A chang chuan thil i theihnghilh thin em? A nih loh leh i kut leh ke chet harsa i ti em? I thusawi hian i thusawi chu i slur em? Heng thilte hi a pung zel niin a lang a nih chuan tunlaia kan sawi tak `(Corticobasal Degeneration)` tih hi i hriat chian a pawimawh hle mai thei. Ngaihtuah buai suh, he thu hi awlsam takin sawi ila.
``Corticobasal Degeneration'' tih hi eng nge ni?
A awlsam zawngin, `(Corticobasal Degeneration)` hi kan thluak khawihtu thluak lam natna (neurological condition) a ni. Mi thenkhat chuan `(Corticobasal Syndrome) an ti bawk.` Hemiah hian thil thleng chu kan thluaka cell thenkhat a chhe vek a, zawi zawiin a chhe vek thin. Hun kal zelah hmanraw thenkhat a chhe vek ang bawkin. Chumi avang chuan kan thusawi thiamna te, chaw ei thiamna te, kan taksa chet thiamna te, thil hriatrengna te chu a tlahniam zauh zauh thei a ni. Thil lungchhiatthlak tak chu heng symptoms te hi hun kal zelah a pung (progress) zauh zauh thin hi a ni.
A hminga "corticobasal" tih hian thluak hmun hnih, natnain a tihchhiat berte a kawk a ni:
- Cerebral cortex: Hei hi kan thluaka nervous tissue pawn lam ber a ni. He part hi kan hriatrengna, kan zirlai, mahni duhthua kan chetna leh kan hriatna atan a pawimawh hle.
- Basal ganglia: Hei hi thluak chhung thuk taka awm nerve cell awmkhawm a ni. Zirna leh motor hnathawhna atan a pawimawh hle.
"Degeneration" tih thumal hian "deterioration" emaw "loss of function" tihna a ni. Chuvangin he natnaah hian thil thleng chu heng thluak peng pahnih hnathawh hi a tlahniam zauh zauh thin.
He natna, ``Corticobasal Degeneration`` hian mi dam chhung a ti tawi thei a, nunna atana hlauhawm harsatna a thlen thei bawk. Taksa pumpuiah a natna lan chhuah dan a darh zel chuan mahni inrintawkna neia hnathawh a harsa thei hle.
`(Corticobasal Degeneration)` natna lan chhuah dan chu engte nge ni?
He natna lan chhuah dan hi mi hrang hrangah a inang lo thei a, mahse a tlangpuiin a nghawng theih theihna chu:
- Movement harsatna (`Apraxia`): Chumi awmzia chu button button emaw, ei tur spoon vawn emaw ang chi thil a harsat phah tihna a ni. Thluak hian kut hnenah thuchah thawn mah se, an ti tha thei lo.
- Hriatrengna (Memory impairment): Thil thar hriat reng a harsa a, thil hlui chu a theihnghilh zauh zauh thin.
- Mit lama harsatna: Mi thenkhat chuan mit lama harsatna an nei thei bawk.
- Thusawi harsatna (`Aphasia`): Thumal hmuh harsa, i sawi duh chu slurring, leh a chang chuan thusawi hloh vek.
- Chaw ei harsa: Ei leh in i ei hian i rilru a buai ang maiin i inhria thei.
Hei bakah hian heng ang chi natna dang pawh hmuh tur a awm thei bawk:
- Muscle spasm, twitches, muscle khauh emaw, khur emaw.
- Hna tenau, nalh tak tak (e.g., kawr button siam, pen hmanga ziah) tih harsa.
- Alien hand syndrome: I duh ang anga kut emaw ke pakhat emaw control theih lohna (`Alien hand syndrome`). I kut pakhatin i duh loh thil a ti a, i thunun thei lo ang maiin i inhria ang tih han ngaihtuah teh.
- Taksa sir khatah rilru hah lutuk.
- Movement slow tak tak (`Bradykinesia`) emaw, taksa peng hrang hrang che thei lo (`Akinesia`) emaw a awm thin.
- Rilru hnathawh tlahniam, chu chu finna tlahniam (Dementia) tihna a ni.
- Ṭanpuina tel lova kal harsa.
- Mod leh nungchang inthlak danglamna (ngaihtuahna tlakchham, thinrim thut, ngaihsak lohna).
He natna hian mi zawng zawng a nghawng dan inang vek lo. Zawi zawiin a kal zel fo thin. A chang chuan a natna lan chhuah dan chu kut pakhatah a intan a, chutah chuan kut leh ke dangah a darh leh thin. I kal laiin i tlu ang maiin i inhriat tan mai thei a, chumi hnuah chuan tanpuina tel lovin i kal thei tawh lo mai thei. Thu i sawi laiin i thusawi chu i sawisel ṭan mai thei a, hun kal zelah chuan thumal awmze nei tak pakhat mah i sawi thei lo mai thei bawk.
He natna hian thluak hmun tam zawk a nghawng chuan a natna lan chhuah dan chu a na zual sauh sauh a ni. Hei hi zawi zawiin a thleng thin.
Engtikah nge `(Corticobasal Degeneration)` symptoms hi a lo intan?
Kum 50 leh 70 inkar atanga natna lanchhuahna hi a intan tlangpui a, mi tam zawk chuan kum 64 vel atang hian an natna lanchhuahna hi an nei thin a, kum 40 atanga tan tirh lamah pawh a intan tlem hle nachungin, kum hmasa lama natna hi a lo awm tih report a la awm lo.
`(Corticobasal Degeneration)` awm chhante chu engte nge ni?
Hei hi a chhan ber chu thluak cell leh tissue te chu zawi zawiin an inthen a, an thi thin a ni. A tam zawkah chuan he chhiatna hi a hmaa kan sawi tawhna hmunah cerebral cortex leh basal ganglia an tih atang hian a intan thin. Natna a zual zel chuan thluak hmun dang pawh a nghawng thei a ni.
Zirchiangtute chuan he natnaah hian protein pakhat "Tau" an tih hi a inrawlh niin an ngai. He protein hi a tlangpuiin thluak cell-ah a awm thin. Mahse he natnaah hian he protein hi a pangngai lo takin a inzawm khawm a, a inzawm khawm thin. Heng clump te hi "neurofibrillar tangles" an ti a. Heng clump te hian thluak cell te chu a ti chhe a, a thi ta a ni. Chumi avang chuan chetna, tawng leh hriatrengna lama harsatna a awm thin.
Tau protein hi a inzawm khawm chhan dik tak hi hriat a la ni lo. Corticobasal Degeneration vei tam tak chuan chromosome 17-ah hian H1 haplotype an tih, genetic variant (mutation) an nei tih hmuhchhuah a ni a, he genetic variation hian Tau protein chu a siam tam lutuk a, a inzawm khawm thei a, a nih loh leh Tau gene-ah methyl group a inzawm a, a hnathawh a nghawng thei bawk.
Mahse zirchiangtute chuan he gene hi a chhan awmchhun a ni lo tih an hria. Mipui zingah hian mi tam takin he gene hi an neih avangin ``Corticobasal Degeneration.`` symptoms an nei lo. Chuvangin he natna thlen chhan dik tak hi zawn chhuah a la ni reng a ni.
`(Corticobasal Degeneration)` hi thlahtute atanga lo chhuak a ni em?
Medical expert-te chuan mi thenkhatin Corticobasal Degeneration an neih chhan hi an la hre lo. Chhungkaw khata mite tan he natna hi an vei hi a tlem hle. Chumi awmzia chu thlahtu natna a ni tih sawi a har tihna a ni.
Eng harsatna nge awm thei?
Natna a zual zel chuan nunna atana hlauhawm harsatna a thlen theihna a awm a, chungte chu:
- Bacteria natna hrik kai
- Thisen zam leh pulmonary embolism te a awm
- Taksa accident (tlu ang chi) .
- Pneumonia natna (Pneumonia) a ni
- Sepsis (thisen chhunga hrik lut avanga natna khirh tak) .
He natna hi Doctor ten engtin nge an hriat chian? (`Diagnosis`) tih a ni.
`(Corticobasal Degeneration)` hriat chian dan danglam tak chu thih hnua thluak enfiah chauhvin chiang taka finfiah theih a ni. Chumi hnuah chauh chuan doctor emaw, pathologist emaw chuan thluak chhiatna zau zawng chu dik takin a hre thei ang.
Mahse, i dam chhung hian i doctor chuan i natna lan chhuah dan a zirin he natna hi "Corticobasal Syndrome" tiin a sawi thei a ni.
Diagnosis siam tur chuan i doctor chuan taksa a enfiah hmasa ang. I symptoms te chu uluk takin an lo en ang.
Natna tam takin a lan chhuah dan inang an neih avângin, i doctor chuan a chhan dik tak hriat nân test chi hrang hrang a ti thei a ni. Chûng zîngah chuan:
- Thisen test a ni
- Thluak thlalak (`Imaging scans`) - entirnan `(MRI)` emaw `(CT scan`)
- Thluak hnathawh leh hriatrengna tehna atan neuropsychological testing neih a ni
Hei bakah hian doctor chuan nuclear damdawi scan `(FDG-PET (Fluorodeoxyglucose Positron Emission Tomography))` leh `(DAT (Dopamine Transporter))` te pawh a order thei bawk. A châng chuan, `skin biopsy` pawh hian natna hriat theihna kawngah a pui thei bawk.
`(Corticobasal Degeneration)` hi eng enkawlna nge ni?
I doctor chuan he natna lan chhuah dan hrang hrang control nan damdawi chi hrang hrang a pe thei ang.
Tunah hian he natna hi damdawi emaw, a natna lan chhuahna titawp thei tur damdawi emaw a la awm lo tih hre reng ang che. Mahse, a natna lan chhuah dan avanga lungawi lohna tihziaawmna tur thil a awm.
Muscle-related symptoms enkawlna damdawi te chu:
- Zawi zawia che emaw, taksa ruh nghet lo emaw: `(Levodopa)`
- Taksa ruh natna tan: Clonazepam (Benzodiazepines) .
- Muscle stiffness emaw movement control emaw atan: `(Botulinum toxin)` (Botox injection) .
- Muscle khauh nan: `(Cyclobenzaprine)`, `(Levetiracetam)` emaw `(Baclofen)` emaw
Hriatrengna lama harsatna nei tan chuan i doctor chuan heng damdawi chi hrang hrang zinga pakhat, ``Cholinesterase inhibitors'' tih hi a pe thei ang:
- `(Donepezil)` tih a ni
- `(Rivastigmine)`
- `(Galantamine)` tih a ni
Damdawi thenkhat chuan mi zawng zawng symptoms atan a thawk tha tawk lo a, chuvangin i doctor chuan i tana tha ber tur zawng turin chi hrang hrang a lo enchhin mai thei.
Tin, damdawi zawng zawng ang bawkin side effect awm thei a awm bawk. I doctor chuan hemi chungchang hi a sawipui ang che. Damdawi a thawk tha em tih leh harsatna a awm leh awm loh an enfiah fo ang che. Side effect i neih chuan doctor hnenah i hrilh nghal tur a ni.
A pawimawh ber chu tun dinhmunah hian heng natna lan chhuah dan tur titawp tur emaw, natna tihdam kim theihna tur emaw damdawi a la awm lo.
Engtin nge symptoms te hi kan enkawl ang?
``Corticobasal Syndrome'' symptoms nena kan nun hian a hnuaia therapies te hian a enkawl theih nan a pui thei ang:
- Occupational therapy: Hei hian nitin hna thawh dan thar zir turin a pui thei che a, a theih ang anga rei i independence vawng reng thei bawk. A tul chuan assistive mobility device hman dan pawh i zir thei bawk.
- Physical therapy: Hei hian taksa chetna vawng reng turin a pui a, taksa ruh nena inzawm symptoms avanga harsatna awmte a tiziaawm bawk. Exercise hian taksa ruh a tichak thei a, flexibility a vawng reng thei bawk.
- Speech therapy: Hei hian tawng leh ei harsatnaah a pui thin. Ngaihtuahna sawi chhuah dan, thumal sawi dan, leh ei tur him taka ei dan ang chi thilah a pui thei a ni.
I doctor chuan i symptoms te enkawl dan tha ber ber zawng turin a thawkpui ang che. Heng strategy te hi mi hrang hrangah a inang lo thei a, hun kal zelah i dinhmun a inthlak danglam zel chuan siamthat a ngai thei bawk.
Engtikah nge doctor i hmuh ang?
Nangmah emaw, i hmangaih tak emaw hian heng `(Corticobasal Degeneration)` symptoms te hi i neih chuan doctor pan nghal rawh:
- Kea kal harsatna emaw, i ke leh ke i thunun emaw i neih chuan.
- Hriatrengna lama harsatna emaw, dementia symptoms emaw i neih chuan.
- Thusawi, ei leh in, thawk harsa i neih chuan.
- Tremors a awm chuan.
`(Corticobasal Degeneration)` hi eng nge a hmalam hun?
Dik tak chuan Corticobasal Degeneration thlirna hi a beisei awm vak lo. Natna zual zel a ni a, hun kal zelah a natna lan chhuah dan a na zual tihna a ni.Mahse hei hi zawi zawiin, kum tam tak chhungin a thleng fo thin. I doctor chuan i natna lan chhuah dan tur leh i enkawl dan tur enkawlna a pe ang che. Heng enkawlnate hian i natna lanchhuahna nasatzia a tihziaawm theih laiin, a zual zel tur chu a titawp thei lo. I natna lan chhuah dan a na zual zel chuan nangmah chauha enkawl chu a harsa zual thei hle.
He natna hi zawi zawiin a kal zel avangin i hmalam hun tur ruahmanna siamna hun i nei a ni. Diagnosis i hmuh hunah heng thilte hi i tih nghal a ngai lo. I tana tha ber tur ngaihtuah turin hun i neih a ngai a ni. I duhzawng leh eng enkawlna nge i mamawh tih buatsaih turin i doctor leh i rintlak mite nen thawhhona tha tak i neih a ngai a ni.
`(Corticobasal Degeneration)` vei dam rei zawng chu engzat nge ni ang?
A vaiin mi tam zawk hi Corticobasal Degeneration symptom hmasa ber a lo lan atanga kum ruk atanga kum riat vel an dam a ni. Mahse, hei hi mi zawng zawng tan a inang lo va, mi thenkhat chu an dam rei zawk hle. I dinhmun hi statistics nen a inmil lo mai thei a, chuvangin he thil chungchanga inbiakna tur tha ber chu i doctor hi a ni.
Eng dinhmun dang nge hetiang chhinchhiahna nei?
`(Corticobasal Degeneration)` chhinchhiahna thenkhat chu natna dang lanchhuahna nen a inang thei a, chungte chu:
- Thluak cancer (`Thluak cancer / thluaka natna hrik`) .
- `(Frontotemporal dementia)` tih a ni
- Alzheimer natna a ni
- `(System tam tak atrophy)`
- Parkinson natna a ni
- `(Supranuclear palsy hmasawn zel)`
- Thai
Chuvangin, natna lanchhuahna i neih chuan doctor pan vat a pawimawh hle a, a hmaa enkawl hian nunna a chhanhim thei a, a bik takin paralysis ang chi ah chuan.
`(Corticobasal Degeneration)` ang chi diagnosis nena lo awm emotion te hi enkawl a harsa thei hle. Nakin hun tur chu hlauhna leh lungkhamna i nei mai thei. Kum tam tak chhûnga natna lan chhuah dân a lo lan chhoh zêl chuan, engtin nge hun tin chu a ṭha thei ang bera hman theih ang tih i ngaihtuah mai thei. Heng zawng zawng hi vawi khata hmachhawn chu a harsa thei hle. He hun harsa tak karah hian rilru lam hriselna lama mithiamte nen pawh tanpuina dil turin i sawi duh mai thei bawk.
Heng zawng zawngah hian nangmah chauh i ni lo tih hre reng ang che. Ṭanpuina i mamawh chuan i medical team te biak hreh ngai suh.
A tawp berah chuan thil hriat reng tur
Okay, chuti a nih chuan `(Corticobasal Degeneration)` chungchanga kan sawi tawh thenkhat, i tana pawimawh ka tihte chu hetiang hi a ni:
- Hei hi thluak a nghawng a, hun kal zelah a symptoms a pung zauh zauh thin.
- Hei hi a chhan dik tak erawh hriat a la ni lo a, mahse protein pakhat `(Tau)` nen a inzawm nia ngaih a ni.
- Tunah hian he natna hi tidam kim thei tur damdawi a la awm lo.
- Mahse, natna lan chhuah dan enkawl dan tur leh nun awlsam zawka siam theihna tur enkawlna a awm.(Damdawi, taksa lam enkawlna, hnathawhna lama enkawlna, thusawi hmanga enkawlna ang chi).
- Damdawi lam thurawn lak vat a pawimawh.
- Nakin hun tur ruahmanna siam la, i mamawh tanpuina dawng rawh.
- Nangmah chauh i ni lo. Rilru chak taka awm reng a pawimawh hle bawk. Doctor, chhungte leh ṭhiante hnen aṭangin ṭanpuina la rawh.
He thu hi in tan a tangkai ngei ka beisei. Zawhna i neih chuan Doctor nen inbiakna neih hreh suh.
` Corticobasal Degeneration, Thluak Natna, Thluak lam natna, Incheina lama harsatna, Hriatrengna lama harsatna, Thusawi lama harsatna, Tau Protein, CBS, Brain Atrophy, Apraxia, Aphasia, Dementia
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