Primary Biliary Cholangitis (PBC) natna ngawi renga awm, thin (liver) tibuaitu hi i hrechiang ang u

Chhan awm lovin i chau emaw, i itchy emaw fo thin em? A chang chuan heng thilte hi kan nitin nunah thil pangngai angin kan ngaihven vak lo mai thei. Amaherawhchu, hengte hi a chang chuan kan taksa chhung a\anga vaukhânna chhinchhiahna a ni thei. A bik takin kan thin (liver) lama harsatna kan neih chhinchhiahna hmasa ber an ni thei. Vawiin hian ngawi renga taksa tichhe thei natna chungchang kan sawi dawn a ni. Chu chu Primary Biliary Cholangitis, a tawi zawngin PBC a ni.

A awlsam zawngin, Primary Biliary Cholangitis (PBC) hi eng nge ni?

I liver chhungah hian tube te tak te, te tak te tak tak system a awm tih han ngaihtuah teh. Thing hnah zung chhuak ang mai a ni. Hengte hi bile duct kan tih te hi an ni. Heng duct te hnathawh ber chu thin atanga tui chhuak ‘Bile’ an tih chu thin atanga chhuah tir a ni a, chu chu kan chaw ei danah a phur lut a ni. He bile hi kan tan a pawimawh hle a, a chhan chu he bile hian kan ei tur thau awmte chu a tithianghlim thei a ni.

Tunah chuan Primary Biliary Cholangitis (PBC) an tih natnaah hian kan taksa hriselna (immune system) hian heng bile duct te hi a rawn bei sual a ni. Hei hian bile duct-ah inflammation, a nih loh leh swelling a thlen thin. Hun a kal zel a, he inflammation hian bile ducts a tichhia a, zawi zawiin a tichhia a ni.

Chuti a nih chuan eng nge thleng? Tui pipe khar ang maiin bile a luang thei lo va, liver chhungah a tang ta a ni. Bile nghet tak hian liver cells a tichhia tan thin. Hetiang chhiatna hi a kal zel chuan liver tissue hrisel aiah scar tissue a lo awm tan ta a ni. A tawpah chuan liver chu a khauh zauh zauh a, a hnathawh pawh a tlahniam ta a ni. Hetiang dinhmun hi cirrhosis kan ti a . Tun hma chuan he natna hi Primary Biliary Cirrhosis an ti bawk.

He natna hi a na tak tak em?

PBC hi natna zual zel leh rei tak a ni. Chumi awmzia chu zan khat thil thuah a dam lo tihna a ni a, hun kal zelah a symptoms a zual thei bawk. A tir lamah chuan symptoms a awm lo thei. Amaherawhchu, he natna hi thunun theih a nih loh chuan a tawpah chuan thin (liver failure) a thlen thei a ni. Chutih hunah chuan liver transplant tih loh chuan nunna atana hlauhawm tak a ni thei.

He natna hi tuin nge vei tam ber?

He natna chungchang sawi hian thil langsar tak pakhat chu hmeichhia zingah a hluar hle tih hi a ni.Chu chu. He natna hi mipa vei apiangin hmeichhia 10 velin an vei thin. Chutiang gap chu a awm.

• He natna hi kum 40 an tlin hnuah hmuhchhuah a ni fo.
• Tin, i chhûngkuaa mi pakhatin autoimmune natna dang a neih chuan , i vei theihna a sang zâwk thei a, chu chuan genetic link a awm thei tih a târ lang a ni.

PBC natna lanchhuahna leh harsatna awmte chu engte nge ni?

Mi tam tak chuan natna lan chhuah tirh lamah engmah an nei lo. A chang chuan chhan dang avanga thisen test an tih hian accidentally hmuhchhuah a ni. Mahse natna a zual zel chuan symptoms a lo lang tan thin.

Symptoms tlangpui lo lang hmasa ber

• Chauhna: Hei hi a lan chhuah tam ber a ni. Eng ang pawhin mut emaw, chawlh hahdam emaw i neih pawhin i hahna chu a reh lo.
• Itchy skin: Itchy a awm thei a, a bik takin kutphah leh kephah ah a awm thei. Mahse, taksa khawi hmunah pawh a awm thei. Mi thenkhat tan chuan a itching hi tuar theih loh a ni thei.

Heng symptoms te hi mi zawng zawng tan a inang vek lo. Ṭhenkhat tan chuan natna bul tan tirh lamah chiah an lang a, thenkhat tan chuan a hnu lawkah an lo lang thung.

Natna a zual zel angin harsatna lo awm thei te

Bile a luang tha thei lo a nih chuan kan thisenah a pung khawm tan thin. Tin, digestive system-in bile a dawn loh avangin harsatna a awm bawk. Liver scars a san chuan liver kal tlanga thisen kalna kawngte pawh pressure a lo sang chho zel bawk. Hei hian harsatna hrang hrang a thlen thei a ni. Hengte hi dawhkan pakhatah han en ila.

PBC awm chhan dik tak chu eng nge ni?

Kan sawi tawh ang khan PBC hi autoimmune disease a ni . A awlsam zawngin kan taksa "sipai" (immune system) hian kan cell tha tak takte hi a rawn bei sual a ni. Mahni ram mipuite beih, hmelma anga inngaia beih ang mai a ni. PBC-ah chuan he "attack" hi liver-a bile duct-ah a thleng thin.

Doctor-te chuan hetiang thil hi a thlen chhan chiang takin an la hre lo a, mahse a chhan awm thei engemaw zat a awm niin an ngai a ni:

1. Genetic factor: Chhungkuaa mi tu emaw hian heng natna te hi a neih chuan midang pawhin an vei tam zawk.

2. Environmental factors: Virus, bacteria emaw chemical emaw taksaa a luh chuan genetically predisposed mi immune system chu a thawk dik lo thei a ni.

He natna hi engtin nge an hriat chhuah? (Diagnosis) tih a ni.

I doctor hnenah i natna lan chhuah dan i hrilh chuan a enfiah ang che a, i natna hriat chian nan test eng emaw zat a ti ang.

1. Thisen Test: Hei hi test pawimawh ber a ni. Thil pahnih a bik taka thlir a ni.

• Antibodies: PBC vei zinga 95% vel chuan an thisenah antibody bik Antimitochondrial Antibody (AMA) an nei a.
• Liver Enzymes: Liver a chhiat chuan thisenah enzyme thenkhat (a bik takin Alkaline Phosphatase - ALP ) a pung thin.

2. Imaging Test: Thisen test-ah PBC a awm tih a hriat chuan i doctor chuan i liver leh gallbladder en turin scan a ti thei ang. Hei hian i natna lan chhuahna chhan dangte pawh a paih chhuak thei bawk. Ultrasound scan hi test hmasa ber a ni tlangpui. MRI scan hmangin thlalak chiang zawk hmuh theih a ni.Pakhat pawh i refer thei bawk.

3. Liver Biopsy: A chang chuan (a bik takin thisenah AMA antibodies nei lote tan), liver tissue te tak te tak te lak a, microscope hmanga enfiah a, a natna hriat chian leh liver chhiatna a thlen dan dik tak hriat theih a ni.

PBC enkawl dan tur chu engte nge ni?

PBC hi damdawi a la awm lo. Mahse, natna avanga thin (liver) chhiatna tihziaawmna tur, natna kal zel dan tur thunun thei tur leh natna lan chhuah dan tur enkawl dan tur damdawi tha tak tak a awm a ni.

Damdawi ei tur

• Ursodeoxycholic acid (UDCA): Hei hi PBC damdawi ber a ni. A pianphung atanga lo awm bile acid a ni. He damdawi hian liver atanga bile paih chhuahna a pui a, liver chhiatna a ti tlem bawk. Natna bul tan a nih chuan a hlawk hle thei a ni.
• Damdawi dang: UDCA dawng tha lo tan chuan i doctor chuan damdawi dang, obeticholic acid . Hei bakah hian damdawi thar zawk, seladelpar leh elafibrinor te pawh hman a ni tawh bawk.
• Symptoms hriat theihna tur damdawi: 1.1.
• Vun natna tan: Damdawi Cholestyramine, antihistamines, leh ultraviolet light therapy te hman a ni.
• Vitamin tlakchhamna atan: Vitamin A, D, E, leh K awmna Supplement pek thin a ni.
• Chauhna atan: Mi thenkhat chuan modafinil ang chi stimulant damdawi atang hian hahdamna engemaw zat an hmu thei.

Inzai

I liver hnathawh a tlahniam chhunzawm zel a, damdawi hmanga control a nih loh chuan i doctor chuan liver transplant nghah tur list-ah a dah thei che a ni . PBC tan liver transplant hi a hlawhtling hle. Transplant hnuah pawh nun pangngaiin i nung thei a ni. PBC hi liver thara kir leh theih ni mahse, a tlem hle.

He natna nen hian eng nge ka hriat tur?

PBC hi a kal zawi zawi hle fo thin. He natna hian a tawp ber a thlen theih nan kum 15-20 vel a la ngai thei a ni. He natna hi a hmaa hriatchhuah a, enkawl a nih chuan natna khirh tak takte chu ven theih a ni emaw, tihkhawtlai theih a ni bawk. Mi tam tak chuan an natna lan chhuah dan chu damdawi hmangin an enkawl a, kum tam tak chhung chu an nitin nun tibuaitu lian tham awm lovin an nung thin.

Amaherawhchu, mi thenkhat chuan natna hi a zual chak zawk thei a ni. Chauh lutuk leh thisena bilirubin level sang lutuk hi natna a zual zel tih chhinchhiahna a ni thei.

I liver venhimna atana i tih theih thilte

Nunphung tha leh ei leh in dan tha zawm hian a rei thei ang bera i thin a hrisel theih nan a pui ang.

• Meizial zu, zu leh ruihhlo tul lo taka hman chu bansan vek rawh.Hengte hi thin (liver) tan a pawi hle.
• Processed, packaged foods ai chuan whole foods, thlai thar, thei, leh herbs te ei tam zawk rawh.
• Saturated fats tihtlem la, unsaturated emaw "tha" emaw (e.g. avocado, nuts, olive oil) awmna ei tur thlang rawh.
• Nitin exercise engemaw zat nei thin ang che. Kea kal ang chi thil awlsam tak pawh hi a tha. Weight-bearing exercise hian ruh a tichak thei a ni.

Hetiang natna khirh tak nena nun hi rilru hahthlak tak a ni thei. I taksa, rilru leh rilru lama harsatna tihziaawm theih dan tur i doctor nen sawiho rawh. A tul chuan counseling zawng rawh. I hriselna pum pui hi he natna aiin a lian zawk tih hre reng ang che.