"Sulfa drugs" tih hi i hre tawh ngei ang. Doctor pakhatin i vunah hnawih tur cream a pe che a, "Hei hi sulfa damdawi a ni," a ti mai thei. Sulfonamides hi eng nge ni tak tak? Antibiotics chauh an ni em ? Ni lo, chu aia thawnthu chu a sei zawk hle. Vawiin hian he thu hi a thupui ber i han luhchilh ang u.
A awlsam zawngin, heng sulfonamides te hi engte nge ni?
Sulfonamides hi damdawi chi khat, synthetically siam, chu chu laboratory-a siam a ni. An pianphungah an awm lo. Hetiang damdawi chi hrang hranga damdawi zawng zawng hian an chemical structure-ah element “sulphur” an nei vek a. Chuvang chuan “sulfonamides” tia koh an ni.
Tunah chuan hengte hian engtin nge hna an thawh tih i lo en ang u. A bik takin bacteria infection hnena pek a nih chuan heng damdawi te hian an tih tur chu bacteria te hian an mamawh " folate " an tih thil an siam loh nan a titawp thin. Folate hi vitamin B9 a ni tih pawh kan hria . Ngaihtuah teh, he nutrient folate an tih hi bacteria nung leh darh zel tur chuan a pawimawh hle. Chuvangin sulfonamide damdawi taksaah a luh chuan an kal a, bacteria te hian he folate siam hi an titawp thin. Chaw ei lova riltam ang mai a ni a, bacteria chu a chak lo zauh zauh a, a thi ta a ni.
“Anih chuan kan taksa tan harsatna a awm lo maw?” i ngaihtuah mai thei. No. A chhan chu keini, chu chu mihringte hian kan taksa mamawh folate hi kan ei leh in atang hian kan hmu thin. Kan taksa chhungah folate kan siam lo. Chuvangin he damdawi hian kan taksa chhunga cell te chu chutiang chuan a nghawng lo tlangpui.
Penicillin an hmuhchhuah hma, kum 1930 chho vel khan sulfonamides hi bacteria infection enkawlna atana damdawi tha ber pawl a ni. Chutih lai chuan , heng damdawi te hian natna hrik kai vanga thihna chu nasa takin a tihtlem phah a ni. Mahse tunlai hian bacteria infection atan chauh an hmang lo. He class a damdawi hi natna dang tam takah hman a ni .
Sulfonamides hi eng natna atan nge hman?
Tun hma chuan bacteria infection enkawlna leh venna atan an hmang ber a. Mahse tunlai hian he damdawi class hi a lo insiam chho nasa hle a ni. Sulfonamides hi natna chi hrang hrang enkawlna atan hman a ni a, chung zingah chuan type 2 diabetes, thisen sang, HIV infection, leh vun cancer chi khat melanoma te pawh a tel.
Eng damdawi dang nge he category-a tel, eng natna atana hman nge tih i lo en ang u. A awlsam zawk nan hengte hi hmun hnih ah kan then ang.
1. Sulfonamides antibiotics atana hman thin
Hengte hi bacteria infection damdawi pek a ni ber.
| Antibiotics chi hrang hrang: sulfonamides |
|---|
| Mafenide (Sulfamylon®) hmanga siam a ni. |
| Sulfadiazene (Silvadene® emaw Thermazene®) – (kangmei chhuahna atana hman tlanglawn tak) . |
| Sulfamethizole a ni |
| Sulfisoxazole a ni |
| Sulfasalazine (Azulfidine®) – (Ulcerative colitis tan pawh hman a ni) |
| Sulfadoxine – (malaria enkawlna atana hman thin) . |
2. Antibiotic ni lo sulfonamide te
Hengte hi bacteria thattu damdawi an ni lo. Natna dang engemaw zat enkawlna atan an hmang thin. He list hi a sei deuh a, mahse he damdawi chi hrang hrang zau zawng hi a hriat theih phah a ni.
| Ruihhlo Hming | A hman dan |
|---|---|
| Acetohexamide, Chlorpropamide, Tolazamide, Tolbutamide te a awm bawk | Type 2 zunthlum vei a ni |
| Furosemide (Lasix®), Bumetanide, Torsemide, Chlorthalidone, Hydrochlorothiazide, Indapamide te a awm a, hei hi a chhuahna tur hmun leh a hmanna tur hmun a ni | Diuretics hi thisen sang leh congestive heart failure avanga lo hring chhuak enkawl nan an hmang thin. |
| Celecoxib (Celebrex®) hmanga tihdam theih a ni. | Joint na leh swelling condition hrang hrang, arthritis ang chi te. |
| Darunavir (Prezista®) hmanga tihdam theih a ni. | HIV hrik kai theihna tur antiretroviral damdawi a ni. |
| Sumatriptan (Imitrex®) tih a ni a, a man hi a to hle. | Migraine lu na tan chuan. |
| Sildenafil (Viagra®, Revatio®) hmanga siam a ni. | Erectile dysfunction leh pulmonary arterial hypertension te a awm bawk. |
| Tamsulosin (Flomax®) hmanga siam a ni. | Prostate gland lian vanga zun harsatna (benign prostatic hyperplasia) tan. |
| Zonisamide (Zonegran®) hmanga siam a ni. | Epilepsy avanga seizures awm thin. |
Sulfonamides hi allergy nei thei a ni em?
Ni e, i ti thei. Miin, "Sulfa damdawi hi ka allergy a ni," an tih hi i hre tawh ngei ang . Khawvel mihring 3% leh 8% inkar hian sulfa damdawi chi khat allergy an nei a. Mahse hei hi penicillin allergy nen a inang tlangpui.
Thil pawimawh tak chu hei hi a ni: sulfonamide damdawi pakhat i allergy vang mai mai chuan he class-a damdawi dang zawng zawng hi allergy i nei tihna a ni hauh lo. Hei hi tunah chuan doctor-te pawhin an pawm tawh a ni.
Chuvangin, a hmaa sulfonamide allergy i neih tawh chuan damdawi thar i ei tan hmain doctor hnenah hrilh hmasa phawt ang che. I tan damdawi dang remchang tak a rawn rawt thei ang che.
Hetiang damdawi chi hi eng nge a that lohna?
Damdawi dang ang bawkin sulfonamides hian chhiatna leh nghawng tha lo engemaw zat a nei thei a ni. A bulpui berte chu:
- Bacterial resistance: Antibiotic pakhat hi rei tak i hman chuan bacteria thenkhat chuan chu damdawi laka resistance an nei thin. Chumi awmzia chu damdawi chuan chu bacteria-ah chuan hna a thawk tawh lo tihna a ni. Hei hi sulfonamides-ah pawh a thleng thei bawk.
- Bacteria thenkhat chunga nghawng a neih hloh: Bacteria chi thenkhat chu an pianphungah heng damdawi te hi an do thei a ni.
- Side effects na tak tak: Hengte hi a tlem hle a , mahse mi thenkhat chuan vun natna khirh tak tak Stevens-Johnson syndrome leh toxic epidermal necrolysis te an nei thei a ni.
Heng side effects te hi mi hrang hrangah leh damdawi hrang hrangah a inang lo thei hle. Chuvangin, i doctor-in i damdawi an pek dan te, a thatna leh a hlauhawmna te hriat theihna tur tha ber a ni. Chumi chungchang chu zawt rawh.
BactrimTM pawh hi sulfonamide a ni em?
Ni e, a then chu. BactrimTM hian sulfamethizole a pai a, hei hi sulfonamide chi khat a ni. Hei bakah hian damdawi dang trimethoprim tih a pai bawk. An pahnih hian hna an thawk dun a.
Celebrex® pawh hi sulfonamide a ni em?
Awle. Celecoxib (brand name Celebrex® tia hriat fo), arthritis natna enkawlna atana hman thin hi sulfonamide a ni bawk.
He damdawi hian zun chhungah crystal a siam thei em?
Ni e, sulfa damdawi thenkhat hian zun chhungah crystal a siam thei a. Mahse, hei hi side effect tlanglawn tak a ni lo. I doctor chuan i damdawi ei hian hetiang hi a thlen theih leh theih loh leh a venna atana i tih theih dan tur a hrilh ang che (entir nan, tui tam tak in rawh).
Take-Home Thuchah a ni
- Sulfonamides hi antibiotics chauh a ni lo. Natna chi hrang hrang enkawlna atana hman thin damdawi class lian tak an ni.
- He damdawi chi hi natna tam takah hman a ni a, bacteria infection atanga zunthlum, thisen sang, leh migraine thlengin an hmang thin.
- Sulfa damdawiah hian allergy a awm thei. Mahse, chi khat allergy i neih chuan chu class-a damdawi zawng zawng chu allergy i nei vek dawn tihna a ni lo.
- Damdawi thar i ei tan hmain i doctor hnenah damdawi lam harsatna dang i neih leh a hmaa damdawi allergy i neih tawh zawng zawng kha hrilh hmasa phawt ang che.
Sulfonamides, sulfa damdawi, sulfonamides, antibiotic, damdawi allergy, Stevens-Johnson syndrome, Bactrim, Celebrex, Lasix te pawh a awm bawk
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