Nangmah emaw, i hmangaih tu emaw cancer vei tih i hriat chuan i rilru put hmang chu thumal hmanga sawi a harsa hle. I doctor-in damdawi thar, PRRT ang chi a hrilh che hian hlauhna leh hriat duhna i neih hi thil pangngai a ni a, chu chu thumal hriat loh tak a ni. Mahse, lungngai suh. Hei hi thupui buaithlak deuh ni mahse, vawiinah hian PRRT chu eng nge a nih, eng nge a tih, a thatna leh that lohna te, awlsam takin i hriatthiam theih tur angin kan sawi dawn a ni.
PRRT hian eng nge a awmzia mai?
A awlsam zawngin, PRRT hi enkawlna hmasawn tak a ni a, cancer cells te chu a target a, a zawng chhuak a, a tichhia a, ‘guided missile’ ang chiah a ni. A bik takin cancer chi khat `Neuroendocrine Tumors (NETs)' tih enkawlna atan hman a ni.
He enkawlna specialty chu a radioactive material (radioactivity) a chhuah chu cancer cell-ah direct-in a lut a, a tichhia a ni. Chuvangin, cell hriselte chhiatna chu radiation therapy pangngai aiin a tlem zawk hle.
He enkawlna hian taksa chhungah engtin nge hna a thawh?
Hei hi hrethiam tur chuan entirnan awlsam tak hmang ila. I cancer cell te hi kawngkhar, ‘keyhole’ bik (`receptors`) tam tak awmna angin han ngaihtuah teh. Kawngkhar tin hian a pianzia bik nei chabi chauh a fit a ni.
He damdawi, PRRT tia koh hi thil pahnih inzawmkhawma siam a ni a:
1. The Key: Hei hi protein a ni. He chabi hi cancer cell-te ‘keyhole’-ah chauh a in fit thei a ni. Cell hrisel takah a in fit lo.
2. The Radioactive Passenger: He key hian radioactive element (`radionuclide`) te tak te tak mai a nei a.
Chuvangin, he damdawi hi i taksa i pek hian he ‘chabi’ hian taksa pum puiah a fang kual a, cancer cell-a ‘keyholes’ awmte chu a zawng a, chutah chuan a inzawm tlat a ni. Tichuan, chabi-a ‘radioactive passenger’ chu cancer cell chhungah a lut a, chu cell DNA chu a tichhia a, chu cell chhung atang chuan a tichhia a ni.
Hetiang method hian cancer cell chauh thlan chhuah hmanga tihchhiat theihna a siam a, cell hrisel te chu nasa taka tihchhiat a ni lo. Hei hi he enkawlna thatna lian ber a ni.
Tunlaia PRRT damdawi hman lar ber chu `lutetium Lu 177 dotatate (LUTATHERA®)` a ni.
PRRT hi tute tan nge enkawl a tha?
He enkawlna hi cancer vei zawng zawng tan a tha lo. Tunah hian `gastroenteropancreatic NETs` an tih cancer tan a tha ber a, chungte chu chaw ei kawng (intestines, stomach, rectum) leh pancreas cancer te an ni. He enkawlna hi i tan a tha thei tur dinhmun engemaw zat a awm.
| Nihna | Hrilhfiahna |
|---|---|
| Surgery atan a tha lo | Cancer hi taksa hmun hrang hrangah a darh ( metastasized ) a nih chuan operation chauh hian a dam kim a rinawm loh. NET vei tam tak chuan cancer an vei tih hmuhchhuah a nih chuan an darh tawh mai thei. |
| Enkawlna dang pawh a hlawhtling lo | Surgery tih theih lohna hmunah chuan hormone therapy ang chi thil an pe thin. Mahse, a châng chuan, chutiang enkawlnate chuan cancer cell-te chu thunun theih lohvin a tipung chhunzawm zêl a ni. Chutiang mite tan chuan PRRT hi duhthlan tur tha tak a ni. |
| Cancer cell te hian chu ‘keyhole’ chu an nei a. | Hei hi a pawimawh ber a ni. PRRT damdawi hian ‘key’ a thlen theih nan leh a inzawm theih nan chuan cancer cell chung lamah somatostatin receptor an tih ‘keyholes’ a awm a ngai a ni. I doctor chuan i cancer cell-te hian hengte hi an nei em tih en turin scan bik, octreotide scan emaw PET scan emaw ang chi a ti ang. |
Enkawl hma leh enkawl lai hian eng nge thleng?
Enkawl hmain
NETs damdawi dang (a bik takin somatostatin analogs) i ei a nih chuan i doctor chuan PRRT hma kar tlemteah ei tawh loh turin a fuih mai thei che. I doctor pawhin i enkawl hma kar khat vel khan thisen test a nei mai thei a, chu chuan i kal hnathawh leh thisen cell zat a enfiah ang a, chu chuan i taksa chu enkawlna dawng thei tura a dinhmun a tha em tih a enfiah ang.
Enkawlna ni ah
He enkawlna hi thla hnih danah thla 8 chhung session 4 chhung pek thin a ni tlangpui. Hei hi outpatient procedure a ni a, damdawi ina awm ngai lovin. Procedure zawng zawng hi darkar 5-6 vel a ni.
- A hmasa berin i kut chhunga vein pakhatah tube te tak te (cannula) dahin saline line siam a ni.
- Enkawl tan hma darkar khat velah chuan natna leh luak chhuak lo turin damdawi pek thin a ni.
- Tichuan, i kal venhimna tur amino acid awmna saline solution darkar 4 vel pek i ni ang. Hei hi a pawimawh hle.
- Amino acids pek tan atanga minute 30 vel hnuah PRRT damdawi hi saline hmangin taksaah minute 30-45 chhung pek a ni.
- Saline zawng zawng pek zawh chuan arm chhunga tube chu lakchhuah a ni.
Enkawl zawh ni khatah scan dang i nei leh ang a, i taksaah radioactive damdawi chu khawiah nge a kal tih i enfiah ang a, a bik takin cancer natna thlenna hmun chu i enfiah leh ang.
A side effect leh risk te chu engte nge ni?
Enkawlna dang ang bawkin, side effect engemaw zat a awm thei bawk.
Side effects awm tam ber chu:
The most common side effects are nausea and vomiting , mahse hengte hi a tam zawk chu enkawl hmasak hian control theih a ni.
Harsatna dang awm thei:
- Kidney emaw liver function-a nghawng eng pawh.
- Thisen cell (thisen var, thisen sen, platelet) a tlahniam. Hei hian thawk harsatna a thlen thei a, natna hrik kai awlsamna a tipung thei a, thisen chhuah emaw, hliam emaw a thlen theihna a tipung thei bawk.
- A tlem hle a, thisen cancer dang myelodysplastic syndrome emaw leukemia emaw vei theihna chance a tlem hle.
I doctor chuan i enkawlna chhung zawngin i thisen level a enfiah reng ang. Harsatna a awm chuan a dose thlak emaw, i enkawlna tihtawp emaw an tum mai thei.
Thil awmdan pawi tak, ngaihven nghal ngai!
Carcinoid crisis hi a awm lo hle a, mahse nunna atana hlauhawm thei tak a ni a, he enkawlna chhung hian a thleng thei a ni. Cancer cell atanga hormone tam tak thisenah a chhuah thut avanga lo awm a ni. Enkawlna an dawn atanga darkar 48 hmasa berah symptoms a lang thei.
Heng symptoms te hi i neih chuan damdawi in hnai ber Emergency Department (ETU) ah kal nghal la, 1990 ah call rawh:
* Thâwk harsa
* Hmai emaw kawr a sen, taksaah lum emaw kang emaw hriatna (Flushing) .
* Thisen sang tlahniam nghal (luak chhuak) .
* Lung natna
* Luak chhuak na tak
Enkawl hnu nitin nun
Mi tam zawk chuan he enkawlna hi an tuar tha hle a, an dam thuai thin.
Radioactivity leh himna: 1.1.
Enkawlnaah hian radiation tlemte chauh hman a ni. Hei hi ni engemaw zat chhungin i zun leh ek chhungah i taksa atangin a kal chhuak ang. Hemi chhung hian i doctor chuan midangte radiation an tawrh loh nan thupek a pe ang che.
- A bik takin hmeichhe naupai leh naupang tête laka ni engemaw zat inthiarfihlim a pawimawh hle.
- Toilet i hman zawhah sahbawn hmangin i kut uluk takin sil thin ang che.
Khualzinna:
I enkawl hnu thla 3 thleng i taksaah hian radiation tlemte chauh a awm thei. Hei hian airport emaw ramri emaw-ah radiation detector a tichhuak thei a ni. Chuvangin damdawi in atanga special card i dawn leh i enkawl dan kimchang chu i hnenah vawng reng ang che. Hei hi zin chhuah huna harsatna awm lo turin a pawimawh hle.
Take-Home Thuchah a ni
- PRRT hi enkawlna hmasawn tak a ni a, cancer cell-te tan bik radiation a pe chhuak a ni. Neuroendocrine Tumors (NETs) tan bik hman a ni.
- Hei hi cancer tidam vek thei damdawi ni lo mah se, tumor lian zel tihtlem emaw tihtawp emaw a pui a, symptoms control a, dam rei zawng tihpunna hmangin nunphung a tichangtlung bawk.
- Enkawlna hnu ni engemaw zat chhung chu midangte radiation laka venhimna (a bik takin naupang tê leh naupai laka inthiarfihlim) tura thupek pekte zawm tur a ni.
- Carcinoid crisis (thâwk harsa, flushing, riltam na tak, heart rate sang) symptoms te hriat reng tur a ni. Heng symptoms zinga pakhat tal i neih chuan damdawi in ETU- ah kal nghal rawh.
- I doctor hnenah side effect emaw harsatna i neih theih dan tur sawi hreh suh.
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