I taksaah hian hriat loh lumps emaw bumps emaw i nei em? Schwannomatosis a ni thei!

I taksaah hian a chang chuan sawifiah theih loh khawpa natna i nei fo em? A nih loh leh i vun hnuaiah hian hnim hring te te i nei fo thin em? Heng thilte hi kan ngaihven vak lo tak zet a, mahse a chang chuan damdawi lam dinhmun chhinchhiahna a ni thei. Vawiin hian damdawi lam dinhmun hriat tur awm lo, mahse hriat tur pawimawh tak chungchang kan sawi dawn a ni. Chu chu `Schwannomatosis` an tih dinhmun a ni.

`Schwannomatosis` tih hi eng nge ni? A awlsam zawngin i hrethiam ang u!

A awlsam zawngin sawi ila, Schwannomatosis hi kan genes-a inthlak danglamna engemaw zat avanga lo awm a ni. Hei hi kan taksa nervous system, chu chu nerve-a tumor (tumor) a lo awm hian a ni. Heng tumor te hi `schwannomas` kan ti a. Heng `schwannomas` te hi kan nerve hual veltu leh insulator anga thawk cell chi khat bik atanga lo piang chhuak a ni. Heng cell te hi `Schwann cells` an ti a. Kan peripheral nervous system -ah an awm ber - chu chu thluak leh ruhro atanga chhuak nerve-ah te, nerve zungteah te, leh nerve-te taksa ruh nena inzawmna hmunah te an awm a ni.

Schwannomatosis hi puitling naupang, kum 20 leh 40 inkar zingah natna khirh tak nen a awm tlangpui a, neurofibromatosis chi dang a ni a, nervous system-a tumor pawl pakhat a lo awm a ni.

Schwannomatosis chi hrang hrang a awm em?

Ni e, Schwannomatosis hi chi hrang hrang lian tak tak a awm. Chungte chu chi hrang hrang thlentu genetic variant a zirin an thliar hrang a ni. Heng chi hrang hrangte hi:

• `NF2` - a kaihhnawih `schwannomatosis` (hmanlai chuan `neurofibromatosis type 2` tia koh thin).
• `SMARCB1` - `schwannomatosis` nena inzawm.
• `LZTR1` - `schwannomatosis` nena inzawm.
• `22q` - related `schwannomatosis` (hei hi chromosome 22 hmun thenkhat inthlak danglamna avanga lo awm a ni).
• Schwannomatosis tih hi a danglamna a awm lo (NOS).
• Schwannomatosis hmun danga classified loh (NEC) a awm.

Heng hmingte hi a buaithlak deuhin lang mah se, hetianga category hrang hranga dah hi doctor-te tan chuan natna dik tak hriatchhuahna leh thurawn \ha tak pekna kawngah a \angkai hle.

Hetiang dinhmun hi `Schwannomatosis` an tih hi engtiang chiahin nge a tlem?

Schwannomatosis hi neurofibromatosis chi khat zingah chuan a tlem ber a ni. Mi engzat nge nei tih chhut dik tak chu a inang lo. Zirna thenkhatah chuan NF2 nena inzawm schwannomatosis hian mi 30,000 zinga pakhat vel a vei thei tih an sawi . A chi dangte chu an inzawm khawm chuan mi 70,000 zinga pakhat velin a nghawng a ni .

Schwannoma vei zawng zawng hian schwannomatosis an nei vek lo. Schwannomatosis-ah chuan schwannoma tam tak a lo awm thin. A tlangpuiin schwannoma pakhat hi multiple schwannomatosis aiin a tam zawk. Chumi awmzia chu mi tam takah a thleng tak tak lo tihna a ni.

Schwannomatosis natna lan chhuah dan chu engte nge ni?

Hetiang dinhmunah hian symptom langsar ber leh hmuh tam ber chu natna hi a ni . Hetiang natna hi schwannoma tumor hian nerve leh a chhehvel tissue te a compress vang a ni. He hrehawmna hi eng ang nge ni thei ang?

• It can be chronic pain , chu chu thla tam tak, kum tam tak chhung pawh a daih thei tihna a ni.
• Natna awm dan hi a nasat loh atanga a nasat thlengin a awm thei .
• He natna hi taksa khawi hmunah pawh hriat theih a ni , tumor awmna hmunah chauh ni lovin. A chang chuan, natna hi tumor awmna hmun nena inzawmna nei lo hmunah a awm thei bawk.
• Hun kal zelah a natna a zual thei.

Ngaihtuah teh, i ke hnuai lam pan zel tur natna i nei a, chu chu rilru hahna nen a inzawm a ni. Damdawi ei hnuah pawh a bo ngai lo. Khawsik mai mai niin i ngai mai thei. Mahse Schwannomatosis avanga natna a ni thei.

Natna bakah hian tumor awmna hmun azirin symptom dang a awm thei bawk. Entir nan:

• Tingling sensation emaw electric shock ang maia hriatna emaw .
• Muscle chak lohna emaw muscle hnathawh tlahniam emaw.
• Kut hnuaiah hian vun hnuai lam (tumor siamna hmun) lumps emaw swellings emaw a awm thei.

Heng symptoms te hi kum 20 hnu leh kum 40 hmaa intan thin mahse, zirchianna atanga a lan dan chuan kum eng pawhah a lang thei tak tak a ni.

Eng thilin nge Schwannomatosis hi a thlen?

Schwannomatosis thlentu ber chu genetic variant (mutation) a ni. Hei hi NF2, SMARCB1, emaw LZTR1 tih hming pu genes tan chuan a dik hle. Heng genes te hi chromosome 22 ah an awm a .

Heng genes te hian `tumor suppressors` angin hna an thawk a, chu chuan kan taksaa tumor siam dan a thunun a ni . Chu chu, heng genes te hian cell te hi vawi engzat nge an lo thang lian tur leh an inthen tur tih an thunun tihna a ni. Chuvangin, hetiang hian `tumor suppressor` gene-ah hian `mutation` a awm a nih chuan kan cell te hian cell thanna control nan an mamawh instruction an dawng lo. Chumi avang chuan cell te chu an thang lian tan a, an inthen chak lutuk a, thunun theih lohvin. Chutiang chuan heng `tumors` te hi an lo piang ta a ni.

Schwannomatosis vei thenkhatah chuan a chhan dik tak hriat a ni lo mai thei. Hei hian tuna genetic mutation hriat chhuah tawh loh pawhin he natna hi a awm thei tihna a ni.

Hei hi rochan a ni em? (`Schwannomatosis hi thlahtute atanga lo chhuak a ni em?`)

`Schwannomatosis` vei thenkhatRochun theih a ni . A tlangpuiin Schwannomatosis vei zinga 15% leh 25% inkar chuan chhungkaw history-ah he natna hi an nei tawh a ni. Autosomal dominant pattern-in a kai darh a ni. A awlsam zawngin, nu leh pa zinga pakhatin genetic change kengtu gene copy a rochun chuan naupang chuan chu natna chu a nei ve mai thei a ni.

Mahse, Schwannomatosis vei tam zawk hi chu random takin a thleng thin . Hei hian a awmzia chu mi pakhatin he genetic mutation hi siamin Schwannomatosis a vei thei tihna a ni a, chhungkaw zingah tumahin he natna hi an la nei lo a nih pawhin a vei thei tihna a ni.

Schwannomatosis natna avanga harsatna awm thei te chu engte nge ni?

Schwannoma tumor tam zawk hi cancer ni lo, hlauhawm lo tumor (benign tumor) an ni. Chu chu cancer an ni lo tihna a ni. Mahse, a tlem hle a, tumor thenkhat chu cancer a ni thei. Chuvang chuan doctor te pawhin hei hi an ngaihven hle a ni.

Thil lian dang chu natna khirh tak a ni . He natna kal zel hian mi rilru hriselnaah nghawng lian tak a nei thei a ni. Nitin hna thawh a harsat a, anmahni an nih theih loh hunah chuan lungngaihna leh lungkhamna ang chi dinhmun a lo awm thei a ni. Chuvangin, mi tam tak chuan chutiang dinhmunah chuan rilru lam hriselna lama counselor biak chu a \angkai hle niin an hria.

Engtin nge Schwannomatosis hi hmuhchhuah a nih?

Doctor chuan he natna hi taksa enfiahna leh test hmangin a hre thei ang . Exam chhung hian doctor chuan i natna lan chhuah dan te, eng chen nge a awm tawh tih te, i chhungte zingah hetiang natna hi an nei tawh em tih te a zawt ang che.

Schwannomatosis natna lan chhuah dan hi natna dang nen a inang a, a natna lo chhuahna hmun hriat chian a harsa thei a, a chang chuan diagnosis siam nghal a harsa thei bawk. Mahse, tunah chuan doctor-te chuan updated diagnostic criteria an hman avangin schwannomatosis chi hrang hrang hriat a awlsam tawh hle. Entirnan, SMARCB1-related schwannomatosis i vei tih hriat theih nan a hnuaia mi pakhat tal i neih a ngai a ni:

• Schwannoma pakhat tal a awm tur a ni a, thisen emaw, chi emaw hmanga genetic test neih chuan SMARCB1 gene-ah mutation a awm tih a finfiah tur a ni.
• Schwannoma pahnih tal a awm tur a ni a, tumor pakhat biopsy hmangin SMARCB1 genetic mutation a nei tih a chiang tur a ni.

Schwannomatosis hi eng test nge hman thin?

Imaging test MRI (Magnetic Resonance Imaging) te hian i doctor chu schwannoma a hmuchhuak thei a ni. He test-ah hian tumor hmuh a nih chuan i doctor chuan tumor sample tlemte chu test (biopsy) atan a la thei a ni.Order theih a ni. Tichuan, microscope hmanga cell te en hian eng tumor chi nge a nih tih chiang takin i hre thei ang. Chu bakah, genetic blood test hmangin chi hrang hrang thlentu genetic change i neih leh neih loh a hriat theih bawk.

Schwannomatosis hi engtin nge enkawl a nih?

Dik tak chuan tunah hian Schwannomatosis hi damdawi a la awm lo a , chuvangin enkawlna tum ber chu symptoms enkawl hi a ni .

I doctor chuan i natna tihziaawmna tur damdawi chi hrang hrang a pe thei ang . Heng damdawi te hi i natna awmna hmun leh a nasat dan te a innghat ang.

Damdawi hmanga natna chu a thunun loh chuan, emaw, a natna chu a na hle a nih chuan, i doctor chuan schwannoma chu surgery hmanga lak chhuah emaw, clinical trial- a refer emaw a ngaihtuah thei ang Mahse, hengte hi i tan a him em tih chu i doctor chuan a rel ang. Surgery hian nerve a tichhia thei a, an lakchhuah hnuah tumor a lo thang leh thei bawk.

Schwannomatosis vei tan chuan eng prognosis nge a awm?

Hei hi mi hrang hrangah a inang lo tak zet a ni . I taksaa schwannoma tumor awm zat, a tam leh tam loh leh awmna hmunah a innghat a ni. Mi ṭhenkhat chuan tlemte chauh an nei thei a, ṭhenkhat erawh chuan tam tak an nei thei thung. Taksa hmun khatah chauh an awm thei a, hmun tam takah an inzar pharh thei bawk. Chuvangin symptoms hi mi zawng zawng tan a inang vek lo.

Schwannomatosis natna lan chhuahna lungchhiatthlak ber chu natna rei tak a ni . Natna nena nun, a bik takin a nasat chuan harsatna tak tak a ni thei. He natna hian i rilru leh taksa hriselna a nghawng thei a ni. Schwannomatosis symptoms hian i rilru a ti na emaw, i mimal emaw, khawtlang nunah emaw i thawk thei lo a nih chuan doctor nen inbiakna neihpui ngei ang che. Mental health counselor nena inbiakna pawh hian a pui thei bawk.

Symptoms control na tur enkawlna a awm. Mi tam tak chuan damdawi hmangin natna lan chhuah dan atang hian hahdamna an hmu thin. Mi dangte chuan cyst lakchhuah nan operation an mamawh thei bawk. Mahse, hre reng ang che, cyst hi lakchhuah a nih hnuah a lo thang leh theihna chance a awm.

Schwannomatosis hian dam chhung a nghawng em?

Schwannomatosis hian dam rei zawng a nghawng nghal lo . Mahse, natna rei tak leh a lan chhuah dan dangte hian nunphung a nghawng thei a ni. Hemi chungchangah hian ngaihtuahna i neih chuan doctor nen direct-a inbiakna neih a tha ber. Mi zawng zawng dinhmun a inang lo vek avângin, amah chauhvin i dinhmun chungchânga thu thar ber ber a pe thei che a ni.

Engtikah nge Doctor ka hmuh ang?

A chhan i hmuh theih loh hrehawmna.If you have symptoms like muscle weakness , doctor pan ngei ngei tur a ni. Tin, i taksa khawi hmunah pawh lump thar emaw tumor thar emaw i hmuh chuan doctor hnena entir a pawimawh bawk.

Schwannomatosis i vei tawh a nih chuan i natna lan chhuahnaah danglamna i hmuh chuan i doctor hnenah hriattir la, chu chu natna tihpun ang chi hi a ni.

Doctor hnenah eng zawhna nge ka zawh ang?

Doctor i hmuh hian hetiang zawhna hi zawh hi a \angkai hle ang:

• Eng nge ka tih theih ang, a natna chu ka enkawl theih ang?
• Painkiller tih loh chu duhthlan tur dang a awm em?
• Surgery ka mamawh dawn em?
• Enkawlna hian eng side effect nge a neih?
• Ka fate hian nakin lawkah he dinhmun hi an rochun thei ang em?

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Schwannomatosis natna avanga natna khirh tak nena nun hi a harsa tak zet thei a ni. Ni thenkhat chu a dang aiin a awlsam zawk. Ruahmanna i nei a nih pawhin, chu natna chuan chu chu sawn a, chawlh hahdam turin in lama awm turin a nawr thei che a ni. Hei hian i mimal leh khawtlang nun a tibuai thei a ni. Mahse Schwannomatosis hian i nun a thunun tir suh.

Doctor chuan i natna lan chhuah dan tur enkawl dan tur tha ber zawng turin a pui thei che a ni . Natna rei tak hian i rilru hriselna a nghawng a nih chuan, rilru lam hriselna chungchanga counselor i hmuh pawhin i hlawkpui thei bawk . Surgery leh clinical trial pawh hi duhthlan tur a ni thei bawk. Chuvangin, Schwannomatosis symptoms hmachhawn tura pui thei tur thil awmte chu i doctor zawt rawh. Nangmah chauh i ni lo tih hre reng la, he zinkawng zawh tura pui turin doctor leh support group an awm bawk.

` Schwannomatosis, neurofibromatosis, natna rei tak, genetic natna, NF2, SMARCB1, LZTR1, thluak lam natna