Waldenström Macroglobulinemia tih hi i hre tawh em? Hming sei tak, sawi harsa tak a ni lawm ni? A nihna takah chuan cancer chi khat, thisenah zawi zawiin a lo thang lian thin. I hre lo mai thei, a chhan chu a natna hlauhawm tak a nih vang a ni. Mahse chu chu a pawi lo, vawiinah hian awlsam takin, i hriatthiam theih dan tur angin kan sawi dawn a ni.
Waldenstrom macroglobulinemia (WM) hi eng nge ni?
A awlsam zawngin, Waldenstrom macroglobulinemia, a nih loh leh WM a tawi zawngin, thisen cancer a ni . Cancer chi khat non-Hodgkin lymphoma an tih a ni a, lymphoplasmacytic lymphoma tia hriat bawk a ni. A nihna takah chuan a tlem hle. Ngaihtuah teh, America ang ramah pawh hian mi maktaduai khat zinga mi pathum atanga pali chauhvin he natna hi an vei thin.
Chuti a nih chuan, engtin nge he `(WM)` hi a lo thanglian? Kan taksaah ruhro (bone marrow) kan nei a, chutah chuan kan thisen cell siam a ni. He natna hi he ruhro chhunga cell thenkhat `(B cells)` (hengte hi kan immune system-a cell chi khat, chu chu natna laka min vengtu cell) an tih te hi cancer cell an lo nih atanga intan a ni.
Heng cancer cell te hian anmahni chauha awm mai lovin anmahni ang cell tam zawk an siam tan ta a ni. Ramngaw chhunga hnim hring ang maiin. Chuti a nih chuan eng nge thleng? Kan taksa mamawh thisen cell hrisel tak takte hian hmun an nei lo va, an tlahniam tan ta a ni.
- Thisen sen (red blood cells) a hniam chuan thisen tlakchham (anemia) a awm thin. Hei hian i chau a, i pale bawk.
- Thisen var a tlem chuan ``neutropenia'' tih natna a lo awm a, chu chuan natna i vei awlsam zawk a ni.
- Platelet (thisen titawp tura puitu cell) a hniam (thrombocytopenia) chuan thisen chhuah chu awlsam takin a tawp lo mai thei.
Chu mai ni lovin heng cancer cell te hian protein pangngai lo tak `(immunoglobulin M)` emaw `(IgM)` emaw an siam chhuak thin. He `(IgM)` protein hi thisenah a tam lutuk chuan kan thisen chu a thim a, khawizu ang maiin a thim ta a ni . Hei hi `(hyperviscosity syndrome) an ti a.` Hetianga thisen a thim chuan taksa pum puia thisen kalna kawng te tak te kal tlanga thisen kal a harsa thin. Tichuan, symptom na tak tak a lo lang thei ta a ni.
A pawimawh ber chu WM damdawi a la awm lo. Mahse, lungngai suh. Damdawi chi hrang hrang a awm a, chu chuan natna lan chhuah dan a thunun thei a, a chang chuan a ti bo thei a, hrisel taka i awm theih nan a pui thei bawk. WM hi natna lian tham tak a nih fo avangin kum tam tak chhung chu i nunpui thei a ni.
He `(WM)` natna lan chhuah dan chu engte nge ni?
Ngaihtuah teh, he natna vei mi pali zînga pakhat vêl chuan engmah chhinchhiahna an nei lo . He natna chungchang hi chhan dang vanga Doctor pan tura an kal veleh chauh an hrechhuak thin. Mahse, symptoms a lan chhuah chuan zawi zawiin a lo lang fo thin . Heng symptoms te hi eng nge ni tih hi han thlir ila:
- Chak lohna leh hah rengna:Battery a thi tawh ang maiin a lang.
- Khawsik: Taksa chu chhan awm lovin a lum tih a hriat.
- Anorexia: Chaw ei duhna nei lo.
- Zan lama thawmhnaw: Mut laiin thawk hah tam.
- Weight loss: Chhan bik nei lovin i thau thin.
- Buaina: Thil ngaihtuah harsa, a rilru a buai deuh.
- Liver, spleen emaw lymph node emaw a hring: Doctor chauhvin chiang takin a hrilh thei che a ni.
- Peripheral neuropathy symptoms, kut zungtang leh ke ruh natna : Tingling sensation, emaw sensation hloh ang maiin a awm.
- Thisen zam chhinchhiahna: hnar thisen chhuak, ha sil laiin hmui thisen chhuak, luak chhuak, lu na, leh mit hmuhna fiah lo.
Heng symptom pakhat emaw pahnih emaw i neih vang mai mai hian WM i nei tihna a ni lo. Mahse heng symptoms te hi a la awm reng a nih chuan doctor thurawn lak a tha ber.
`(WM)` din chhan te chu engte nge ni?
Waldenstrom-a macroglobulinemia thlentu ber chu genetic mutations a ni . He natna vei zinga 90% aia tam, mi sawm zinga 9 te hian MYD88 an tih gene-ah mutation an nei a ni. Mi 40% vel pawhin CXCR4 an tih gene-ah mutation an nei bawk. Heng genetic mutations pahnih hian WM-a cell pangngai lote chu rang taka inthen darh turin a pui a ni.
A pawimawh ber chu heng genetic changes te hi hereditary a ni lo . Chu chu i nu leh pate hnen atanga i dawn thil an ni lo va, i fate hnena i hlan chhawn pawh an ni lo. Nun chhung zawngin an thleng thin. Mahse, zirchiangtute chuan a tir lamah chuan heng genetic mutations te hi eng thilin nge a thlen tih erawh an la chiang lo.
Tute nge he natna vei theihna sang zawk? (Risk factor hrang hrang) 1.1.
`(WM)` lo awm theihna chance tipungtu thil engemaw zat a awm. Eng nge an nih i en ang u:
- Kum: He natna hi kum 65 aia upa te zingah hmuh chhuah a ni ber.
- Hnam: He natna hi mi var zingah a tam ber.
- Gender: Mipa hian he natna hi an vei tam zawk.
- Damdawi lam thil dang: Natna `(Hepatitis C)`, `(AIDS)`, `(Sjögren's Syndrome)`, emaw `(MGUS - Monoclonal Gammopathy of Undetermined Significance)` (hei hi `(WM)` hmahruaitu a ni) tih ang chi natna i neih chuan i hlauhawmna a sang thei hle. Amaherawhchu, `(MGUS)` nei zawng zawng hian `(WM)` an lo thanglian vek dawn lo tih hriat reng a pawimawh.
- Chhungkaw chanchin: I thisen chhungte hian WM emaw lymphoma chi dang emaw an vei tawh a nih chuan i hlauhawm thei bawk.
He natna hian eng harsatna nge a thlen theih?
A nasat deuh thenkhatah chuan WM hian harsatna dang a thlen thei bawk.
- Amyloidosis: Hei hi protein dik lo chu thinlung, lung leh kal (kidney) ang chi taksa peng hrang hranga a awm hian a ni.
- Cryoglobulinemia: Hetiang dinhmunah hian thisen protein thenkhat, khawsik laka chhangtu chu taksa peng hrang hrangah an pung khawm a, an inzawm khawm thin. Hei hian natna a thlen thei a, blue/white discoloration (cyanosis) a thlen thei bawk.
He natna hi Doctor ten engtin nge an hriat chian? (Diagnosis) tih a ni.
I doctor chuan WM i neih leh neih loh hriat nan test engemaw zat a hmang thei ang. Cancer cell leh a hmaa kan sawi tawh IgM protein te hi an zawng ber a ni.
- Thisen leh zun test: Thisen leh zun sample lak a, WM chhinchhiahna a awm leh awm loh enfiah a ni. Thisen cell hniam leh IgM protein pangngai lo ang chi thil an zawng thin.
- Imaging tests: CT scan emaw CT-PET scan emaw, CT leh PET scan inkawp hmanga taksa chhunga WM chhinchhiahna zawng chhuah a ni. Heng test te hian taksa peng hrang hrang (swellen organs) leh lymph node te ang chi thil te an zawng thin.
- Mit enfiah: Mit hnunglam chhunga thisen chhuak leh awm loh a enfiah thin. Hei hi thisen zam a nihna chhinchhiahna a ni.
- Bone marrow biopsy: Hei hian ruhro sample te tak te lak a, microscope hmanga en a, cancer cell a awm leh awm loh en a ni.
Engtin nge `(WM)` hi enkawl a nih?
Kan sawi tawh ang khan he natna hi damdawi a la awm lo. Chuvangin, enkawlna tha ber chu symptoms tihziaawm hi a ni a, side effects tlemte chauh a awm . I doctor chuan a bia ang che a, i tana tha tur treatment plan a siam ang che. `(WM)` enkawlna tur thenkhat chu hetiang hi a ni:
- Fimkhur taka nghah: Symptom i neih loh chuan i doctor chuan enkawlna a tan lo mai thei. WM vei thenkhat chuan kum tam tak chhung enkawl an mamawh lo mai thei.
- Plasmapheresis / plasma exchange: Hei hi i thisen liquid part plasma atanga IgM protein pangngai lo filter chhuah nan machine hmanga filter chhuah a ni. Chumi hnuah chuan plasma tihfai chu i thisenah dah leh a ni. He enkawlna hi thisen zam tihziaawmna atan hman a ni.
- Immunotherapy: He enkawlna hian nangmah ngeiin i immune system hmangin WM cells te chu a tichhe emaw, a ti hniam emaw a ni. Damdawi Rituximab (Rituxan®) hi a chauh emaw, chemotherapy nen emaw pek a ni fo thin.
- Chemotherapy: Cancer cell thattu damdawi hi a ringawt emaw, immunotherapy nen emaw pek theih a ni.
- Corticosteroids: Steroid chi khat, dexamethasone ang chi hi immunosuppressive therapy leh chemotherapy nen pek theih a ni. Cancer dona kawngah an pui a, enkawlna avanga side effects pawh an ti tlem bawk.
- Targeted therapy hmanga enkawlna: 1.1.He enkawlna hian cancer cell-te’n an thanlenna atana an hman protein te chu a block a ni. Ibrutinib (Imbruvica®) leh zanubrutinib (Brukinsa®) te hi U.S. Food and Drug Administration (FDA)-in WM enkawlna atana a pawmpui, targeted therapies pahnih an ni.
- Stem cell transplant: Hei hian cell pangngai loin a nghawng ruhro chu ruh hrisel hmanga thlak a ni. Hei hi tih fo a ni lo va, damlo thlan bik tak takah chauh tih a ni.
Engtikah nge damdawi lam thurawn ka lak ang?
WM i vei tih hmuhchhuah a nih chuan i doctor nen inbia nghal la , symptom thar i neih emaw, symptom awm tawh i ngaihtuah chuan emaw. WM i vei tih hmuhchhuah a nih hnuah, i beisei tur hriat nan zawhna zawh a pawimawh. Doctor i zawh theih tur zawhna thenkhat chu hetiang hi a ni:
- `(WM)` hi engtiang chiahin nge a serious? Hei hian engtin nge ka nun a nghawng ang?
- Hun rei lote leh hun rei tak chhungin eng nge ka beisei ang?
- Enkawl tan nghal a ngai em?
- Eng ang enkawlna nge i rawt?
- Enkawlna atang hian eng side effect nge beisei theih ang?
Hetiang dinhmun hi ka neih chuan eng nge ka beisei theih ang?
Waldenstrom-a macroglobulinemia ang natna zawi zawia zual zel nei zawng zawng hi an inang vek lo. Research atanga a lan dan chuan 66%, a nih loh leh mi pathum zinga pahnih aia tam chu an natna hmuhchhuah atanga kum 10 hnuah pawh an la dam a ni. Mahse, dam rei hun chu kum a zirin a inang lo thei . Kum 65 chunglam (kum group) tam zawk chu WM nena inzawm lo thil vangin an thi thin.
Thil tam takin i natna prognosis a nghawng a ni. Entir nan:
- i kum zat
- Thisen test result a ni
- Genetic mutation chi (a chang chuan `(MYD88)` mutation awm lohna hian a rah chhuah tha lo a tilang thei)
I dinhmun chungchanga zawhna i neih chuan i doctor nen inbia . Ani chuan nangmah leh i hriselna tichhe thei thilte chu a hre chiang ber che a ni.
Ka rilru a hahdam theih nan tih theih a awm em?
Waldenstrom’s macroglobulinemia ang lymphoma neia nun hian i nunah inthlak danglamna lian tak tak i siam thei a ni. Resource i neih zawng zawng hman a pawimawh. I doctor nen eng ei tur nge i ei tur tih leh mahni invenna tur eng nge i tih tur tih sawipui rawh .
Mahni chauha inhriat loh nan he natna hmuh tur awm lo vei midangte nen inzawmna siam rawh. He natna i vei tih i hriat veleh a tir lamah chutiang chuan i inhria a nih pawhin, he zinkawngah hian nangmah chauh i ni lo . I doctor zawt la, support group-ah tel ve rawh.
A tawp berah chuan hei hi hre reng ang che.
Waldenstrom macroglobulinemia (WM) damdawi hi zirchiangtute chuan an la hmu lo. Mahse, natna nena nun awlsam zawkna tur enkawlna engemaw zat an hmuchhuak a ni . Mi tam tak chu he natna nen hian kum tam tak chhung chu natna lanchhuahna nei lovin an khawsa a. Enkawlna tharte chuan WM vei te chu a hma aia rei zawk an dam theih phah a, an nunphung pawh tihlawhtling lovin an dam thei ta a ni.
Hetiang diagnosis hi i dawng a nih chuan hlauthawng suh la, i doctor hnenah hun rei lote leh hun rei tak chhunga thil awm dan tur zawt rawh. I tana enkawlna tur ruahmanna tha ber tur ngaihtuah turin an pui ang che. Damdawi lam thurawn leh puihna dik tak i dawn chuan he natna hi hlawhtling takin i nung thei tih hre reng ang che.
` Waldenstrom macroglobulinemia, WM, thisen cancer, IgM protein, hyperviscosity syndrome, ruhro, lymphoma te a ni
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