I hnaih ber tu emaw hian heng inthlak danglamna te hi a nei em? Pick's Disease chungchang hi i zir dawn teh ang

Kan hmangaih thenkhatte nungchang leh thusawiah beisei loh taka inthlak danglamna kan hmuh hian mak kan ti fo thin a ni lawm ni? Vawiin hian hetiang inthlak danglamna hnuaia awm thei damdawi lam dinhmun kan sawi dawn a ni. Hei hi thupui buaithlak deuh ni mahse, awlsam taka hriatthiam tum ila.

Pick’s Disease hi eng nge ni? Niemann-Pick natna nen engtin nge a danglam?

A awlsam zawngin Pick’s Disease hi thluak a nghawng a, zawi zawiin cell te a that thin. Dementia chi khat a ni a, frontotemporal dementia (FTD) an ti a ni. Kum 65 hnuai lam ah hmuh tur a tam ber a, tun hma chuan frontotemporal dementia ngei pawh hi Pick’s disease an ti bawk. Mahse tunah chuan doctor-te chuan he hming hi tehfung thenkhat zawm a nih chuan an hmang chauh a ni.

Tunah chuan, "Aw... Pick natna leh Niemann-Pick natna hi a inang em?" Ni lo, natna chi hrang hrang pahnih an ni. A hminga "Pick" tih hi a remchan dan angin inang mahse, natna pahnih hi a inzawm lo.

• Pick’s Disease: Czech neurologist leh psychiatrist Arnold Pick hming chawia sak a ni a, kum 1892 khan he natna hi a hmuchhuak hmasa ber a, frontotemporal dementia (FTD) chi khat a ni a, i thluak chauh a nghawng tihna a ni.
• Niemann-Pick Disease: German doctor pahnih Albert Niemann leh Ludwig Pick hming chawia sak a ni a, he natna hi taksaa lipids awmkhawmna leh a control danah harsatna a awm vang a ni. Lipids a awm khawm chuan taksa peng tam tak a nghawng thei a, chung zingah chuan thluak, thin, ril, ruhro leh lung te pawh a tel.

A danglamna chu i hrethiam em? Pakhat chu thluaka inkhuarna thil a ni a, pakhat zawk chu taksa peng hrang hrang khawih thei thil a ni.

He natna hi tuin nge vei? Engtiang chiahin nge a hluar?

Pick natna hi dementia ang chi natna dang aiin kum naupang zawkah hmuhchhuah a ni tlangpui. Kum 50 leh 60 inkar te zingah a awm tam ber. Mahse, a chang chuan kum 20 emaw, kum 80 emaw velah a awm thei.

Chhungkaw hrang hrangah he natna hi a kal thei tih finfiahna engemaw zat a awm. Researcher-te chuan a kaihhnawih gene mutation pathum tal an hmuchhuak a ni. Mahse, a tam zawkah chuan natna hi a awm fo thin. Chumi awmzia chu mi tu emaw chuan chhungkaw history engmah nei lovin a nei thei tihna a ni.

He natna hi engtiang chiahin nge a hluar tih sawi chian a har hle. Mithiamte chuan mi 100,000-ah hri kai hi 15 atanga 22 inkar an awm niin an chhut. Mahse, heng statistics te hi a dik leh dik lohah rinhlelhna a awm a, a chhan chu dam chhungin natna hi hriat a harsa hle a, a chang chuan thih hnuah pawh hriat chian a harsa hle. Chuvangin damlo awm zat tak tak chu a tam zawk mai thei.

Pick’s Disease hian engtin nge taksa a nghawng?

Pick natna hi neurodegenerative disease a ni a, dementia chi khat, frontotemporal dementia (FTD) an tih a ni. A awlsam zawngin, thluaka nerve cell (neurons) te hian zawi zawiin hna an thawk tawh lo. Thluak hmun a nghawng te chu a lo tlem tan (atrophy). Tichuan, chu part-te’n an thunun ṭhin theihna chu i hloh ta a ni. Alzheimer natna nen hian inanna engemaw zat nei mahse, Pick natna hi kum naupang zawk atanga tan a ni tlangpui a, danglamna pawimawh tak tak a awm bawk.

Pick’s Disease hian thluak hmun thenkhat chauh a nghawng avangin, a lan chhuahna ber chu nungchang emaw, tawng thiamna emaw inthlak danglamna a ni . Vawi tam tak chu Pick’s Disease vei te hian harsatna emaw, dinhmun emaw an nei tih an hre thei lo. Hei hi an thluak hian an dinhmun chungchanga information a process theih loh vang a ni. Hei hi "hriatthiam lohna" an ti.

Pick’s Disease natna lanchhuahna chu engte nge ni?

Pick’s Disease hi chi hnih a awm a, pakhat chu behavioral variant frontotemporal dementia (bvFTD) , a ni a, pakhat chu primary progressive aphasia (PPA) a ni a, chu chuan thluaka ṭawng nena inzawm hmunte a nghawng a ni.

Thiltih dan danglam tak frontotemporal dementia (bvFTD) 1.1.

He bvFTD natna lan chhuah dan hi chi parukah then theih a ni:

• Inhibition hloh: "Inhibition" tih hi thluak chhunga "hei hi ti suh" min titu a ni. Heng a then te hi a chhiat chuan thil dik lo sawi emaw tih emaw kan titawp thei lo.
• Thusawi tur "filter" awm lohna: I rilru a awm, a chang chuan midang tihnat zawnga sawi hi, zah lohna, a dik lo tihna a ni. Entîr nân, chhûngkaw inkhâwmnaa mi pakhat sawichhiat thut.
• Mi dangte zah lohna: Mi dangte thuruk an zah lo thei a, duh loh zawngin an khawih thei a, mipat hmeichhiatna lama ṭha lo taka awm an tum thei a, rang takin an thinrim emaw, an buai emaw pawh a ni thei.
• Thiltih leh nungchang ngaihsak lo: Hei hian mawhphurhna nei lo taka sum hman te, dawr rukbo te pawh a huam thei a ni.

• Apathy: Hei hi depression ang maiin a lang thei a, mahse a danglam deuh.
• Eng thil pawh ngaihvenna hloh: Hmanlai thil hlimawm (hobbies, thiante nena hun hman) ngaihvenna hloh.
• Social withdrawal: Thiante leh chhungte bula awm loh.
• Mahni inenkawlna tlahniam: Inbual, thawmhnaw thlak leh inthiarfihlim duhna hloh.

• Lainatna hloh: 1.1.Hei hi "emotional blunting" an ti bawk. Midangte rilru put hmang hriatthiam a harsa ta hle mai. Midangte lungngaihna emaw, hlimna emaw-ah pawh tun hma angin an thlawpna an lantir lo.

• Compulsive behaviors: He natna vei te hian midangte aiin nungchang danglam tak an lantir thin.
• Repetitive movements: Thil tenawm tak tak tih nawn fo, kut beng, ke pen, leh kal leh haw te.
• Complex emaw ritualistic behaviors: movie inang en nawn leh, lehkhabu inang chhiar, thil chi hrang hrang khawlkhawm. Hei hian hoarding pawh a huam tel bawk.
• Repetition: Aw, thumal leh sentence inang chiah chiah sawi nawn leh nawn leh.

• Ei leh in lama inthlak danglamna emaw, hmui lam hawi thil tih dan: He natna vei te hian "hyperorality" an tih ang chi natna an nei thei a, chu chu ka nena inzawm thil ngaihvenna danglam tak a ni.
• Ei leh in lama inthlak danglamna: Mite chuan an ei duh ber, a bik takin snack, sweets, leh zu te chu an ei nasa lutuk thin. Hei hian taksa rihna a tipung thei a ni.
• Compulsive oral behaviors: Meizial zuk, ei tam lutuk, etc. Tin, oral exploration. Hei hi naupang tê tête tân chuan khawvêl an chhui laia tih chu thil pangngai a nih laiin, puitlingte tân chuan thil mak tak a ni.
• Pica: Hei hi ei theih loh, ei tur tha lo (coins, dirt, pebbles) ei ngei ngei tura tih a ni.

• Executive function hloh mahse theihna dang awm lo: "Executive function" tih hian ni khata ruahmanna siam thiamna, harsatna chinfel thiamna leh thil tihfel theihna a kawk a ni. He natna vei teah hian heng theihna te hi tihchhiat ni mahse, theihna dang, hriatrengna leh mit tihhmasawn te hi a tir lamah chuan a nghawng vak lo. Hei hi frontotemporal dementia leh Alzheimer natna thliar hrangtu pawimawh tak a ni.

A rilru a buai em em a, a rilru a hah em em bawk a. Primary Progressive Aphasia (PPA) .

PPA hi Pick natna vang pawh a ni thei. Hei hian tawng thiamna a hloh zauh zauh a, chu chu mi dangte thusawi thiamna leh hriatthiamna te hi a ni. PPA hi subtype lian pathum awm mahse, Pick natna nena inzawm thei chi hnih lian ber chu:

• Nonfluent variant PPA (nfvPPA): Hetiang chiah hian thumal inmil leh grammar dik hman a harsa hle. Thumal pakhat leh sentence awlsam tak takte chu hriatthiam theih ni mah se, sentence complex tak takte chuan hriatthiam harsa an ti hle.
• Semantic variant PPA (svPPA) a ni a, a awmzia chu:Hetiang chi hian thumal dik thlan emaw, thumal awmzia hriatthiamna kawngah emaw harsatna a nei a. Thu thenkhat sawiin awmzia a nei lo mai thei a, mi dangte sawi chu hriatthiam a har hle. Lehkhabu chhiar leh ziakah harsatna a awm thei a, mahse chutiang bawk chuan mi dangte thusawi chu an sawi nawn leh thei a ni.

Ngaihtuah teh, i pa chu a nihna hmasa nen a danglam thut a, mi zawng zawng a hau a, fimkhur lo takin sum a hmang a, a nih loh leh nilengin hla pakhat a hum a. A nih loh leh, i biak hian a thusawi chu a inzawm khawm a, i thusawi chu a hrethiam lo ang maiin a inhria. Hengte hi kan sawi tawh ang chite entir nan kan hmang a ni.

Eng thilin nge he dinhmun hi a thlen? Hri kai theih a ni em?

Pick’s Disease hi frontotemporal dementia (FTD) chi khat a ni a, a chhan bik tak a nei a ni. Kan thluak leh nerve cell ah hian protein bik tau tih a awm a . Heng protein te hian pianzia bik an neih a ngai a, chuti lo chuan an thawk tha lo ang.

Tau proteins te chu an thawk tha lo va, an inzawm khawm a, neurons chhunga an awm khawm chuan chu cell te chu a chhe vek a, a chhe vek bawk. Neuron chhia te hi "Pick cells" an ti a. An lo hring chhuak a, balloon ang maiin an lo awm ta a ni. Cell chhunga tau protein clumps inzawmkhawmte chu "Pick bodies" an ti a. Chungte chu microscope hmangin hmuh theih a ni. Pawimawh tak chu heng Pick cell leh Pick body te hi natna dang ah hmuh tur a awm lo.

Engvangin nge heng tau proteins te hi an thawk tha lo tih hi thil mak tak a la ni reng. Zirchiangtute chuan genetic mutations thenkhat chu hei nen hian inzawm tir mahse, a tam zawkah chuan he natna hi thlahtute atanga lo chhuak a ni lo.

He natna hi kai theih a ni lo. Mi pakhat atanga mi dangah a kai lo. Chhuan hrang hranga kal zel theihna awm mah se, a tam zawkah chuan a thleng ngai lo.

Engtin nge Pick’s Disease hi hriat chhuah a nih? Eng test nge tih thin?

Doctor-te chuan frontotemporal dementia (FTD) hi taksa leh thluak enfiahna hmangin, diagnostic leh imaging test hmangin an hmu thei a, a result chuan behavioral FTD nge PPA subtype a nih leh nih loh a hriat theih a ni.

Mahse, mi pakhatin frontotemporal dementia (FTD) a neih hi Pick natna avanga lo awm a ni em tih chiang taka hriat theihna awmchhun chu an thluak tissue-a Pick taksa leh Pick cell zawng chhuah hi a ni. Hei hi thluak tissue sample pakhat microscope hmanga enfiah chauhvin a hriat theih. Hei hian Pick natna hi mi a thih hnuah, autopsy-ah chauh chiang taka hriat theih a ni tihna a ni.

FTD hriat theihna atan hetiang test hi tih theih a ni:

• Thisen test: Hengte hian natna thenkhat hriat theihna tura pui thei tur chemical marker "biomarkers" an zawng thin.
• Cerebrospinal fluid test hrang hrang: 1.1.Hei hi ruh (spinal tap / lumbar puncture) atanga tui lak atanga tih a ni.
• CT scan (Computerized tomography - CT scan) hmanga tih theih a ni.
• EEG (Electroencephalogram) hmanga chhut a ni.
• Genetic testing neih a ni
• MRI scan (Magnetic resonance imaging - MRI) hmanga enfiah a ni.
• PET scan (Positron emission tomography - PET scan) hmanga enfiah a ni.

Pick’s Disease enkawlna tur a awm em? Dam theih a ni em?

Vanduaithlak takin Pick natna hi damdawi, enkawl leh venna a awm lo. Doctor-te chuan depression, apathy, leh aggressive behavior te ang chi symptoms te enkawlna atana pui turin damdawi an pe thei a ni. Amaherawhchu, heng enkawlnate hi mi tinah a inang lo a, i doctor chu biak tur tha ber a ni.

He natna vei theihna hi tihziaawm theih a ni em?

Pick’s Disease hi sawi lawk theih loh, hriat loh kawng hrang hrangin a lo awm thin. Chuvangin tun dinhmunah chuan ven dan tur emaw, a vei theihna tur tihziaawmna tur emaw a awm lo.

He natna vei hian eng ang hmalam hun nge a beisei theih ang?

FTD chi hrang hrang, Pick’s Disease pawh tiamin, thluak hi a chhe zauh zauh a. A tih ang zelin thluaka a nghawngte chuan an hnathawh theihna an hloh ta a ni. Pick’s Disease-ah chuan hei hian thluak chhunga nungchang thununtu emaw, thluaka thusawi inzawmkhawmtu leh midangte thusawi hriatthiam theihna emaw a nghawng tlangpui.

I dinhmun pawh i hre lo thei bawk. Chu chu he natna avang hian a natna lan chhuah dan leh i chunga thil thleng hriat thiamna i hloh mai thei tihna a ni.

Frontotemporal dementia (FTD) vei te hian zawi zawiin mahni inrintawkna nei lovin an khawsa thei lo. Natna a zual zel chuan an hmangaih tak tak emaw, mi thiam thiam tak emaw hnen atangin darkar 24 chhung enkawl an ngai mai thei. Hei hian hun rei tak enkawl a ngai pawh a ni thei.

FTD vei te hian ei leh in harsatna (dysphagia) an nei thei a, chu chuan ei leh in, leh thusawi a ti harsa thei a ni. Hei hian pneumonia emaw thawk lama harsatna emaw ang chi natna a thlen theihna a tipung a ni.

FTD chi hrang hrang, Pick natna pawh tiamin, dam chhung zawnga natna awm thei a ni. He natna hi a na hle a, zawi zawiin thluak hmun lian tak tak a tichhe vek a ni. Harsatna hi a na hle thei a, thihna pawh a thlen thei bawk. Mi tin dam rei zawng hi a inang lo a, natnain engtin nge a nghawng ang che tih leh eng chen nge a daih dawn tih chiang taka sawi a harsa hle. Hemi chungchang hi i doctor (a nih loh leh i hmangaih enkawltu doctor) chuan a hrilh belh thei che a ni.

Nangmah ngeiin thutlukna i siam thei lo a nih chuan engtin nge i duhzawng i hman theih ang?

Frontotemporal dementia (FTD) hi a tir lamah i vei tih hmuhchhuah a nih chuan i doctor, i chhungte emaw, i hmangaih tak takte emaw, i tana thutlukna pawimawh siam thei tur i rintlak te nen inbiakna neih a pawimawh hle. He inbiakna hi a harsa mai thei a, mahse, a hnu lama sawi ni lovin heng thilte hi a hmaa sawi chuan i thil neihte i sawi thei lo emaw, thutlukna i siam thei lo emaw a nih chuan i hmangaihte chuan i duhzawng chu eng nge ni tih an hriat theih nan a pui ang.

Chu inbiakna bakah chuan i duhthusam leh thutlukna chu ziakin i neih a pawimawh bawk. I in enkawl thei lo a nih chuan, emaw, i enkawlna emaw, i hamthatna emaw chungchangah thutlukna i siam thei lo a nih chuan, dan anga lehkha buatsaih chu ngaihtuah rawh. Heng document te buatsaih tur hian ukil hnen atangin tanpuina i dawng thei a, mahse a then chu nangmah ngeiin i buatsaih thei bawk (i awmna hmuna dan azirin notary emaw official dang emaw phalna lak a ngai mai thei).

I hnaih ber tu emaw hian heng symptoms te hi a lantir a nih chuan engtin nge i tih ang?

FTD vei te hian an natna lan chhuah dan emaw, an dinhmun emaw an hre lo fo thin. Harsatna an nei tih an hmuh loh avangin damdawi lam pan ngai an ring lo. Hetianga hriatthiam lohna hi natna lan chhuahna nei leh a hnaih berte tan chuan lungngaihna leh hlauhawm tak a ni thei.

I hnaih bertu mi pakhatin FTD emaw, chutiang chi natna emaw a neih chuan hengte hian tanpui i tum thei ang:

• Engtin nge i ṭanpui theih ang tih zawt rawh: FTD vei te hian natna lan chhuah dan nei mah se, hengte hi thluak lama harsatna lian tak chhinchhiahna a ni tih an hre lo mai thei. An thusawi ngaihthlak a, i thlawpna i hlan hian an rintlak mite nen inzawmna an nei tih an inhria thei a, doctor hmu tura an mamawh fuihna pawh an dawng thei bawk.
• Ṭanpuina zawng turin fuih rawh: Frontotemporal dementia (FTD) hi damdawi leh enkawlna nei lo natna a nih laiin, a lan chhuah dan ṭhenkhat enkawl leh enkawl dan a awm. Heng hmalaknate hian he natna vei mi pakhat nunphung tihchangtlunna kawngah kawng thui tak a zawh thei a ni. Doctor hmuh hian FTD vei chu diagnosis a neih theih nan a pui thei a ni. Specialized care hian he natna vei te leh an chhungte tan chuan natna lan chhuah dan nuam lo thenkhat atanga chhanchhuahna a pe thei a ni.
• Ngawi renga awm la, thil chu mimal takin la suh: FTD vei te hian an thusawi emaw, an thiltih emaw chu an thunun thei lo fo thin. Hei hi tumruh taka midang tihthinrim, tihmualpho, tihnat tum ang maiin a lang thei a, mahse a takah chuan damdawi lam harsatna a ni.
• Ṭanpuina dil hlau suh: FTD vei enkawl hi a harsa hle thei a, a bik takin hun kal zelah a natna a zual zel avangin. Ṭanpuina emaw, resources emaw dil hlau suh. Mipui leh mimal agency tam tak chuan puitling daycare, respite care, leh skilled home nursing care te ang chi support system leh service an pe a ni.
• Hun rei tak enkawlna chu duhthlanna ṭha ber a ni thei: Mi tam tak tân chuan FTD vei an hmangaih tak enkawl chu hun pumhlum hna ang maiin a lang thei a ni. Mi zawng zawng hian kan hmangaih tak enkawl nân chutiang hun leh thawhrimna chu an hmang thei lo. Chuvangin, i hmangaih tak hian nursing thiam tak tak awmna hmun rei tak enkawlna hmunah enkawl a mamawh em tih ngaihtuah a pawimawh hle. Hei hi thu tlûkna siam harsa tak a ni thei a, mahse, chutiang enkawlna chu an him a, an hlim a, enkawltu thiam tak tak, zirtîrte nêna an awm theih nân kawng ṭha ber a ni thei.

A tawp berah chuan take-home message

Pick’s Disease hi frontotemporal dementia (FTD) an tih a ni a, kum upat avanga thluak natna dang aiin kum naupang zawkah thluak a tichhe zauh zauh thin. FTD hian thluak peng hrang hrang, mi pakhatin a nungchang a remchan dan leh a remchan lohzia a hriatthiam theih nan a nghawng bawk. Hei hian lungngaihna te, inhriatthiam lohna te, leh a kaihhnawih zawng zawngte nun tibuaitu lian tham dangte a thlen thei a ni. Symptom thenkhat chu enkawl theih a nih laiin, natna ngei pawh tidanglam thei damdawi a awm lo va, he natna vei te hian darkar 24 chhung enkawl reng an mamawh fo thin.

Nangmah emaw, i hnaih ber tu emaw hian heng symptoms te hi i nei a nih chuan a tha ber chu doctor thurawn lak hi a ni. Nangmah chauh i ni lo tih hre reng la, tanpuina dawnna hmun a awm bawk.

` Pick’s Disease, Frontotemporal Dementia, Dementia, Thluak natna, Neurodegenerative, Tau Protein, Nungchang inthlak danglamna