I hriatrengna leh i chetna te chu a chhe zauh zauh em? He (Corticobasal Degeneration) chungchang hi i zir chiang ang u!

A chang chuan thil i theihnghilh thin em? A nih loh leh i kut leh ke chet harsa i ti em? I thusawi hian i thusawi chu i slur em? Heng thilte hi a pung zel niin a lang a nih chuan tunlaia kan sawi tak (Corticobasal Degeneration) tih hi i hriat chian a pawimawh hle mai thei. Ngaihtuah buai suh, he thu hi awlsam takin sawi ila.

Corticobasal Degeneration'' tih hi eng nge ni?

A awlsam zawngin, (Corticobasal Degeneration) hi kan thluak khawihtu thluak lam natna (neurological condition) a ni. Mi thenkhat chuan (Corticobasal Syndrome) an ti bawk. Hemiah hian thil thleng chu kan thluaka cell thenkhat a chhe vek a, zawi zawiin a chhe vek thin. Hun kal zelah hmanraw thenkhat a chhe vek ang bawkin. Chumi avang chuan kan thusawi thiamna te, chaw ei thiamna te, kan taksa chet thiamna te, thil hriatrengna te chu a tlahniam zauh zauh thei a ni. Thil lungchhiatthlak tak chu heng symptoms te hi hun kal zelah a pung (progress) zauh zauh thin hi a ni.

A hminga "corticobasal" tih hian thluak hmun hnih, natnain a tihchhiat berte a kawk a ni:

• Cerebral cortex: Hei hi kan thluaka nervous tissue pawn lam ber a ni. He part hi kan hriatrengna, kan zirlai, mahni duhthua kan chetna leh kan hriatna atan a pawimawh hle.
• Basal ganglia: Hei hi thluak chhung thuk taka awm nerve cell awmkhawm a ni. Zirna leh motor hnathawhna atan a pawimawh hle.

"Degeneration" tih thumal hian "deterioration" emaw "loss of function" tihna a ni. Chuvangin he natnaah hian thil thleng chu heng thluak peng pahnih hnathawh hi a tlahniam zauh zauh thin.

He natna, Corticobasal Degeneration hian mi dam chhung a ti tawi thei a, nunna atana hlauhawm harsatna a thlen thei bawk. Taksa pumpuiah a natna lan chhuah dan a darh zel chuan mahni inrintawkna neia hnathawh a harsa thei hle.

(Corticobasal Degeneration) natna lan chhuah dan chu engte nge ni?

He natna lan chhuah dan hi mi hrang hrangah a inang lo thei a, mahse a tlangpuiin a nghawng theih theihna chu:

• Movement harsatna (Apraxia): Chumi awmzia chu button button emaw, ei tur spoon vawn emaw ang chi thil a harsat phah tihna a ni. Thluak hian kut hnenah thuchah thawn mah se, an ti tha thei lo.
• Hriatrengna (Memory impairment): Thil thar hriat reng a harsa a, thil hlui chu a theihnghilh zauh zauh thin.
• Mit lama harsatna: Mi thenkhat chuan mit lama harsatna an nei thei bawk.
• Thusawi harsatna (Aphasia): Thumal hmuh harsa, i sawi duh chu slurring, leh a chang chuan thusawi hloh vek.
• Chaw ei harsa: Ei leh in i ei hian i rilru a buai ang maiin i inhria thei.

Hei bakah hian heng ang chi natna dang pawh hmuh tur a awm thei bawk:

• Muscle spasm, twitches, muscle khauh emaw, khur emaw.
• Hna tenau, nalh tak tak (e.g., kawr button siam, pen hmanga ziah) tih harsa.
• Alien hand syndrome: I duh ang anga kut emaw ke pakhat emaw control theih lohna (Alien hand syndrome). I kut pakhatin i duh loh thil a ti a, i thunun thei lo ang maiin i inhria ang tih han ngaihtuah teh.
• Taksa sir khatah rilru hah lutuk.
• Movement slow tak tak (Bradykinesia) emaw, taksa peng hrang hrang che thei lo (Akinesia) emaw a awm thin.
• Rilru hnathawh tlahniam, chu chu finna tlahniam (Dementia) tihna a ni.
• Ṭanpuina tel lova kal harsa.
• Mod leh nungchang inthlak danglamna (ngaihtuahna tlakchham, thinrim thut, ngaihsak lohna).

He natna hian mi zawng zawng a nghawng dan inang vek lo. Zawi zawiin a kal zel fo thin. A chang chuan a natna lan chhuah dan chu kut pakhatah a intan a, chutah chuan kut leh ke dangah a darh leh thin. I kal laiin i tlu ang maiin i inhriat tan mai thei a, chumi hnuah chuan tanpuina tel lovin i kal thei tawh lo mai thei. Thu i ​​sawi laiin i thusawi chu i sawisel ṭan mai thei a, hun kal zelah chuan thumal awmze nei tak pakhat mah i sawi thei lo mai thei bawk.

He natna hian thluak hmun tam zawk a nghawng chuan a natna lan chhuah dan chu a na zual sauh sauh a ni. Hei hi zawi zawiin a thleng thin.

Engtikah nge (Corticobasal Degeneration) symptoms hi a lo intan?

Kum 50 leh 70 inkar atanga natna lanchhuahna hi a intan tlangpui a, mi tam zawk chuan kum 64 vel atang hian an natna lanchhuahna hi an nei thin a, kum 40 atanga tan tirh lamah pawh a intan tlem hle nachungin, kum hmasa lama natna hi a lo awm tih report a la awm lo.

(Corticobasal Degeneration) awm chhante chu engte nge ni?

Hei hi a chhan ber chu thluak cell leh tissue te chu zawi zawiin an inthen a, an thi thin a ni. A tam zawkah chuan he chhiatna hi a hmaa kan sawi tawhna hmunah cerebral cortex leh basal ganglia an tih atang hian a intan thin. Natna a zual zel chuan thluak hmun dang pawh a nghawng thei a ni.

Zirchiangtute chuan he natnaah hian protein pakhat "Tau" an tih hi a inrawlh niin an ngai. He protein hi a tlangpuiin thluak cell-ah a awm thin. Mahse he natnaah hian he protein hi a pangngai lo takin a inzawm khawm a, a inzawm khawm thin. Heng clump te hi "neurofibrillar tangles" an ti a. Heng clump te hian thluak cell te chu a ti chhe a, a thi ta a ni. Chumi avang chuan chetna, tawng leh hriatrengna lama harsatna a awm thin.

Tau protein hi a inzawm khawm chhan dik tak hi hriat a la ni lo. Corticobasal Degeneration vei tam tak chuan chromosome 17-ah hian H1 haplotype an tih, genetic variant (mutation) an nei tih hmuhchhuah a ni a, he genetic variation hian Tau protein chu a siam tam lutuk a, a inzawm khawm thei a, a nih loh leh Tau gene-ah methyl group a inzawm a, a hnathawh a nghawng thei bawk.

Mahse zirchiangtute chuan he gene hi a chhan awmchhun a ni lo tih an hria. Mipui zingah hian mi tam takin he gene hi an neih avangin Corticobasal Degeneration. symptoms an nei lo. Chuvangin he natna thlen chhan dik tak hi zawn chhuah a la ni reng a ni.

(Corticobasal Degeneration) hi thlahtute atanga lo chhuak a ni em?

Medical expert-te chuan mi thenkhatin Corticobasal Degeneration an neih chhan hi an la hre lo. Chhungkaw khata mite tan he natna hi an vei hi a tlem hle. Chumi awmzia chu thlahtu natna a ni tih sawi a har tihna a ni.

Eng harsatna nge awm thei?

Natna a zual zel chuan nunna atana hlauhawm harsatna a thlen theihna a awm a, chungte chu:

• Bacteria natna hrik kai
• Thisen zam leh pulmonary embolism te a awm
• Taksa accident (tlu ang chi) .
• Pneumonia natna (Pneumonia) a ni
• Sepsis (thisen chhunga hrik lut avanga natna khirh tak) .

He natna hi Doctor ten engtin nge an hriat chian? (Diagnosis) tih a ni.

(Corticobasal Degeneration) hriat chian dan danglam tak chu thih hnua thluak enfiah chauhvin chiang taka finfiah theih a ni. Chumi hnuah chauh chuan doctor emaw, pathologist emaw chuan thluak chhiatna zau zawng chu dik takin a hre thei ang.

Mahse, i dam chhung hian i doctor chuan i natna lan chhuah dan a zirin he natna hi "Corticobasal Syndrome" tiin a sawi thei a ni.

Diagnosis siam tur chuan i doctor chuan taksa a enfiah hmasa ang. I symptoms te chu uluk takin an lo en ang.

Natna tam takin a lan chhuah dan inang an neih avângin, i doctor chuan a chhan dik tak hriat nân test chi hrang hrang a ti thei a ni. Chûng zîngah chuan:

• Thisen test a ni
• Thluak thlalak (Imaging scans) - entirnan (MRI) emaw (CT scan)
• Thluak hnathawh leh hriatrengna tehna atan neuropsychological testing neih a ni

Hei bakah hian doctor chuan nuclear damdawi scan (FDG-PET (Fluorodeoxyglucose Positron Emission Tomography)) leh (DAT (Dopamine Transporter)) te pawh a order thei bawk. A châng chuan, skin biopsy pawh hian natna hriat theihna kawngah a pui thei bawk.

(Corticobasal Degeneration) hi eng enkawlna nge ni?

I doctor chuan he natna lan chhuah dan hrang hrang control nan damdawi chi hrang hrang a pe thei ang.

Tunah hian he natna hi damdawi emaw, a natna lan chhuahna titawp thei tur damdawi emaw a la awm lo tih hre reng ang che. Mahse, a natna lan chhuah dan avanga lungawi lohna tihziaawmna tur thil a awm.

Muscle-related symptoms enkawlna damdawi te chu:

• Zawi zawia che emaw, taksa ruh nghet lo emaw: (Levodopa)
• Taksa ruh natna tan: Clonazepam (Benzodiazepines) .
• Muscle stiffness emaw movement control emaw atan: (Botulinum toxin) (Botox injection) .
• Muscle khauh nan: (Cyclobenzaprine), (Levetiracetam) emaw (Baclofen) emaw

Hriatrengna lama harsatna nei tan chuan i doctor chuan heng damdawi chi hrang hrang zinga pakhat, Cholinesterase inhibitors'' tih hi a pe thei ang:

• (Donepezil) tih a ni
• (Rivastigmine)
• (Galantamine) tih a ni

Damdawi thenkhat chuan mi zawng zawng symptoms atan a thawk tha tawk lo a, chuvangin i doctor chuan i tana tha ber tur zawng turin chi hrang hrang a lo enchhin mai thei.

Tin, damdawi zawng zawng ang bawkin side effect awm thei a awm bawk. I doctor chuan hemi chungchang hi a sawipui ang che. Damdawi a thawk tha em tih leh harsatna a awm leh awm loh an enfiah fo ang che. Side effect i neih chuan doctor hnenah i hrilh nghal tur a ni.

A pawimawh ber chu tun dinhmunah hian heng natna lan chhuah dan tur titawp tur emaw, natna tihdam kim theihna tur emaw damdawi a la awm lo.

Engtin nge symptoms te hi kan enkawl ang?

Corticobasal Syndrome'' symptoms nena kan nun hian a hnuaia therapies te hian a enkawl theih nan a pui thei ang:

• Occupational therapy: Hei hian nitin hna thawh dan thar zir turin a pui thei che a, a theih ang anga rei i independence vawng reng thei bawk. A tul chuan assistive mobility device hman dan pawh i zir thei bawk.
• Physical therapy: Hei hian taksa chetna vawng reng turin a pui a, taksa ruh nena inzawm symptoms avanga harsatna awmte a tiziaawm bawk. Exercise hian taksa ruh a tichak thei a, flexibility a vawng reng thei bawk.
• Speech therapy: Hei hian tawng leh ei harsatnaah a pui thin. Ngaihtuahna sawi chhuah dan, thumal sawi dan, leh ei tur him taka ei dan ang chi thilah a pui thei a ni.

I doctor chuan i symptoms te enkawl dan tha ber ber zawng turin a thawkpui ang che. Heng strategy te hi mi hrang hrangah a inang lo thei a, hun kal zelah i dinhmun a inthlak danglam zel chuan siamthat a ngai thei bawk.

Engtikah nge doctor i hmuh ang?

Nangmah emaw, i hmangaih tak emaw hian heng (Corticobasal Degeneration) symptoms te hi i neih chuan doctor pan nghal rawh:

• Kea kal harsatna emaw, i ke leh ke i thunun emaw i neih chuan.
• Hriatrengna lama harsatna emaw, dementia symptoms emaw i neih chuan.
• Thusawi, ei leh in, thawk harsa i neih chuan.
• Tremors a awm chuan.

(Corticobasal Degeneration) hi eng nge a hmalam hun?

Dik tak chuan Corticobasal Degeneration thlirna hi a beisei awm vak lo. Natna zual zel a ni a, hun kal zelah a natna lan chhuah dan a na zual tihna a ni.Mahse hei hi zawi zawiin, kum tam tak chhungin a thleng fo thin. I doctor chuan i natna lan chhuah dan tur leh i enkawl dan tur enkawlna a pe ang che. Heng enkawlnate hian i natna lanchhuahna nasatzia a tihziaawm theih laiin, a zual zel tur chu a titawp thei lo. I natna lan chhuah dan a na zual zel chuan nangmah chauha enkawl chu a harsa zual thei hle.

He natna hi zawi zawiin a kal zel avangin i hmalam hun tur ruahmanna siamna hun i nei a ni. Diagnosis i hmuh hunah heng thilte hi i tih nghal a ngai lo. I tana tha ber tur ngaihtuah turin hun i neih a ngai a ni. I duhzawng leh eng enkawlna nge i mamawh tih buatsaih turin i doctor leh i rintlak mite nen thawhhona tha tak i neih a ngai a ni.

(Corticobasal Degeneration) vei dam rei zawng chu engzat nge ni ang?

A vaiin mi tam zawk hi Corticobasal Degeneration symptom hmasa ber a lo lan atanga kum ruk atanga kum riat vel an dam a ni. Mahse, hei hi mi zawng zawng tan a inang lo va, mi thenkhat chu an dam rei zawk hle. I dinhmun hi statistics nen a inmil lo mai thei a, chuvangin he thil chungchanga inbiakna tur tha ber chu i doctor hi a ni.

Eng dinhmun dang nge hetiang chhinchhiahna nei?

(Corticobasal Degeneration) chhinchhiahna thenkhat chu natna dang lanchhuahna nen a inang thei a, chungte chu:

• Thluak cancer (Thluak cancer / thluaka natna hrik) .
• (Frontotemporal dementia) tih a ni
• Alzheimer natna a ni
• (System tam tak atrophy)
• Parkinson natna a ni
• (Supranuclear palsy hmasawn zel)
• Thai

Chuvangin, natna lanchhuahna i neih chuan doctor pan vat a pawimawh hle a, a hmaa enkawl hian nunna a chhanhim thei a, a bik takin paralysis ang chi ah chuan.

(Corticobasal Degeneration) ang chi diagnosis nena lo awm emotion te hi enkawl a harsa thei hle. Nakin hun tur chu hlauhna leh lungkhamna i nei mai thei. Kum tam tak chhûnga natna lan chhuah dân a lo lan chhoh zêl chuan, engtin nge hun tin chu a ṭha thei ang bera hman theih ang tih i ngaihtuah mai thei. Heng zawng zawng hi vawi khata hmachhawn chu a harsa thei hle. He hun harsa tak karah hian rilru lam hriselna lama mithiamte nen pawh tanpuina dil turin i sawi duh mai thei bawk.

Heng zawng zawngah hian nangmah chauh i ni lo tih hre reng ang che. Ṭanpuina i mamawh chuan i medical team te biak hreh ngai suh.

A tawp berah chuan thil hriat reng tur

Okay, chuti a nih chuan (Corticobasal Degeneration) chungchanga kan sawi tawh thenkhat, i tana pawimawh ka tihte chu hetiang hi a ni:

• Hei hi thluak a nghawng a, hun kal zelah a symptoms a pung zauh zauh thin.
• Hei hi a chhan dik tak erawh hriat a la ni lo a, mahse protein pakhat (Tau) nen a inzawm nia ngaih a ni.
• Tunah hian he natna hi tidam kim thei tur damdawi a la awm lo.
• Mahse, natna lan chhuah dan enkawl dan tur leh nun awlsam zawka siam theihna tur enkawlna a awm.(Damdawi, taksa lam enkawlna, hnathawhna lama enkawlna, thusawi hmanga enkawlna ang chi).
• Damdawi lam thurawn lak vat a pawimawh.
• Nakin hun tur ruahmanna siam la, i mamawh tanpuina dawng rawh.
• Nangmah chauh i ni lo. Rilru chak taka awm reng a pawimawh hle bawk. Doctor, chhungte leh ṭhiante hnen aṭangin ṭanpuina la rawh.

He thu hi in tan a tangkai ngei ka beisei. Zawhna i neih chuan Doctor nen inbiakna neih hreh suh.