Miin kidney transplant thar a dawn chuan nun thar a neih ang mai a ni. Mahse chutiang surgery lian tak hnuah chuan a chang chuan beisei loh khawpa harsatna a awm thei a ni. Entirnan, kidney transplant nei tawhah natna khirh tak a awm thei chu BK Viral Nephritis an ti a. Hei hian i kal thar hnathawh a nghawng thei a, transplant hlawhtlinna pawh a tikhawlo thei bawk. Mahse lungngai suh u, hei hi dik taka kan hriat chuan he dinhmun laka inven dan tur a awm. Chuvangin, vawiin hian he thu hi chipchiar takin sawi ila.
He BK virus hi eng nge ni?
A awlsam zawngin sawi ila, BK virus nephritis hi natna hlauhawm tak a ni a, chu chu BK polyomavirus reactivation avanga lo awm a ni a, chu chu i taksaah a muhil (latent) a, chu chu kal transplant hnuah a lo awm tawh a ni. He virus hi kum 1971 khan kidney transplant patient pakhatah hmuhchhuah a ni a, a initials "BK" tih a ni. Chuvang chuan BK virus an ti a ni.
BK virus hi a takah chuan a tlangpuiin, a tam zawkah chuan asymptomatic, thawkna lama natna hrik, mucus ang chi secretion hmanga darh thin a ni. Mi hrisel chuan he hripui hi an kai tih pawh an hre lo. Amaherawhchu, virus hi taksaa a luh veleh chuan kan dam chhung zawngin kan taksaah a muhil thei a, harsatna a siam lo.
Zirchianna atanga a lan dan chuan khawvel mihring 80% aia tam hian he hri laka antibody an nei a ni. Chumi awmzia chu kan naupan lai atang tawhin he hri hi kan kai vek tawh tihna a ni. Mi pangngai, kal (kidney transplant) nei lo chuan he hri hian an taksaah a tichhe lovang.
Engtin nge hei hi kal thlak tawh tan chuan a hlauhawm theih ang?
Kidney transplant i neih hnuah i taksain kidney thar a hnawl loh nan damdawi bik pek i ni ang. Chungte chu anti-rejection leh immunosuppressant damdawi an ti a . Heng damdawi te hian i taksa natural immune system a tichak lo a, hna a thawk a ni. Hei hian kidney thar chu i taksaah a insiamrem thei a, a beih loh phah a ni.
Mahse i immune system a chak loh chuan i taksain natna dang a do theihna pawh a tlahniam bawk. Chutih lai chuan i taksaa BK virus lo muhil tawh chu a "harh chhuak" a, chu chu a thawk leh ta tihna a ni.
He activated virus hian i kidney thar chu direct in a bei thin. Hei hian kidney leh ureters inflammation, a nih loh leh swelling a thlen thin. Hei hi nephritis kan tih chu a ni .
He inflammation hian zawi zawiin kal (kidney) te chu a tichak lo hle. Hetiang dinhmun hi a na zual chuan BK virus nephropathy an ti a.Nephropathy an ti a. Chumi awmzia chu kal (kidney) chu nasa takin a chhia a, a tawpah chuan a chhe vek thei tihna a ni. Kidney transplant dawngtu zinga 2% velin he nephropathy hi an vei nia chhut a ni.
BK Viral Nephritis natna lan chhuah dan chu engte nge ni?
A tam zawkah chuan he natna vei te hian symptom an nei lo. Mahse, symptoms a lo lang tak tak chuan a hnuaia thilte hi i hriat chian a ngai a ni.
| Symptom a ni | Hrilhfiahna |
|---|---|
| Zun inthlak danglamna | Zun chhunga thisen emaw, zun sen emaw, sen-brown-a inthlak emaw. |
| Zun harsatna | Zun laiin natna emaw kang emaw, zun harsat. |
| Bladder a hring vek lo | Zun hnuah zun a la awm ang maia hriat. |
| Sudden thau lutuk | Hun rei lote chhunga taksa rih zawng kilogram khat emaw a aia tam emaw, darkar 48 chhunga tihpun. |
| Na | Pum emaw, pum hnuai lam emaw a na emaw, a hring emaw. |
Tin, i doctor chuan i thisen leh zun test report-ah creatinine level sang leh thisena urea nitrogen level sang ang chi thil a hmu thei bawk.
Heng symptoms te hi i neih chuan i kidney specialist hnenah zawh nghal rawh. Heng natna tam zawk hi chu kal thlak hnu thla thum chhungin a thleng thin.Chuvangin he hun chhung hian i taksa hi i enkawl tha hle a ngai a ni.
He hri kai hian hriselna atana hlauhawm engte nge a thlen?
BK virus nephritis vei theihna ber chu i kal thar tihchhiat a ni. Thil na tak tak thenkhatah chuan graft hloh kim theihna chu 30% atanga 80% thleng a ni thei.
He hri hian kal (kidney) a tihchhiat bakah hian hriselna lama harsatna lian tham dang a thlen thei bawk.
- Cancer: He virus hian cell te chu a pangngai lo takin a tipung thei a, taksa peng hrang hrangah cancer tumor a siam thei bawk.
- Capillary leak syndrome: Thisen plasma chu thisen kalna kawng te tak te atanga a chhehvel thau, taksa peng leh tissue-a a luang chhuak avanga natna khirh tak a ni.
- Encephalitis: He hri hi thluaka a darh chuan thluak tissue a lo hring thei. Hei hian mize danglam leh seizure ang chi symptoms a thlen thei a ni.
- Pneumonia: He hri hi lungah a darh a, tuiin a khat avangin thawk harsatna a thlen thin.
- Viral hepatitis: Liver-a virus a darh chuan thin a ti na thei a ni.
He natna hi engtin nge dik taka kan hriat theih ang?
I doctor chuan he natna hi i vei em tih finfiah nan test eng emaw zat a kalpui ang.
| Fiahna | Eng nge i check? |
|---|---|
| Thisen test a ni | Thisenah hian BK virus DNA emaw mRNA fragment emaw a awm leh awm loh an enfiah thin. |
| Zun test a ni | Zun hi cell chi khat bik "decoy cells" tih test a ni. Hengte hi kidney cell hri kai atanga siam, zun atanga chhuak cell te an ni. He virus DNA/mRNA fragment awm leh awm loh an test bawk. |
| Kidney biopsy tih a ni | Hei hi natna hriat chian dan rintlak ber a ni. Kidney atanga tissue te tak te pahnih lakchhuah a ni a, enfiah a ni. |
Engtin nge i enkawl ang a, i inven ang?
He natna hi enkawlna pakhat, definitively approved treatment a awm lo. Mahse, i doctor chuan a natna hi a enkawl dan tur chi hrang hrang a hmang ang.
- Immunosuppressants dose tihtlem: Hei hi enkawlna ber a ni. Virus hi a active tih finfiah a nih chuan i doctor chuan i damdawi ei zat tihtlem a rel ang.
- Antiviral damdawi: Damdawi thenkhat chu taksaa virus awm zat tihtlem nan pek theih a ni.
- Damdawi dang: I immunosuppressive damdawi i thlak a ngai mai thei a, secondary infection tan antibiotics pek i ngai thei bawk.
Engtin nge he thil lakah hian kan inven theih ang?
He hri hi naupan laia kan kai vek avangin taksaa a luh dan hi kan thunun thei lo. Mahse, kal thlak hnua he natna hi i vei theihna tur tihtlem nan thil engemaw zat i tih theih a awm. A pawimawh ber chu doctor thurawn angin screening neih fo hi a ni.
- Symptoms a lan hma hian a hun takah thisen leh zun test a, virus hi a active tawh em tih enfiah thin a ni.
- A tlangpuiin, transplantation hnu kum hnih hmasa berah thla 3 danah enfiah a tha a, kum nga chhung chu kum tin enfiah a tha.
- Heng test-te hian virus a hmuhchhuah chuan doctor chuan immunosuppressive drugs dose a siamrem ang.
I tih tur chu natna lan chhuahna tenau te i neih chuan ngaihven la, i doctor hnenah report nghal la, a rawtna test te chu a hun taka tihsak mai tur a ni. Chutianga i tih chuan he natna khirh tak lakah hian i him ang a, i kal thar nen hian hun rei tak chhung hrisel takin i awm thei ang.
Take-Home Thuchah a ni
- BK virus hi virus tlanglawn tak a ni a, mi hrisel tan chuan a pawi lo hle a, mahse kal (kidney transplant) nei tawh tan chuan a hlauhawm thei hle.
- Kidney transplant hnuah taksaa virus lo muhil tawh chu immunosuppressants vangin a thawk leh thei a ni.
- Zun inthlak danglam, zun laiin natna, leh taksa rihna sang nghal te ang chi symptoms te chu fimkhur rawh.
- Hetiang natna laka invenna tha ber chu doctor-in a rawt angin a hun taka screening neih hi a ni.
- Ringhlelna emaw symptom emaw i neih chuan tihkhawtlai suh la, doctor rawn la, thurawn la rawh.
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