei hian bacteria infection thenkhat leh gut bacteria-a inthlauhna te hian immune system tibuaitu PBC lo awm chhan a ni thei tih a tilang a ni.

3. Genes leh heredity-in nghawng a neih dan

"Hei hi thlahtu natna a ni em?" i ngaihtuah mai thei. Ni e, eng emaw chen chu gene-te hian chanvo an nei ve tho.

• PBC vei zinga 1% leh 9% inkar chuan chhungkaw member dang he natna vei an nei bawk.
• Twin inang pahnih zinga pakhatin PBC a neih chuan a dang pawhin a vei theihna chance 63% a awm.

Heng zawng zawng aiin a pawimawh zawk chu X chromosome inrawlhna hi a ni . A awlsam zawngin sawi ila, hmeichhia hian X chromosome pahnih (XX) an nei a, mipa erawh chuan X chromosome pakhat leh Y chromosome pakhat (XY) an nei thung. Research atanga a lan dan chuan PBC vei hmeichhiate hian X chromosome pakhat an nei lo emaw, an taksa cell thenkhatah X chromosome ah inthlak danglamna engemaw zat an nei emaw a ni. Heng inthlak danglamna hian immune system-a inrawlh gene-te hnathawh a nghawng thei a, hei hian he autoimmune natna vei theihna a tipung thei a ni.

PBC nen hian nun that theih a ni em?

A ni tak zet! PBC hi damdawi inenkawlna mumal tak leh nunphung tihdanglamna hmanga enkawl that theih a ni. He natna hi a hmaa hriatchhuah a nih chuan thin (liver) chhiatna thunun a awlsam zawk thin. He natna nena kan nun lai hian a pawimawh ber chu doctor nen inzawmna neih reng hi a ni . Damdawi a pekte chu a hun taka ei a, a hun taka clinic-a kal a pawimawh hle. Chu bâkah, ei leh in inthlau tak ei a, zu in loh vek a, doctor thurâwn angin exercise dik tak i tih chuan nun hrisel tak i nei thei a ni. Tunah chuan natna lan chhuah dan, hah lutuk leh vun na lutuk te thunun nan enkawlna tha tak tak a awm ta. Chuvangin i doctor nen inhawng takin sawi rawh. PBC, Primary Biliary Cholangitis, Thin natna, Hmeichhe hriselna, Autoimmune Natna, Estrogen, Hormone, Genes, Thin Natna Hmeichhia Sinhala, akmawe leda