I taksa immune system hi defense system mak tak a ni. Mahse a chang chuan he system hi a hnathawh dan a danglam deuh thei. A châng chuan a thawk nasa lutuk thei a, kan taksa ngei pawh a tichhe thei a, a châng chuan cancer cell ang chi hmêlma dona kawngah ṭanpuina a mamawh bawk. Chutiang hunah chuan kan taksa hriselna tichaktu leh a hnathawh dan thunun thei enkawlna bik kan sawi a ni. Chu chu photopheresis a ni.
A awlsam zawngin, photopheresis chu eng nge ni?
Photopheresis hi êng hmanga i thisen var, lymphocyte an tihte hnathawh dan tidanglam thei damdawi a ni. Heng cell, lymphocyte tia koh te hi kan immune system sipai ber an ni. Cancer cell, bacteria, virus ang chi thil tichhetu an ni. Chuvangin, heng lymphocytes te hi harsatna a awm chuan photopheresis treatment hi a tangkai hle.
Hetiang hian han ngaihtuah teh. I thisen thenkhat chu an la a, machine-ah an dah a, thisen var lymphocyte an tih chauh an thliar hrang chhuak thin. Tichuan, damdawi bik nen an pawlh a, UV light-ah an dah a, chu chuan chu cell-te hnathawh dan chu a tidanglam a ni. A tawp berah chuan heng cell enkawl tawhte hi i thisen dang nen i taksaah dah leh a ni.
Hetiang hmang hian kan taksa hriselna (immune system) kan tichak thei a, a nih loh leh duh loh zawnga thil a tih chuan kan thunun thei bawk. Phên dangin sawi ila, he enkawlna hian a tul angin immune system ‘switch on leh off’ theihna a nei a ni.
He enkawlna hi eng dinhmunah nge hman a nih?
Photopheresis hi immunotherapy chi khat a ni a. Chu chu keimahni immune system hmanga natna enkawl dan a ni tihna a ni. A hmanna lian ber ber engemaw zat a awm.
| Damdawi lam dinhmun | A sawifiahna awlsam tak |
|---|---|
| Vun atanga lo chhuak T-cell lymphoma (CTCL) . | Hei hi thisen cancer chi khat hmuh tur awm lo tak a ni a, vun a nghawng a ni. He natna enkawlna atan hian Photopheresis therapy hi hman tan a ni. Enkawl tawh lymphocyte te taksaah an rawn luh leh chuan cancer cells te tihchhiat nan an pui thin. |
| Graft leh Host natna (GVHD) inkara natna (GVHD) . | Bone marrow transplant ang chi thil engemaw hnuah chuan stem cells dawn tharte chuan nangmah ngei pawh hi ‘hmêlma’ ang maiin an rawn bei tan thei a ni. He enkawlna hian chu duh loh zawnga beihna chu a titawp thei a, a thunun thei bawk. |
| Organ transplant hnawl a ni | Organ lian tak, lung, thin, a nih loh leh thinlung ang chi, taksa peng lian tak tak thlak a nih hnuah chuan taksa hriselna (immune system) chuan taksa peng thar chu a hnawl thei a ni. He enkawlna hian chutiang chu a veng thei a ni. |
Damdawi lam thil dang
Heng natna lian ber berte bakah hian doctor-te chuan damdawi lam natna dang engemaw zat atan photopheresis hman an rawt thei bawk.
- Crohn natna a ni
- Eczema (Atopic dermatitis) natna hi a awm thei lo.
- Scleroderma a ni
- Psoriasis, vun natna a ni
- Type 1 zunthlum vei a ni
Engtin nge inenkawl hmain kan inbuatsaih ang?
I doctor chuan hei hi a hrilhfiah ang che. A tlangpuiin, enkawl hmain heng thilte hi enkawl turin an ti ang che.
- Tui tam in tur: Enkawl hma ni hnih chhung ni khatah tui glass 8 tal in thin tur a ni. Hei hian i thisen a kal tha zawk ang a, enkawl laiin thisen lak a awlsam phah ang.
- Caffeine leh zu hi pumpelh rawh: Tea, coffee, zu ang chi thilte hian taksaah tui a tichhe thei a, chu chuan thisen a tikhawtlai a ni.
- Chaw thau tak tak ei loh tur: Thau tamna ei tur, fried foods leh sweets te i ei hian thisen atanga thisen var thliar hrangtu machine tan a hna thawh chu a harsa deuh thei a ni.
Engtin nge he enkawlna hian hna a thawh?
Hetiang zawng zawng hi khumah nuam taka i mut laiin a thleng vek a ni. Painless procedure a ni.
1. Thisen lak: Nurse emaw doctor emaw chuan i kut a vein atang emaw, i rilru chhunga special tube (catheter) dah hmangin emaw thisen a la ang. A tul chuan a natna ven nan numbing cream hnawih theih a ni.
2. Cell inthen dan: 1.1.Thisen i lak chu machine bik ah a lut nghal vek a. He machine hian i thisen chhunga thisen sen leh platelet awm atang hian thisen var lymphocyte an tih chauh a thliar hrang a ni.
3. Damdawi dah belh: Thisen var hran hran hranah hian thlai damdawi him tak `8-methoxypsoralen (8-MOP)` an dah tel a. He damdawi hian ênga a awm chauhvin hna a thawk a ni.
4. Light therapy: Tunah chuan he damdawi nena awm thisen var te hi machine chhungah ultraviolet A light (UVA light) hmangin an inhmu ta a ni. Tichuan, damdawi chuan hna a thawk a, thisen var hnathawh chu a thlak danglam ta a ni.
5. Reinfusion: A tawp berah chuan hetianga enkawl tawh thisen var te hi i taksaah an infuse leh a, a hmaa thisen peng dang inthen tawhte nen.
Hetiang zawng zawng hi darkar 3-4 vel a ni thei.
A side effect leh kan hriat tur thilte chu engte nge ni?
Photopheresis hi enkawlna him tak anga ngaih a ni , mi tam zawk chuan side effects an nei lo.
Mahse, a chang chuan thil tenawm tak tak a thleng thei.
- Enkawl laiin i thisen sang a tlahniam deuh thei. Chutiang a nih chuan a pangngaia a awm leh theih nan intravenous fluids pek i ni thei bawk.
- Thisen pek lai ang bawkin i luak chhuak thei a, i luak chhuak thei a, i khawsik pawh i nei thei bawk. Hetianga i hriat chuan nurse hnenah hrilh nghal rawh.
- I enkawl hnu darkar 6-8 hnuah i sen, luak chhuak, khawsik i nei thei. I khawsik chu 37.8 degree Celsius (100 degree Fahrenheit) aia sang a nih chuan doctor hnenah hrilh rawh. Paracetamol ang damdawi ei a rawt mai thei.
Enkawl hnua kan fimkhur bik tur thilte
Hei hi a pawimawh hle. Photopheresis hmanga enkawl hian i vun leh mit chu ni êng lakah a sensitive hle.
Enkawl hnu darkar 24 chhung chu ni êng direct leh indirect-a awm loh tur a ni. Indirect sunlight chu window emaw curtain atanga light lo chhuak a ni.
- Pawnah i chhuak a nih chuan i taksa pum huap thawmhnaw ha la. Sunscreen SPF 30 aia sang hmang rawh.
- UVA rays laka invenna, in chhung leh pawnah darkar 24 chhung sunglass vuah thin ang che. Mit pahnih khuh thei "wraparound" sunglass hi a tha ber.
Results hmuh tur hian eng chen nge hun a duh?
Hei hi i dinhmun leh enkawlna zat a zirin a danglam ang. Mi thenkhat chuan thla 3-4 chhungin an natna lan chhuah danah hmasawnna nasa tak an hmu thin. Condition thenkhat (scleroderma ang chi) tan chuan a natna lan chhuah dan tur chu thla 6-12 vel a ngai thei. Chuvangin he enkawlna kawngah hian dawhtheihna a pawimawh hle. I dinhmun a zirin result hmuh beisei theih hun chhung chu doctor zawt rawh.
Take-Home Thuchah a ni
- Photopheresis hi damdawi him tak a ni a, light hmangin nangmah ngeiin thisen var a enkawl a, immune system hnathawh a control bawk.
- Hei hi CTCL cancer, GVHD condition, leh organ transplant hnua rejection venna ang chi thil atan hman a ni ber.
- Enkawlna hi a na lo hle a, mahse enkawl hnu darkar 24 chhung chu ni laka inven a ngai a ni.
- Results hmuh nan hun engemaw chen a la ngai thei a, chuvangin dawhthei taka enkawl a, enkawlna zawn a pawimawh hle.
- Hemi chungchanga harsatna, hlauhthawnna, rinhlelhna i neih apiang chu i doctor nen zalen takin sawipui rawh.
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