I ētahi wā ka kite tātou he maha ngā mema o te whānau e pāngia ana e te momo mate pukupuku kotahi. E kīia ana rānei he nui ake te tūponotanga o te pāngia o ngā mema o te whānau kotahi e te mate. Koinei te mea ka kōrerohia e tātou i tēnei rā. Ahakoa he kaupapa uaua tēnei, me ngana tātou ki te mārama ngāwari.
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He aha te HNPCC me te Lynch Syndrome?
Ki te whakarapopoto, ko te HNPCC (Hereditary Nonpolyposis Colorectal Cancer) he momo mate pukupuku colorectal i puta mai i ngā whakarerekētanga ira. Nā te mea ko ētahi ira e riro mai ana i ō tātou mātua ka nui ake te tūponotanga ka pā mai he pūtau mate pukupuku ki a tātou.
Kua rongo pea koe i te mate Lynch, e kiia ana hoki ko te mate Lynch . He whanaunga te HNPCC me te mate Lynch, engari kāore i te tino ōrite. Ka kīia te HNPCC ko te mate pukupuku e pā ana ki te mate Lynch kua kitea i mua i te 50 tau te pakeke. Kāore pea i te mate pukupuku koroni anake tēnei, engari ko ngā mate pukupuku o te arai o te kōpū (endometrium), te whekau iti, te ureter, me te pelvis whatukuhu. I roto i te HNPCC, ko te mate pukupuku te mea tino kitea i te taha matau o te koroni.
He pēhea te noa o te HNPCC?
E 2% ki te 4% o ngā mate pukupuku koroni katoa te HNPCC. Ka pā mai pea i ngā tau katoa, engari he maha ngā wā ka puta ngā tohu, ā, ka kitea te mate i mua i te 50 tau.
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Check Availability →He aha ngā tohu o te HNPCC?
I ngā wāhanga tōmua, kāore pea he tohu e puta mai i te HNPCC. Ko te tikanga ka taea e te mate pukupuku te tipu i roto i tō tinana me te kore koe e rongo i tetahi mea. Engari i te tipu haere o te mate pukupuku, ka pāngia pea koe e ngā tohu pēnei i:
- Te mamae o te puku, te pupuhi rānei.
- Kāore he reka o te kai.
- He toto kei roto i te tūtae. (He tohu tino nui tēnei, kaua e warewarehia!)
- Te ngenge tonu.
- Te whakahekenga taumaha me te kore he take mārama.
He aha ngā take o te HNPCC?
E ai ki tā mātou i kōrero ai i mua ake nei, ko te HNPCC te take o ngā whakarerekētanga ira i tukuna iho mai i ō tātou mātua. Ina tukuna iho ēnei hapa ira mai i tētahi whakatipuranga ki tētahi whakatipuranga, ka piki ake te mōrearea o te mate pukupuku i roto i taua whānau. Ka kiia tēnei he 'mate pukupuku whānau'.
Ko te mate pukupuku whānau matua e puta ai te HNPCC ko te mate Lynch . Ka puta mai i ngā whakarerekētanga ira i roto i ngā ira MLH1, MSH2, MSH6, PMS2, me te EPCAM . Ko te mahi a ēnei ira he whakatika i ngā hapa e puta ana i te wā o te tāruarua DNA i te wā e wehea ana ō tātou pūtau. Whakaarohia, ki te kore ēnei ira e mahi tika ana, kāore aua hapa e whakatikahia. Kātahi ka nui ake te tūponotanga o ngā pūtau noa kia huri hei pūtau matepukupuku.
He mate hopuhopu te HNPCC?
Kāo, ehara te HNPCC i te mate hopuhopu. Ko te tikanga tēnei kāore e horapa mai i tētahi tangata ki tētahi atu mā te pā atu, mā te tihe rānei. Heoi, ko te whakarerekētanga ira e puta ai te HNPCC ka tukuna iho i tētahi whakatipuranga ki tētahi whakatipuranga . Nō reira, he maha ngā mema o ngā whānau e pāngia ana e tēnei whakarerekētanga ira ka pāngia e te mate pukupuku koroni, e ētahi atu mate pukupuku rānei e pā ana ki te mate Lynch.
Ko te mea nui, ka taea te tuku iho i tēnei ira hapa me te mōrearea o te whakawhanake i te HNPCC mai i ngā mātua ki ngā tamariki.
Me pēhea te tautuhi a ngā tākuta i te mate pukupuku koroni?
I te nuinga o te wā ka tirotirohia e ngā tākuta te tinana hei tirotiro mēnā he matepukupuku koroni. Kātahi ka tūtohu rātou kia whakamahia he koroni , arā, te whakauru i tētahi ngongo iti, he rama kei roto i tō nono hei tirotiro i te roto o tō koroni.
Mena kei te pāngia tetahi o tō whānau e te HNPCC, me kōrero koe ki tō tākuta . He mea tino nui tēnei.
He aha ngā whakamātautau e mahia ana hei whakaū i te HNPCC?
Tērā pea ka tūtohu tō tākuta kia whakamātauria he whakamātautau ira hei whakatau mēnā kei a koe te whakarerekētanga ira e pā ana ki te mate Lynch. Ka pātai atu anō tō tākuta mō:
- Kua pāngia tetahi o tō whānau tata (whaea, pāpā, tuākana/teina) e te mate pukupuku koroni? Ina koa mēnā i kitea i mua i te 50 tau te pakeke.
- Ka whakarite hoki kāore koe e pāngia e tētahi atu mate pukupuku koroni ira tuku iho e kiia nei ko te Familial Adenomatous Polyposis (FAP) , e puta mai ana i tētahi whakarerekētanga ira rerekē i te HNPCC.
He mea tika te pokanga mō te HNPCC?
Ae, he maha ngā wā ka rongoatia te HNPCC mā te pokanga. Ka kiia tēnei pokanga he colectomy . Ko te tango i tētahi wāhanga, i te katoa rānei o te whekau nui. He maha ngā momo pokanga:
- Te tango i te wāhanga o te koroni me te mate pukupuku: I roto i tēnei, ko te wāhanga anake o te koroni me te mate pukupuku ka tangohia.
- Proctectomy: Ko te tango i te koroni me te rectum.
- Ko te tango katoa i te koroni: I roto i tēnei, ka tangohia te koroni katoa.
He aha atu ngā maimoatanga e wātea ana mō te HNPCC?
Mena kua horapa te mate pukupuku koroni (metastasized) ki ētahi atu wāhanga o te tinana, ka tūtohu pea tō tākuta i ngā maimoatanga pēnei i:
- Te rongoā matū: Kei roto i tēnei ko te hoatu rongoā hei whakangaro i ngā pūtau matepukupuku.
- Te rongoā ārai mate: Kei roto i tēnei ko te whakaoho i te pūnaha ārai mate o tō tātou tinana kia whawhai ki ngā pūtau matepukupuku.
He pai ake ki ngā tākuta te rongoā ārai mate nā te mea he nui ake te whai huatanga , ā, he iti ake ngā pānga taha.
Ka taea te ārai i te HNPCC?
Ko ēnei mate pukupuku whānau ka puta mai i ngā whakarerekētanga ira tuku iho. Nō reira, kāore he huarahi hei ārai i ēnei whakarerekētanga ira kei puta . Heoi, ki te mea he mate Lynch, he HNPCC rānei tō tētahi o tō whānau, he mea tino nui kia kōrero koe ki tō tākuta mō te mea me whai whakamātautau ira anō hoki koe.
Mā te tirotiro auau, me te pokanga ārai mēnā e tika ana, ka taea te whakaiti i te mōrearea o te mate mō te hunga whai HNPCC.
Me pēhea taku mōhio mēnā kei te tūpono ahau ki te whakawhanake i te HNPCC?
Mena ka whakaūtia e te whakamātautau ira he whakarerekētanga ira tōu e pā ana ki te mate Lynch, ka tūtohu pea tō tākuta kia tīmata te tirotiro i te mate pukupuku koroni i roto i ō tau 20. Mena ka kitea wawe te mate pukupuku, ka nui ake te tūponotanga ka angitu te maimoatanga.
Mena kei a au te HNPCC, he aha atu ngā mea hei tumanako māku?
Mena kei a koe te HNPCC, tera pea ka nui ake tō tūponotanga ki te whakawhanake i ētahi atu mate pukupuku e pā ana ki te HNPCC. Nō reira, ka tirotirohia pea koe e tō tākuta mō ēnei momo mate pukupuku:
- Matepukupuku roro
- Matepukupuku whatukuhu
- Matepukupuku ate
- Matepukupuku ovarian
- Matepukupuku puku
- Matepukupuku kiri
- Matepukupuku kōpū/Endometrial
Ka taea te rongoā i te HNPCC?
Kāore e taea te whakaora katoa i te mate Lynch nā te mea he mate ira. Heoi, mā te pokanga hei tango i te koroni katoa (total colectomy) ka taea te rongoā i te HNPCC me te ārai i te whanaketanga o te mate pukupuku koroni .
He aha te āhua o te mate mō te hunga whai HNPCC?
Tata ki te 60% o te hunga kua tāpaetia he HNPCC kei te ora tonu i muri i ngā tau e rima . Ko te tikanga, e 60 i roto i te 100 o ngā tūroro kei te ora tonu i ngā tau e rima i muri i tā rātou tāpaetanga HNPCC. Ko te reiti oranga 10-tau mō te hunga e pāngia ana e te mate Lynch kei waenga i te 70% me te 88%. Tērā pea he āhua whakamataku ēnei tatauranga, engari kia mahara mā te kitenga wawe me te maimoatanga tika, ka taea te whakahaere i tēnei āhuatanga .
Me pēhea taku tiaki i ahau anō mēnā kei a au te HNPCC?
Mena kei a koe ētahi tohu hou o te matepukupuku koroni, me kōrero tonu atu ki tō tākuta . Hei āwhina i te ārai i te matepukupuku koroni, ka taea e koe te mahi i ēnei mea:
- Kaua e kai hikareti.
- Kai i tētahi kai hauora.
- Whakakorikori tinana i ia wā, i ia wā.
- Me whai i ngā whakamātautau mate pukupuku katoa i tūtohutia e tō tākuta.
- Whakawhāitihia te inu waipiro.
- Kia mau tonu te taumaha hauora.
Kei te mōrearea taku tamaiti ki te pāngia e te HNPCC?
Mena kei a koe te mate Lynch syndrome, e 50% te tūponotanga o tāu tamaiti ki te whiwhi i te whakarerekētanga ira e hua ai taua whakarerekētanga. Ko te tikanga tēnei, ki te rua āu tamariki, ka riro pea i tētahi te ira, engari kāore pea i tētahi. Mena ka riro mai taua whakarerekētanga ira, ka nui ake te tūponotanga o taua tamaiti ki te pāngia e te HNPCC.
He rite tonu ngā matepukupuku kōpiro FAP me te HNPCC?
He mate pukupuku koroni ira te HNPCC me te FAP (Familial Adenomatous Polyposis) , engari he rerekē ngā ira e puta ai.
He maha ngā polyp e puta mai ana i roto i te koroni o te hunga whai FAP. I ētahi wā he mano tini o ēnei tipu ririki e kiia nei ko ngā polyp. Heoi, kāore e maha ngā polyp e puta mai ana i te hunga whai HNPCC, ā, i ētahi wā ka taea e te mate pukupuku te puta mai me te kore he polyp. Ko ngā polyp e puta mai ana i roto i te HNPCC he papatahi noa iho.
Ko ngā polyp e tupu ana i roto i ēnei āhuatanga e rua e kiia ana he mate pukupuku o mua , arā, ka taea e rātou te huri hei mate pukupuku i roto i te wā poto.
Ko ngā mea tino nui hei maumahara mā tātou i tēnei pūrākau ko
Ko te HNPCC (Hereditary Nonpolyposis Colorectal Cancer) he momo mate pukupuku colorectal i puta mai i tētahi hapa ira ka tukuna iho i roto i ngā whakatipuranga. E pā ana hoki ki te mate Lynch.
- Mena he hītori whānau tō te mate pukupuku, he mea tino nui kia kōrero koe ki tō tākuta mō tēnei.
- Ahakoa kāore he tohu, ki te mea kei roto koe i te mōrearea , me tirotiro tonu koe.
- Ki te kitea wawe, he nui ake te tūponotanga ka angitu te maimoatanga.
- Ehara te HNPCC i te mate hopuhopu, engari ka taea te tuku iho i ngā ira.
- He mea tino nui te whai i ngā tohutohu hauora me te whai i ngā tohutohu a te taote.
Mena he pātai anō āu mō tēnei, kaua e wehi ki te pātai atu ki tō tākuta. Mā rātou koe e āwhina.
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