Nangmah emaw, i hriat tu emaw chuan hnute cancer a vei a nih chuan, enkawlna thar zir chu beiseina a ni thei a, zawhnain a khat thei bawk. Vawiin hian chutiang beiseina thar pakhat, damdawi Trodelvy tih chu kan sawi dawn a ni. Breast cancer chi hnih (Triple-negative breast cancer - TNBC leh HR+/HER2- breast cancer), operation hmanga lak chhuah theih loh khawpa darh tawh emaw, enkawlna dang pahnih dawng lo emaw enkawlna a ni. Hemi chungchang hi awlsam tak leh friendly takin i sawi ang u.
Engtin nge Trodelvy hian taksa chhungah hna a thawh?
A awlsam zawngin Trodelvy hi "targeted therapy" a ni. Chumi awmzia chu he damdawi hian taksa chhunga kal mai mai ai chuan cancer cell zawng chhuakin a bei nghal zawk tihna a ni.
Hei hi missile target lam pan nghal mai angin ngaihtuah rawh.
1. Cancer cell hriatchhuah: Hnute cancer cell tam tak hian an chung lamah protein Trop-2 an tih chu an nei a. Trodelvy damdawi hian he Trop-2 protein-a inzawm thei tur special part (monoclonal antibody) a nei a. Hei hi cancer cell chiang taka hriat theihna a ni.
2. Damdawi pek dan: Cancer cell-a a innghah hnuah Trodelvy hian cancer cell chhunga thup, chemical damdawi chak tak (chemotherapy damdawi SN-38 an tih) chu a tichhuak a.
3. Cancer cell tihchhiat: Cancer cell chhunga a luh hnu chuan he SN-38 damdawi hian cell chu a inthen darh a, cell tam zawk siam (a DNA copy) a titawp a ni. Tichuan cancer cell chu a thang lian thei tawh lo va, a thi ta a ni.
Hetiang method hian a thatna lian ber chu cancer cell chauh a target a, a attack a, cell hrisel te tihchhiat a ti tlem hle.
Engtin nge he enkawlna hi pek a nih?
Trodelvy hi damdawi a ni a, saline solution angin vein (IV Infusion) ah pek thin a ni . Hei hi damdawi in emaw cancer enkawlna hmunah emaw, doctor emaw, trained nursing staff emaw enkawlna hnuaiah i dawng ang.
Enkawlna hi ni 21 chhunga pek thin a ni. Chu chu damdawi chu ni khatna leh ni riatnaah pek a ni tihna a ni . Tichuan, ni 21 chhung chu a zo ta a, a dawt leh tur chu a intan leh ta a ni.
- Damdawi pek hmasak ber hian darkar 3 vel a daih thei.
- Chumi hnuah chuan darkar 1-2 chhungin i zo thei ang.
Damdawi i pek hmain i doctor chuan acetaminophen (Panadol ang chi), antihistamines (Pyridoxine ang chi) , leh khawsik, rilru hahna, leh vun allergy ang chi thil venna atan steroid a pe ang che.
He damdawi hman tangkai dan tur hi eng zirchianna nge neih tawh?
Trodelvy hi a him leh him loh finfiah nan clinical study lian tak tak eng emaw zat neih a ni tawh bawk. ASCENT leh TROPiCS-02 te hi zirchianna lian ber pahnih an ni.
Heng zirchiannate hian Trodelvy dawngtu damlote chu standard chemotherapy dawngtu damlote nen an khaikhin a ni. Thupui pahnih an ngaihtuah a, chungte chu:
- Progression-Free Survival (PFS): Hei hi damloin cancer natna a zual zel loh hun chhung a ni.
- Overall Survival (OS): Hei hian damlo dam chhung zawng zawng a kawk a ni.
Research atanga result hlawk tak tak a lantir
Heng zirchianna pahnihte hian result tha tak tak a nei a ni.
ASCENT zirchianna (TNBC cancer tan):
- Trodelvy ei thin damlote chu an cancer chu a na zual lova thla 5.6 chhung control a nih laiin, damdawi pangngai ei thinte tan chuan thla 1.7 chauh a ni.
- Trodelvy ei damlote dam rei zawng zawng (OS) chu thla 11.8 vel a ni a, group dang zawng zawngah chuan thla 6.9 vel a ni thung.
TROPiCS-02 zirchianna (HR+/HER2- cancer tan):
- Trodelvy ei thin damlote chu thla 5.5 chhung zet an cancer chu a darh lova control a nih laiin, damdawi pangngai ei thinte tan chuan thla 4 chhung a ni.
- Trodelvy ei thin damlote chu midang aiin thla 3.2 velin an dam rei zawk (thla 14.4 vs thla 11.2).
- Trodelvy ei thin zingah hian tumor shrinkage rate pawh a sang zawk (21% vs 14%).
A awlsam zawngin sawi ila, zirchianna pahnihte hian Trodelvy hmanga enkawl damlote chu natna control-na kawngah an dam rei zawk a, standard chemotherapy hmanga enkawl damlote aiin a pumpuiah an dam rei zawk tih an hmuchhuak.
Damdawi ei avanga side effects leh a hmachhawn dan tur
Damdawi dang ang bawkin Trodelvy hian side effect a nei thei a ni. A pawimawh ber chu anmahni hriat chian a, doctor nen thawhhona tha tak neia enkawl hi a ni. Hetah hian side effects awm tam ber leh i tih theih dan te tarlan a ni.
| Side Effect a awm thei | Thuziak leh enkawl dan |
|---|---|
| Thisen var tlahniam (Neutropenia) . | Hei hian hri kai theihna a tipung a ni. I doctor chuan i thisen a test ang. Khawsik i neih chuan natna kai chhinchhiahna a ni thei a, chuvangin doctor hnenah hrilh nghal rawh. |
| Kawthalo | Stool loose tak tak a awm. Tui leh broth ang chi tui tam tak in thin ang che. Diarrhea a nasat emaw, ni engemaw zat a awm emaw chuan i doctor hnenah hrilh ngei ang che . |
| Nausea leh luak chhuak | Hriak rimtui tak tak lakah inthiarfihlim rawh. Chaw lian ei ai chuan chaw te te ei thin ang che. Doctor chuan nausea tan damdawi a pe ang. |
| Chau | Chau lutuk tih hi thil pangngai a ni. Chawlh hahdam tam rawh. I doctor phalna la hmasain light exercise nei rawh. |
| Sam tlakchhamna | Hun engemaw chen chu i sam thenkhat emaw, a zawng zawng emaw a tla thei. Hei hi hun eng emaw chen atan a ni. A tul chuan wig emaw lu khuhna emaw i hmang thei bawk. |
| Thisen sen (Red blood cells) tlahniam (Anemia) . | Hei hian chak lohna leh hahna rilru a thlen thei a ni. Doctor chuan i thisen a test ang a, a tul anga enkawl dan tur a hrilh ang che. |
Naupai leh nau hnute pek chungchangah a bik takin awareness
Naupai lai hian Trodelvy enkawl hi a tha lo . Nausen piang lai a tichhe thei a ni. Chuvangin, enkawl lai leh a dose hnuhnung ber atanga thla 6 chhung atan naupai venna tha tak hman a pawimawh hle. Nu hnute pe mekte chuan enkawl lai leh a hnuhnung ber an pek hnu thla 1 chhung chu nau hnute pek loh tur a ni.
Damdawi leh ei tur dang nena inzawmna a awm em?
Trodelvy tan hian ei leh in inzawmna chiang tak a awm lo. Mahse, zu in hian side effect a thlen theihna a tipung thei a ni.Side effects, nausea, diarrhea, leh hahna te hi a na zawk thei.
Damdawi dang nena inzawmna a awm thei bawk. Damdawi thenkhat chuan Trodelvy natna a tihziaawm thei a, thenkhat chuan Trodelvy natna a tipung thei a, a side effect a ti na zual thei bawk.
Chuvangin, damdawi i ei zawng zawng, over-the-counter emaw, vitamin emaw, herbal supplement emaw pawh ni se, i doctor hnenah hrilh ngei ang che. Hei hi a pawimawh hle.
He damdawi hi tuin nge hmang lo tur?
Trodelvy emaw a thil tel emaw allergy i neih chuan he damdawi hi hmang suh. Mi thenkhat chuan allergy na tak an nei thei bawk. Heng ang symptoms te hi en reng ang che:
- Thâwk harsa (wheezing) .
- Hmai, ril a hring
- Thisen sang hniam
- Vun natna nasa tak a awm
Heng symptoms zinga pakhat tal i neih chuan emergency a ni. Damdawi in hnai ber Emergency Department (ETU) ah kal nghal rawh.
Enkawlna i tan hmaa i doctor hnena hrilh tur thil
- Thin natna: Thin natna i neih chuan doctor hrilh rawh.
- UGT1A1 gene: Mi thenkhat chuan he gene hi a danglamna an nei a, hei hian thisen var cell count hniam ang chi side effects an neih theihna chance a sang zawk a ni. I doctor chuan a tul chuan hei hi a test thei ang.
- Naupai tum dan: Nangmah emaw, i kawppui emaw hian nau pai i tum a nih chuan i doctor hnenah hrilh rawh. Mipa kawppui hian enkawlna a la a nih chuan nau pai venna chi khat, condom ang chi, enkawl lai leh a dose hnuhnung ber atanga thla 3 chhung hman tur a ni.
Take-Home Thuchah a ni
- Trodelvy hi targeted therapy a ni a, advanced breast cancer chi hrang hrang tan hman a ni.
- Traditional chemotherapy aiin a thawk danglam a, cancer cell direct-in a target a ni.
- He enkawlna hi damdawi inah vein hmanga pek thin a ni.
- Side effects, diarrhea leh white blood cell count tlem te hi a awm thei a, chu chu enkawl turin doctor nen thawhhona tha tak neih a pawimawh hle.
- Damdawi dang zawng zawng, vitamin, leh traditional herbs i ei zawng zawng pawh i doctor hnenah hrilh rawh.
- He enkawlna hi naupai lai emaw, nau hnute pek lai emaw hian a him lo.
- Khawngaihin he enkawlna hi i tan a tha em tih leh a kaihhnawih thutlukna zawng zawngte chu i oncologist nen sawiho rawh.
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