Me kōrero tātou mō te Autophagy: Te Tukanga 'Hangarua' ā-Taiao o te Tinana!

Kua whakaaro koe me pēhea te mahi pai o ngā tiriona pūtau i roto i ō tātou tinana mō ngā tau? Pērā i te motuka, i roto i te wā, ka tawhito ētahi wāhanga o ō tātou pūtau, ka pakaru, ka kore e whai hua. Nā, he aha te mea ka pā ki tēnei 'para' kua kohia? Me pēhea te horoi a tō tātou tinana i a ia anō i tēnei? Koinei te wāhi e uru mai ai tā tātou kaikorero, te tukanga whakamiharo e kiia nei ko te Autophagy (e kīia ana ko te auto-phagy). He mea nui tēnei mō te hauora o tō tātou tinana. I tēnei rā, ka kōrerohia e tātou tēnei mea mā te ngāwari, i roto i te huarahi e mārama ai koe.

He aha te tikanga o te autophagy?

He whakarāpopototanga noa iho, ko te autophagy he tukanga e horoi ai, e whakatikatika ai hoki ngā pūtau o te tinana i a rātou anō. He rite ki te tango i ngā para e kohia ana i roto i ō tātou kāinga i ia rā, ā, ka hangarua anō i ngā mea ka taea te whakamahi.

Whakaarohia tō whare. Ka aha tātou ina kohia e tātou ngā mea tawhito, ngā tūru pakaru, me ngā pepa koretake? Ko ētahi o aua mea ka makahia e tātou, ko ētahi ka tangohia ngā wāhanga pai ka hangaia he mea hou. Ko te autophagy he momo 'horoi hohonu' me te 'hangarua' e tupu ana i roto i ō tātou pūtau.

Ko ia kiko me ia okana o roto i tō tātou tinana he mea hanga mai i ngā poraka hanga taketake e kiia nei ko ngā pūtau. Kei roto i ia pūtau he maha ngā wāhanga ririki hei āwhina i a ia ki te mahi i tana mahi. I roto i te wā, ka kore e mahi tika ētahi o ēnei wāhanga, ka pakaru, ka noho rānei hei 'para' koretake. Ka rapua e te tukanga o te autophagy ēnei wāhanga koretake, ka wāwāhia, ka tangohia ngā rauemi whai hua mai i a rātou hei hanga wāhanga hou mō te pūtau. Ka tangohia ngā wāhanga koretake.

He aha te hiranga o te autophagy ki ō tātou tinana?

Ehara i te mea he mahi horoi noa te autophagy. He mea nui mō te oranga me te hauora o ō tātou pūtau. He maha ngā take matua mō tēnei:

• Te hangarua anō i ngā wāhanga pakaru: Ka hurihia ngā wāhanga pūtau tawhito, kāore e mahi pai ana, hei wāhanga hou, hei wāhanga mahi. He rite ki te whakarewa i te konganuku tawhito hei hanga i tētahi hua hou. Ko te tikanga, kāore te pūtau e hiahia ki te tango i ngā rauemi mata e hiahiatia ana hei hanga i ngā wāhanga hou.
• Te tango i ngā wāhanga kāore e hiahiatia: Ka tangohia e ngā pūtau ngā wāhanga koretake e noho wāhi ana, e whakararuraru ana i ā rātou mahi. Ka whakanui ake tēnei i te mahi a te pūtau.
• Te tiaki i ngā mate urutā: Ka āwhina hoki te autophagy ki te kimi me te whakangaro i ngā pathogens, pērā i ngā huaketo me ngā huakita, e whakaeke ana i ō tātou pūtau. He wāhanga nui o tō tātou pūnaha ārai mate.
• Te whakahaere i te koroheketanga:I a tātou e pakeke haere ana, ka pōturi haere tēnei tukanga Autophagy. Kātahi ka tīmata te kohikohi o ngā 'para' ki roto i ngā pūtau. Nō reira, ka mutu te mahi tika a ngā pūtau. Koinei tētahi take e piki ake ai te mōrearea o te pāngia e ngā mate i a tātou e pakeke haere ana. E whakaponohia ana mā te pupuri i te tukanga Autophagy kia ora tonu ai tātou, kia taitamariki ai hoki.

He pēhea te puta o tēnei tukanga e kiia nei ko te Autophagy?

Tērā pea he ahua uaua te ingoa. E rua ngā kupu Kariki o te kupu autophagy.

• Ko te tikanga o "Autos" ko "whaiaro".
• Ko te tikanga o "Phagomai" he 'kai'.

Ko te tikanga o tēnā ko te 'kai i a ia anō.' Ko tā te pūtau e mahi nei ko te 'kai' i ōna ake wāhanga kāore e hiahiatia, me te pure i a ia anō.

Ka puta tēnei tukanga penei:

1. Tuatahi, ka tautuhia e te pūtau ngā wāhanga kua pakaru, kāore rānei e hiahiatia ana i roto i a ia anō.

2. Kātahi ka hangaia he 'pēke' motuhake e kiia nei ko te "Autophagosome" hei karapoti i ēnei wahi para. He rite tēnei ki te wā e kohia ana e tātou te para ka maka ki roto i te pēke para.

3. Muri iho, ka haere tēnei 'pēke para' ki tētahi wāhanga o te pūtau e kiia nei ko te `(Lysosome)`. He rite te `(Lysosome)` ki te `(Pūtahi Hangarua)` o te pūtau.

4. Ka nakunaku ngā para e ngā whākōkī kaha i roto i tēnei pokapū, ka wāwāhia rānei kia ririki.

5. I muri i te wāwāhitanga pēnei, ka whakamahia anōtia e te pūtau ngā rauemi mata whai hua (hei tauira, ngā waikawa amino). Ka taea ēnei te whakamahi hei hanga pūmua hou me ngā wāhanga hou e hiahiatia ana e te pūtau.

Mā tēnei ara, ka whakamahia e te pūtau ōna ake rauemi hei pupuri i a ia anō kia ma, kia ora hoki.

Āhea ka tīmata te tukanga autophagy?

He mea e tupu tonu ana te autophagy i tētahi taumata i roto i ō tātou pūtau. Heoi, i ētahi wā motuhake, ka tere ake tēnei tukanga.

I te whakarapopototanga, ka tere ake tēnei tukanga ina pāngia ngā pūtau e te ahotea. Ko ētahi o ngā huarahi matua ka puta ai tēnei ahotea ko:

• Te korenga o ngā matūkai: Ina kore ngā pūtau e whiwhi i ngā matūkai e hiahiatia ana e rātou.
• Te korenga o te hāora: Ina heke te nui o te hāora e tae atu ana ki ngā pūtau.
• Te kino o ngā pūtau: Ina pakaru ngā pūtau nā te mate urutā, te paitini, tētahi atu take rānei.

Whakaarohia kei te takoto kau koe, kāore he kai, kāore he inu. He aha tāu e mahi ai? Ka tino tupato koe ki te whakamahi i ngā rauemi kei a koe, kāore? He pērā anō ngā pūtau. Ina kore te kai e puta mai i waho, ka 'kai' rātou i ngā wāhanga tawhito, kāore e hiahiatia ana i roto i a rātou anō hei hanga pūngao me ngā rauemi mata hei oranga mō rātou. Ko te Autophagy tēnei. Arā, he tikanga tiaki tino nui tēnei mō te oranga o te pūtau.

Ka taea e tātou te whakaoho i te Autophagy i te wā e hiahiatia ana?

Ae, kua kitea e ngā rangahau mā te hanga i ētahi huringa ki tō tātou momo noho me te whakarato i te ahotea whakahaere ki ngā pūtau, ka taea e tātou te whakaoho i te tukanga autophagy. He maha ngā huarahi matua hei mahi i tēnei.

He whakatūpato tino nui!

Engari he mea tino nui tēnei. Ehara i te mea pai mō te katoa te whai i ēnei tikanga hei whakaoho i te Autophagy. Ehara hoki i te mea pai kia mahia tēnei me te kore he tohutohu hauora.

Hei tauira,

• Ngā whaea hapū
• Ngā whaea e whāngai ana i ngā pēpi
• Ngā tāngata whai mate pūmau pēnei i te mate huka
• Te hunga e rongoatia ana mō tētahi atu mate hauora

He mea morearea pea te nohopuku, te whakawhāiti rānei i ngā kaora mō ēnei tāngata, ā, ehara hoki i te mea pai te tīmata ohorere i ngā mahi whakakori tinana uaua me te kore he tohutohu hauora.

He aha te whanaungatanga i waenga i te autophagy me te mate?

I whakaaro ngā kaipūtaiao i mua ko te autophagy he tukanga noa iho e tiaki ana i te 'whakahaere' o ngā pūtau. Heoi, kua kitea e ngā rangahau hou he mea nui anō hoki tana mahi ki te ārai me te whawhai ki ngā mate.

Ka taea te hono atu ki tētahi ngoikoretanga, ki tētahi āhua rerekē rānei o te tukanga autophagy me ngā momo mate. Hei tauira:

• Te mate a Parkinson
• Te mate a Huntington
• Mate huka
• Mate ngakau
• Te mate a Crohn
• Te mate whatukuhu me te ate

E rua ngā āhuatanga o te autophagy mō te mate pukupuku. E kī ana ētahi rangahau, ina pai te haere o tēnei tukanga, ka ārai i te kohikohinga o ngā 'para' i roto i ngā pūtau, ka kino te DNA, ka ārai hoki i te hanganga o te mate pukupuku. Arā, he pūnaha parepare e ārai ana i te hanganga o te mate pukupuku.

Engari, i tētahi atu taha, kua kitea i muri i te whanaketanga o te mate pukupuku, ka taea e te autophagy te whāngai i ngā pūtau mate pukupuku, hei āwhina i a rātou kia ora me te tipu pai ake.

Nō reira, he nui tonu ngā rangahau e haere tonu ana i tēnei wāhanga. Kāore anō kia mahia te nuinga o ngā rangahau o nāianei ki te tangata. Kua mahia ki ngā kararehe pērā i te kiore. Nō reira, he wawe rawa ki te kī me pēhea te whakamahi i te autophagy hei rongoā mō ngā mate.

I ēnei rā, e kite ana ētahi i te Autophagy hei 'makutu' hei pupuri i te taitamarikitanga me te hauora. Engari ehara i te mea ngāwari te kōrero. He pono ko te Autophagy he tukanga nui mō ngā pūtau hauora. He pono anō hoki ko ngā ngoikoretanga o te Autophagy e pā ana ki ētahi mate. Heoi anō, kāore anō kia nui ngā taunakitanga pūtaiao hei taunaki i te whakaoho i te Autophagy hei rautaki hei whakapai ake i te oranga.