E mōhio ana koe ki te mate pukupuku ū kino HER2? Me kōrero tāua!

Kua rongo pea koe i ngā kōrero maha mō te mate pukupuku o te ū. Engari e mōhio ana koe he aha te ingoa o tēnei momo mate pukupuku ko te 'HER2-negative'? He rerekē te whanonga i ētahi atu momo mate pukupuku o te ū, ā, he rerekē pea te maimoatanga. Kaua e manukanuka, i tēnei rā ka kōrero tātou mō tēnei 'HER2-Negative' Mate Pukupuku o te Ū i roto i tētahi huarahi māmā e mārama ai koe, āe?

He aha te matepukupuku ū kino-HER2?

I roto i ngā kupu māmā noa iho, ko te tikanga o te 'matepukupuku ū HER2-negative' kāore i te nui rawa, i te iti rawa rānei o te pūmua motuhake e kiia nei ko te 'human epidermal growth factor 2' (HER2) i roto i ngā pūtau matepukupuku i roto i tō ū. I mōhio koe ko te matepukupuku ū ka puta ake nā ngā homoni (ina koa ko te estrogen me te progesterone) nā tēnei pūmua 'HER2' rānei? Hei tauira, i roto i te matepukupuku ū 'HER2-positive', kei runga i te mata o ngā pūtau te pūmua 'HER2', ka tere te wehewehe o ngā pūtau matepukupuku, ka hanga he pukupuku.

Engari i roto i ngā take 'HER2-kino', kāore te mate pukupuku e whanake nā te mea he nui rawa te pūmua 'HER2'. Arā, kei reira ētahi atu āhuatanga e whai wāhi ana.

Ina tāpaetia koe e tō tākuta he mate pukupuku ū tōu, ka rapua e rātou tō tūnga `HER2` (arā, he pai, he kino rānei). Koinei ngā āhuatanga motuhake o ngā pūtau mate pukupuku, e kiia nei e tātou he `biomarkers` , ā, ina mārama tika, ka taea e ngā tākuta te whakatau ko tēhea te maimoatanga e tino tika ana, e tino whai hua ana hoki māu. Kei te mārama koe?

He aha ngā momo matua o te mate pukupuku ū HER2-kino?

Ko te nuinga o ngā mate pukupuku ū e kitea ana i tēnei wā he momo 'HER2-kino'. E rua ngā momo matua o tēnei, me titiro tātou ki ēnei:

1. Te mate pukupuku o te ū e pai ana ki te kaiwhakawhiwhi homoni me te mate pukupuku HER2-kino (HR+/HER2-) :

Koinei te momo mate pukupuku ū tino noa, e 70 ōrau (70%) o ngā mate pukupuku ū katoa. I tēnei wā, he kaiwhakawhiwhi kei ngā pūtau mate pukupuku e aro ana ki te homoni estrogen (ER+), te homoni progesterone (PR+), ngā mea e rua rānei. He māmā noa iho, ina herea ēnei homoni ki ēnei kaiwhakawhiwhi, ka tīmata te tipu o ngā pūtau mate pukupuku. Heoi, kāore i te nui te taumata o te pūmua HER2 i roto i ēnei momo mate pukupuku. Koia rātou i huaina ai ko HR+/HER2-.

2. Te mate pukupuku o te ū kāore i te whai i te homoni me te mate pukupuku HER2 kāore i te whai i te HER2 (HR-/HER2-) :

E 11 ōrau (11%) o ngā mate pukupuku ū katoa te take o tēnei momo. Kāore he kaiwhakawhiwhi mō te estrogen, te progesterone rānei i roto i ēnei pūtau mate pukupuku. Waihoki, e ai ki te kōrero i mua ake nei, kāore te pūmua `HER2` i te teitei. Ko te tikanga, kāore ngā homoni me te pūmua `HER2` e whai wāhi ki te tipu o tēnei mate pukupuku . Ko tētahi atu ingoa mō tēnei ko te 'Mate Pukupuku Uma Toru-Negative' . Nā te mea he 'kino' katoa te kaiwhakawhiwhi estrogen, te kaiwhakawhiwhi progesterone, me te pūmua `HER2` i tēnei take.

He aha ngā tohu o te mate pukupuku ū HER2-kino?

Ina hoki, he tino rite ngā tohu o te mate pukupuku ū HER2-kino ki ērā o tētahi atu mate pukupuku ū. Me mōhio koe ki ēnei e whai ake nei:

• Mena ka kite koe i tētahi panoni rerekē o te rahi, o te āhua rānei o tētahi, o ō ū e rua rānei.
• Ki te kite koe i tētahi puku hou, puku, pakari rānei i roto i tō ū, i tō kēkē rānei, ina koa mēnā kāore te puku e rerekē me tō huringa paheketanga o ia marama.
• Ngā panonitanga o te kiri o te ū, o te uma rānei. Hei tauira:
• Te pupuhi o te kiri, pērā i te kiri karaka
• Te miro o te kiri, te kōpeketanga
• Kiri unahi
• He mākūkū tonu
• Ngā panonitanga o te tae kiri (whero, papura, parauri, pouri kē rānei).
• Te rerenga mai i te uma . Tērā pea he whero pēnei i te toto, he wai mārama, he mā miraka rānei (mēnā kāore koe i te hapu, i te whāngai u rānei).
• Te hurihanga o te uma (mēnā kāore i reira i mua).

He mea nui kia mōhio koe , kāore te mate pukupuku o te ū e puta ai ngā huringa mārama ki tō āhua . Waihoki, he maha o ēnei huringa ka kitea i roto i ngā āhuatanga pai, noa (hei tauira, ngā pūwero, te fibroadenoma). Koia te mea nui kia aroturukihia tonutia ō ū me te whiwhi tirotiro mate pukupuku o te ū e tika ana mō te tau . Mena he āwangawanga āu mō tētahi huringa, kia kite i te tākuta kia kitea ai mēnā he tohu mate pukupuku, he tohu rānei nō tētahi atu āhuatanga.

He aha ngā take o te mate pukupuku ū HER2-kino?

Ki te kī ngāwari, ko te mate pukupuku ū HER2-kino ka puta mai i ngā huringa o ngā ira, te DNA rānei, i roto i ngā pūtau ū, e kiia nei ko ngā whakarerekētanga ira , e meinga ai aua pūtau kia huri hei pūtau matepukupuku. Kātahi ka wehea, ka whakanuia teretia ēnei pūtau matepukupuku me te kore e taea te whakahaere, ka hanga he pukupuku.

Ngā Take Mōrearea

Kāore anō kia tino mōhiotia e ngā tohunga te tino take o ēnei whakarerekētanga ira i roto i ngā mate pukupuku ū HER2-kino. Heoi, kua tautuhia e rātou ētahi āhuatanga ka piki ake te mōrearea o te mate pukupuku ū whānui. Ko ētahi o ēnei ko:

• Ngā whakarerekētanga ira tuku iho : Kāore he whakarerekētanga ira motuhake e pā ana ki te mate pukupuku ū e pā ana ki te HER2. Heoi, ki te riro i te tangata tētahi whakarerekētanga ira pēnei i te BRCA1, te BRCA2 rānei, he nui ake te tūponotanga ki te pāngia e te mate pukupuku ū (me ētahi atu mate pukupuku) whānui.
• Kua pāngia koe, tētahi rānei o tō whānau e te mate pukupuku ū i mua.Mena kua pāngia koe e te mate pukupuku ū i mua, tera pea ka hoki mai anō. Waihoki, mena kua pāngia ō whanaunga toto (ina koa ko tō whaea, tō pāpā, ō tuākana, tuākana, tamariki), he paku teitei ake tō tūponotanga.
• Te pānga roa ki ngā homoni estrogen, progesterone rānei : Mena i tīmata tō paheketanga tuatahi i te wā taitamariki (hei tauira, i mua i te 12 tau), i te wā rānei kua roa tō paheketanga (hei tauira, i muri i te 55 tau), kua roa tō tinana e pāngia ana e ēnei homoni ira tangata. He take mōrearea anō hoki tēnei. Ka taea hoki e ētahi rongoā whakakapinga homoni te whakanui ake i tō mōrearea ina tangohia mō te wā roa.
• Te inu waipiro : Kua kitea e ngā rangahau ko te inu i te neke atu i te kotahi inu paerewa ia rā ka piki ake te mōrearea o te mate pukupuku o te ū.

Haunga tēnei, ko ngā āhuatanga pēnei i te kaumātuatanga, te momonatanga, me te kore whakakori tinana ka piki ake te mōrearea o te mate pukupuku o te ū whānui.

Me pēhea te tautuhi i te mate pukupuku ū HER2-kino?

Ko te tikanga, ka tātaritatia e ngā tākuta te mate pukupuku ū HER2-kino mā te tango i tētahi tauira iti (he wāhanga) o te kiko mai i tētahi puku , i tētahi wāhi rānei e whakapaetia ana, ka tukuna ki tētahi taiwhanga. I reira, ka tirohia e te tohunga mate te tauira i raro i tētahi karuārai hei tirotiro mēnā he pūtau matepukupuku kei roto.

Mena ka whakaūtia ngā pūtau matepukupuku, ka whakahaerehia he whakamātautau motuhake hei tirotiro i te nui o te pūmua `HER2` kei te mata o aua pūtau matepukupuku, te maha rānei o ngā tārua o te ira `HER2` kei reira.

• Mena he iti noa (he noa) te nui o te pūmua, te ira rānei 'HER2', he mate pukupuku ū 'HER2-kino' tōu.

Ko ngā whakamātautau taiwhanga matua e rua e mahia ana mō tēnei kaupapa ko:

1. Immunohistochemistry (IHC) : Ka whakamahia e tēnei whakamātautau ngā paturopi me ngā tae motuhake hei kite i te pūmua HER2 i runga i te mata o ngā pūtau matepukupuku. Mena he 0, he 1+ rānei te hua IHC, ka kiia te matepukupuku he HER2-kino. Mena he 2+ te hua (i ētahi wā ka kiia he "equivocal" he "borderline" rānei), ka mahia hoki he whakamātautau e kiia nei ko FISH hei whakaū i te tūnga HER2.

2. Te whakawhānaungatanga i roto i te ira (FISH) : Ka tirohia e tēnei whakamātautau te maha o ngā tārua o te ira HER2, e hanga ana i te pūmua HER2, kei roto i ngā pūtau matepukupuku. Ka whakamahia he karuārai motuhake me ngā tohu whakawhānaungatanga (e whakaputa ana i te mārama). Mēnā kāore e taea te whakatau i te hua o te whakamātautau IHC, pērā i te 2+, ka taea e te whakamātautau FISH te whakaū i te tūnga HER2 (kino, pai rānei).

Haunga ēnei whakamātautau 'HER2', ka tirohia anō hoki e te tākuta mate te tauira koiora, ā, ka rapua te aroaro o ngā kaiwhakawhiwhi estrogen (ETU) me ngā kaiwhakawhiwhi progesterone (PR) i roto i te matepukupuku.

Me whai pea koe i ngā tikanga whakaahua pēnei i te mammogram, te ultrasound, te CT scan, te MRI scan rānei hei kimi i te wāhanga o tō matepukupuku (arā, kia kite i te rahi o te pukupuku me te mea kua horapa ki ngā kōpū lymph, ki ētahi atu wāhanga tawhiti rānei o te tinana).

Ka whakakotahi tō tākuta i ēnei mōhiohio katoa (te tūnga HER2, te tūnga HR, te wāhanga o te mate pukupuku, me ngā āhuatanga o te mate pukupuku) hei waihanga i te mahere maimoatanga tino tika māu.

He aha ngā maimoatanga mō te mate pukupuku ū HER2-kino?

Ka rerekē pea te maimoatanga pai rawa atu mō te mate pukupuku ū HER2-kino i ia tangata, i ia tangata. He maha ngā āhuatanga e whakawhirinaki ana ki tēnei, tae atu ki te wāhanga o tō mate pukupuku, ahakoa he pai te kaiwhakawhiwhi homoni, he kino rānei (HR+/HER2- HR-/HER2- rānei), me tō hauora whānui.

I te nuinga o te wā, ko ngā maimoatanga ka uru pea ki:

• Pokanga matepukupuku o te ū : Te tango i te pukupuku matepukupuku me ētahi kiko hauora pea e karapoti ana. Tērā pea he pokanga tango i te ū, arā, he tango i tētahi wāhanga o te ū, he tango rānei i te ū katoa.
• Te rongoā irahiko : Ka whakamahia ngā hihi kaha-nui hei whakangaro i ngā pūtau matepukupuku e toe ana i muri i te pokanga, hei whakaiti rānei i te pukupuku i mua i te pokanga.

Haunga ēnei maimoatanga taketake, kei reira anō ētahi atu maimoatanga motuhake e ai ki te momo mate pukupuku:

Te maimoatanga mō te mate pukupuku o te ū HR+/HER2- (hormone receptor-positive, HER2-negative)

Nā te mea he whakawhirinaki tēnei momo mate pukupuku ki ngā homoni, he mea nui anō hoki ēnei maimoatanga hei tāpiri atu ki te pokanga me/ranei te rongoā irahiko:

• Te rongoā homoni : Ka mahi ēnei maimoatanga mā te whakaiti i ngā taumata o ngā homoni estrogen, progesterone rānei e āwhina ana i te tipu o te mate pukupuku, mā te aukati rānei i aua homoni kia kaua e herea ki ngā pūtau mate pukupuku. Hei tauira:
• Ngā aukati aromatase (hei tauira, Anastrozole, Letrozole, Exemestane)
• Ngā kaiwhakaoho i te homoni tuku-gonadotropin (GnRH) (aukati i ngā ovaries ki te whakaputa homoni)
• `Ngā whakarerekētanga kaiwhiwhi estrogen whiriwhiri (SERM)` (hei tauira, Tamoxifen, Raloxifene)

I ētahi wā, me pokanga pea koe (oophorectomy) hei tango i ō ovaries, e whakaputa ana i te estrogen. Ka taea te hoatu takitahi i te rongoā homoni, i te whakakotahitanga rānei me te rongoā kua tohua mō ētahi tau.

• Te rongoā arotahi : Ka arotahi ēnei maimoatanga ki ngā ngoikoretanga motuhake o ngā pūtau matepukupuku, ā, ka whakaekea e rātou hei aukati i te tipu me te horapa o ngā pūtau matepukupuku. Mō ngā matepukupuku HR+/HER2-, ka whakamahia ngā rongoā e kiia nei ko ngā aukati CDK4/6 (hei tauira, Palbociclib, Ribociclib, Abemaciclib) me te rongoā homoni. Ka āraihia e ēnei he whākōkī e whakahaere ana i te wehenga o ngā pūtau matepukupuku.
• Te rongoā matū: Mō ētahi mate pukupuku ū HR+/HER2-, inā koa kua horapa te mate pukupuku, kua kaha rānei, ka tūtohu pea ngā tākuta i te rongoā matū me te rongoā homoni me/te rongoā arotahi rānei.

Te rongoā mō te mate pukupuku ū HR-/HER2- (toru-kino)

Nā te mea kāore te mate pukupuku ū e toru-kino e whakawhirinaki ana ki ngā homoni, kāore te rongoā homoni e whai hua. Haunga te pokanga me/ranei te rongoā irahiko, ko ngā maimoatanga e whai ake nei te nuinga e whakamahia ana:

• Te rongoā matū : He maimoatanga tino nui te rongoā matū mō te mate pukupuku toru-kino. He rerekē ngā momo rongoā matū e whakamahia ana e ngā tākuta. Ka hoatu pea e rātou he rongoā kotahi, he huinga rānei o ētahi rongoā.
• Te Whakaora Ārai Mate : He maimoatanga hou tēnei. Ka mahi mā te whakaoho i te pūnaha ārai mate o tō tinana kia kite me te whakangaro i ngā pūtau matepukupuku. Ko te Pembrolizumab (Keytruda®) he rongoā whakaora ārai mate kua whakaaetia e te Food and Drug Administration (FDA) ā, ka hoatu tahi me te chemotherapy mō ētahi momo matepukupuku ū triple-negative.
• Te rongoā arotahi : Mō ngā mate pukupuku toru-kino me te whakarerekētanga ira BRCA, ka whakamahia ngā rongoā arotahi e kiia nei ko ngā aukati PARP (hei tauira, Olaparib, Talazoparib). Waihoki, mō te mate kua horapa, kei te wātea inaianei ngā momo rongoā arotahi hou (hei tauira, ngā hononga paturopi-rongoā).

He aha ngā pānga taha o ngā maimoatanga?

Ahakoa ka taea e ngā maimoatanga mate pukupuku te whawhai whai hua ki te mate pukupuku, ka pā mai ētahi pānga taha i ngā maimoatanga katoa, tae atu ki te chemotherapy, te radiation therapy, te hormone therapy, te arotahi therapy, me te immunotherapy. Ka pā mai ēnei pānga mō te wā poto, mō te wā roa rānei. Hei tauira, te ngenge, te whakapairuaki, te ruaki, te ngaronga o te makawe, te ngaronga o te hiahia kai, te mate waha, te panoni kiri, te korere, te mate kōroke rānei, me te iti o te maha o ngā pūtau toto.

Kia tino kōrero koe ki tō tākuta mō ēnei pānga taha, te roa o te wā e mau tonu ai, me pēhea te whakahaere i aua pānga. Tērā pea ka tukuna koe e rātou ki ngā tohunga tiaki mamae . Ehara i te mea ko ngā wāhanga whakamutunga anake o te mate pukupuku te tiaki mamae, engari ka āwhina anō hoki i a koe ki te pupuri i te kounga o tō oranga mā te whakahaere i ngā tohu me ngā pānga taha puta noa i te maimoatanga.

He aha te auau whakaora mō te mate pukupuku ū HER2-kino?

I roto i ngā mate pukupuku ū katoa he HER2-kino, he nui ake te tere ora ina noho noa te mate pukupuku ki te ū, ā, kāore anō kia horapa (wāhanga ā-rohe) i te wā kua horapa te mate pukupuku ki ngā whekau tawhiti o te tinana (hei tauira, te ate, ngā pukahukahu, te roro, ngā wheua) (te mate pukupuku horapa, te wāhanga tawhiti rānei).Kei waenganui i tēnā te ōrau oranga mō ngā matepukupuku kua horapa noa ki ngā kōpū waiariki tata engari kāore i horapa ki ngā whekau tawhiti (wāhanga rohe).

Heoi, he mea nui kia maumahara ko ō tupono ki te ora, ko tō matapae rānei, ka whakawhirinaki ki ngā āhuatanga motuhake e pā ana ki tō tātaritanga. Kei roto i ēnei ko te tawhiti o te horapa o te mate pukupuku (te wāhanga), te āhua o te kaiwhakawhiwhi homoni o te mate pukupuku (HR+/HER2- HR-/HER2- rānei), te kaha o te kaha o ngā pūtau mate pukupuku (te taumata), tō tau, te hauora whānui, me te āhua o tō urupare ki te maimoatanga. Koinei ngā mea ka taea e tō tākuta te kōrero ki a koe me te whakamārama atu ki a koe he aha ngā mea hei tumanako atu. He toharite noa iho ngā tatauranga, ā, e kore e ōrite mō te katoa.

Me pēhea taku tiaki i ahau anō? (Te tiaki i ahau anō)

Ahakoa he tangata koe e pāngia ana e te mate pukupuku ū HER2-kino i te wā tōmua, he tangata rānei e ora ana me te mate pukupuku kua horapa, he mea nui kia whai wā koe ki te tiaki i a koe anō. Ka āwhina tēnei i a koe i te taha tinana me te taha hinengaro. Anei ētahi mea ka taea e koe te mahi:

• Okioki ina hiahiatia : He mea noa te ngenge me te ngenge, mai i ngā maimoatanga mate pukupuku me te mate pukupuku. Ina ngenge koe, okioki, ā, whakarongo ki tō tinana.
• Kai i tētahi kai hauora, whai kiko hoki : Ka pā pea ētahi maimoatanga mate pukupuku ki tō hiahia kai me tō arero reka. Engari ngana ki te kai i tētahi kai taurite kia whiwhi ai koe i ngā matūkai e hiahiatia ana e tō tinana. Whakaurua ngā hua rākau, ngā huawhenua, te muka, me ngā kai whai pūmua. Ki te kore koe e tino mōhio he aha ngā kai hei kai me ngā mea kāore, kōrero ki tētahi tohunga kai mō ngā tohutohu.
• Korikori tinana (engari kaua e nui rawa) : He mea nui kia mahi i ngā mahi korikori tinana i ia wā i te taumata e tika ana māu, e ai ki tā tō tākuta i tūtohu ai. Ahakoa te hikoi māmā, te yoga rānei, he pai tonu. Ka taea e ia te whakanui ake i tō kaha, te whakapai ake i tō wairua, me te āwhina ki te whakaiti i ngā pānga taha. Heoi, pātai atu ki tō tākuta he aha te momo korikori tinana e tika ana māu, me te nui o te mahi me mahi e koe, i runga i tō tātaritanga me tō maimoatanga.
• Whakahaerehia te ahotea : He mea noa te māharahara, te manukanuka, me te mataku i roto i tētahi mate pēnei. Kimihia ngā huarahi hei whakahaere i tēnei mate e pai ana māu. Ahakoa he pai te whakaaroaro me ngā mahi manawa mō ētahi, ko ētahi e pai ake ana ki te whai wāhi ki ngā mahi auaha pēnei i te pānui pukapuka, te whakarongo waiata, te tuhi, te māra rānei. Whakaritea he wā i ia rā mō ngā mahi katoa e āwhina ana i a koe kia marino, kia wātea hoki.
• Whiwhi tautoko hinengaroHe mea nui kia kōrerohia ō kare ā-roto ki te whānau me ngā hoa tata. He mea whakamana hoki te hono atu ki ētahi atu e pāngia ana e te mate pukupuku me te whakapuaki i ō rātou wheako. Pātai atu ki tō tākuta mō ngā rōpū tautoko, ngā kaupapa oranga mate pukupuku rānei.

Āhea ahau me kite i te tākuta?

He mea tino nui kia mau tonu tō whakapā atu ki tō tākuta, i te wā e rongoatia ana, me muri hoki i te maimoatanga.

• Ki te puta mai he tohu hou ki a koe (hei tauira, he mamae tonu, he puku hou, he uaua ki te manawa, he ngaronga taumaha kāore i te whakamāramatia), ki te āhua kino haere rānei ō tohu o nāianei , me toro atu ki tō tākuta tonu, me whakamōhio atu rānei ki a koe .
• I muri i te maimoatanga, ka whakaritea e tō tākuta he wā tirotiro i ngā wā katoa . Kia mau tonu ēnei wā tirotiro. Ko ēnei hei tirotiro mēnā ka hoki anō te mate, hei whakahaere i ngā pānga taha roa o te maimoatanga, me te tirotiro i tō hauora whānui. He mea nui rawa ēnei wā tirotiro i ngā tau tuatahi e rima i muri i te maimoatanga . Koinei te wā ka hoki anō te mate pukupuku.

He aha ngā pātai me pātai atu e au ki taku tākuta?

I a koe e kōrero ana ki tō tākuta, kaua e wehi ki te pātai i ō pātai, ahakoa te iti. Anei ētahi pātai ka taea e koe te pātai hei āwhina i a koe:

• He pai, he kino rānei te kaiwhiwhi homoni matepukupuku?
• He aha te momo me te wāhanga motuhake o taku mate pukupuku?
• He aha te maimoatanga e taunaki ana koe māku? He aha ai?
• He aha ngā pānga taha mō te wā poto me te wā roa e pā mai ana i ēnei maimoatanga? Me aha hei whakaiti i ēnei pānga?
• Kia pēhea te roa o te maimoatanga?
• He aha tāu e taea te kōrero mai mō taku matapae?
• Ka taea e au te mahi tonu i aku mahi o ia rā (ngā mahi o te whare, ngā mahi o te whare) i te wā e rongoatia ana?
• He mea motuhake anō kei te hiahia ahau kia aro atu ki taku kai me taku whakakori tinana?
• He aha taku e taea ai hei whakaiti i te tūponotanga o te hokinga mai o te mate pukupuku?
• Mena e hiahia ana ahau ki ngā ratonga tautoko, ki ngā ratonga tohutohu rānei, ka taea e au te tiki i tētahi tohutoro mō taua mea?

He mea pai kia tuhia ēnei pātai, kia kore ai e warewaretia tetahi mea.

He pai ake te whai HER2-pai, te kore rānei?

He pātai tēnei e pātaihia ana e te tini tāngata. Engari he uaua ki te hoatu i tētahi whakautu māmā ki tēnei, nā te mea ko te pono he 'tērā pea' .

Hei tauira, ko ngā mate pukupuku ū he HER2-pai, he tere ake te tipu, ā, he kaha ake te kaha atu i ngā mate pukupuku he HER2-kino. Heoi, he painga anō tēnei. He rongoā motuhake kei reira hei aro atu ki ngā pūmua HER2, hei tauira, ko Herceptin, ko Perjeta, ā, he tino whai hua ēnei mō ngā mate pukupuku he HER2-pai. Kāore ēnei maimoatanga e mahi mō ngā mate pukupuku he HER2-kino, nā te mea kāore i te nui te pūmua HER2 hei aro atu ki aua mate pukupuku.

I tētahi atu taha, ki te mea he momo `HR+` (he pai te kaiwhakawhiwhi homoni) te mate pukupuku `HER2-kino`, arā, he momo `HR+/HER2-`, kāti he tino whai hua ngā rongoā homoni me ngā rongoā arotahi pērā i ngā `aukati CDK4/6`. Inaa, ko te mate pukupuku ū `HR+/HER2-` te mea e kiia ana he pai rawa te matapae i roto i ngā momo mate pukupuku ū o nāianei.

Engari, ki te mea he `HER2-negative` (HR-) te mate pukupuku (hormone receptor-negative), arā, he triple-negative, ka kaha ake te kaha i ētahi atu momo, ā, ka uaua ake te maimoatanga. Engari ināianei kei reira ngā rongoā chemotherapy, immunotherapy, me ngā rongoā hou kua arotahihia mō tēnā.

Nō reira, kāore e taea te kī he "pai ake" he "kino ake" rānei tētahi i tētahi. Ko te mea nui ko te tautuhi tika i te momo motuhake o tō mate pukupuku, me te whiwhi i te maimoatanga tino whai hua e tika ana mōna.

Hei whakamutunga, me kī atu ahau ki a koe... (Karere hei tango ki te kāinga)

Ina kitea he mate pukupuku ū 'HER2-negative' koe, he mea noa te mataku me te manukanuka. Engari kia maumahara, ehara tēnei i te mutunga o te ao. He tino matatau te pūtaiao me te hangarau hauora i ēnei rā, ā, he maha ngā maimoatanga whai hua mō tēnei momo mate pukupuku.

Ko te mea tino nui ko:

• Te whakamōhio tika mō tēnei āhuatanga.
• Kia tūpato tonu ki ngā huringa o tō tinana, inā koa ō ū.
• Mena he feaa āu, me toro atu ki te tākuta i te wā tika, ā, me tirotirohia koe.
• Kōrerohia mahorahora, pono hoki ki tō tākuta, pātaihia ō pātai katoa, ā, kia mārama pai hoki koe ki ngā kōwhiringa maimoatanga.

Kia maumahara, kāore koe i te mokemoke i tēnei haerenga. Kei reira ngā tākuta, ngā nēhi, tō whānau, me ō hoa tata hei āwhina me te tautoko i a koe. Kia mau ki te whakaaro pai, kia tika te whai i ngā tohutohu a ō tākuta, ā, kia whiwhi koe i te tautoko e hiahiatia ana e koe, ā, ka tino taea e koe te aro atu ki tēnei āhuatanga me te ora anō. Kia kaha koe!

` Matepukupuku ū, HER2-kino, ngā tohumatepukupuku, maimoatanga matepukupuku, hauora o ngā wāhine, rongoā homoni, triple-kino