Kei te āwangawanga anō hoki koe mō te pikinga ake o ngā homoni tāne i roto i te tinana? Me kōrero tātou mō te hyperandrogenism!

Kei te āwangawanga koe mō ētahi huringa o tō tinana? Tērā pea ko te pikinga ake o te nui o te androgen, he momo homoni tāne, i roto i te tinana. Ko te ingoa hauora o tēnei āhuatanga ko te hyperandrogenism . Kaua e manukanuka, ka kōrerohia tēnei mō te ngāwari, i roto i te huarahi e mārama ai koe.

He aha tonu te hyperandrogenism?

Ki te whakarapopototanga, ko te tikanga o te hyperandrogenism he nui rawa ngā androgens i roto i tō tinana, he momo homoni ira tangata. He mea nui ngā androgens mō te pakeketanga, te hauora uri, me te tipu o te tinana.

Titiro mai, he matū ngā homoni i roto i ō tātou tinana. He rite ki ngā karere. Ka haere rātou i roto i te toto, ka tohutohu i ō tātou whekau, uaua, me ētahi atu kiko he aha te mea hei mahi, me te wā hoki hei mahi.

Ka hangaia ngā androgens i roto i te tinana o te tangata. Engari ko ngā tāne te mea nui rawa atu. Tata ki te tekau mā rua o te nui o te testosterone ka hangaia e ngā wāhine i roto i te tinana o te tāne. Ko te testosterone te mea matua o ēnei androgens.

Ka hangaia ngā androgen e ngā testicle i roto i ngā tāne, me ngā ovaries i roto i ngā wāhine. Ka hangaia hoki ēnei homoni e ngā repe adrenal kei runga ake i ō tātou whatukuhu. Ka āwhina hoki rātou ki te huri i ngā androgen ngoikore ki ngā mea kaha ake i ngā wāhi pēnei i te kiko ngako me te kiri.

Ka rerekē ngā tohu o tēnei mate, e kiia nei ko te hyperandrogenism, i runga i tō tau me tō ira tangata. He maha ngā take pea, ā, he maimoatanga anō hoki mōna.

He rite tonu te Hyperandrogenism me te PCOS?

He tokomaha te hunga e whakaaro ana he rite tonu te mate hyperandrogenism me te polycystic ovary syndrome (PCOS) . Ahakoa he hononga tata kei waenganui i ngā mea e rua, he rerekē te āhua.

Ko te hyperandrogenism tētahi āhuatanga matua o te PCOS. Ko te PCOS he kore taurite o ngā homoni e puta mai ana i te nui rawa o ngā homoni tāne e whakaputaina ana e ngā ovaries. Ka pā ki ngā wāhine.

Nō reira, ahakoa he take noa te PCOS mō te hyperandrogenism, tera pea ētahi atu take o te hyperandrogenism. Waihoki, he tohu anō kei te PCOS, pērā i ngā ovarian cysts, hei tāpiri atu ki ngā tohu o te hyperandrogenism.

Ko wai te hunga e tino pāngia ana e tēnei mate? He pēhea te noa o tōna pānga?

Ka pāngia te tangata e te hyperandrogenism - tamariki nohinohi, pakeke, katoa. Heoi, ko te nuinga o te wā ka pā ki ngā wāhine e whānau ana .

I waenga i te 5% me te 10% o ngā wāhine o te tau whānau tamarikiHe pānga nui tēnei āhuatanga. Arā, ehara tēnei i te mea onge pērā i tō whakaaro.

Kāore pea tēnei mate e pā ki ngā tama me ngā tāne pakeke.

He aha ngā tohu o tēnei?

He rerekē ngā tohu o te hyperandrogenism i runga i tō ira tangata me te mea kua pāngia koe e te pakeketanga.

Engari he mea nui tēnei hei maumahara. Ahakoa kei a koe ēnei tohu, tera pea he noa ngā taumata o te androgen i roto i tō toto. Nā te mea he take kē atu pea o ia tohu. Waihoki, ahakoa e whakaatu ana ngā whakamātautau toto he teitei ō taumata androgen, tera pea kāore he tohu nui e pā mai ana ki a koe.

Ko te mea nui, ki te puta ohorere mai ēnei tohu, me toro atu koe ki te tākuta i te wā e taea ai, nā te mea i roto i ēnei āhuatanga, ko te take pea he pukupuku e huna ana i te androgen.

Nā, kia kite tātou me pēhea te pānga o tēnei ki ngā tāngata rerekē.

Mō ngā kōtiro (i mua i te pakeketanga)

• Te kiore nui kua whakanuia .
• He kiri hakihaki me te kiri hinuhinu.
• Te tupu kore e hiahiatia o te huruhuru tinana (hirsutism) . Ko te tikanga o tēnei ka whakakapia te "huruhuru parauri mārama" e te huruhuru taratara, taratara i ngā wāhi pēnei i te ngutu o runga, te kauae, te uma, te puku, me te tuara.

Mō ngā tamariki tāne (i mua i te pakeketanga)

• Ure kua whakanuia .
• Te tupu wawe, te nui rawa rānei o ngā huruhuru i te wāhi tūmataiti me ngā kēkē.
• Te hōhonutanga o te reo.

Mō ngā wāhine pakeke

• He kiri hakihaki me te kiri hinuhinu.
• Te tipu kore e hiahiatia o ngā pūkahukahu o te tinana ( hirsutism) .
• Te huringa paheketanga koretake o ia marama.
• Te uaua ki te whānau tamariki (te kore tamariki) .
• Te ngaronga o te makawe tauira tāne ( androgenic alopecia) .

Mō ngā tāne pakeke

Ko te pānga o tēnei ki ngā tāne pakeke, kei runga i te mea nō ngā repe adrenal ngā homoni tāpiri, nō tētahi mea rānei i tangohia mai i waho (pērā i ngā werohanga steroid anabolic ). Mēnā ka piki ake ngā androgens mai i ngā repe adrenal, tērā pea kāore ngā tāne pakeke e kite i ngā huringa nui o te tinana. Heoi, ka taea e ia te whakaiti i te mahi a ngā testicles, ā, ka uaua ai te whānau tamariki.

He aha tēnei e tupu nei? He aha ngā take?

Ka hangaia ngā homoni androgen e ngā ovaries, ngā repe adrenal, me ngā pūtau ngako i roto i ngā wāhine, ā, e ngā testicles me ngā repe adrenal i roto i ngā tāne.

He maha atu anō ngā homoni e pā ana ki te whakaputanga me te tukunga o ēnei androgens. Hei tauira , ko te homoni luteinizing (LH) me te homoni adrenocorticotrophic (ACTH) . Ka tukuna ēnei homoni e te repe pituitary.

Mena kāore tētahi, ētahi rānei o ēnei whekau, o tētahi rānei o ēnei homoni e mahi tika ana, ka puta pea te hyperandrogenism.

He maha ngā take matua mō tēnei:

• Te mate ovary polycystic (PCOS) - Koinei te tino take.
• Te Whakarahirahitanga Rerekē Whetu (CAH) .
• Te mate a Cushing .
• Ngā pukupuku e huna ana i te androgen.
• Ētahi rongoā.

Nā, kia tirohia tātou ia take me ētahi atu taipitopito.

Te mate ovarian polycystic (PCOS)

I roto i ngā wāhine taitamariki me ngā wāhine kaumātua, ko te PCOS te tino take o te hyperandrogenism pumau i muri i te pakeketanga. I waenga i te 80% me te 90% o ngā wāhine e pāngia ana e te hyperandrogenism he PCOS anō hoki .

I roto i te PCOS, ka nui ake ngā androgens e whakaputaina ana e ngā ovaries nā te nui tonu o te LH me te insulin (hyperinsulinemia). Hei tāpiri, ko te pikinga o ngā taumata insulin ka aukati i te ate ki te whakaputa i tētahi pūmua e kiia nei ko te Sex Hormone Binding Globulin (SHBG) . Ka piki ake te taumata o te testosterone kore utu i roto i te toto.

Te hyperplasia adrenal whānau `(CAH)`

Ko te Congenital adrenal hyperplasia (CAH) he rōpū āhuatanga ira e pā ana ki ngā repe adrenal.

I roto i te CAH, ka puta he ngoikore o tētahi whākōkī e kiia nei ko te 21-hydroxylase nā ngā whakarerekētanga ira, e āwhina ana i te tinana ki te hanga homoni. I roto i te tini o te hunga whai CAH, ka puta he nui ake o ētahi atu homoni mai i ngā repe adrenal, pērā i te testosterone, nā tēnei ngoikore o te whākōkī.

Ko te tino take o te hyperandrogenism i roto i ngā wāhine he hyperplasia adrenal ehara i te mea tawhito . He āhuatanga tēnei e kore e tino kitea te whākōkī 21-hydroxylase. E pāngia ana e tēnei āhuatanga te 2% o ngā wāhine he hyperandrogenism.

Te mate a Cushing

Ko te mate a Cushing he momo mate e kiia nei ko te Cushing syndrome . He mate onge te Cushing syndrome e puta ana ina nui rawa te cortisol (he homoni anō hoki) i roto i te tinana.

Ko te mate a Cushing i puta mai i tētahi pukupuku ehara i te matepukupuku i roto i te repe pituitary. Ka huna e tēnei pukupuku te nui rawa o te ACTH (adrenocorticotropic hormone), e whakanui ana i ngā taumata cortisol.

Mā te nui rawa o te ACTH ka tukuna e ngā repe adrenal te nui rawa o ngā androgens, ā, koinei te take o te hyperandrogenism.

He maha atu anō ngā tohu o te mate Cushing:

• Ngā tohu totoro papura i runga i te puku.
• Te pikinga tere o te taumaha i te mata, te puku, me te kaki.
• Te toto toto tiketike.

Mena kei a koe ēnei tohu, he mea tino nui kia toro atu koe ki te tākuta i te wā e taea ai.

Ngā pukupuku e huna ana i te androgen

Ka taea e ētahi pukupuku repe adrenal, arā, ngā pukupuku i roto i ngā ovaries, i ngā testicles rānei, te whakaputa me te huna i ngā androgens. Nā tēnei ka nui ake ngā taumata androgen o te tinana i te mea noa. Ko te āhua o te hyperandrogenism e hua mai ana i ēnei pukupuku he tino kino, ā, ka puta ohorere mai .

He onge te hyperandrogenism, e puta mai ana i ngā pukupuku ovarian, adrenal rānei. Tata ki te 0.2% noa iho o te tangata ka pāngia. Heoi, ki te puta ohorere mai ngā tohu o te hyperandrogenism, me toro atu ki te tākuta tonu.

Ētahi rongoā

Ka taea hoki e ētahi rongoā te whakaputa i te hyperandrogenism. Ko ngā rongoā matua e hua ai tēnei ko:

• Ngā steroids anabolic-androgenic (he momo testosterone hangai ēnei, e whakamahia hētia ana e ētahi kaitākaro hei whakarei ake i te mahi).
• Ngā progestin hangai (he rongoā ēnei e puta ai ngā huringa i roto i te kōpū, ā, e whakamahia ana mō ngā momo mea).
• Ngā rongoā ārai mate haurangi ( ngā rongoā hei ārai i ngā hopukanga ).

Me pēhea te kimi i tēnei? (Tauātanga)

Mena he wahine koe, ā, e whakapae ana koe he hyperandrogenism tōu, ka tirotirohia e tō tākuta he tohu pēnei i te tupu o te makawe kāore e hiahiatia. Ka pātai atu hoki rātou ki a koe i ētahi pātai mō tō hītori hauora:

• Te tau ka tīmata te whanake o ngā ū.
• Ko te tau ka tīmata te puta o te makawe i te wāhi tūmataiti.
• Te tau i te paheketanga tuatahi.
• Ka tangohia e koe ngā huruhuru (ka heu koe, kua tangohia rānei ō huruhuru mā te whakamahi i te laser)?
• Kua whakamahia e koe ngā steroids anabolic, ngā testosterone rānei, me te kore he whakahaunga a te tākuta?
• Ngā mea pēnei i te auau o te paheketanga, te maha o ngā rā e roa ai, me te nui o te toto e toto ana koe.

Ki te whakapae tō tākuta kei te pāngia koe e te hyperandrogenism, ka tonoa e rātou he whakamātautau toto hei tirotiro i ētahi taumata homoni. Ka taea e ēnei whakamātautau te āwhina i te tautuhi i te mate.

He aha ngā momo whakamātautau e mahia ana?

Mena kei a koe ngā tohu o te hyperandrogenism, ka tono pea tō tākuta i ngā whakamātautau toto penei:

• Te testosterone katoaKa ine tēnei i te nui katoa o te testosterone i roto i tō toto. Tērā pea he paku teitei ake tēnei taumata i roto i ngā wāhine whai PCOS. Mēnā he tino teitei, tera pea he pukupuku kei roto i ngā ovaries, i ngā testicles rānei.
• Testosterone kore utu : Kāore tēnei testosterone e herea ki tētahi pūmua. He iti noa iho tēnei o te testosterone katoa. Tērā pea ka piki ake tēnei taumata i roto i ngā wāhine whai PCOS.
• Androstenedione : He homoni steroid tēnei, he iti noa te pānga androgenic ki te tinana. Heoi, ko te nuinga o te wā he takahanga waenga i te hanga o te testosterone me te estrogen i roto i te tinana. Mena he teitei ōna taumata, tera pea kei te kitea te PCOS.
• Te Dehydroepiandrosterone sulfate (DHEAS) : Ko te DHEAS he homoni ira tangata e hangaia ana e ngā repe adrenal. Nō reira, he tohu pai tēnei mō te hanga androgen adrenal. He mea noa mō ngā wāhine whai PCOS te piki haere o ngā taumata DHEAS. Mena he tino tiketike, he tohu pea tēnei mō te pukupuku adrenal.
• 17-hydroxyprogesterone : Ko te ine i te taumata o te 17-hydroxyprogesterone i roto i te toto he whakamātautau taketake hei tirotiro i te aroaro o te hyperplasia adrenal whānau-kore-tūturu, he āhuatanga e uru ana ki te hyperandrogenism.

I te mea he take kē atu pea mō ngā tohu o te hyperandrogenism, ka whakahau tō tākuta i ētahi atu whakamātautau toto hei whakakore i aua take.

Hei tāpiritanga, ka taea te whakahaere i ngā whakamātautau whakaahua pēnei i ēnei hei whakatau i te take o te hyperandrogenism:

• He whakamātautau oro-kanohi o te hope hei tirotiro mō ngā pukupuku ovarian (tētahi atu tohu o te PCOS) me ētahi atu puku rānei.
• Hei tirotiro i ngā pukupuku o te repe adrenal , ka whakahaerehia ngā whakamātautau CT scan (Computed tomography - CT) me te MRI scan (Magnetic resonance imaging - MRI) .

Ko te whāinga a ngā tākuta he whakaiti i te hanga androgen mai i ngā ovaries, i ngā repe adrenal rānei, he whakaiti i ngā taumata androgen kore utu, me te aukati i te mahi a te androgen.

Heoi, ko te hunga e pāngia ana e te hyperandrogenism ka rapu tohutohu hauora hei rongoā i ngā tohu matua, pērā i te tupu o te makawe kāore e hiahiatia, te hakihaki, me te paheketanga koretake.

He aha ngā maimoatanga mō tēnei?

Ko te maimoatanga mō te hyperandrogenism e whakawhirinaki ana ki te take. Hei tauira:

• Ka taea te whakahaere i te hyperandrogenism adrenal mā te whakamahi i ngā corticosteroids horopeta iti.
• Mena he pukupuku kei roto i ngā ovaries, ngā testicles, ngā repe adrenal rānei, me tango pea mā te pokanga. Mō ngā wāhine perimenopausal, menopause rānei e pāngia ana e te hyperandrogenism nui, me tango pea he oophorectomy (tango i tētahi, i ngā ovaries e rua rānei) .
• Mena nā te rongoā e tangohia ana e koe te hyperandrogenism, ka tūtohu tō tākuta kia mutu te rongoā, kia huri rānei ki tētahi atu rongoā.

He rongoā noa anō hoki ngā rongoā antiandrogen mō te hyperandrogenism. Ka āraihia e rātou ngā pānga o ngā androgens, pērā i te testosterone.

He maha ngā momo rongoā antiandrogen:

• Ngā ārai hapūtanga/pire whakahaere whānau kei roto ko te ethinyl estradiol (estrogen) me te progesterone antiandrogenic: Hei tauira, ko ngā pire kei roto ko te cyproterone acetate (hei tauira, Diane®-35), drospirenone (hei tauira, Yasmin®, Yaz®) dienogest rānei (hei tauira, Valette®). Ka taea e ēnei te rongoā i te hakihaki, te tupu o te makawe kāore e hiahiatia me te paheketanga koretake.
• Spironolactone (Aldactone®) : Ka rongoā tēnei antiandrogen i te hakihaki me te tipu o ngā makawe kāore e hiahiatia e hua mai ana i ngā homoni.
• Cyproterone : Ka āwhina tēnei rongoā ki te rongoā i te PCOS, ki te whakaheke i ngā taumata testosterone, me te whakaiti i te hanga hinu e puta ai te hakihaki.

Te rongoā i ngā tohu

Ko te hunga e pāngia ana e te hyperandrogenism ka rapu maimoatanga motuhake mō ā rātou tohu:

• Hakihaki : Ko ngā maimoatanga mō te hakihaki ko te whakamahi i ngā rongoā ā-waha, ngā paturopi ā-waha pērā i te tetracycline , ngā antiandrogens (tae atu ki te rongoā homoni, ngā pire ārai whānau), me ngā pire isotretinoin .
• Te tupu o te makawe kāore e hiahiatia (hirsutism) : He maha ngā wāhine e pāngia ana e te hirsutism ka whakamahi i ngā tikanga pēnei i te tango huruhuru, te heu, me te tango huruhuru laser. Tērā pea ka tango pire ārai whānau anō hoki rātou.
• Te paheketanga kore taurite : Ka taea e ngā wāhine te whakamahi i ngā tikanga whakahaere whānau homoni hei whakahaere i ō rātou huringa paheketanga.

Ki te kore ēnei tohu e pai ki ngā maimoatanga paerewa nā te kore taurite o ngā homoni, ka whakaarohia pea e tō tākuta ngā rongoā antiandrogen kaha ake.

Kāore e taea te ārai i tēnei?

Engari, kāore he huarahi mārama hei ārai i te hyperandrogenism.

Kāore anō kia whai huarahi kua whakamātauhia hei ārai i te PCOS, te tino take o te hyperandrogenism. Engari ka taea e koe te mahi i ngā mahi iti hei whakaiti i ō tohu. Hei tauira, te kai i tētahi kai totika,Mā te whakakori tinana auau me te whakahaere i tō taumaha ka āwhina i te whakaiti i ngā pānga o te PCOS me te hyperandrogenism.

He aha ngā mea ka puta i te heke mai? (Te Matapae)

He maha ngā āhuatanga e puta ai te hyperandrogenism me rongoā mō te wā katoa. I ētahi wā, ka tino heke te taumaha o ngā wāhine e pāngia ana e te hyperandrogenism nā te PCOS, ā, ka ngaro atu ō rātou PCOS. Heoi, ko te nuinga o te iwi me rongoā mō te wā katoa hei whakaiti i ngā tohu o te hyperandrogenism.

Ka pāngia tō whakaaro nui ki a koe anō me tō hauora hinengaro e ngā tohu o te hyperandrogenism. Mena kei te pāngia koe e te ahotea, te manukanuka, me te/ranei te pouri i ēnei tohu, he mea nui kia rapu āwhina koe i tētahi tohunga hinengaro, i tētahi kaiwhakatakoto whakaaro rānei.

Āhea ahau me toro atu ki te tākuta?

Mena kua tāpaetia koe he hyperandrogenism, ā, kei te tango rongoā koe mōna, me toro atu koe ki te tākuta i ia wā, kia mōhio ai kei te tika te mahi a tō maimoatanga.

Mena kei te pāngia tō hauora hinengaro e te hyperandrogenism, he mea nui kia kite koe i tētahi tohunga hinengaro, i tētahi kaiwhakatakoto whakaaro rānei mō te awhina.

Hei whakamutunga, he karere hei kawe ki te kāinga:

He mate noa te hyperandrogenism i waenga i ngā wāhine. Ka whakama koe, ka kore hoki e pai ki a koe ōna tohu. Engari kia maumahara, ehara i te mea ko koe anake, ā, ka taea te rongoā i tēnei mate. Kōrero ki tō tākuta mō ngā kōwhiringa maimoatanga. Waihoki, ki te pāngia tō hauora hinengaro, kia kite koe i tētahi tohunga hinengaro, i tētahi kaiwhakatakoto whakaaro rānei. Ko te tiaki i tō hauora te mea nui rawa atu.

` Te Hyperandrogenism, Androgen, Testosterone, PCOS, Hirsutism, Hakihaki, Tauritekore o ngā Hormone, Hauora o ngā Wahine, Tauritekore o ngā Hormone